Sepsis Quick Reference Guide

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Sepsis

Quick Reference Guide


Recognition HR HR RR SBP
Age
High Low High Low
Suspected infection
0 mins Tachycardia/ Tachypnoea
0-1
Altered mental status month
>180 <100 >50 <65
low DIASTOLIC pressure
< 1
>180 <100 >34 <100
year
Intervention
Intravenous access * 2: use IO/external jugular if difficult 2-5
5 mins U+Es Blood glucose, ABG, LFTs, FBC, X-match & clotting >140 <90 >22 <100
years
Blood culture, PCR
8-12
years >130 N/A >18 <105
Resuscitation
High flow O2 & 20mls/kg isotonic fluid bolus > 13
Ceftriaxone 80mg/kg OR Cefotaxime 50mg/kg years >110 N/A >14 <117
Consider Aciclovir (<6 weeks old, vesicular rash, coagulopathy)

Reassessment to detect fluid overload COLD SHOCK WARM SHOCK


Hepatomegaly
Worsening crackles on auscultation
CRT > 3 seconds CRT < 3 seconds

NO
Bounding Peripheral
Weak Peripheral Pulse
Pulse
Reassessment to detect resolution of shock
Heart rate and respiratory rate in age normal range
Cold extremities Warm around the edge
Capillary refill time < 3 seconds
Palpable peripheral pulses
Blood pressure in age normal range
Narrow Pulse Pressure Wide Pulse Pressure
Serum lactate < 2 mmol/L

NO
TIME ACTION AMOUNT

15 mins 20 - 40 mls/kg isotonic fluid bolus Fluid ml

Antibiotics mg
Fluid refractory shock
CALL SORT for advice re management
Fluid ml
Start peripheral dopamine at 5-10 mcg/kg/min
Intubate and ventilate (Expect decompensation)
Fluid ml

Dopamine Mcg/kg/min
60 mins
Attempt central venous access Intubation

Fluid ml
Warm Shock Cold Shock
Mcg/kg/min
Adrenaline

Noradrenaline Adrenaline Mcg/kg/min
Noradrenaline
0.1 mcg/kg/min 0.1 mcg/kg/min
Max 1 mcg/kg/min Max 1 mcg/kg/min Fluid ml

Fluid ml
Relative adrenal Insufficiency
Consider Hydrocortisone 1 mg/kg [max
100mg] (2.5mg/kg in neonates) SORT May 2018 Review 2021
(Discuss with SORT) www.sort.nhs.uk

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