NIH Public Access: Author Manuscript
NIH Public Access: Author Manuscript
NIH Public Access: Author Manuscript
Author Manuscript
Clin Obstet Gynecol. Author manuscript; available in PMC 2010 September 1.
Published in final edited form as:
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Abstract
Postpartum depression (PPD) is the most common medical complication of childbearing. Universal
screening maximizes the likelihood of prompt identification of PPD. Obstetrician-gynecologists
routinely evaluate postpartum women for a general health examination and review of family planning
options at approximately 6 weeks after birth; therefore, they are well-positioned to identify PPD. In
this paper, we review the diagnostic criteria for postpartum depressive disorders and clinical risk
factors predictive of PPD. We examine depression screening tools, appropriate cut-points associated
with positive screens, the optimal timing for screening and the acceptability of depression screening
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in obstetrical settings. Lastly, we explore how to manage patients who screen positive for depression
and treatment options for women with PPD.
Keywords
postpartum depression; identification; screening tools
INTRODUCTION
Postpartum depresssion (PPD) is the most common medical complication of childbearing. PPD
occurs in 10 to 15% of new mothers (1). Groups of women at higher risk include inner city
women (50–60%)(2), mothers of pre-term infants (3) and adolescents (4,5). Depression after
delivery persists for more than 7 months in 25–50% of women (6,7). Lengthy post-birth
depressive episodes may result in maternal social (8) or relational problems even after recovery
(7,9–11). Moreover, PPD is associated with increased chronic medical disorders (12) and risk-
related behaviors such as tobacco smoking (13) and alcohol abuse (14). Universal screening
is an optimal approach to detection of new mothers who are suffering from depression
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The substantial negative impact of PPD for mothers, infants, and their families has been
established (16,17). Competent maternal function is critically important for ensuring the
infant’s safety and well being. Difficult temperament, poor self-regulation and behavioral
problems have been observed in infants of depressed mothers (18). The depressed mother may
not experience a positive and satisfying relationship with her infant, which serves to offset the
stresses of newborn care and postpartum recovery (19). Maternal depression that disrupts the
relationship between the mother and her infant contributes to a higher risk for poor infant and
child developmental outcomes.
Correspondence: Dorothy K. Sit, M.D., Assistant Professor of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and
Clinic, 3811 O’Hara Street, Oxford Building 410, Pittsburgh, PA 15213, Phone: 412-246-5248, Fax: 412-246-6960, sitdk@upmc.edu.
Sit and Wisner Page 2
planning options. Several national and state-based agencies, such as the US Preventive Health
Task Force, 2002 (20), American College of Obstetricians and Gynecologists-ACOG, April
2008 (21), State of New Jersey http://www.njleg.state.nj.us/2006/Bills/PL06/12.HTM, and the
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Michigan Quality Improvement Consortium (22) strongly advocate for routine screening to
improve the identification of depressed perinatal patients (20).
In this paper, we review the diagnostic criteria for postpartum depressive disorders, the
differential diagnosis and clinical risk factors that are predictive of PPD. We examine
depression screening tools, appropriate cut-points for positive screens, the optimal timing of
screening and the acceptability of depression screening in OB settings. Lastly, we explore how
to manage patients with positive screens, suicidality and PPD.
poor sleep and emotional reactivity. The baby blues affect 75% of new mothers, onset within
1–2 days and resolve by 10 days post-delivery. Although presentations vary, mothers with
major depression typically describe a diminished pleasure in interacting with people or
formerly enjoyable activities as well as feelings of low self-efficacy (24) rather than having
depressed mood. Severe symptoms may include difficulty making simple decisions, anxiety,
agitation, poor self-care, intense hopelessness and suicidal ideation or plan. One example is a
tired mother who has a terrible appetite; lost 40 pounds after delivery; feels she is a bad mother;
cannot fall asleep even when the baby sleeps soundly; and worries incessantly about harm
befalling her family.
Differential Diagnosis
Mothers with rapid onset of intense mood disturbance, confusion, strange or delusional beliefs,
hallucinations and disorganized behaviors have symptoms of postpartum psychosis, which is
most commonly form of Bipolar Disorder (BD) (25). Within the first month of childbirth,
women who have BD are at the high risk for episode emergence than at any other point in the
life cycle (26)(RR=21.7)(27). BD is characterized by recurrent episodes of major depression
that alternate with episodes of mania or hypomania. Clinicians can recognize mania or
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Other illnesses that cause postpartum distress include anxiety disorders e.g. panic disorder or
obsessive compulsive disorder (OCD), schizophrenia and medical conditions such as
hyperthyroidism or hypothyroidism, which are addressed in excellent references (29–32). The
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first post-natal months are a period of high risk for the onset of anxiety disorders (29,33). New
mothers with panic attacks have discrete, intense episodes of fear or discomfort that last 5–15
minutes along with symptoms of palpitations, sweating, shortness of breath, choking, nausea,
abdominal discomfort, dizziness, unsteadiness, numbness or tingling, chills, hot flashes, or a
fear of dying or losing control. The patients with panic disorder describe recurrent panic attacks
that are associated with a dread of future attacks; in severe cases, patients restrict their outside
activities due to fear of having a panic attack where help is unavailable (agoraphobia). One
patient reported that she only drives 1–2 miles to grocery-shop for her husband and children,
avoids bridges or tunnels which trigger panic attacks and feels intense anxiety when she is not
accompanied by a trusted family member.
OCD is characterized by intrusive thoughts and compulsive behaviors performed to relieve the
distress that stems from the intrusive thoughts. Symptoms last for more than one hour daily
and cause impaired function. The postpartum parent with OCD might check her healthy, full-
term baby every ten minutes throughout the night to make sure that the infant continues to
breathe, or count to 30 every time she diapers the baby to prevent some harm from occurring.
Other common intrusive thoughts center on a range of themes: contamination, causing harm,
offensive images, religious preoccupations and urges for symmetry or order. Compulsions
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include cleaning or washing, checking, repeating, rearranging, hoarding, and mental rituals
like counting and praying.
New mothers with solely panic disorder or OCD do not describe a low or depressed mood and
are still able to enjoy their usual activities. However, women with depression during the
postpartum period may present with concurrent panic disorder or OCD. Patients with OCD are
distressed by their unwanted disturbing cognitions (ego-dystonic). This characteristic
distinguishes OCD patients from the patients with schizophrenia who have fixed unusual or
bizarre beliefs (delusional thoughts), hallucinations, disorganized thoughts or behaviors and
poor insight into their symptoms or illness. Since the symptoms of hyperthyroidism overlap
with anxiety and panic symptoms, women with the onset anxiety disorders after delivery
require thyroid function tests.
Predictors of PPD
Exploring the predictors of PPD during antepartum or early postnatal visits can uncover
maternal liability for depression (34–36). Predictors include previous episodes of major
depression, family history of depression (37) and depression during pregnancy (38). Other
important demographic and clinical data predictive of PPD are recent immigrant status (39),
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increased stressful life events(40), history of childhood sexual abuse (36) and decision to stop
antidepressant therapy during pregnancy (41).
DEPRESSION SCREENING
“You can’t tell by looking” was the theme of The Perinatal Foundation’s Public Awareness
Campaign for Perinatal Mood Disorders (www.perinatalweb.org) to counter the myth that
depression can be diagnosed without a clinical examination. Universal depression screening
in outpatient settings improves detection rates compared to routine care (35.4% and 6.3%,
respectively; P=0.001) (42). Psychometric properties that define an excellent screening tool
are: sensitivity (the proportion of women with major depression who were true positives),
specificity (the proportion of non-depressed women who were true negatives) and the positive
predictive value (the probability that women with positive screens actually have a depressive
disorder).
over the past week. The EPDS has been validated extensively for use in the postpartum period
(43–45) and during pregnancy (21,46,47).
When to screen?
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The optimal time to screen for PPD is at the first postnatal obstetrical visit, since extensive
data suggest the onset of postpartum disorders occur within the first month of childbirth (26).
Patients who report the onset of symptoms within days of delivery (36,53) can be assessed by
telephone with the EPDS. The new mother who scores above the EPDS≥13 cut-point should
be scheduled for an earlier post-natal visit to review her mood symptoms and physical state.
Partner ratings
An important component of PPD may be the relational disorder in the marriage across domains
of lack of support, loss of emotional closeness and sexual dissatisfaction (54,55). For
postpartum mothers who are accompanied by supportive spouses, obtaining partner ratings of
symptom levels is another strategy to assess maternal depression (that reduces self-report bias).
The EPDS and EPDS-Partner (P) ratings (55) could be used in treatment sessions to probe each
partner’s experience of the mother’s depression. Of 101 couples who recently became parents,
investigators quantified symptom levels with the EPDS, EPDS-P, Beck Depression Inventory
(BDI) and HRSD (55). Their findings suggested very acceptable psychometric properties of
the EPDS-P. The internal consistency measurements on the Cronbach’s coefficient were
alpha=0.80 for EPDS-P (n=93) and alpha=0.85 for EPDS (n=90); retest scores were stable at
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2 and 6 weeks; the EPDS-P at 2 weeks was significantly correlated with the HRSD at 6 weeks
(55). Therefore, the EPDS-P is another reliable measure of maternal depression after childbirth
and is predictive of maternal depression levels beyond the contribution of the EPDS.
The 9-item depression module of the Patient Health Questionnaire (PHQ-9)(59) is another
common screening measure. Responses at 4 levels (not at all, several days, more than half the
days and nearly every day) apply to how the patient has felt in the past 2 weeks. The full PHQ
and the PHQ-9 (brief version) effectively identified patients with and without major depression
in primary care and obstetrical settings (59). The high sensitivity (88%) and specificity (88%)
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assure the validity of the PHQ for identifying depression risk (59,60). However, further
validation data are needed for the evaluation of postpartum patients (61).
These instruments all had sufficient data that demonstrated validity among women who speak
different languages (67)(72). The EPDS and BDI correlated highly with anxiety measures;
high scores on either instrument could suggest risk for anxiety disorders also. To identify
additional psychiatric comorbidities, the GHQ may be a more helpful instrument (72). The IDS
is useful for assessments of inner city or other ethnic populations of women (69).
In a study of the acceptability of antenatal and postnatal screening, patients and professionals
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reported that the EPDS was “easy or fairly easy” to complete among 93.4% (n=860) of patients,
83% nurses (n=230), 76% (n=194) of midwives and only 71% (n=118) of GPs (75). Despite
evidence of the benefits of screening, only 54% of general practitioners incorporated routine
screening into their practice, compared to 89% or nurses and 68% of midwives (75). Changing
practice patterns may be difficult (73). Physicians often prefer the direct interviewing style,
may not recognize the efficiency of the screening tools and feel less need from further training
(75). Provider education may be necessary to improve awareness of the benefits and efficiency
of the screening tools.
Screening Recommendations
In ambulatory clinics, the EPDS is an appropriate self-report tool for depression screening.
The recommended cut-point to detect PPD is an EPDS≥13. The optimal time to screen is 4–6
weeks after delivery. For mothers with supportive partners, the EPDS-P is a helpful adjunctive
tool for assessing maternal depression. The CES-D is an acceptable instrument to use with new
adolescent mothers. In OB and primary care settings, the PHQ or GHQ are efficient tools for
identifying PPD and comorbid disorders. When screening is conducted for Spanish speaking
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women, the PDSS may be a useful (albeit costly) instrument; for women belonging to ethnic
or minority communities, the IDS is an effective screening tool.
with managing depression rather than pursue professional treatment (74). This pilot model
suggests that routine screening and provision of a care manager are feasible and may improve
depression outcomes for OB patients in different settings.
(12.4% 234/1880) was significantly lower than the risk of patients assigned to usual care
(16.7% 166/995)(odds ratio 0.67 95%CI=0.51–0.87 p=0.003)(78). These studies demonstrated
that innovative programs that expand the maternal support network may improve maternal
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mood outcomes. The cost and cost-effectiveness of these programs still needs to be calculated.
Antidepressants are efficacious for the treatment of PPD. Appleby et al. (81) found that
fluoxetine (20 mg/day) was significantly more effective than placebo. Sertraline prescribed at
50–200 mg/day induced remission (HRSD ≤7) in 14/21 (66%) of patients who completed an
8 week trial (82). Cohen et al. (83) found that venlafaxine (75–225 mg/day) resulted in an 80%
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remission rate. In the only randomized comparative trial of antidepressants for women with
PPD, patients responded equivalently to treatment with the tricyclic agent nortriptyline and the
serotonin reuptake inhibitor sertraline (84). The majority of patients required dosing of
sertraline >100mg daily or nortriptyline ≥75mg daily for full response (84). Antidepressant
transmission through breast milk is a consideration in PPD treatment. Low or undetectable
levels of the majority of antidepressants have been found in infant sera, and no developmental
problems have been described (85)(and see this issue, Lanza di Scalia, 2009). Treatment choice
is best informed by the patient’s response to past treatment trials. Recommendations for the
clinical care of postpartum disorders and a decision-making model to assess risks and benefits
of antidepressant treatments are available (79)(85)(86)(87)(88).
Increasing the range of treatment options may improve the likelihood the patient will accept
treatment and reinforce her central role in choosing a treatment plan. Investigation of novel
therapies for childbearing women include bright light treatment, which is efficacious for both
seasonal and non-seasonal depression (89–91); nutritional intervention (92,93); essential fatty
acid supplements (94,95); regular aerobic exercise (96,97); and transdermal estradiol therapy
(see this issue - Moses-Kolko, 2009). Although the evidence base is not as extensive as for
psychotherapy and antidepressants, the availability of high-quality studies on promising new
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therapies provides hope for women who decline standard treatments. Provision of novel
therapies allows establishment of a relationship which may pave the way for sequential
treatments if the chosen therapy does not result in achievement of the patients’ goals.
CONCLUSION
Routine depression screening in OB settings is an efficient and feasible method to improve the
identification of postpartum depressed patients with minimal risk for harm. The majority of
risk factors for the development of PPD are present during the antenatal period, underscoring
the importance of the medical history in the identification of high risk populations.
The EPDS is an acceptable instrument for routine screening. The recommended cut-point is
an EPDS≥13; the optimal time to screen for depression is 4–6 weeks after delivery. Patients
who score above this cut-point require prompt treatment planning and possible referral for
mental health care. The patient with suicidal ideation, thoughts to harm others or disorganized
ACKNOWLEDGMENTS
Dr. Sit’s contributions were supported by National Institute of Mental Health for the grants R01 MH60335 (PI: K.L.
Wisner) and K23 MH082114-01A2 (PI: D. Sit), and the International Society of Bipolar Disorders Fellowship Award
(PI: D. Sit). Dr. Wisner’s contributions were supported primarily by the National Institute of Mental Health for the
following grants: R01 MH60335, R01 MH071825 and R01 MH075921 (PI: K.L. Wisner). Dr. Wisner has also received
grant support from the Society for Bariatric Surgery, the Heinz Foundation, the New York—Mid-Atlantic Consortium
for Genetics and Newborn Screening Services, Novogyne, Pfizer, the Stanley Medical Research Foundation, and the
State of Pennsylvania.
REFERENCES
1. Gaynes BNGN, Meltzer-Brody S, Lohr KN, Swinson T, Gartlehner G, Brody S, Miller WC. Perinatal
depression: prevalence, screening accuracy, and screening outcomes. Summary, Evidence Report/
Technology Assessment No. 119. 2005AHRQ Publication No. 05-E006-1
2. Hobfoll SE, Ritter C, Lavin J, Hulsizer MR, Cameron RP. Depression prevalence and incidence among
inner-city pregnant and postpartum women. Journal of Consulting & Clinical Psychology 1995;63(3):
NIH-PA Author Manuscript
15. Wisner KL, Chambers C, Sit DK. Postpartum depression: a major public health problem. JAMA
2006;296(21):2616–2618. [PubMed: 17148727][comment]
16. Bonari L, Pinto N, Ahn C, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression
NIH-PA Author Manuscript
37. O'Hara M, Neunaber D, Zekoski E. Prospective study of postpartum depression: Prevalence, course,
and predictive factors. Journal of Abnormal Psychology 1984;93:158–171. [PubMed: 6725749]
38. O'Hara MW, Swain AM. Rates and risks of postpartum depression - a meta-analysis. International
NIH-PA Author Manuscript
52. Felice E, Saliba J, Grech V, Cox J. Validation of the Maltese version of the Edinburgh Postnatal
Depression Scale. Archives of Women's Mental Health 2006;9(2):75–80.
53. Hannah P, Adams D, Lee A, Glover V, Sandler M. Links between early post-partum mood and post-
natal depression. British Journal of Psychiatry 1992;160:777–780. [PubMed: 1617360][see
comment]
54. Gotlib, IH.; Hooley, JM. Depression and marital distress: current status and future directions. Duck,
S., editor.
55. Moran TE, O'Hara MW. A partner-rating scale of postpartum depression: the Edinburgh Postnatal
Depression Scale - Partner (EPDS-P). Archives of Women's Mental Health 2006;9(4):173–180.
56. Beeghly M, Olson KL, Weinberg MK, Pierre SC, Downey N, Tronick EZ. Prevalence, stability, and
socio-demographic correlates of depressive symptoms in Black mothers during the first 18 months
postpartum. Maternal & Child Health Journal 2003;7(3):157–168. [PubMed: 14509411]
57. Beeghly M, Weinberg MK, Olson KL, Kernan H, Riley J, Tronick EZ. Stability and change in level
of maternal depressive symptomatology during the first postpartum year. Journal of Affective
Disorders 2002;71(1–3):169–180. [PubMed: 12167513]
NIH-PA Author Manuscript
58. Roberts R, Andrews JA, Lewinsohn PM, Hops H. Assessment of depression in adolescents using the
Center for Epidemiologic Studies depression scale. Psychological Assessment 1990;2:122–128.
59. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure.
Journal of General Internal Medicine 2001;16(9):606–613. [PubMed: 11556941]
60. Spitzer RL, Kroenke K, Williams JB, et al. Validation and utility of a self-report version of PRIME-
MD: The PHQ Primary Care Study. The Journal of the American Medical Association
1999;282:1737–1744.
61. Hanusa BH, Scholle SH, Haskett RF, Spadaro K, Wisner KL. Screening for depression in the
postpartum period: a comparison of three instruments. Journal of Women's Health 2008;17(4):585–
596.
62. Beck CT, Gable RK. Comparative analysis of the performance of the Postpartum Depression
Screening Scale with two other depression instruments. Nursing Research 2001;50(4):242–250.
[PubMed: 11480533]
63. Beck CT, Gable RK. Postpartum Depression Screening Scale: development and psychometric testing.
Nursing Research 2000;49(5):272–282. [PubMed: 11009122]
64. Mitchell AM, Mittelstaedt ME, Schott-Baer D. Postpartum depression: the reliability of telephone
screening. MCN, American Journal of Maternal Child Nursing 2006;31(6):382–387.
65. Beck CT, Froman RD, Bernal H. Acculturation level and postpartum depression in Hispanic mothers.
NIH-PA Author Manuscript
11246101]
73. Chaudron LH, Szilagyi PG, Kitzman HJ, Wadkins HI, Conwell Y. Detection of postpartum depressive
symptoms by screening at well-child visits. Pediatrics 2004;113(3 Pt 1):551–558. [PubMed:
14993549]
74. Matthey S, White T, Phillips J, Taouk R, Chee TT, Barnett B. Acceptability of routine antenatal
psychosocial assessments to women from English and non-English speaking backgrounds. Archives
of Women's Mental Health 2005;8(3):171–180.
75. Buist A, Condon J, Brooks J, Speelman C, Milgrom J, Hayes B, et al. Acceptability of routine
screening for perinatal depression. Journal of Affective Disorders 2006;93(1–3):233–237. [PubMed:
16647761]
76. Scholle SH, Kelleher KJ. Assessing primary care among young, low-income women. Women and
Health 2003;37(1):15–30.
77. Dennis CL, Hodnett E, Kenton L, Weston J, Zupancic J, Stewart DE, et al. Effect of peer support on
prevention of postnatal depression among high risk women: multisite randomised controlled trial.
BMJ 2009;338:a3064. [PubMed: 19147637][see comment]
78. Morrell CJ, Slade P, Warner R, Paley G, Dixon S, Walters SJ, et al. Clinical effectiveness of health
visitor training in psychologically informed approaches for depression in postnatal women: pragmatic
cluster randomised trial in primary care. BMJ 2009;338:a3045. [PubMed: 19147636][see comment]
NIH-PA Author Manuscript
79. Wisner K, Parry B, Piontek C. Clinical Practice: Postpartum depression. New England Journal of
Medicine 2002;347:194–199. [PubMed: 12124409]
80. O'Hara MW, Stuart S, Gorman LL, Wenzel A. Efficacy of interpersonal psychotherapy for postpartum
depression. Archives of General Psychiatry 2000;57(11):1039–1045. [PubMed: 11074869]
81. Appleby L, Warner R, Whitton A, Faragher B. A controlled study of fluoxetine and cognitive-
behavioral counselling in the treatment of postnatal depression. BMJ 1997;314(7085):932–936.
[PubMed: 9099116]
82. Stowe Z, Nemeroff C. Women at risk for postpartum-onset major depression. American Journal of
Obstetrics & Gynecology 1995;173(2):639–645. [PubMed: 7645646]
83. Cohen LS, Viguera AC, Bouffard SM, Nonacs RM, Morabito C, Collins MH, et al. Venlafaxine in
the treatment of postpartum depression. Journal of Clinical Psychiatry 2001;62(8):592–596.
[PubMed: 11561929]
84. Wisner KL, Hanusa BH, Perel JM, Peindl KS, Piontek CM, Sit DK, et al. Postpartum depression: a
randomized trial of sertraline versus nortriptyline. Journal of Clinical Psychopharmacology 2006;26
(4):353–360. [PubMed: 16855451][see comment]
85. Weissman A, Levy B, Hartz A, Bentler S, Donohue M, Ellingrod V, et al. Pooled analysis of
antidepressant levels in lactating mothers, breast milk, and nursing infants. American Journal of
Psychiatry 2004;161:1066–1078. [PubMed: 15169695]
NIH-PA Author Manuscript
86. Sit DK, Wisner KL. Decision Making for Postpartum Depression Treatment. Psychiatric Annals
2005;35(7):577–584.
87. Wisner K, Zarin D, Holmboe E, Appelbaum P, Gelenberg A, Leonard H, et al. Risk-benefit decision
making for treatment of depression during pregnancy. American Journal of Psychiatry
2000;157:1933–1940. [PubMed: 11097953]
88. Moses-Kolko E, Bogen D, Perel J, Bregar A, Uhl K, Levin B, et al. Neonatal signs after late in utero
exposure to serontonin reputake inhibitors: Literature review and implications for clinical
applications. JAMA 2005;293:2372–2383. [PubMed: 15900008]
89. Golden RN, Gaynes BN, Ekstrom RD, Hamer RM, Jacobsen FM, Suppes T, et al. The efficacy of
light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence.
American Journal of Psychiatry 2005;162(4):656–662. [PubMed: 15800134][see comment]
90. Oren D, Wisner K, Spinelli M, Epperson C, Peindl K, Terman T, et al. An open trial of morning light
therapy for treatment of antepartum depression. American Journal of Psychiatry 2002;159:666–669.
[PubMed: 11925310]
91. Epperson C, Terman M, Terman J, Hanusa B, Oren D, Peindl K, et al. Randomized clinical trial of
bright light therapy for antepartum depression: Preliminary findings. Journal of Clinical Psychiatry
2004;65:421–425. [PubMed: 15096083]
92. Bodnar LM, Sunder KR, Wisner KL. Treatment with selective serotonin reuptake inhibitors during
pregnancy: deceleration of weight gain because of depression or drug?[erratum appears in Am J
NIH-PA Author Manuscript