A. Nursing Practice: Introduction To Pharmacology

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INTRODUCTION TO PHARMACOLOGY

Definition of term
Pharmacology
 Study of drugs
 Actions on the living organ
Drugs
 Chemicals that have an effect on living organism
Medicines
 Therapeutic drugs used in the prevention of treatment of diseases
 *food is not a drug because it is considered something essential for survival, while drugs are used as a method to treat a condition

Significance
A. Nursing practice
 Administration of drug was the 1st medical function delegated by doctors
 Nurses are expected to counsel clients regarding management of their drug regimen
 Nurses are expected to exercise judgment in management of drug therapy
 when should you take it, mechanism of actions, adverse effects
 Eventually this may involve prescription of medication in selected patient situation
 Nurses are not writing but the physician
 Doctors will decide if therapy is safe
 In some countries they allow nurses to write prescriptions (nurse practitioners similar to general practitioner the difference for gen
nurse preselected patients

Nursing CARE 4 levels


4 LEVELS OF NURSING CARE
1. 1ST LEVEL: PREVENTION of problems in healthy client
o Health impact on environmental pollutants and health aspects of social, medicinal & illegal drug use
o Function of nurse is mainly educational
2. 2ND LEVEL: EARLY DETECTION of disruption in healthy client
o Case finding and referral
o Seeks early evidence of drug habituation, toxicity, addiction or untoward side effects form use of drugs and exposure to chemical
o Untoward effects from use of drugs
o Exposure to chemicals
3. 3RD LEVEL: CARE needed for clients with acute health needs
o Occurs in an institutional setting
o Traditional tasks of administering drugs to clients that are acutely ill clients
o Most demanding (most active)
4. 4th LEVEL REHABILITATION & RESUMPTION of normal living for recovering clients from acute health problem
o Long term use of drug is necessary to control chronic disease process

B. Nursing Education
 Integrated in the curriculum
 Too little content that this may result in failure that this may result in failure of student to acquire comprehensive knowledge
 Separate subjects are proposed to prevent this from happening

Ethical principles in Human Research


A. Respect for the person
 Capable of making their own decision
 Informed consent
 PANACEA-Drug used to treat anything
 Opium: narcotic, stomach pain, or baby with kabag (English?)
 When medications are made: Is it safe
 Substitute animals first
B. Beneficence
 Duty not to do harm
 Maximize all possible benefits and minizine possible harm

C. Justice
 Social benefits and burden can be allocated objectively
 Those with equivalent circumstances should be treated equally

D. Nursing research
 Human testing for different drugs is usually divided into 3 phases

DEVELOPING AND APPROVING A DRUG


Preclinical phase
 Animal research (the question is will it work on a living being)
 Some chemicals are discarded for the ff reasons:
o Lacks therapeutic activity
o Too toxic
o Highly teratogenic – harmful for fetuses
o Very small safety margin – not useful in clinical setting
1. PHASE 1
 Studies pharmacologic properties such as pharmacokinetics, metabolism and toxicity
 Study population maybe normal volunteers or people who are to be treated
 Usually, 20-100 subjects done in 4-6 weeks
 Some chemicals are discarded for the ff reasons:
o Lacks therapeutic activity in humans
o Too toxic
o Highly teratogenic – harmful for fetuses
o Very small safety margin – not useful in clinical setting

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