Calculation Raghad

Rules needed:-
- Clearance (Cl)= Clearance rate (Ke) * Volume of distribution (Vd)
- Infusion Rate= Blood conc (Cp) * Clearance (Cl)
- t1/2 = 0.693 / Ke
- 1 Ib = 16 oz
- 1 kg = 2.2 Ib
- mmol = wt / Mwt
- Mwt for KCl = 74.6
- mg = (MEq*Mwt) / valency
- loading dose (Ld) = Blood conc (Cp) * Volume of distribution (Vd)
- sensitivity requirement (SR) = minimum quantity to be weighed * error%
- C1 V1 = C2 V2
Question numbers that are not mentioned here in this file:
30 - 38 – 104
Go back to calculation file.

1) "no. 23" A physician want to switch a terminally- ill pt. from slow release
morphine sulphate tab. 15 mg bid to a liquid morphine sulphate dosage form,
because pt has difficulty in swallowing tab. If a morphine sulphate solution
contain 5mg per ml is prescribed q4hr … What volume should be dispensed for a
20 day supply to provide the same pain relief as the tab. Regimen??
a. 120ml.
2) Cancer patient receive 20mg/ 4hrs syrup and want to shift to tab. Morphine
what is the best starting dose;
a* 60mg BID
‫ ساعات‬4 ‫ ملج كل‬20 ‫بياخد‬

‫ ملج‬120 ‫يعني بياخد‬
‫في اليوم‬
120 ‫ يعني ياخد‬once daily
aw 60 BID (twice daily)
3) "no. 101" 10 ml ampoule of 3% drug how many ml required to give 150mg dose?
a-3ml
b-5ml
c-7ml
d-9ml
NB. 3.......100
X.......10
X= 0.3g so 300mg/10ml
To give 150mg u need 5ml

4) 50% alcohol is to be diluted with purified water, how many parts of purified
water (0% alchohol) to prepare 20% preparation.?
a- 30parts water + 20 parts 50% alchohol
NB. By allegation method 50% 20 parts
20%
0% 30 parts
Calculated by minusing 50-20 to give the 30 which gives number of parts of the
0% and vice versa
5) Patient dose is 1.2 mg\kg, patient weight 27 kg, what is the dose?
32.4 mg = 32 mg
6) "no. 39" Dose for patient is 75mg, how ml needed from 125mg/5ml solution :
a. 5 ml
b. 3 ml
c. 15 ml
NB. 125mg…..5ml
75mg……x criss cross
7) How many gram of 5% ointment will be prepared from 2 gm :

answer.. (5%= 5gm ----100 ,,2gm---?
2*100/5 = 40 gm
8) How many gram will be in 250 ml of 5% solution :

answer.. 5% = 5gm ---100ml
??--------250ml
= 250 *5 /100 = 12.5 gm
9) If dose of drug is 0.2 ml, How many dose will be in 15ml :

answer.. 15ml /0.2 ml =75 doses
10) "no. 99" Patient taking an infusion of 200mg/500ml at a rate of 0.5 mg/ml.
What is the concentration in micrograms/ml?
400 mcg/ml
(N.B.this is simple &tricky: u just consider the infusion conc 200mg/500ml &
convert simply to microgram..don't pay attention to the rate !!!)
11) "no. 100" How ml u need to add to 1ml of 1:1000 to converted to 1:2500?
1.5 ml
C1 V1 = C2 V2
(1/1000)(1ml) = (1/2500)(V2) V2 = 2.5 ml
2.5 – 1 = 1.5 ml
12) "no. 32" clindamycin for a child 35 kg (8-20mg) for 4 doses and strength of
tablet 100 mg what is the safe dose for him :
 70mg every 6 hr
 700mg every 6 hr
 150 mg every 6 hr
His max dose will be 35kg*20mg= 700mg
13) "no. 24" patient using dopamine infusion with 2.5mcg/kg/min, pt wt 80kg,how
many ml of dopamine pt will consume if dopamine ampoule con 0.8mg/1ml with in
24 hours(360ml, 120ml,250ml).
Daily dose = 2.5mcg x 80kg x 60 minutes x 24 hr = 288000 mcg
1ml 800 mcg
(X) 288000 mcg X = 360ml
14) "no. 111" Heparin is given to patient wt 75 Kg premixed with 25,000 unit in 250 ml of
D5W , rate 5 unit/Kg/hr, what total amount of heparin in 6 hrs?
22.5 ml
5 unit * 75 kg * 6 hr =2250 units

(2250 unit * 250 ml) / 25000 unit = 22.5 ml
15) "no. 110" Prescription was 4 mg bid, pharmacist dispense 120 mg, what is the amount
remained with patient after 7 days?
8 * 7 = 56 120 – 56 = 64 mg
16) "no. 98" you use a 2.5mg of a drug in a tablet form of 60% bioavailability.
And you want to switch to the elixir form 0.05mg/ml which is 70%
bioavailability. How many ml you will take?
4.3 ml
17) "no. 36" Child 6 month wieght 3 Ib 7 oz dose to take inection 600gm/50ml,
How many mills to be taken as following :
10mg/kg/day divided every 12 hr
a- 0.56
b- 0.67 Ans,,,,b
18) If the dose 2mg /Kg want to add to 500 ml of dextran 5% .and the patient
is 80 kg. How many milliliter we need to add to dextrose if we have drug 5mg
/10ml ? 320ml
Patient dose=2*80=160mg
5mg 10ml
So 160mg x = 320ml
19) Patient currently take 220mg of anhydrous Znso4 to receive amount of

elemental zinc ,how many mg of ZnSO4 (.7H2O)would the pt have to take(mwt
Zn 65, ZnSO4 161,H2O 18)
a. 123mg,
b. 220mg
c. 300mg,
d. 392mg
e. 545mg
161 65
220 x x = 88.8
287 65
y 88.8
y = 392
20) Serum concentration of Theophylline is 10-20 micro per ml. What is its
value in micromole per litre; M.wt = 180
a. 55-110micro/l (they answered this in the previous exam)
b. 0.055-0.011micro/l (this is what I answered)
another explanation:
Weight 10
MMol = ------------------ = --------- = 10 ÷ 180 = 0.055 mmol
mol.wieght 180
Weight 20
M Mol = ------------------ = --------- = 20 ÷ 180 = 0.111 mmol
mol.wieght 180
1 ----------------- 1000 ml 1 ------------------ 1000 ml
0.055 ------------------ x 0.111 ------------------ x
X = 55 m mol/l X = 111 m mol/l
55+111
21) "no. 34" vial of 50 ml added to 10 ml sterile water then diluted with 0.9%
natural saline what is final volume :
55.5 = 50 ml
22) "no. 37" IV infusion of 40 mEq KCL diluted with D5W and 0.9% saline to a
final volume 1000 ml and administration as 12 drop/ min through an
administration set that deliver 15 drop per ml
i. How many ml of solution will be administration in 15 hr?

720 ml
ii. How many mmoles will be administrated in 15 hr?

28.8
23) "no. 28" Diazepam rectaly for febrile convulsion for child wt 22kg is: NB:-
(dose is 250 micro/kg IV or 500mic/kg rectaly max 30mg)
- 12.5mg - 25mg - 50mg
24) "no. 21" What the infusion rate, if conc. Of drug in blood is 10ug/ml and
clearance Rate is 0.25/hr, and Vd is 12 litre
a. 10 mg/hr b. 20 ug/hr c. 30ug/hr
CSS*Vd*cl= 10*0.25*12= 30 ug\hr

25) Pediatric patient on regular cimetidine 125mg/every 6h. He is using
125mg/5ml and the available stock is 250mg/5ml, How mny mls will you give for
the 250mg/5ml per dose? 2.5ml
26) "no. 31" child have to take 2ml every 8 hr. How many ml you have to dispense
for 7days?? 42ml
27) 100 ml sol contains 10 ml 2% drug what is the conc of the final drug?
a. 200mg/ml
b. 20mg/ml
c. 10mg/ml
d. 2mg/ml
there is conflicts, some answered a and some b!
28) Which of the following most closely describes as the clearnace rate of drug
that is infused at rate of 4 mg/min and produces a steady state concentratin of
6mg/L in plasma.
a.1,200 ml/min
b.667 ml/min
c.300 ml/min
d.132 ml/min
e.67 ml/min
29) formula of paraffin to 100 % has 1%A...,15%B....,12% starch....how many Gms

of paraffin needed from 250gm of this formula?
(180gm,200gm,150gm…).
Percentage of formula ---------- = 1% + 15% + 12% = 28%
28--------------- 100
X --------------- 250
X = 70 ingredients
So base = 250 – 70 = 180gm
30) "no. 8" pt using suspention with dose 5ml twice daily,he has 150 ml of the
suspention, how many days pt will consume this suspention
1. 15days
2. 10days
3. 20days
4. 15 ml
exam 11/12/2011.
Daily dose = 5mlx2 =10ml
150ml ÷ 10mh = 15 days
31) drug with t1/2 3 h, volume of distribution is 7 liter how much is clearance?
t1/2 = 0.693/ ke ke = 0.693/ 3 =0.231
CL = (Ke xVd)
Cl = 0.231x7000 =1.617

32) "no. 27" A drug with t1/2 is 3 hr, after how many of this drugs will remain in
the body after 24 hr?
100, 87, 12.5, 6.125, less than 1
tips:- 0.39 will remain after 24 hr
24 / 3 = 8 100 / (2)8 = 0.39 so, less than 1
33) "no. 3" Metaproternol salt 15mg/1ml (mwt 520,base 211) how much is the %
strength of Metaproternol base in the soln( 0.6%
34) "no. 48" A patient is given phenytoin, plasma conc is 15mg/L, t1/2=20hours,
Vd=45. What is the loading dose?
LD = Cp x Vd = 15 x 45 = 675
35) "no.49" What is the loading dose, if the initiating loading dose is 2.2mg/kg
for girl weight 44Ib?
44mg
36) "no.50" The child dose of drug is reported as 1.2mg/kg body weight. What is
the appropriated dose are needed for child weighting 60 Ib?
32.7 mg
37) "no. 85" What is the minimum amount of a potent drug that may be
weighted on a prescription balance with a sensitivity requirement of 6 mg if at
least 98% accuracy is required?
300 mg
Error% = 100 – 98 = 2%
sensitivity requirement (SR) = minimum quantity to be weighed * error%
6 mg = x * 2% x = 300 mg
38) "no. 96"An adult recommended dose of drug is 5mg/kg/day, how many
milligrams of drug is required to be taken twice daily? Patient weight is
176pound
200mg
Wt in kg= 176/2.2=80kg so dose/day = 400 mg if BID then 200 mg

Calculation Raghad

Uploaded by

Copyright:

Available Formats

Calculation Raghad

Uploaded by

Document Information

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Calculation Raghad

Uploaded by

Copyright:

Available Formats

What are the main formulas and calculations discussed in the document?

What are the main formulas and calculations discussed in the document?

What are some examples of dosage calculations provided in the text?

What are some examples of dosage calculations provided in the text?

Rules needed:-

- Clearance (Cl)= Clearance rate (Ke) * Volume of distribution (Vd)

- Infusion Rate= Blood conc (Cp) * Clearance (Cl)

- Mwt for KCl = 74.6

- loading dose (Ld) = Blood conc (Cp) * Volume of distribution (Vd)

- sensitivity requirement (SR) = minimum quantity to be weighed * error%

Question numbers that are not mentioned here in this file:

Go back to calculation file.

‫ ساعات‬4 ‫ ملج كل‬20 ‫بياخد‬

120 ‫ يعني ياخد‬once daily

aw 60 BID (twice daily)

To give 150mg u need 5ml

7) How many gram of 5% ointment will be prepared from 2 gm :

8) How many gram will be in 250 ml of 5% solution :

9) If dose of drug is 0.2 ml, How many dose will be in 15ml :

His max dose will be 35kg*20mg= 700mg

5 unit * 75 kg * 6 hr =2250 units

10mg/kg/day divided every 12 hr

19) Patient currently take 220mg of anhydrous Znso4 to receive amount of

a. 55-110micro/l (they answered this in the previous exam)

b. 0.055-0.011micro/l (this is what I answered)

i. How many ml of solution will be administration in 15 hr?

ii. How many mmoles will be administrated in 15 hr?

a. 10 mg/hr b. 20 ug/hr c. 30ug/hr

CSS*Vd*cl= 10*0.25*12= 30 ug\hr

there is conflicts, some answered a and some b!

29) formula of paraffin to 100 % has 1%A...,15%B....,12% starch....how many Gms

sensitivity requirement (SR) = minimum quantity to be weighed * error%

Wt in kg= 176/2.2=80kg so dose/day = 400 mg if BID then 200 mg

You might also like

CSSVdcl= 100.2512= 30 ug\hr