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    More Common in Women Pollutants: 1.2.1 Genetic Risk Factors

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    Ruchi Sharma
    RA is more common in women than men and can be affected by environmental pollutants as women living closer to roads had an increased risk. Genetic factors also contribute to risk such as polymorphisms in the HLA-DRB1 and PTPN22 genes, though over half of genetic risk factors remain unknown.

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    More Common in Women Pollutants: 1.2.1 Genetic Risk Factors

    Uploaded by

    Ruchi Sharma
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    RA is more common in women than men and can be affected by environmental pollutants as women living closer to roads had an increased risk. Genetic factors also contribute to risk such as polymorphisms in the HLA-DRB1 and PTPN22 genes, though over half of genetic risk factors remain unknown.

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    RA is more common in women than men and can be affected by environmental pollutants as women living closer to roads had an increased risk. Genetic factors also contribute to risk such as polymorphisms in the HLA-DRB1 and PTPN22 genes, though over half of genetic risk factors remain unknown.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    14 views1 page

    More Common in Women Pollutants: 1.2.1 Genetic Risk Factors

    Uploaded by

    Ruchi Sharma
    RA is more common in women than men and can be affected by environmental pollutants as women living closer to roads had an increased risk. Genetic factors also contribute to risk such as polymorphisms in the HLA-DRB1 and PTPN22 genes, though over half of genetic risk factors remain unknown.

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    Figure 5.

    [10,11]

    RA is far more common in women than in men (3:1). Pollutants may affect the risk of


    developing RA. Women living within 50m of a road had an increased risk of RA (hazard
    ratio: 1.31) compared to 200m (Tobón GJ et al., 2010). Other causes of RA include
    smoking and vitamin D deficiency (Sokolove, 2017).

    1.2.1 Genetic Risk Factors


    The main genetic factor is HLA-DRB1*04 and *01 clusters which encode the "shared-
    epitope" sequences in MHC region. Polymorphisms of PTPN22, TRAF1-
    C5 and TNFAIP3 have also been described in RA. However, more than half of the genetic
    risk factors remain to be identified (Stahl et al., 2010)

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