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    Lactuloza

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    Raluca Elena Raluca Elena
    Lactulose (brand name Duphalac) is a synthetic sugar used to treat constipation and reduce ammonia levels in patients with liver disease. It works by drawing water into the colon through osmosis, which softens stool, and extracting ammonia from the bloodstream to be eliminated. Common side effects include gas, bloating, and abdominal discomfort. Lactulose is generally safe for use during pregnancy and breastfeeding when taken as directed.

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    Lactuloza

    Uploaded by

    Raluca Elena Raluca Elena
    191 views2 pages
    Lactulose (brand name Duphalac) is a synthetic sugar used to treat constipation and reduce ammonia levels in patients with liver disease. It works by drawing water into the colon through osmosis, which softens stool, and extracting ammonia from the bloodstream to be eliminated. Common side effects include gas, bloating, and abdominal discomfort. Lactulose is generally safe for use during pregnancy and breastfeeding when taken as directed.

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    Lactuloza

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    Lactulose (brand name Duphalac) is a synthetic sugar used to treat constipation and reduce ammonia levels in patients with liver disease. It works by drawing water into the colon through osmosis, which softens stool, and extracting ammonia from the bloodstream to be eliminated. Common side effects include gas, bloating, and abdominal discomfort. Lactulose is generally safe for use during pregnancy and breastfeeding when taken as directed.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    191 views2 pages

    Lactuloza

    Uploaded by

    Raluca Elena Raluca Elena
    Lactulose (brand name Duphalac) is a synthetic sugar used to treat constipation and reduce ammonia levels in patients with liver disease. It works by drawing water into the colon through osmosis, which softens stool, and extracting ammonia from the bloodstream to be eliminated. Common side effects include gas, bloating, and abdominal discomfort. Lactulose is generally safe for use during pregnancy and breastfeeding when taken as directed.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Lactulose (Duphalac): Best Laxative For

    Constipation
    Lactulose (Brand Name:Duphalac) is a synthetic sugar that is used to treat constipation.

    It breaks down in the colon in products that draw water from the body and into the colon. This
    water softens the stool.

    Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver
    disease. It works by extracting ammonia from the blood into the colon, where it is eliminated
    from the body.

    Duphalac Uses
    Duphalac is used in the treatment of

     Constipation
     Hepatic encephalopathy.

    The FDA approved lactulose in March 1976.

    Duphalac Mechanism Of Action


    In the colon the lactulose (Duphalac) is degraded mainly by the action of beta-galactosidase of
    the colon bacteria, which leads to an increase in osmotic pressure and a slight acidification of the
    large intestine to lactic acid and small amounts of formic and acetic acid. This in turn causes an
    increase in the water content of the stool and softens the stool.

    In the treatment of liver diseases (hepatic encephalopathy), it is believed that lactulose extracts
    ammonia from the body in the same way that it draws water into the colon.

    Duphalac Side effects


    Common side effect associated with the use of Duphalac include

     Belching,
     Flatulence,
     Abdominal discomfort (e.g.cramping).
     Dehydration and hyponatremiain infants.
     wind (farting and burping)
     feeling sick
     stomach pain
     vomiting
    While serious Side effect include

     Irregular heartbeat
     Severe diarrhoea or vomiting
     Muscle cramps or
     weakness

    Precautions
    Before taking Duphalac

     Tell your doctor and pharmacist what other medicines you are taking, in particular
    antacids, antibiotics such as neomycin and other laxatives.
     Tell your doctor and pharmacist if you are allergic to lactulose or any other medicines.
     Tell your doctor if you have diabetes or if you need a low-lactose diet.
     If you are having surgery or a test on your colon or rectum, tell the doctor that you are
    taking lactulose.

    Duphalac in pregnancy
    Lactulose is usually taken during pregnancy and while breast-feeding.

    Duphalac Dosage
    Normal dose for constipation:

    The usual dose for adults and children 14 years of age is between 15 ml and 45 ml once or twice
    daily. This dose can be reduced to 15 ml to 30 ml once or twice a day after starting work.

    The usual dose for children aged 7 to 14 years is 15 ml once or twice a day; This dose can be
    reduced to 10 ml to 15 ml once or twice a day after starting work.

    The usual dose for children aged 1 to 6 years (under the supervision of a doctor) is between 5 ml
    and 10 ml once or twice daily

    And the dose for babies under 1 year (only under medical supervision) is up to 5 ml once or
    twice a day

    For Hepatic encephalopathy

    In adults with hepatic encephalopathy the normal dose is between 30 ml and 45 ml 3 to 4 times
    daily.

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