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Material Safety Data Sheet

Version 5.0
Revision Date 05/09/2012
Print Date 03/19/2013

1. PRODUCT AND COMPANY IDENTIFICATION

Product name : tert-Butyllithium solution
Product Number : 186198
Brand : Aldrich

Supplier : Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
Telephone : +1 800-325-5832
Fax : +1 800-325-5052
Emergency Phone # (For : (314) 776-6555
both supplier and
manufacturer)
Preparation Information : Sigma-Aldrich Corporation
Product Safety - Americas Region
1-800-521-8956

2. HAZARDS IDENTIFICATION
Emergency Overview
OSHA Hazards
Flammable liquid, Pyrophoric, Target Organ Effect, Corrosive
Target Organs
Central nervous system, Heart, Lungs, Nerves.
GHS Classification
Flammable liquids (Category 2)
Pyrophoric liquids (Category 1)
Substances, which in contact with water, emit flammable gases (Category 1)
Acute toxicity, Dermal (Category 5)
Skin corrosion (Category 1B)
Serious eye damage (Category 1)
Specific target organ toxicity - single exposure (Category 3)
Aspiration hazard (Category 1)
Acute aquatic toxicity (Category 2)
GHS Label elements, including precautionary statements
Pictogram

Signal word Danger

Hazard statement(s)
H225 Highly flammable liquid and vapour.
H250 Catches fire spontaneously if exposed to air.
H260 In contact with water releases flammable gases which may ignite spontaneously.
H304 May be fatal if swallowed and enters airways.
H313 May be harmful in contact with skin.
H314 Causes severe skin burns and eye damage.
H336 May cause drowsiness or dizziness.
H401 Toxic to aquatic life.

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 Precautionary statement(s)
P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P222 Do not allow contact with air.
P223 Keep away from any possible contact with water, because of violent reaction and
possible flash fire.
P231 + P232 Handle under inert gas. Protect from moisture.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
P331 Do NOT induce vomiting.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction.
P422 Store contents under inert gas.
HMIS Classification
Health hazard: 3
Chronic Health Hazard: *
Flammability: 4
Physical hazards: 3
NFPA Rating
Health hazard: 3
Fire: 3
Reactivity Hazard: 3
Potential Health Effects
Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of the mucous
membranes and upper respiratory tract. Vapours may cause drowsiness and
dizziness.
Skin May be harmful if absorbed through skin. Causes skin burns.
Eyes Causes eye burns.
Ingestion May be harmful if swallowed. Aspiration hazard if swallowed - can enter lungs and
cause damage.

3. COMPOSITION/INFORMATION ON INGREDIENTS
Synonyms : Lithium-2-methyl-2-propanide
t-BuLi

Formula : C4H9Li
Molecular Weight : 64.06 g/mol
Component Classification Concentration
n-Pentane
CAS-No. 109-66-0 Flam. Liq. 2; STOT SE 3; Asp. 60 - 100 %
EC-No. 203-692-4 Tox. 1; Aquatic Chronic 2;
Index-No. 601-006-00-1 H225, H304, H336, H411,
EUH066
tert-Butyllithium
CAS-No. 594-19-4 Pyr. Liq. 1; Water-react. 1; 10 - 30 %
EC-No. 209-831-5 Skin Corr. 1B; H250, H260,
H314
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

4. FIRST AID MEASURES

General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

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 In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.Continue rinsing eyes during
transport to hospital.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a
physician.

5. FIREFIGHTING MEASURES
Suitable extinguishing media
Dry powderDry powder Carbon dioxide (CO2)
Extinguishing media which shall not be used for safety reasons
Water Carbon dioxide (CO2)Water
Special protective equipment for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Hazardous combustion products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Lithium oxides

6. ACCIDENTAL RELEASE MEASURES

Personal precautions
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all
sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive
concentrations. Vapours can accumulate in low areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment
must be avoided.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in
container for disposal according to local regulations (see section 13). Do not flush with water.

7. HANDLING AND STORAGE

Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build
up of electrostatic charge.
Conditions for safe storage
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must
be carefully resealed and kept upright to prevent leakage.
Never allow product to get in contact with water during storage.
Recommended storage temperature: 2 - 8 °C
Air and moisture sensitive. Handle and store under inert gas. Sensitive to carbon dioxide

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Components with workplace control parameters

Components CAS-No. Value Control Basis

parameters
n-Pentane 109-66-0 TWA 600 ppm USA. OSHA - TABLE Z-1 Limits for Air Contaminants -
1,800 mg/m3 1910.1000
STEL 750 ppm USA. OSHA - TABLE Z-1 Limits for Air Contaminants -
2,250 mg/m3 1910.1000
TWA 1,000 ppm USA. Occupational Exposure Limits (OSHA) - Table Z-1
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 2,950 mg/m3 Limits for Air Contaminants
Remarks The value in mg/m3 is approximate.

TWA 600 ppm USA. ACGIH Threshold Limit Values (TLV)

TWA 600 ppm USA. ACGIH Threshold Limit Values (TLV)

Peripheral neuropathy

TWA 120 ppm USA. NIOSH Recommended Exposure Limits

350 mg/m3
15 minute ceiling value

C 610 ppm USA. NIOSH Recommended Exposure Limits

1,800 mg/m3
15 minute ceiling value

Personal protective equipment

Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the
respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components
tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching
glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in
accordance with applicable laws and good laboratory practices. Wash and dry hands. Protective gloves against
thermal risks

Eye protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved
under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
Choose body protection according to the amount and concentration of the dangerous substance at the work place.,
Flame retardant protective clothing. Antistatic safety boots.Complete suit protecting against chemicals, Flame
retardant antistatic protective clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of
workday.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance
Form liquid
Colour light yellow
Safety data
pH no data available
Melting no data available
point/freezing point
Boiling point no data available
Flash point -49 °C (-56 °F) - closed cup
Ignition temperature no data available
Autoignition no data available

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 temperature
Lower explosion limit no data available
Upper explosion limit no data available
Vapour pressure no data available
Density 0.652 g/mL at 25 °C (77 °F)
Water solubility no data available
Partition coefficient: no data available
n-octanol/water
Relative vapour no data available
density
Odour no data available
Odour Threshold no data available
Evaporation rate no data available

10. STABILITY AND REACTIVITY

Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions

Vapours may form explosive mixture with air.

Reacts violently with water.
Conditions to avoid
Heat, flames and sparks. Extremes of temperature and direct sunlight. Exposure to moisture.
Materials to avoid
acids, Water, Alcohols, Carbon dioxide (CO2), Humid air, Halogenated hydrocarbon, Amines
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Lithium oxides
Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION

Acute toxicity
Oral LD50
no data available
Inhalation LC50
Dermal LD50
Other information on acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
Eyes: no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity

no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
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 probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a
known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by OSHA.
Reproductive toxicity
no data available

Teratogenicity

no data available

Specific target organ toxicity - single exposure (Globally Harmonized System)

no data available
Specific target organ toxicity - repeated exposure (Globally Harmonized System)
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of the mucous
membranes and upper respiratory tract. Vapours may cause drowsiness and dizziness.
Ingestion May be harmful if swallowed. Aspiration hazard if swallowed - can enter lungs and cause
damage.
Skin May be harmful if absorbed through skin. Causes skin burns.
Eyes Causes eye burns.
Synergistic effects
no data available
Additional Information
RTECS: Not available

12. ECOLOGICAL INFORMATION

Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
Toxic to aquatic life.

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13. DISPOSAL CONSIDERATIONS
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material
is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

14. TRANSPORT INFORMATION

DOT (US)
UN number: 3394 Class: 4.2 (4.3) Packing group: I
Proper shipping name: Organometallic substance, liquid, pyrophoric, water-reactive (tert-Butyllithium)
Marine pollutant: No
Poison Inhalation Hazard: No

IMDG
UN number: 3394 Class: 4.2 (4.3) Packing group: I EMS-No: F-G, S-M
Proper shipping name: ORGANOMETALLIC SUBSTANCE, LIQUID, PYROPHORIC, WATER-REACTIVE (tert-
Butyllithium)
Marine pollutant: No

IATA
UN number: 3394 Class: 4.2 (4.3)
Proper shipping name: Organometallic substance, liquid, pyrophoric, water-reactive (tert-Butyllithium)
IATA Passenger: Not permitted for transport
IATA Cargo: Not permitted for transport

15. REGULATORY INFORMATION

OSHA Hazards
Flammable liquid, Pyrophoric, Target Organ Effect, Corrosive
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold
(De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Fire Hazard, Reactivity Hazard, Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
CAS-No. Revision Date
n-Pentane 109-66-0 2007-03-01
Pennsylvania Right To Know Components
CAS-No. Revision Date
n-Pentane 109-66-0 2007-03-01
tert-Butyllithium 594-19-4
New Jersey Right To Know Components
CAS-No. Revision Date
n-Pentane 109-66-0 2007-03-01
tert-Butyllithium 594-19-4
California Prop. 65 Components
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other
reproductive harm.

16. OTHER INFORMATION

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 Text of H-code(s) and R-phrase(s) mentioned in Section 3
Aquatic Chronic Chronic aquatic toxicity
Asp. Tox. Aspiration hazard
EUH066 Repeated exposure may cause skin dryness or cracking.
Flam. Liq. Flammable liquids
H225 Highly flammable liquid and vapour.
H250 Catches fire spontaneously if exposed to air.
H260 In contact with water releases flammable gases which may ignite spontaneously.
H304 May be fatal if swallowed and enters airways.
H314 Causes severe skin burns and eye damage.
H336 May cause drowsiness or dizziness.
H411 Toxic to aquatic life with long lasting effects.
Pyr. Liq. Pyrophoric liquids
Skin Corr. Skin corrosion
STOT SE Specific target organ toxicity - single exposure
Water-react. Substances, which in contact with water, emit flammable gases
Further information
Copyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or
from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for
additional terms and conditions of sale.

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