FORMULASI

R/ Paracetamol 1 gram
Monosodium phosphate dihydrate 0,1002 gram
Disodium phosphate dihydrate 0,0785 gram
Sodium Cloride 0,65 gram
Water for injection ad 100 ml

Penimbangan Bahan
1. Paracetamol = 1 gram + (1 gram x 20%)
= 1 gram + 0,2 gram
= 1,2 gram
2. Monosodium phosphate dihydrate = 0,1002 gram + (0,1002 x 20%)
= 0,1002 gram + 0,02004
= 0,12024 gram
3. Disodium phosphate dihydrate = 0,0785 gram + (0,0785 x 20%)
= 0,0785 gram + (0,0157)
= 0,0942 gram
4. Sodium Cloride = 0,65 gram + (0,65 x 20%)
= 0,65 gram + 0,13
= 0,78 gram
5. Water for injection = 100 ml + (100 x 20%)
= 100 ml + 20 ml
= 120 ml – (1,2 + 0,12024 + 0,0942
+ 0,78)
= 120 ml – 2,19444 ml
= 117,80556 ml

Persen Bahan :
1g
1. Paracetamol = x 100 % = 0,8334 %
120 ml
0,8334 g
=( ¿
100 ml
= 8,334 g/l
 0,1002 g
2. Monosodium phosphate dihydrate = x 100 % = 0,0835 %
120 ml
0,0835 g
=( ¿
100 ml
= 0,835 g/l
0,0785 g
3. Disodium phosphate dihydrate = x 100 % = 0,06542%
120 ml
0,06542 g
=( ¿
100 ml
= 0,6542 g/l
0,65 g
4. Natrium klorida = x 100 % = 0,5417%
120 ml
0,5417 g
=( ¿
100 ml
= 5,417 g/l

Perhitungan Osmolaritas :
g/l
Rumus = X jumlah spesimen X 1000
BM
8,334 100
1. Paracetamol = x 1 x 1000
151,163 176,13
= 55,1325 osmo/L
0,835 100
2. Monosodium phosphate dihydrate = x 3 x 1000
119,98 176,13
= 20,8535 osmo/L
0,6542 100
3. Disodium phosphate dihydrate = x 4 x 1000
141,96 176,13
= 18,4334 osmo/L
5,417 100
4. Natrium klorida = x 2 x 1000
58,44 176,13
= 185,3867 osmo/L
Total = 279,8061 osmo/L (Isotonis karena nilai berada direntang 270-328)
Perhitungan tonisitas
1. Perhitungan Faktor Disosiasi :
Fa gram
Rumus : x
ma L
1,5
1. Paracetamol = x 8,334 g/l
151,16
= 0,0827
1,8
2. Monosodium Phosphate dihidrat = x 0,835 g/l
119,98
= 0,0125
1 ,8
3. Disodium Phosphate dihidrat = x 0,6542 g/l
141,96
= 0,008295 =0,0083
1,8
4. Sodium chlorida = x 5,417 g/l
58,44
= 0,1668
Total = 0,2703
Xh = 32 x (0,28-0,2703)
= 32 x 0,0097
= 0,3104
0,3104 x
 = => x = 0,0372 gram /120ml = 37,2 mg/120ml
1000 ml 120 ml

2. Ekuivalen Nacl
Liso
Rumus : E = x 17 x % bahan
BM
1,9
1. Paracetamol = x 17
176,13
= 0,183 x 1%
= 0,183 %
2. Monosodium Phosphate dihidrat = 0,42
3. Disodium Phosphate dihidrat = 0,44
 4. Sodium chlorida =1
Total = 1,286 %
= 0,9 %- 2,78705 %
= -0,386%
−0,386 x
 = => -0,232 g/60ml
100 ml 60 ml
 -232 mg/60 ml
Sediaan hipertonis, kelebihan 232 mg NaCl
3. Metode Trioskopik
g 1000
Rumus : ∆Tf = Liso x x
BM vol
0,6 1000
1. Asam askorbat = 1,9 x x
176,13 60 ml
= 0,108 oC
0,003 1000
2. Dinatrium edetat = 4,8 x x
336,2 60 ml
= 0,00071 oC
0,834 1000
3. Natrium bikarbonat = 3,2 x x
84,01 60 ml
= 0,529 oC
0,3 1000
4. Na Benzoat = 3,4 x x
144,11 60 ml
= 0,118 oC
Total = 0,756 oC
 (0,52 – 0,756) oC = -0,236 oC
0,9 % x
 = => -0,408 %
0,52 −0,236
−0,408 x
 = => -0,244 g
100 60 ml
 - 244 mg
Sediaan Hipertonis , kelebihan 244 mg NaCl
4. White Vincent
Rumus : 0,9% = g X E
0,9 0,6 x 0,183
1. asam askorbat : =
100 vol Zat
 Vol zat = 12,2 ml
0,9 0,834 x 0,648
2. Natrium bikarbonat : =
100 vol Zat
Vol zat = 60,048 ml
0,9 0,003 x 0,243
3. dinatrium edetat : =
100 vol Zat
Vol zat = 0,081 ml
0,9 0,3 x 0,401
4. Na Benzoat : =
100 vol Zat
Vol zat = 13,367 ml
Total = 85,696 ml
 60-85,696 = -25,696 ml
0,9 x
 =
100 −25,696
 -0,231 g
 -231 mg

Sediaan Hipertonis, kelebihan 231 mg NaCl

5. Perhitungan Sprawls
0,3 1000
Rumus : 0,52 = Liso x x
BM v
0,3 1000
1. asam askorbat => 0,52 = 1,9 x x
176,13 v
0,3 0,6 g
=> 6,224 => =
6,224 x
= 12,448 ml
0,3 1000
2. Dinatrium edetat => 0,52 = 4,8 x x
336,2 v
0,3 0,003 g
=> 8,237 => =
8,237 x
= 0,082 ml
0,3 1000
3. Natrium bikarbonat => 0,52 = 3,2 x x
84,007 v
0,3 0,834 g
=> 21,976 => =
21,976 x
= 61,092 ml
 0,3 1000
4. Natrium benzoat => 0,52 = 3,4 x x
144,11 v
0,3 0,3 g
=> 13,611 => =
13,611 x
= 13,611 ml
Total = 87,233 ml
 60 ml – 87,233 ml = -27,233 ml
0,9 x
 = => - 0,245gram = -245 mg
100 −27,233

Sediaan hipertonis, kelebihan 245 mg NaCl