MLS3174 Clinical Haematology FEB 18 PDF

FINAL EXAMINATION
FEBRUARY 2018 SEMESTER
COURSE : CLINICAL HAEMATOLOGY

COURSE CODE : MLS 3174
DURATION : 2 HOURS 30 MINUTES
FACULTY : ENGINEERING AND LIFE SCIENCES
DEPARTMENT : HEALTH SCIENCES
PROGRAMME : BACHELOR IN MEDICAL LABORATORY SCIENCE
(HONS) – HS402 & HS403
LECTURER : MR MOHD JAAMIA QAADIR BIN MOHD BADRIN
INSTRUCTIONS TO CANDIDATES
This question paper consists of three (3) sections:
Section A - 20 questions (objective questions)

Section B - 4 questions (short answer questions)
Section C - 3 questions (essay questions)
Answer all questions in Section A and B, and only two questions in Section C.
All answer of:
Section A must be answered in OMR objective paper provided

Section B and C must be written in the answer booklet provided.
The answer for each question must start on a new page.
Candidates are NOT ALLOWED to bring any unauthorized items into the exam hall except
with the permission of the invigilator.
Do Not Open the Question Paper Until Instructed

This Question Paper Consists of Nine (9) Printed Pages
CONFIDENTIAL
FELS/MLS3174/FEB2018
SECTION A: OBJECTIVE QUESTIONS (20 MARKS)

CHOOSE ONE BEST STATEMENT TO ANSWER THE QUESTIONS
1. Which is term to describe the low concentration of polymorphonuclear cells in the body?
(A) neutropenia
(B) eosinopenia
(C) neutrophilia
(D) eoshinophila
2. What is the term used when the complete blood count values are suppressed?
(A) leukopenia
(B) pancytopenia
(C) erythroplasia
(D) thrombocytoplasia

3. When haemoglobin combines with oxygen, its iron must be in what state?
(A) ferritin
(B) transferin
(C) hemoglobin
(D) hemosiderin
4. What is the major metabolically available storage form of iron in the body?
(A) the oxygen tension is raised

(B) the oxygen tension is lowered
(C) an electrophoretic pattern is run
(D) highly oxygenated blood is observed
CONFIDENTIAL/2
5. Sickle cells lost the characteristic of
(A) fluidity
(B) elasticity
(C) permeability
(D) transformability
6. In haemoglobin electrophoresis, how is haemoglobin A2 is differentiated from haemoglobin

S?
(A) quantity present

(B) degree of mobility
(C) colour after staining
(D) symptoms of patients
7. Which of the following is NOT present in vitamin B12 deficiency?
(A) glossitis
(B) dizziness
(C) muscle wasting
(D) neurological problem

8. Macrocytic anaemia is defined by
(A) low mean cell volume

(B) high mean cell volume
(C) low mean cell haemoglobin
(D) high mean cell haemoglobin
9. Paroxysmal nocturnal haematuria patients can develop
(A) aplastic anaemia

(B) microcytic anaemia
(C) macrocytic anaemia
(D) megaloblastic anaemia
CONFIDENTIAL/3
10. Which of the following can give high values for mean cell volume of erythrocytes?
(A) B12 deficiency.

(B) sickle cell disease.
(C) hereditary spherocytosis.
(D) pyruvate kinase deficiency.
11. Haemolysis that occurs in the body can be presented as
(A) pallor, styes, pale urine

(B) jaundice, styes, dark urine
(C) pallor, malaise, dark urine
(D) jaundice, malaise, pale urine

12. Which of the following is NOT affected in leucophilia?
(A) platelets
(B) neutrophils
(C) eosinophils
(D) lymphocytes
13. Which of the following can develop anaemia with high mean cell volume?
(A) iron deficiency

(B) pyruvate deficiency
(C) vitamin B12 deficiency
(D) Glucose-6-phosphate deficiency
14. Which of the following gives result a lesser than the normal time in osmotic fragility testing?
(A) sickle cell anaemia

(B) hereditary spherocytosis
(C) acquired haemolytic anaemia
(D) haemolytic disease of the newborn
CONFIDENTIAL/4
15. Leukaemic blood smears often appear to present
(A) Dohle bodies

(B) juvenile cells
(C) Prince nez cells
(D) vacuolated bodies
16. The blood smear of a leukemic reaction often mimic the presentation of
(A) pernicious anaemia

(B) haemolytic anaemia
(C) acute myeloid leukaemia
(D) chronic myeloid leukaemia

17. Which of the following is a characteristic in idiopathic thrombocytic purpura?
(A) inherited condition

(B) comes with thrombocytopenia
(C) common among pregnant women
(D) comes with bone marrow abnormalities
18. Which of the following is a characteristic in thrombotic thromboplastic purpura?
(A) inherited condition

(B) comes with thrombocytosis
(C) common among pregnant women
(D) comes with bone marrow abnormalities
19. Which of the following often present in hereditary problems?
I. sickle cells
II. ovalocytes
III. spherocytes
IV. crenated cells
(A) I, II and III

(B) I, II and IV
(C) II, III and IV
(D) I, II, III and IV
CONFIDENTIAL/5
20. Haemophiliac patients comes with
I. two types A and B

II. A type is mainly in males
III. B type is mainly in female
IV. a sex linked recessive disorder
(A) I, II and III

(B) I, II and IV
(C) I, III and IV
(D) I, II, III and IV
CONFIDENTIAL/6
SECTION B: SHORT ANSWER QUESTIONS (40 MARKS)

ANSWER ALL QUESTIONS
1. Summarize anemia according to aetiology and morphology. (10 Marks)
2. Summarize the approach towards thrombocytopenia. (10 Marks)
3. Describe Prothrombin Time and Partial Thromoplastin Time according to the coagulation
cascade. (10 Marks)
4. Differentiate between haemophilia A, haemophilia B and von Willebrand factor disease.

(10 Marks)
CONFIDENTIAL/7
SECTION C: ESSAY QUESTIONS (40 MARKS)

ANSWER TWO (2) QUESTIONS ONLY
Question1
Bone marrow aspirate shows erythroid hyperplasia with megaloblastic maturation. Large
polychromatic and orthochromatic megaloblasts show nuclear karyorrhexis and other
dyserythropoietic changes. Multiple Howell Jolly bodies are seen in both megaloblasts and oval
macrocytes. Neutrophils show premature nuclear segmentation, with giant metamyelocytes and
band forms. Red blood cell folate gives 131 ug/L (RF: 160-600) and B12 136 ug/L (RF: 250-
900). Diagnose this condition.
(20 Marks)
Question 2
A 36-year-old man presents to the emergency department complaining of severe low back pain.
He reports a six-week history of progressive fatigue and worsening night sweats, and he notes
gingival bleeding when he brushes his teeth. Physical examination is notable for borderline
tachycardia and scattered ecchymoses on the extremities. His laboratory results reveal the
following: abnormal WBC count (42.1 x 109/L), abnormal haemoglobin level (8.3 g/dL) and
abnormal platelet count (18 x 109/L). White blood cell differential is notable for 82 percent
blasts. Bone marrow aspiration and biopsy is performed, revealing a hypercellular marrow
involved with malignant lymphocytes comprising 65 percent of total cellularity. Discuss your
diagnosis.
(20 Marks)
CONFIDENTIAL/8
Question 3
A 47-year-old woman presents to the emergency department complaining of fatigue and

shortness of breath. She reports a two-week history of worsening exercise tolerance and a rather
abrupt onset of shortness of breath over the past several hours. The patient has no major past
medical history and works as an architect. Prior to this illness, she exercised three to four times
weekly. Her breathing appears somewhat labored. Physical examination is notable for
tachycardia, tachypnea, an erythematous rash on her chest and back, and scattered ecchymosis on
the extremities. Her laboratory results reveal the following: abnormal WBC count (174.1 x
109/L), abnormal haemoglobin level (7.3 g/dL) and abnormal platelet count (24 x 109/L). White
blood cell (WBC) differential is notable for 89 percent blasts. Peripheral blood smear shows a
vast majority of cells are large blasts with occasional cytoplasmic granules and pseudopodia.
Bone marrow aspiration and biopsy is performed, revealing a hypercellular marrow involved
with monocytic-appearing blasts comprising 80 percent of bone marrow cellularity. Discuss your
diagnosis.
(20 Marks)
END OF QUESTION PAPER

CONFIDENTIAL/9

MLS3174 Clinical Haematology FEB 18 PDF

Uploaded by

Copyright:

Available Formats

MLS3174 Clinical Haematology FEB 18 PDF

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

MLS3174 Clinical Haematology FEB 18 PDF

Uploaded by

Copyright:

Available Formats

FINAL EXAMINATION

FEBRUARY 2018 SEMESTER

COURSE : CLINICAL HAEMATOLOGY

This question paper consists of three (3) sections:

Section A - 20 questions (objective questions)

All answer of:

Section A must be answered in OMR objective paper provided

Do Not Open the Question Paper Until Instructed

SECTION A: OBJECTIVE QUESTIONS (20 MARKS)

(A) the oxygen tension is raised

5. Sickle cells lost the characteristic of

6. In haemoglobin electrophoresis, how is haemoglobin A2 is differentiated from haemoglobin

(A) quantity present

7. Which of the following is NOT present in vitamin B12 deficiency?

(A) low mean cell volume

9. Paroxysmal nocturnal haematuria patients can develop

(A) aplastic anaemia

(A) B12 deficiency.

11. Haemolysis that occurs in the body can be presented as

(A) pallor, styes, pale urine

(A) iron deficiency

(A) sickle cell anaemia

15. Leukaemic blood smears often appear to present

(A) Dohle bodies

(A) pernicious anaemia

(A) inherited condition

18. Which of the following is a characteristic in thrombotic thromboplastic purpura?

(A) inherited condition

19. Which of the following often present in hereditary problems?

(A) I, II and III

20. Haemophiliac patients comes with

I. two types A and B

(A) I, II and III

SECTION B: SHORT ANSWER QUESTIONS (40 MARKS)

1. Summarize anemia according to aetiology and morphology. (10 Marks)

2. Summarize the approach towards thrombocytopenia. (10 Marks)

4. Differentiate between haemophilia A, haemophilia B and von Willebrand factor disease.

SECTION C: ESSAY QUESTIONS (40 MARKS)

A 47-year-old woman presents to the emergency department complaining of fatigue and

END OF QUESTION PAPER

You might also like