Student Guide: Enzymes - AP STEM Case and Handbook
Student Guide: Enzymes - AP STEM Case and Handbook
Student Guide: Enzymes - AP STEM Case and Handbook
Introduction: Claire, a Great Dane, is experiencing extreme weight loss and lethargy despite
maintaining a normal appetite. As a veterinary technician, you must learn about metabolism,
digestion, and enzymes to help Claire. As part of this Gizmo, you will examine Claire, run lab
tests, and analyze data to determine the cause and treat her weight loss.
Vocabulary: As new vocabulary is introduced, the words are presented in the Gizmo as
orange text - clicking the orange text opens the glossary page for that term. You can use the glossary at any
point.
1. Launch the Gizmo and follow the instructions provided to collect data on Claire. The questions below are
sequential.
Low Energy
Increased Appetite
Weight Loss
3. Define "metabolism"
is the word for all of the chemical reactions that happen in the body.
4. Metabolism is a combination of two types of reactions. What are these? Define them.
type of reaction definition
8. Every chemical reaction, including the reactions that happen inside a living organism, requires an initial input
of energy. The energy needed to start a chemical reaction is called the
9. Several different types of energy can be used to "give" a reaction its activation energy. List these below:
thermal
collision
10. In biological organisms thermal energy cannot be easily added to start a reaction. Instead, enzymes are used.
Explain HOW enzymes speed up the rate of a reaction.
11. Label the reaction graph provided with the following labels:
activation energy, reactant energy, produce energy.
a)
b)
c)
Enzymes do not change the energy of the reactants or the products. They speed up a reaction by lowering the
energy of….
13. Each of your 80 000 enzymes has its own highly specific shape, its structure. What determines the
structure of an enzyme?
14. Because of their specific structure, enzymes differ from each other. Every enzyme has a different active site.
What happens at the active site of an enzyme? Can the substrate of one enzyme fit into the active site of
another?
15. How do high temperature and pH changes affect the workings of an enzyme? Explain.
16. Once you are back to Claire's Lab Data, fill in the table below:
enzyme location function
pepsin
protease
carbohyd
ra se
lipase
17. Low enzyme function can be caused by a range of issues. In your Gizmo, explain how each of these could
affect enzyme function and what happens when you test these in Claire.
Potential explanation Claire's results
issue
active site
mutation
abnormal
pH
low
enzyme
productio
n
18. Science function by asking and testing questions. As more information becomes known new questions can
be asked and hypotheses can be revised to make them more and more accurate. At some point, once enough
information has been gathered, a conclusion can be made. Explain how this Gizmo illustrates that process.
As more evidence gathers, science is replaced by better science. Use a real-life example to explain this. As a
good starting point, ave a look at:
https://www.sciencenews.org/article/coronavirus-covid-19-pandemic-six-months-what-we-know