HIV (Human Immunodeficiency Virus) : 1. Binding and Fusion (Attachment)

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HIV (human immunodeficiency virus)

1. Proses Infeksi HIV/HIV life cycle


1. Binding and fusion (attachment)
HIV attaches to a T-helper cell. It then fuses to it and releases its genetic information
into the cell.

2. Reverse transcription (conversion) and integration


Once inside the T-helper cell, HIV converts its genetic material into HIV DNA, a
process called reverse transcription. The new HIV DNA then enters the nucleus of
the host cell and takes control of it.
3. Transcription and translation (replication)
The infected T-helper cell then produces HIV proteins that are used to produce more
HIV particles inside the cell.

4. Assembly, budding and maturation


The new HIV is put together and then released from the T-helper cell into the
bloodstream to infect other cells; and the process begins again.
2. Response tubuh terhadap HIv
They release a protein called perforin which punctures the infected cells, allowing
enzymes to be injected, triggering auto-destruction. For a while, the defence hols and
virus levels drop, but HIV begins its counterattack.

It disables the cell’s antiviral proteins, allowing new particles to leave the cell. They also
constantly mutates inside the cell to evade detection –The immune system can’t fight
what it can’t see. Eventually, the immune system wears itself out.

Killer T cells activated for too long become exhausted and no longer respond to
infection. Also, the body loses the ability to make new helper T cells to replace those
killed in the fight, and as a result, their numbers plummet.

Ultimately, the body becomes immunodeficient, and this condition is known as AIDS.
Without treatment, exposure to otherwise harmless microbes could be fatal. We still
have no way of eliminating HIV from the body completely. There is no cure, and hidden
reservoirs of HIV will rebound if treatment stops.

However, treatment with antiretroviral drugs can swing the balance, allowing the
immune system to recover from the battle and live to fight another day.

3. Gejala HIV
Stage 1: Acute HIV Infection
Within 2 to 4 weeks after infection with HIV, about two-thirds of people will have a flu-
like illness. This is the body’s natural response to HIV infection.

Flu-like symptoms can include:


 Fever
 Chills
 Rash
 Muscle aches
 Sore throat
 Fatigue
 Swollen lymph nodes
 Mouth ulcers
These symptoms can last anywhere from a few days to several weeks. But some people
do not have any symptoms at all during this early stage of HIV. However, just because
you’re experiencing these symptoms, it might not always be HIV. To be sure, get an HIV
test.
Stage 2: Chronic HIV infection
In this stage, the virus still multiplies, but at very low levels. People in this stage may not
feel sick or have any symptoms.
Stage 3: AIDS (acquired immunodeficiency syndrome)
If you have HIV and you are not on HIV treatment, eventually the virus will weaken your
body’s immune system and you will progress to AIDS. This is the late stage of HIV
infection.
Symptoms of AIDS can include:

 Rapid weight loss


 Recurring fever or profuse night sweats
 Extreme and unexplained tiredness
 Prolonged swelling of the lymph glands in the armpits, groin, or neck
 Diarrhea that lasts for more than a week
 Sores of the mouth, anus, or genitals
 Pneumonia
 Red, brown, pink, or purplish blotches on or under the skin or inside the mouth,
nose, or eyelids
 Memory loss, depression, and other neurologic disorders
When a virus winds up inside the body, it's usually met with a furious onslaught from
the immune system. White blood cells (T helper cells) immediately respond by releasing
antiviral proteins, attacking infect f cells and recruiting backup. Usually this is enough,
but HIV pushes the immune system beyond its limits.

HIV infects one of the immune cells that is central to the body's response to pathogens
—the helper T cell.

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