Abstract Book

ABSTRACT BOOK
A Seminar on
Innovative practices in Pharmaceutical Sciences and Technology
Shri Vivek Shukla

Director
Krishnarpit Group of Institutions, Allahabad
M ASSAGE
It gives me immense pleasure to know that Krishnarpit institute of Pharmacy, Allahabad

is going to organize a National seminar on “Innovative practices in Pharmaceutical Sciences and
Technology on the occasion of National Pharmacy Week 2016”. Krishnarpit institute of
Pharmacy, Allahabad is a courageous and innovative pace in the dynamic process of training the
present generation of pharmacy graduates. The four year full time B. Pharmacy programme of
Krishnarpit institute of Pharmacy, Allahabad, Affiliated to Dr APJ Abdul Kalam Technical
University, (AKTU), Lucknow and Approved by All India Council of Technical Education
(AICTE), New Delhi and Pharmacy Council of India (PCI) aims at blooming the buds of
aspiring young graduates into competent, hardcore and dedicated professionals.
We have created an ambience of latest infrastructure to promote interactive teaching-

learning process. We are proud of our excellent faculty members having adequate academic and
industrial experience who ensure confidence, creativity and competence in perfect development
of young minds. I express my sincere thanks to all faculty, staff and students and I am confident
that we will rise to the future challenges in our quest for excellence and achieve greater heights
in the years ahead.
I congratulate the entire organizing team for their sincere efforts for organizing such a
wonderful scientific event and wish them a grand success.
Krishnarpit Institute of Pharmacy, Allahabad

A Seminar on
Prof. (Dr) Amita Verma

Professor
Christian School of Pharmacy, SHIATS-DU
M ASSAGE
It gives me great pleasure to know that Krishnarpit institute of Pharmacy, Allahabad is

going to organize a National seminar on “Innovative practices in Pharmaceutical Sciences and
Technology”.
I believe that the seminar will provide a right forum for extensive interaction of the
participants and also exchange of ideas and sharing the experience between the experts from the
academics as well as industrial and research institutions in light with current trends of
Pharmaceuticals research and its future prospects.
I congratulate the entire organizing team for their efforts for organizing a wonderful
scientific event and wish them all the success.

A Seminar on
Dr. Raghvendra Raman Mishra

Medical Lab. Technology,
DDU Kaushal Kendra RGSC
Banaras Hindu University, Varanasi
M ASSAGE
We are in the era of scientific revolutions, where we can explore innumerable means to
upgrade our knowledge. This seminar “Innovative practices in Pharmaceutical Sciences and
Technology” organized by Krishnarpit institute of Pharmacy, Allahabad, provides a platform to
discuss and discover the new techniques to overcome the loopholes in education system and
upgrade oneself within the arena of sciences. It is a journey to discover and analyze the strengths
and weaknesses of different approaches to leverage the full potential of this emerging branch
through innovative approaches.
Pharmacy profession is equally holding the responsibility in making society healthy.
Thus up gradation in particular skills and overall development has provided immense
possibilities to improve upon existing education system and enjoy the novelty, practical and
research technicality and improving education systems.
I hope that this seminar will address not only the basic developments, but also the know
how required to successfully introduce and explore the latest technique which will create a huge
market for the pharmacy professionals.
I wish the seminar a grand success.

A Seminar on
Shri Jay Mishra

Administrative Officer
KGI, Allahabad
M ASSAGE
It gives me immense pleasure to welcome you all to the National seminar on “Innovative
practices in Pharmaceutical Sciences and Technology” being organized by Krishnarpit institute
of Pharmacy, Allahabad on 18-19th November, 2016. I extend my heartiest welcome to all the
participants. I am sure the interactive deliberations by the resource personnel as well as the
scientific poster presentations by the delegates will unlock a new horizon of exploration and
developments in the field of Pharmaceutical Sciences and Technology.
I express my heartiest thanks to the entire team of Krishnarpit institute of Pharmacy,
Allahabad and well wishers for their support without which it would have been impossible.

A Seminar on
Shri M. P. Singh
Associate Prof. & Head
M ASSAGE
“Innovative practices in Pharmaceutical Sciences and Technology” organized by

Krishnarpit institute of Pharmacy, Allahabad is a seminar which has been planned with the
common goal of advancing education system, upgrading knowledge, innovation in research
techniques for the upgradation of pharmacy educational systems . The vision of the seminar is to
meet emerging scope and developments, need to upgrade skills and competence of pharmacist
through the smart learning. We hope that this seminar will provide a platform to upgrade the
knowledge of budding pharmacist comprise interactive scientific sessions with the expert’s
views on the technicality, quality, and regulatory considerations of education systems in current
scenario. At last I believe, through this seminar we could expand the knowledge for over
development, innovate teaching techniques for better and smart understanding.
We look forward to welcoming you and hope that you profit from the scientific sessions.

A Seminar on
(Dr) Parjanya Kumar Shukla

Organizing Secretary
Coordinator
Dear distinguished delegates and guests.

It's a great pleasure to welcome you all at National Conference on “Innovative practices
in Pharmaceutical Sciences and Technology” organized by Krishnarpit institute of Pharmacy,
Allahabad during November 18th -19th, 2016. In today’s modern era innovative approach of
learning and exposure to latest techniques opens new way to uphold the responsibilities and
make society healthy.
The theme of this seminar seems to be quite appropriate and matches the present scenario
of developing pharmaceutical education and research. The basic idea of holding such a
conference is to bring the academicians, researchers, industry leaders, pharma consultants,
experts and students on a common platform to discuss about the recent advances in system to
serve the humanity with through discovery and development of safe and effective drugs
medicines.
I am certain that the scientific discussions and deliberations will generate new concept
and ideas for the betterment of pharmaceutical education and go a long way in the empowerment
of each and every one associated with these professions. Wishing very best for the huge success
of the conference.

A Seminar on
SCHEDULE OF DATE 19th November 2016
Registration 9:00 AM – 10:00

Inaugural Function Light and lamp 10:00 AM –10:10
:
Sarshwati Vandana 10:10 AM– 10:20
:
Welcome 10:20 AM –10:25
:
Introductory Remark Mr. M. P. Singh 10:25 AM– 10:30
Welcome : HOD, Associate Prof.
Inaugural Prof. (Dr) Amita Verma 10:30 AM – 10:40

Blessing: Professor, Dept. of Pharm. Sci.
SHIATS-DU, Allahabad
Presidential Address : Mr. Vivek Shukla 10:40 AM – 10:50

Director
Krishnarpit Group of Institutions, Allahabad
Vote of Thanks : (Dr.) Parjanya Kumar Shukla 10: 50 AM - 11:00

Coordinator, Asst. Prof. KIP
Organizing Secretary
Invited Address 1: Dr. Amita Verma 11:20 AM-12:00PM

Pharmaceutical Sciences and Professor Dept. of Pharm. Sci
chemistry SHIATS-DU, Allahabad
Invited Address 2: Dr. Raghvendra Raman Mishra 12:00 PM-12:45

Pharmaceutical Biotechnology Medical Lab Technology
DDU Kaushal Kendra, RGSC
Banaras Hindu University
Poster Session : 12:50 PM-01:20
Certificate distribution Vote of Thanks & Valedictory 01: 20 PM onwards

A Seminar on
Invited Lecture
Drug Discovery & Development Concepts and Approaches
Amita Verma
Department of Pharmaceutical Sciences, FHS, SHIATS-DU, Allahabad
Abstract
Only one in 10,000 potential compounds investigated gets regulatory approval, which in turn takes
efforts of about 15 years and involved R&D expenditure of $1 billion. From here we can assume the
current scenario of developing country like India in drug discovery. In the period of post independency
(up to 1970) several investments had taken place in R&D by private and public sector which had been
demoralized by the application of “the patent act of 1970”.Till 1995 due to lack of product patent
regiment even in Indian majors like Ranbaxy, Dr. Reddy’s spend only 2.35% sale in 1992-93, where 15-
30% by western. The year when TRIPS come into effect there was a moderate increase in R&D. The
analysis of R&D expenditure of pharmaceutical firms’ shows that there had been a growth in the R&D
intensity since 2000-01, but this begin decline or stagnate after 2005-06. Although Govt. Research
institute like CDRI, CSIR, IICT, NIPERs established to aid the drug development and research individually
or in collaboration with private Pharmaceutical Company, still India has stayed away from drug
discovery or out licensed the molecule to large global companies in the early phase of development due
to late entry into the New Chemical Entities (NCEs) research and lack of expertise essential for modern
day drug development and financial resources. Foreign investment and technology collaborations, tax
obligations, exemptions from drug price regulation and product patent rights to pharmaceutical
innovations are needed to reform new drug discovery process in India.

A Seminar on
Invited Lecture
Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model

Raghvendra Raman Mishra
Medical Lab. Technology, DDU Kaushal Kendra RGSC, Banaras Hindu University, Varanasi
Abstract
Methicillin resistant Staphylococcus aureus (MRSA) are the commonest cause of osteomyelitis.
The aim of this study was to evaluate the role of an alternative therapy i.e. application of S.
aureus specific bacteriophages in cases of osteomyelitis caused by MRSA in animal model.
Twenty two rabbits were included in this study. The first two rabbits were used to test the safety
of phage cocktail while the remaining 20 rabbits were divided into three groups; group A (n=4)
to assess the establishment of osteomyelitis; group B (n=4) osteomyelitis developed but therapy
started only after six weeks; and group C (n=12) osteomyelitis developed and therapy started
after three weeks. Groups B and C rabbits were treated with four doses of cocktail of seven
virulent bacteriophages at the interval of 48 h. Comparison between three groups was made on
the basis of observation of clinical, radiological, microbiological, and histopathological
examinations.Experimental group rabbits recovered from the illness in the subsequent two weeks
of the therapy. Appetite and activity of the rabbits improved, local oedema, erythema and
induration subsided. There were minimal changes associated with osteomyelitis in X-ray and
histopathology also showed no signs of infection with new bone formation. Control B group
rabbits also recovered well from the infection.The present study shows a potential of phage
therapy to treat difficult infections caused by multidrug resistant bacteria.

A Seminar on
Review on Nicotine Originated (Active and Passive Diseases at 21century)
Ramesh Patel1, Mahendra Pratap Singh1, Parjanya Kumar Shukla, 1&2 Sudeep Sharma1
1
2
Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom
Institute of Agriculture,Technology & Sciences, Allahabad, India
Abstract
Nicotiana tobacum (Solanacae) plant is very easily available in Indian environment. Nicotianas
are highly toxic plants due to their nicotine. Tobacco plants are also used in plant bioengineering,
and some of the more than 70species are grown as ornamentals. The chemistry of tobacco is
unique with the presence of a wide spectrum of chemical compounds of which nicotine,
solanesol, malic and citric acid were identified as potential chemicals which could be recovered
and converted to value-added products. The effects of nicotine alkaloid are a result of the
summation of actions at ganglionic sites, motor end plates and smooth muscle. The central
nervous system is affected, initially by stimulation, resulting in tremors and convulsions,
progressing to depression. Mostly death rate occurs from respiratory failure. Recent time death
rate occurs use of tobacco at world level by WHO information about 6.0 million population and
in India about 1.5 million population by various tobacco originated disease including 30%
cancerous disease ( By use of Tobacco in form of Cigrate, Pan, Tambacu and various other
Tobacco prepared products).

A Seminar on
Fast Dissolving Oral Films Used As Oral Drug Delivery System
Md Amir1, Faisal Saeed1, Md Zishan1, S.P.Singh1, Suhail Ahmad2, M.P Singh3,

1
Department of Pharmaceutics Integral University Lucknow
2
Department of Pharmacoylogy Integral University Lucknow
3
Krishnarpit Institute of Pharmacy Allahabad
Abstract
Over the past few decades, there has been increased interest for innovative drug delivery system
to improve the safety, efficacy and patient compliance, thereby increasing the product patent
life cycle. In the recent years, many of the pharmaceutical groups are focusing their research on
rapid dissolving technology. Fast dissolving oral films are the most advanced form of oral solid
dosage form due to more flexibility and comfort Fast dissolving oral films are useful in patients
such as paediatric, geriatric, bedridden or developmentally disabled who face difficulty in
swallowing conventional tablets or capsules and liquid orals or syrups leading to ineffective
therapy. The delivery system consists of a very thin oral strip, which is simply placed on the
patient’s tongue or any oral mucosal tissue, instantly wet by saliva the filmrapidly hydrates and
adheres onto the site of application. Fast dissolving oral films are found to be satisfactory in
many situations like allergic conditions, cold and cough, sore throat, nausea, pain, mouth ulcers,
CNS disorders and CVS disorders. Oral film includes various ingredients for its formulation
which includes polymers, active pharmaceutical ingredient, film stabilizing agents, plasticizers,
sweeteners, flavours, colors, saliva stimulating agents, surfactants etc. However, for future
growth point of view the fast dissolving oral films sector is well-positioned. It seems that the
value of the overall oral thin films market will grow significantly.

A Seminar on
Design and In Vitro Characterization of Novel Pulsatile Drug Delivery System of Anti-
Diabetic Drug
Rahul Pandey1*, W. Selvamurthy1

Amity Institute of Pharmacy, Amity University,
Noida, Uttar Pradesh, India
Email: rahulpandey.rp@gmail.com
Abstract
The current work emphasize on development of pulsatile capsular pellets of metformin hydrochloride. It
was characterized by complete release of the drug in pulses after well-defined lag time of 6 h (± 0.20)
(period of no drug release) for the treatment of diabetes mellitus. The novel drug delivery system
consisted of HPC Type H as lag time modifier, and Eudragit L-100 and Eudragit S-100 in different
concentration as pH dependent release modifier in gastrointestinal tract. The pellets were subjected to in
vitro release studies using USP dissolution apparatus- II in distilled water, phosphate buffer of pH 6.8
and 0.1 N HCL and methanol. U.V, I.R. were done for API and formulations

A Seminar on
Epigallocatechin-3-Gallate: Compound help you to Be young and healthy

Gaurav Pandey* Parjanya Kumar Shukla
Krishnarpit Institute of Pharmacy
Allahabad
Abstract
The compound (−)-epigallocatechin-3-gallate.(EGCG) is the major catechin found in greentea
[Camellia sinensis L. Ktze. (Theaceae)]. This polyphenolic compound and several related
catechins are believed to be responsible for the health benefits associated with the consumption
of green tea. The potential health benefits ascribed to green tea and EGCG include antioxidant
effects, cancer chemoprevention, improving cardiovascular health, enhancing weight loss,
protecting the skin from the damage caused by ionizing radiation, and others. The compound
EGCG has been shown to regulate dozens of disease-specific molecular targets. Many of these
molecular targets are only affected by concentrations of EGCG that are far above the levels
achieved by either drinking green tea or consuming moderate doses of green tea extract-based
dietary supplements. In spite of this, well-designed double-blinded controlled clinical studies
have recently demonstrated the efficacy of green tea extracts and purified EGCG products in
patients. Therefore, this review highlights results from what the authors believe to be some of the
most clinically significant recent studies and describes current developments in the
stereoselective total synthesis of EGCG.
The polyphenolic compound (−) epigallocatechin-3-gallate (EGCG) is the major catechin found
in green tea and is thought to impart many of the health benefits attributed to this beverage. The
latest clinical studies have supported some of the potential health benefits of consuming green
tea and EGCG. The results from significant clinical studies and the most recent work in the area
of stereoselective EGCG synthesis are described in this presentation.

A Seminar on
Hybrid 4-aminoquinoline bridged substituted 1,2,4 Triazole: Future Prospect to overcome

microbial resistance.
Anjali Thakur1
1
Institute of Pharma Sciences, Chandigarh University, Punjab
Email ID:anjalipharma07@gmail.com
Abstract
In previous decades, the human population affected with lethal contagious diseases caused by
multidrug resistant gram-positive and gram-negative pathogenic bacteria. Drug resistance
enlarged to an alarming level around the world and one of the major causes of death. During the
past 60 years, various other antibiotics have been used. The antibiotics developed not just to treat
human infectious diseases, but also their property used in veterinary, plant agriculture and
aquaculture. Extensive use has created a robust discerning burden, which unswervingly has
resulted in thespreading of resistant bacteria, the advent of resistance had shown multifaceted
mechanisms by which resistance genes spread across the bacterial demesne, with deceptive
disregard for species barriers. But the bacterial evolutionary response has not been restricted to
the acquisition of resistance of genetic factor. Merging of two or more heterocyclic ring makes
molecule more competent and pharmacological dynamic. Quinoline, heterocyclic ring, is a very
important moiety of various antibacterialagents like ciprofloxacin, ofloxacin, norfloxacin etc.
The 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities
such as antimicrobial, analgesic, anti-inflammatory, anticancer andantioxidant properties. Some
of the current day drugs such as Ribavirin (antiviral agent), Rizatriptan(antimigraine agent),
Alprazolam (anxiolytic agent), Fluconazole and Itraconazole (antifungal agents) are
thepreeminent examples for potent molecules possessing triazole nucleus.Here in present
communication weclubbed 1,2,4 triazole with 4-aminoquinoline using aliphatic bridge for
development towards novel andproficient antibacterial agent.

A Seminar on
Anti Cancer Activity of Cannabis In Breast Cancer
Akanksha Gupta*1, Abhishek kumar Tripathi2

1
Department of Pharmaceutical Chemistry, Krishnarpit Institute of Pharmacy, Ghoorpur,
Allahabad (U.P.) India.
2
Department of Pharmacology, United Institute of Pharmacy, Naini, Allahabad
Abstract
INTRODUCTION: Breast cancer is a very common disease that affects approximately 10

percent women at some point in their lives. CBD's anti-tumorigenic activity was analyzed
against highly aggressive breast cancer cell lines including TNBC subtype. It was shown for the
first time-that CBD significantly inhibits epidermal growth factor (EGF)-induced proliferation
and chemotaxis of breast cancer cells.
MECHANISM OF ACTION: In the present study, CBD's anti-tumorigenic activity against

highly aggressive breast cancer cell lines including TNBC subtype was analyzed. It was
observed that CBD significantly inhibits epidermal growth factor (EGF)-induced proliferation
and chemotaxis of breast cancer cells. Further studies revealed that CBD inhibits EGF-induced
activation of EGFR, ERK, AKT and NF-kB signaling pathways as well as MMP2 and MMP9
secretion.
CONCLUSION: These results suggest CBD as a potent anti-tumor drug with anti-proliferative,
anti-migratory, and anti-invasive properties. These results also suggest a cross-talk between
EGFR and one of the receptors that CBD acts on. Furthermore, CBD has a tumor
microenvironment modulating property which suggests an important role of CBD receptors on
changing the cytokine profile within the tumor microenvironment. This study advocates the use
of CBD in breast cancer patients especially those with highly aggressive and metastatic cancer
cells including TNBC patients, and those who have resistance to conventional EGFR therapy.
SUMMARY: These finding shows that CBD can suppress the activation of EGF/EGFR
signaling transduction pathway and its downstream targets AKT, ERK and NF-kB. It is likely
that CBD, through acting on its receptors, changes the cytokine secretion of cancer cells.

A Seminar on
Insulin used to Diabetic Therapy
Princee kesarwani*, Ramesh Patel, P.K. Shukla
Krishnarpit Institute of Pharmacy ,Ghoorpur Allahabad
Abstract
Insulin was discovered in 1921 by Banting and Best who demonstrated the hypoglycemia
action of an extract of pancreas prepared after degeneration of the exocrine part due to ligation
of pancreatic duct . The insulin are mainly obtain of the animal ,like dogs and pigs and second
one is the beta-cell of pancreas islet in human .
Increase of the glucose in the blood and decrease of the insulin in the body for formation
of beta-cell, is also known as diabetes . Diabetes are also divided into two types that is - Type 1
diabetes ( Insulin Dependent Diabetes Mellitus / IDDM ),and Type 2 diabetes (Non Insulin
Dependent Diabetes Mellitus / NIDDM) .Patient with type 1 diabetes mellitus (DM) require
lifelong insulin therapy . Most require two or more injection of insulin daily ,with doses adjusted
on the basis of self-monitoring of blood glucose level .

A Seminar on
Comparing Ancient Ayurvedic Literature Claims with Modern Pharmacological Findings:

A case of Sarasvata Churna
Rahul Kaushik1*, Jainendra Jain1, Avijit Majumdar2, Akanksha Gupta3

1
Ram-Eesh Institute of Vocational & Technical Education, Greater Noida, 201308.
2
Department of Pharmacy, Noida Institute of Engineering & Technology, Greater Noida.
3
Krishnarpit Institute of Pharmacy, Allahabad.
In Ayurveda a number of synonyms have been assigned to the word Buddhi such as
Prajna, Smriti and Jnana. According to Charaka it is related to the aspects of Dhi, Dhriti, and
Smriti. Dhi means the perception of true knowledge, while Dhriti refers to the power of
controlling the mind and Smriti refers to recalling the past experiences. In Shabdhakalpadruma,
Medha is a type of Buddhi which has power of retaining knowledge for a long period. According
to Vacahspatya it is a type of knowledge which is retained for long period and will not be
forgotten. According to Charaka, Medha is a type of Dhi having the power of retention of
knowledge. According to Sushruta, Medha is meaning of perception and retention power of
knowledge of the text. According to Vagbhata Medha is the faculty of Buddhi. Ayurveda
prescribes Medhya Rasayana therapy for epilepsy and other brain disorders. Nidanparivarjan,
Shodhanchikitsa, Bahiparimarjan, Rasayanachikitsa, Sattvavajaya and Avasthikachikitsa.
Rasayana chikitsa is preferred for long term management of epilepsy which involves the use of
Medhya Rasayana which is a collection of herbs like Mandukparni, Yastimadhu, Guduchi,
Tinospora, Ashwagandha, Shankhpushpi, Vacha, Brahmi etc.
Sarasvata Churna, a Medhya rasayana mentioned by Bhavaprakasha, is a compound

preparation, contains Kushta, Ashwagandha , Lavana, Ajamoda , Jeeraka , Krishna Jeeraka ,
Pippali, Maricha, Shunti, Patha, Shankapushpi, Vacha, which is triturated with Brahmi Swarasa.
Specially mentioned to promote the Buddhi, Medha, Dhriti, Smriti & Kavitashakthi and being
prescribed by some Ayurvedacharyas for management of Apasmara(epilepsy).
Modern pharmacological findings through various in-vitro and in-vivo experiments show
that Kustha posses antioxidant and antiepileptic potential through GABAergic mechanism
whereas Ayuveda claims it to be a Vatahara (relieves abdominal discomforts). Ashwagandha has

A Seminar on
Ayurvedic Preparations in Modern Time
Anupam Srivastava*1
1
Institute of Medical Sciences, BHU,
Varanasi, U.P.
Rasayan properties whereas pharmacological studies proved it to posses Neuroprotective,

neuroregenerative and modulates GABAergic functions. Ajamoda, Krishna Jeeraka and Lavana
are Vatahara as per Ayurvedic literatures whereas research confirms their antioxidant and
antiepileptic properties in various models. Jeeraka is Medhya in nature which is also confirmed
by its anticonvulsant activities in scPTZ and MES models. Shankhpushpi is best among Medhya
rasayanas and pharmacological studies confirmed its antioxidant, anticonvulsant and
neuroprotective role. Brahmi is Medhya, Smritiprada and Rasayani as per Ayurved. Research
confirmed the antioxidant effects of Brahmi on antioxidant enzymes in the brain and its potential
to inhibit seizures in MES model. Vacha is Buddhi Smritida and Medhya which is also
confirmed by its antioxidant and antiepileptic activities in Pilocarpine, MES and INH induced
seizure models. Patha is mentioned to be utilized for improving Intellect and conquering
opponents during debates but studies shows that it acts by increasing the activities of antioxidant
enzymes in brain. It also exhibits Nootropic and hepatoprotective potential. Drugs like Peepli
and Maricha are rasayana and here also modern findings proved them to help in enhancing
bioavailability and also shows antioxidant and antiepileptic potential.

A Seminar on
Natural Products Used As Hepatoprotective Agents
Sahar Idris1, Md Khustar1, Nazma Khan1, Md Zishan2,Zeeshan Ahmad2
Department of Pharmacology1 Integral University Lucknow

Department of Pharmaceutics2 Integral University Lucknow
Abstract
Liver diseases are a major universal health problem, with high endemicity in developing
countries. They are mainly caused by chemicals and some drugs when taken in very high doses.
Despite advances in modern medicine, there is no effective drug available that stimulates liver
function, offer protection to the liver from damage or help to regenerate hepatic cells. There is
urgent need, therefore, for effective drugs to replace/supplement those in current use. The plant
kingdom is undoubtedly valuable as a source of new medicinal agents. The p resent work
constitutes a review of the literature on plant extracts and chemically defined molecules of
natural origin with hepatoprotective activity. The review shows 107 plants, their families,
geographical distribution, plant parts utilized, type of assay and inducer of liver damage. It also
includes 58 compounds isolated from higher plants, classified into appropriate chemical groups.
This work intends to aid researchers in the study of natural products useful in the treatment of
liver diseases.

A Seminar on
Diabetic Retinopathy
Anjali Gupta, Ramesh Patel, P.K. Shukla
Krishnarpit Institute of Pharmacy , Allahabad
Abstract
Diabetic retinopathy remains a frightening prospect to patient and frustrates physician .
Destruction of damaged retina by photo-coagulation remains the primary treatment nearly 50
years. Diabetes retinopathy and diabetes molecular edema (DME) are leading cause of blindness
in the working age population of most developed countries .
The increasing number of individual with diabetes worldwide suggest that DR and DME will
continue to be major contributors to vision loss and associated functional impairment for year to
come increase the control of diabetes associated metabolic abnormalities (i.e. Hyperglycemia,
Hyperlipidemia, Hypertension) my project’s aim is to detect the symptoms of diabetes,
diagnosis and treatment of diabetes retinopathy.

A Seminar on
Vesicular Drug Delivery Systems: A Novel Approach For Drug Targeting
Md Zishan1, Poonam Kushwaha1, Kuldeep Singh1, Vaseem Ansary1, Zeeshan Ahmad1 ,Meena
Singh2
1
Department of Pharmaceutics Integral University, Lucknow
2
Krishnapit Institute of Pharmacy, Allahabad
Abstract
The application of vesicular system in drug delivery has changed the definitions of diagnosis and
treatment in different aspects of biomedical field. Novel drug delivery system aims to deliver the
drug at a rate directed by the needs of the body during the period of treatment, and channel the
active entity to the site of action. The vesicular system as liposomes, niosomes, sphinosomes,
transferosomes and pharmacosomes are used to improve the therapeutic index of both existing
and new drug molecules by encapsulating an active medicament inside vesicular structure in one
such system. It prolong the existence of the drug in systemic circulation and finally reduce the
toxicity. Such different systems are widely used in gene delivery, tumor targeting to brain, liver
targeting.oral formulations, in stability and permeability problems of drugs. In this review we
really focused on different aspects of vesicular system in terms of its advantages, limitation,
application and different marketed product of vesicular system as novel drug delivery.

A Seminar on
An Introduction To Greener Way Of Synthetic Chemistry : 'Green Chemistry’
Ayushi Kushwaha, Parjanya Kumar Shukla
Abstract
Over the past few years, the idea of chemistry has been mobilized to develop new techniques that
are less hazardous to human health and the environment. This new approach has received
extensive attention and goes by many names including Green chemistry, Environmentally
Benign chemistry and clean chemistry. Green chemistry with 12 principles would like to see
changes in the conventional ways that used for decades to make synthetic organic chemical
substances and the use of less toxic starting materials . By changing the methodologies of
organic synthesis health and safety will be advanced in the small scale laboratory level but also
will be extended to the industrial large scale production processes through the new techniques.
Green chemistry would like to increases the efficiency of synthetic methods, to use less toxic
solvents, reduce the stages of synthetic routes and minimize waste as far as practically possible.
In this way, organic synthesis will be part of the effort for sustainable development. In this
presentation I am going to discuss about 12 principles of green chemistry with their examples
and their impact in present and future organic synthetic chemistry.

A Seminar on
Phytosome Used As A Novel Drug Delivery System For Herbal Medicine

Nazma Khan1,Sahar Idris1,Sahla Paeveen1,Sana Farooqui1,Meena Singh2
1
Faculty of Pharmacy Integral University Lucnow
2
Krishnarpit Institute of Pharmacy Allahabad
Abstract
The term “phyto” means plant while “some” means cell-like. Phytosomes are little cell like
structure. This is advanced forms of herbal formulations which contains the bioactive
phytoconsituents of herb extract surrounds and bound by a lipid. Most of the bioactive
constituents of phytomedicines are water-soluble compounds like flavonoids, glycosides;
terpenoids in which flavonoids are a major class of bioactive compounds possesses broad
therapeutic activities. Because of water soluble herbal extract and lipophilic outer layer
phytosomes shows better absorption and as a result produce better bioavailability and actions
than the conventional herbal extracts containing dosage form. They are produced by a patented
process whereby the standardized plant extract or its constituents are bound to phospholipids,
mainly phosphatidylcholine, producing a lipid compatible molecular complex. This phyto-
phospholipid complex (phytosome) resembles a little cell. Phytosomes exhibit better
pharmacokinetic and pharmacodynamic profile than conventional herbal extracts. Phytosome
technology has been effectively used to enhance the bioavailability of many popular herbal
extracts including milk thistle, ginkgo biloba, grape seed, green tea, hawthorn, ginseng etc and
can be developed for various therapeutic uses or dietary supplements.

A Seminar on
Computers in Pharmaceutical Sciences and Research

Sudeep Kumar Sharma, Parjanya Kumar Shukla
Krishnarpit Institute of Management and Technology, Allahabad
Abstract
Computer is compulsory in this highly developed era and pharmacy and related subjects are not
exception to it. This review mainly focuses on the various applications, softwares and use of
computers in pharmacy. Within the pharmaceutical industry we have progressed from the point
where computers in the laboratory were rarely present or used beyond spreadsheet calculations.
Now computers are ubiquitous in pharmaceutical research and development laboratories, and
nearly everyone has at least one used in some way to aid in his or her role.. Computer
significantly reduces the time, expenditure, and manpower required for any kind of work.
Development of various software makes it trouble-free to handle huge data. In short, computers
are playing critical role in pharmacy field, without computers pharmacy research will be long-
lasting and expensive.

A Seminar on
Role of Free Radicals in Breast Cancer
Zeba Parveen1, Zeeshan Ahmad2, Azeemuddin3

1
Department of Bioscience, Faculty of Science, Integral University, Lucknow
2
Department of Pharmaceutics, Faculty of Pharmacy, Integral University, Lucknow
3
Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow
E-Mail:- zebap2086@gmail.com
Abstract
Free radical defined as an atom or molecule containing one or more unpaired electrons in
valence shell or outer orbit and is capable of independent existence. Because of non-bonding
electrons, free radicals have affinity to react with other compounds and act as electron acceptors
or oxidizing agents. Main oxidants include reactive oxygen species (ROS), nitrogen (RNS),
chloride (RCS) and sulfur. The most important antioxidant and major cause of oxidative damage
to the body’s biomolecules is ROS. ROS plays an important role in the formation of reactive
species such as RNS. Free radicals cause different types of chemical changes in DNA; therefore
they could be mutagenic and involved in etiology of cancer. In comparison to normal cells,
cancer cells have higher levels of ROS and more susceptible to mitochondrial dysfunction due to
their higher metabolic rate. Cancer cells display elevated levels of oxidative stress due to
activation of oncogenes and loss of tumor suppressors. ROS altered the growth signals and gene
expression cause continuous proliferation of cancer cells. ROS damage to the breast epithelium
lead to fibroblasts proliferation, hyperplasia of epithelium, cellular atypia and breast cancer.
Majority of breast carcinomas the oxidative stress induced by over expression of thymidine
phosphorylase enzyme which catabolizes thymidine to thymine and 2-deoxy-D-ribose-1-
phosphate; the latter is a powerful reducing sugar that rapidly glycates proteins, generating
oxygen radicals inside the carcinoma cell. Another breast specific mechanism of oxidative stress
induction involves a mammary gland specific lactoperoxidase enzyme catalyzed one electron
oxidation of 17-β-oestradiol to a reactive phenoxyl radical.

A Seminar on
Alzheimer’s Disease: Targeting Through Intranasal Route
Zeeshan Ahmad1, Zeba Parveen2, Md. Zishan1, Mohammad Amir1

1
Department Of Pharmaceutics, Faculty Of Pharmacy, Integral University, Lucknow
2
Department Of Bioscience, Faculty Of Science, Integral University, Lucknow
E-Mail:- zeeshanahmad2086@gmail.com
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by severe

cognitive impairments. Major histopathological hallmark of AD is presence of amyloid deposits
in the parenchyma of the amygdala, hippocampus, and neocortex. β-amyloid is small piece of a
larger protein called “amyloid precursor protein” (APP). The main component of amyloid is β-
Amyloid protein (Aβ), a 39.43 amino acid peptide composed of a portion of the transmembrane
domain and the extracellular domain of APP. Aβ deposition leads to synaptic degeneration and
interacts with different types of CNS receptors; hence, it disrupts neuronal homeostasis.
Moreover, Aβ deposition along the cerebral vessels alters their tonicity and triggers some of the
cerebrovascular deficits. Furthermore, its accumulation disrupts intracellular Ca2+ homeostasis
which ultimately reduces neuronal Ca2+ buffering capacity and increases excitotoxicity
outcomes. The emerging approach is bypassing the BBB by intranasal delivery, which provides a
practical, noninvasive, rapid and simple method to deliver the therapeutic agents to the CNS.
This method works the unique connection between the nose and the brain that has evolved to
sense odors and other chemical stimuli. On the basis of clinical trials (Phase I and II) it is
reported that the intranasal route is feasible for the transport of drug to CNS. Intranasal delivery
does not require any modification of the therapeutic agents and does not require that drugs be
coupled with any carrier like in case of drug delivery across the BBB. A wide variety of
therapeutic agents, including both small molecules and macromolecules can be successfully
delivered, including to the CNS, using the intranasal method.

A Seminar on
Innovative practices in PharmaceUTical Sciences and Technology

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ABSTRACT BOOK

Shri Vivek Shukla

It gives me immense pleasure to know that Krishnarpit institute of Pharmacy, Allahabad

We have created an ambience of latest infrastructure to promote interactive teaching-

Krishnarpit Institute of Pharmacy, Allahabad

Prof. (Dr) Amita Verma

It gives me great pleasure to know that Krishnarpit institute of Pharmacy, Allahabad is

Krishnarpit Institute of Pharmacy, Allahabad

Dr. Raghvendra Raman Mishra

Krishnarpit Institute of Pharmacy, Allahabad

Shri Jay Mishra

Krishnarpit Institute of Pharmacy, Allahabad

“Innovative practices in Pharmaceutical Sciences and Technology” organized by

Krishnarpit Institute of Pharmacy, Allahabad

(Dr) Parjanya Kumar Shukla

Dear distinguished delegates and guests.

Krishnarpit Institute of Pharmacy, Allahabad

SCHEDULE OF DATE 19th November 2016

Registration 9:00 AM – 10:00

Inaugural Prof. (Dr) Amita Verma 10:30 AM – 10:40

Presidential Address : Mr. Vivek Shukla 10:40 AM – 10:50

Vote of Thanks : (Dr.) Parjanya Kumar Shukla 10: 50 AM - 11:00

Invited Address 1: Dr. Amita Verma 11:20 AM-12:00PM

Invited Address 2: Dr. Raghvendra Raman Mishra 12:00 PM-12:45

Poster Session : 12:50 PM-01:20

Certificate distribution Vote of Thanks & Valedictory 01: 20 PM onwards

Krishnarpit Institute of Pharmacy, Allahabad

Drug Discovery & Development Concepts and Approaches

Department of Pharmaceutical Sciences, FHS, SHIATS-DU, Allahabad

Krishnarpit Institute of Pharmacy, Allahabad

Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model

Krishnarpit Institute of Pharmacy, Allahabad

Review on Nicotine Originated (Active and Passive Diseases at 21century)

Krishnarpit Institute of Pharmacy, Allahabad

Fast Dissolving Oral Films Used As Oral Drug Delivery System

Md Amir1, Faisal Saeed1, Md Zishan1, S.P.Singh1, Suhail Ahmad2, M.P Singh3,

Krishnarpit Institute of Pharmacy, Allahabad

Rahul Pandey1*, W. Selvamurthy1

Krishnarpit Institute of Pharmacy, Allahabad

Epigallocatechin-3-Gallate: Compound help you to Be young and healthy

Krishnarpit Institute of Pharmacy, Allahabad

Hybrid 4-aminoquinoline bridged substituted 1,2,4 Triazole: Future Prospect to overcome

Krishnarpit Institute of Pharmacy, Allahabad

Anti Cancer Activity of Cannabis In Breast Cancer

Akanksha Gupta*1, Abhishek kumar Tripathi2

INTRODUCTION: Breast cancer is a very common disease that affects approximately 10

MECHANISM OF ACTION: In the present study, CBD's anti-tumorigenic activity against

Krishnarpit Institute of Pharmacy, Allahabad

Insulin used to Diabetic Therapy

Princee kesarwani*, Ramesh Patel, P.K. Shukla

Krishnarpit Institute of Pharmacy ,Ghoorpur Allahabad

Krishnarpit Institute of Pharmacy, Allahabad

Comparing Ancient Ayurvedic Literature Claims with Modern Pharmacological Findings:

Rahul Kaushik1*, Jainendra Jain1, Avijit Majumdar2, Akanksha Gupta3

Sarasvata Churna, a Medhya rasayana mentioned by Bhavaprakasha, is a compound

Krishnarpit Institute of Pharmacy, Allahabad

Ayurvedic Preparations in Modern Time

Rasayan properties whereas pharmacological studies proved it to posses Neuroprotective,