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    Jaymark Pineda Tiglao
    Doxycycline is a semi-synthetic tetracycline antibiotic derived from oxytetracycline. It is bacteriostatic and works by inhibiting protein synthesis and altering membrane permeability in susceptible organisms. Doxycycline is more lipid-soluble than other tetracyclines, allowing it to reach higher levels in difficult to penetrate areas. It is effective against a broad spectrum of gram-negative and gram-positive bacteria as well as other organisms. Doxycycline is well-absorbed orally and can be used in animals with decreased kidney function as it is primarily eliminated through the GI tract. Common side effects in dogs and cats include GI upset.

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    Asic Information

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    Doxycycline is a semi-synthetic tetracycline antibiotic derived from oxytetracycline. It is bacteriostatic and works by inhibiting protein synthesis and altering membrane permeability in susceptible organisms. Doxycycline is more lipid-soluble than other tetracyclines, allowing it to reach higher levels in difficult to penetrate areas. It is effective against a broad spectrum of gram-negative and gram-positive bacteria as well as other organisms. Doxycycline is well-absorbed orally and can be used in animals with decreased kidney function as it is primarily eliminated through the GI tract. Common side effects in dogs and cats include GI upset.

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    Doxycycline is a semi-synthetic tetracycline antibiotic derived from oxytetracycline. It is bacteriostatic and works by inhibiting protein synthesis and altering membrane permeability in susceptible organisms. Doxycycline is more lipid-soluble than other tetracyclines, allowing it to reach higher levels in difficult to penetrate areas. It is effective against a broad spectrum of gram-negative and gram-positive bacteria as well as other organisms. Doxycycline is well-absorbed orally and can be used in animals with decreased kidney function as it is primarily eliminated through the GI tract. Common side effects in dogs and cats include GI upset.

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    55 views2 pages

    Asic Information

    Uploaded by

    Jaymark Pineda Tiglao
    Doxycycline is a semi-synthetic tetracycline antibiotic derived from oxytetracycline. It is bacteriostatic and works by inhibiting protein synthesis and altering membrane permeability in susceptible organisms. Doxycycline is more lipid-soluble than other tetracyclines, allowing it to reach higher levels in difficult to penetrate areas. It is effective against a broad spectrum of gram-negative and gram-positive bacteria as well as other organisms. Doxycycline is well-absorbed orally and can be used in animals with decreased kidney function as it is primarily eliminated through the GI tract. Common side effects in dogs and cats include GI upset.

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    asic Information

    Doxycycline is a semi-synthetic tetracycline antibiotic, derived from oxytetracycline. It may be used orally (dogs, cats and horses) or intravenously
    (dogs and cats). Tetracycline antibiotics are broad-spectrum and bacteriostatic. Their mechanism of action is through the inhibition of protein
    synthesis, and the alteration of cytoplasmic membrane permeability within the susceptible organism.
    Doxycycline is more lipid-soluble than other tetracycline antibiotics and may reach higher levels in some of the difficult to penetrate areas, such as
    synovial fluid, central nervous system, prostate, and the eyes.
     
    Tetracycline antibiotics, including doxycycline, are effective against a broad spectrum of gram-negative and gram-positive bacteria, and wide
    variety of other organisms including Rickettsia, Spirochetes, Mycoplasma, Leptospira, Anaplasma, and Chlamydia. In addition to its use as an
    antibiotic, doxycycline is used in low doses as an anti-inflammatory and adjunct treatment for arthritis and degenerative joint-disease in dogs and
    horses. This use is based on the inhibition of metallo-matrix proteinases.
    Doxycycline is well-absorbed after oral administration and its absorption is minimally affected by the presence of food in the stomach. Doxycycline
    may be used in animals with decreased kidney function because it is eliminated primarily via the GI tract.

    Dogs and Cats

    Doxycycline is used in dogs to treat susceptible bacterial infections and infections caused by Rickettsia, Canine ehrlichiosis (anaplasmosis),
    Toxoplasma, Borrelia burgdorferi (Lyme disease), Leptospirosis and Neorickettsia helminthoeca (salmon poisoning).

    Doxycycline is used in cats to treat susceptible bacterial infections and infections caused by a number of other organisms including Bartonella,
    Hemoplasma, Chlamydia felis, Ehrlichia, Anaplasma, and Toxoplasma.
    There is some interesting research regarding the use of doxycycline as a “pre-treatment” in animals with circulating microfilaria due to heartworm
    disease. The research indicates that the pathogenic microfilaria are generally infected with a symbiotic bacteria called Wolbachia, which is
    sensitive to doxycycline. Pre-treatment with doxycycline is postulated to adverse reactions to microfilaria death.
    Doxycycline gel is used topically in the mouth of dogs and cats for periodontal disease. Local application in the sulcus provides higher
    concentrations of the drug than may be achieved with systemic antibiotics.

    Horses

    Doxycycline is used in horses to treat susceptible bacterial-infections and tick-borne diseases such as Ehrlichia, Anaplasma, and Borrelia
    burgdorferi (Lyme disease).

    Side Effects

     The most-common side effects in dogs and cats are GI upset, including nausea and vomiting.
     Cats may be at increased risk for esophageal strictures after “dry” pilling with doxycycline. In order to minimize this problem, it has been
    suggested to dose the cat with water after pilling or use a compounded liquid product to minimize esophageal damage.

    Precautions

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