Marpe
Marpe
Marpe
Research
Keywords: maxillary expansion, bone-borne, miniscrew, non-surgical, adult patients, MAPE, MARPE,
success, complication
DOI: https://doi.org/10.21203/rs.3.rs-515793/v1
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Abstract
Introduction: Bone-borne miniscrew assisted palatal expansion (MAPE) is a common technique to
improve maxillary transverse deficiency in young adolescents. Adult patients usually present a challenge,
as they often require additional surgical assisted maxillary expansion (SARPE). There is still no clear
statement about non-surgical expansion in adult patients using this technique. The aim of this study was
to evaluate the success and complication rate of non-surgical palatal expansion in adults utilizing MAPE
with a novel force-controlled polycyclic expansion protocol (FCPC).
Methods: This consecutive study consisted of 33 adult patients with an average age of 29.1 ± 10.2 years
(min. 18 years, max. 58 years), including one dropout patient. First, four miniscrews were inserted and
after 12-weeks latency, the expander was placed and the FCPC protocol was applied (MAPE group). In
case of missing expansion, a SARPE was performed (SARPE group). After maximum expansion, a cone
beam CT was made and widening of the midpalatal suture was measured. The outcome variables were
successful non-surgical expansion and, with sample size power above 80%, the odds of failed non-
surgical expansion and associated complications were evaluated. The primary predictor variable was
age. Statistical analysis was performed using R (Version 3.1) to calculate power, to construct various
models for measuring the odds of requiring surgical intervention/complications, and others.
Results: Successful non-surgical expansion was achieved in 27 patients (84.4%), ranging from 18 to 49
years. Mean age differed significantly between both groups (26.8 ± 8.2 years vs. 41.3 ± 9.9 years; p <
0.001). Mean expansion at the anterior and posterior palate for the MAPE group was 5.4 ± 1.5 mm and
2.5 ± 1.1 mm, respectively. Among these subjects' complications were observed in 18.5%. Age
significantly increased the odds of complications (p = 0.019).
Conclusions:
1. The success rate of MAPE among individuals aged 18 to 49 years was 84.4%.
4. A careful expansion protocol seems to be beneficial to prevent unfavorable results in adult patients.
Background
Widening of the maxilla in children and young adolescents is usually done with hyrax or Haas-type tooth-
borne expanders. Due to the increased skeletal resistance in adolescent age, rapid palatal expansion
(RPE) might be recommended for patients at the final stage of pubertal growth. For adults, however, RPE
has been considered rarely successful and can produce undesirable effects on the dentoalveolar complex
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[1, 2]. With the beginning of fusion of the midpalatal suture with age, maxillary widening can be treated
with surgically-assisted rapid palatal expansion (SARPE) using various appliances [2, 3]. However,
problems persist with respect to the need for a surgical intervention, including osteotomies, and the risk
of root damage or infections, asymmetric maxillary expansion, and device-related technical problems [4–
6]. Along with the development of digital techniques and bone-borne anchorage, a miniscrew or implant
assisted rapid palatal expansion (MARPE) has become available for the treatment of maxillary transverse
deficiency in adults [7–11]. In adults it represents a treatment solution that can potentially reduce the
complications of SARPE and is minimally invasive, secure, and reliably stable [11]. However, when
MARPE is used with a rapid continuously opening expansion protocol in adult patients (two activations
per day, achieving 0.4mm), the overload of the hardware (appliance and miniscrews) or of the involved
anatomical structures can lead to unsatisfactory results [12–15]. In order to reduce these side effects, the
rigidity of the expander used in this current study was improved and a novel 2-stage protocol was applied
for miniscrew assisted palatal expansion (without Rapid expander activation) (MAPE) [16]. With this
protocol (force-controlled polycyclic protocol: FCPC), an activation period is followed by a slow force-
controlled polycyclic expansion period to weaken the circummaxillary sutures and enable maxillary
expansion [17].
The purpose of this present study was to evaluate non-surgical maxillary expansion utilizing a miniscrew
supported appliance with a novel 2-stage polycyclic expansion protocol in adult patients. The specific
aims of the study were: (1) to evaluate the success rate of non-surgical maxillary expansion, (2) to
measure the pattern of expansion in the midpalatal suture, and (3) to evaluate complications among the
non-surgical patients.
This study comprised 33 patients (10 males, and 23 females) who were all treated by the same examiner
(H.W.). All patients had to sign an informed consent. The average age (±SD) was 29.1 ± 10.2 years (min.
18.0 years, max. 58.0 years). All patients were treated with a MICRO-4 device that was used for treatment
of transverse maxillary deficiency as previously described by Winsauer et al. [10]. Under local anesthesia,
four orthodontic miniscrews (diameter, 2.5 mm; length, 14-16 mm; self-drilled type; Dual Top Jetscrew, Jeil
Medical, South Korea) were inserted without surgical incision in the anterior palate and stabilized with
temporary light-curing resin against each other. After 12 weeks latency period (secondary stability),
alginate impressions were taken from the upper jaw and the MICRO-4 device was fabricated in the
laboratory and thereafter bonded to the screw heads (Phase II, Reliance Orthodontic, USA). In this study a
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novel 2-stage protocol (FCPC) was used: first, the device was activated for one week with a wrench
turning the hex nut of the expansion screw two times per day by a one-sixth of a turn, achieving 0.34 mm
per day (= activation period). Thereafter, the amount of force needed to activate the hex nut was
measured by a spring scale (Push-Pull Spring Scale 10N, Arbor Scientific, Ann Arbor, US) to assess the
strain of the device (Fig. 1).
In order to weaken the circummaxillary sutures, all patients were then instructed to apply the following
protocol twice per day: turn the hex nut 6 sides backward, and after 15 minutes, turn the hex nut forward
6 sides again. For each activation the force of the wrench was measured by the spring scale not
exceeding 500cN. Every third day, the device was additionally activated by 0.17mm again not exceeding
500cN until the desired maxilla expansion was reached (= forced controlled polycyclic expansion period)
(Fig.2).
Success was defined when sufficient expansion of the midpalatal suture, according to the definition of
transverse deficiency, was achieved without additional surgery (MAPE group). The patients without
visible diastema within four months, were referred with the expansion device in place to the Department
of Oral and Maxillofacial Surgery. SARPE was performed without osteotomy in the midpalatal bone under
general anesthesia (SARPE group). Separation between the central incisors was accomplished using a
scalpel blade no. 20 (Martin, Tuttlingen, Germany) as a chisel. After 5-days, the activation was started by
turning the expansion screw at a rate of 0.5 mm per day (three turns a day) until the desired maxillary
width was achieved. In both groups the MICRO-4 device was then left in place as a retention device for
about 9 months and then replaced by a mini screw borne transpalatal arch for another 12-15 months.
A 43-year-old female patient was excluded from the study due to not following the activation protocol.
The patient activated the expansion device more frequently, and with higher force. As a consequence, the
right maxillary half, and the including nasal bone on one side expanded more than the contralateral side.
Accordingly, the effective cohort study included 32 patients.
Complications were registered from the patient´s records. Dental (gingival irritation, increased periodontal
probing depth, root resorption or damage, gingival recession, loss of vitality), tissue- (peri-implantitis,
infection, ulceration) and hardware-related side effects (loosening or deformation of miniscrew or
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abutment, fracture or deformation of expansion screw), and anatomical complications (asymmetric
expansion, fracture of bone) were recorded and saved in an Excel spreadsheet.
Statistical Analysis
The statistical evaluations were carried out with the statistical program R (Version 3.1, R Foundation for
Statistical Computing, Vienna, Austria). Normal distribution was tested with Shapiro-Wilk test and graphic
data output. Continuous measures were represented by the means and standard deviations and the
discrete features by absolute frequencies. To model the odds, for example in case of success, or
complications, a generalized logistic regression with logit link function was used. Parameter significance
of the generalized linear models are calculated using the Wald test, with the null hypothesis that the
parameter is 0. A parameter is considered significant if p-value of the test is less than 0.05. Given the
number of possible variables that can explain the outcome, stepwise regression to identify the best model
was selected. Backward stepwise regression is used to find the best model starting from all possible
independent factors. The models are assessed using the Bayesian Information Criteria (BIC), where
higher BIC, indicates that the factor combination of the model is a better model. The final model is then
used as the best fit model for the data we have. Stepwise regression is important to identify the right
combination of variables that best fit the data we have, given the independent assumption of the
variables. For significant testing between two distributions such as age, the non-parametric Wilcoxon test
is used, to avoid operating under the normal distribution assumption in small datasets. For exact count
significance tests like gender count, the fisher test was used. Power calculation of the study was done by
simulating sampling from a statistical distribution representing the effect measured with the same
sample size, while measuring the probability of having a significant outcome (< 0.05). The resulting
power is then defined as the percentage of time we have obtained the significant result under the same
sample size, and the uncertainty in the statistical distributions.
Results
In 27 out of 32 patients the desired expansion was achieved without surgical intervention, resulting in a
success rate of 84.4%. Using a multivariate binomial logistic stepwise regression, the model showed
significantly (p < 0.019 with power > 80%) high odds of 17.9% per year above the baseline age of 18 years.
For gender this effect was not significant. Further detailed descriptive data of the patients, amount, and
pattern of expansion and are displayed in Table 1.
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Table 1
Descriptive Data of the Treatment Groups and Intergroup Comparison
MAPE SARPE P-Value
group group
MAPE: successful non-surgical expansion using the MICRO-4 appliance; SARPE: failed non-surgical
expansion using the MICRO-4 appliance; *Statistically significant for intergroup comparison (P < .05).
As demonstrated in Fig. 3, expansion of the midpalatal suture increased significantly both in the anterior
and the posterior region of the palate. Among the MAPE group, the midpalatal suture opened in a V-
shaped pattern in most patients (25/28), with the smaller increase observed in the posterior palate
(Table 1). Expansion for the anterior and posterior palate was 5.41 ± 1.49 mm, 2.51 ± 1.07 mm,
respectively. This difference was statistically significant (p < 0.001). A stepwise linear regression of the
amount of expansion against duration, age, gender, and complication (as a binary indicator), showed that
the duration of expansion is the only remaining significant (p = 0.031) factor that is correlated with the
amount of expansion. On the other hand, neither age, gender, nor complications showed significant
correlations.
Complications occurred in 18.5% of the subjects with successful non-surgical expansion using the
technique described; the complications of the complete cohort are displayed in Table 2.
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Table 2
List of complications for both groups (MAPE and SARPE)
Type of complication MAPE group SARPE group Total
Tooth related 0 0 0
Patients with any complication 5/27 (18.5%) 2/5 (40.0%) 7/32 (21.9%)
MAPE: successful non-surgical expansion using the MICRO-4 appliance; SARPE: not successful non-
surgical expansion using the MICRO-4 appliance.
Soft tissue inflammation (gingivitis or buccal tissue irritation) was observed in one patient of the SARPE
group without clinical consequences. In six patients, hardware-related problems occurred during the
expansion phase. In one patient, a loosening of the abutment was observed during the retention period,
but this was without clinical relevance. In five further patients, a minor deformation of the mini-screw
shaft (n = 4) or jack-screw (n = 2) was observed (Fig. 4).
Using a multivariate logistic stepwise regression model (complication or not, versus age and gender)
showed that age has a significantly (p = 0.04, with power > 80%) high odd of 9.9%, for every extra year of
age, above the baseline age of 18 years old. No significant effect was seen for gender.
Discussion
The success rate of non-surgical expansion in adults using MAPE with the FCPC protocol was almost
84.4%, and is similar to those obtained in the recent literature [9, 19–21]. In contrast to the literature, the
mean age of the patients in the present study was higher (29.1 years) than similar studies using MARPE
for non-surgical expansion of mostly young adult patients (mean age from 17.1 to 23.3 years) [7, 9, 15,
22–25] or include subjects younger than 18 years old [7, 15, 22, 23, 26]. Moreover, successful expansion
in the present study was achieved in patients up to 49 years. This evidence suggests that non-surgical
palatal expansion, assisted by miniscrews or implants, is achievable even for older patients. This can be
explained by various predictors for midpalatal suture expansion, such as patient´s individual anatomy,
midpalatal suture maturation stage or density ratio [27], design, stability and location of the expansion
appliance used, and the activation protocol applied for the expansion process [7, 19, 21, 25, 28]. In order
to evaluate the success of non-surgical expansion, some studies have stated that the ossification of the
midpalatal suture of each individual should be assessed by CBCT prior to treatment [27, 28]. The results
of a recent study showed that the age differed significantly across midpalatal suture maturation stages,
and correlated significantly with the midpalatal suture opening ratio [25]. Similarly, in the present study
we found a significant correlation of age with both unsuccessful expansion and complications. This
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might be due to an increase of interdigitation occurring in the midpalatal and circummaxillary sutures in
late adolescence, becoming more rigid as age progresses, mainly around 30 years of age [21].
A relevant difference in our study that might explain the high success rate in older patients was the
rigidity of the expander, the location of the inserted miniscrews, and the novel 2-stage protocol [16]. The
MICRO-4 appliance was introduced by Winsauer et al. [10] which due to its rigidity can establish a more
direct transfer of the expansion force to the hard palate. This aspect is especially interesting in older
patients, since age-related changes of the suture may require more expansive force on the suture [16].
However, even with more rigid screws and abutments used some minor deformations were observed in
our study as described in Table 2. Therefore, the needed force for expansion of a mature palate should
never be underestimated.
Secondly, a further difference in our study was the location of the inserted miniscrews in the anterior
palate. In general, placement of the miniscrews for the MARPE appliances is mostly in the middle or
posterior part of the palate with less bone height, close to the midpalatal suture since these appliances
are tooth-and-bone-borne with an additional fixation in the area of the first upper molar [9]. Because of the
greater bone heights between 6 to 10 millimeters in the anterior part of the palate, this position is
preferred for the fixation of the MICRO-4 device in our study [29]. The more stable anchorage of the
miniscrews in this area may explain the high success rate. On the other hand, this location could also be
the explanation of the anterior V-shaped expansion pattern in our study, resulting in 54% less expansion
around the posterior palate as measured on the CBCT. Similar results with a V-shaped expansion of the
dental arch in an antero-posterior plane were also reported with SARPE protocols when using bone-borne
devices [8, 30]. However, the pterygomaxillary junction seems to be the point with the highest resistance
as studied in a finite element study by Holberg et al. [2] and might explain the expansion pattern of the
non-surgical cohort in the present study.
Thirdly, the second stage of the expansion protocol, the polycyclic closing and opening of the appliance,
mimics oscillatory tensile and compressive strains, which are potent stimuli for modulating sutural
growth by stimulating both osteogenesis and osteoclastogenesis [31]. Vij & Mao [32] stated that a cyclic
loading protocol may have clinical implications as novel mechanical stimuli for modulating craniofacial
growth in patients suffering from craniofacial anomalies and dentofacial deformities. This effect was
used in our study and seems to weaken the circummaxillary sutures thus enabling successful expansion
even in older patients. Based on the literature and the author´s experience, the protocol has been adapted
in a pilot study to avoid technical or clinical complications such as loosening or deformation of screws
and expander under rapid and continuous activation [33]. As mentioned above, a 43-year-old patient did
not follow the polycyclic expansion protocol and, as a consequence, an asymmetric expansion of the
nasomaxillary complex with dislocation of the nasal bone was observed. Usually, expansion protocols for
MARPE (range 0.2–0.4 mm per day) [25] and for SARPE (0.5–1.0 mm per day) [6, 30] are much faster
than the protocol used in our study. Therefore, the term “rapid” (as used in MARPE) is misleading and
should not be used for non-surgical expansion in adult patients. However, some of the unsuccessful
expansions observed in the present study were even younger than in the successful treatment group. The
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regression model showed an increase of almost 18% per year to experience unsuccessful expansion in
our study. Although, a recommending baseline could not be found, this protocol can be used in all adult
patients with the need for maxillary expansion. Due to the higher morbidity rate of SARPE procedure with
the need for general anesthesia most patients prefer an orthodontic procedure rather than a surgical.
Starting with MAPE utilizing the FCPC protocol, the SARPE procedure can be followed in case of missing
diastema during the activation or early expansion period without any pre-treatment or changes in the
hardware as described in our study. Interestingly, in the surgeon´s experience the bone between the
central incisors was easy to separate using only a surgical blade as a chisel. The polycyclic activation
seems to weaken the midline of the alveolar process and this positive side effect may reduce the risk of
tooth damage even in cases with narrow space between the central incisors.
Expansion in adult patients might be associated with various complications and the prevalence of
complications in patients undergoing SARPE is up to 34% [6]. Due to greater resistance in maturing
maxillary bone, classical tooth-borne expanders cause a strong increase of dental side effects after
attempting the expansion [34]. Some studies reported that bone-borne devices are associated with a risk
of root lesions or infections, asymmetric maxillary expansion, periodontal damage, or loss of the
distractor components [6, 30]. The complication rate of non-surgical expansion using MAPE was 18.5% in
the present study. Although no severe complications of MARPE have been reported in the literature, the
reduced elasticity of the bony structures in adults, might lead to microfractures with injury of nervous and
vascular structures of the mid- or skull base [2]. The most frequent complication observed using MARPE
were inflammation and hyperplasia of the mucosa around the miniimplant/screw or loosening or
deformation of the screws used. A decrease in bone level and thickness at first molars was observed in
41% and undesirable effects like ulcerations, oedema of the palatal mucosa were observed in 22% of
cases [14]. In a retrospective study on 69 patients, 5% of the miniscrews dislodged during expansion and
13% showed clinically visible mobility [15]. The most frequent cause for complications in our study was
appliance-related. Generally, difficulties related to non-surgical expansion are associated with the device
or with the expansion protocol itself, with the soft tissue around the anchorage of the device, the teeth,
and the movement of the maxillary halves.
Using the regression model in our study the risk of complications increased by almost 10% per year
above the baseline of 18 years. In other words, patients with 30 years had 1.2 folds higher risk for
complication than compared with patients of 18 years old. However, problems with the appliance itself
occurred also in two younger patients (23.5 and 25.6 years). Nevertheless, all appliance-related problems
were without clinical relevance and a dislodge of miniscrews was not observed. The 12-weeks latency
period after insertion of the miniscrews seems to allow osseointegration to enable sufficient force for
maxillary expansion. As a consequence of the overload of the midface with asymmetric expansion in our
study, all patients had to report the activation and progress with a written protocol daily during the first
two weeks until the diastema was clearly visible.
Finally, the results of the present study are quite encouraging, showing that the protocol introduced, along
with the MAPE appliance is forcing the expansion of the maxilla with an acceptable complication rate in
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adults. In case of unsuccessful expansion SARPE can be followed with the same appliance in place. The
ease of surgery after pre-treatment justifies the protocol even in older patients.
Limitations
Since this study had a small sample size, it was not possible to evaluate different age groups (e. g. 20–
30, 30–40, 40 and older) with respect to success and complications. In order to deal with the issue of
small sample sizes, it would be more reliable to observe prospective cohort groups and to compare
different activation protocols (gradual expansion versus forced controlled polycyclic expansion). A
biased selection of subjects (i.e. gender, age, palatal vault) may have occurred in the course of clinical
contingencies. The subjects were not randomly selected which limits the ability to generalize the results
and could introduce bias. If CBCT is available for future studies a combination of midpalatal suture
maturation staging or including density ratio as described by Angelieri et al. [27] should be implemented
in the study design. However, further RCTs are needed to compare different activation protocols and to
demonstrate how the patient´s age may influence treatment outcome in a larger number of patients and
on long-term evaluation. Another question that raised during the present study is the influence of the pre-
treatment on the amount of surgery during SARPE in cases of failed expansion. Is it still necessary to
perform a complete osteotomy or can a minimal invasive surgery without splitting of the midpalatal
suture, as demonstrated in our study, lead to the same results as a complete osteotomy and reduce
morbidity of the patients?
Conclusions
1. Successful non-surgical expansion using MAPE was observed in 84.4% adult subjects (25/28).
2. Midpalatal openings displays an anterior V-shaped pattern (22/25).
3. The complication rate for non-surgical expansion was 18.5% and age was the only relating factor
studied.
4. A careful design and expansion protocol (polycyclic and slow) with MAPE seems beneficial to avoid
unreliable results in older patients.
Abbreviations
BIC Bayesian Information Criteria
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MICRO-4 mini-implant collar retained orthodontic expander on 4 miniscrews
WALA point point at the cross section of a central vertical line of the first lower molar crown and the band
of keratinized soft tissue directly adjacent to the mucogingival line [18].
Declarations
Ethics approval and consent to participate
The study obtained the approval of the local Review Board (RB No. EK-2-2014/0016). All
patients were fully informed about the nature of this study and signed an informed consent form for this
treatment.
The authors obtained written consent for publication from the patients enrolled in this study.
The datasets used and/or analyzed during the current study are available
Competing interests
Funding
None to declare.
Authors’ contributions
Acknowledgements
Rafik Salman (Oxford university) for data curation, formal analysis, statistics;
Marc Sauri and Clemens Winsauer for ideas to expander design, preparing measurements and figures.
References
1. Barber AF, Sims MR. Rapid maxillary expansion and external root resorption in man: A scanning
electron microscope study. Am J Orthod. 1981;79:630–52.
2. Holberg C, Rudzki-Janson I. Stresses at the cranial base induced by rapid maxillary expansion. Angle
Orthod. 2006;76:543–50.
3. Mommaerts MY. Transpalatal distraction as a method of maxillary expansion. Br J Oral Maxillofac
Surg. 1999;37:268–72.
4. Verlinden CRA, Gooris PG, Becking AG. Complications in Transpalatal Distraction Osteogenesis: A
Retrospective Clinical Study. J Oral Maxillofac Surg. 2011;69:899–905.
5. Koudstaal MJ, Wolvius EB, Schulten AJM, Hop WCJ, van der Wal KGH. Stability, tipping and relapse
of bone-borne versus tooth-borne surgically assisted rapid maxillary expansion; a prospective
randomized patient trial. Int J Oral Maxillofac Surg. 2009;38:308–15.
6. Williams BJD, Currimbhoy S, Silva A, O’Ryan FS. Complications following surgically assisted rapid
palatal expansion: A retrospective cohort study. J Oral Maxillofac Surg. 2012;70:2394–402.
7. Cantarella D, Dominguez-Mompell R, Mallya SM, Moschik C, Pan HC, Miller J, et al. Changes in the
midpalatal and pterygopalatine sutures induced by micro-implant-supported skeletal expander,
analyzed with a novel 3D method based on CBCT imaging. Prog Orthod. 2017;18:34.
8. Carlson C, Sung J, McComb RW, Machado AW, Moon W. Microimplant-assisted rapid palatal
expansion appliance to orthopedically correct transverse maxillary deficiency in an adult. Am J
Orthod Dentofac Orthop. 2016;149:716–28.
9. Lee K-JJ, Park Y-CC, Park J-YY, Hwang W-SS. Miniscrew-assisted nonsurgical palatal expansion
before orthognathic surgery for a patient with severe mandibular prognathism. Am J Orthod
Dentofac Orthop. 2010;137:830–9.
10. Winsauer H, Vlachojannis J, Winsauer C, Ludwig B, Walter A. A bone-borne appliance for rapid
maxillary expansion. J Clin Orthod. 2013;47:375–81.
11. Lee JS, Kim DH, Park YC, Kyung SH, Kim TK. The efficient use of midpalatal miniscrew implants.
Angle Orthod. 2004;74:711–4.
Page 12/18
12. MacGinnis M, Chu H, Youssef G, Wu KW, Machado AWilsoW, Moon W. The effects of micro-implant
assisted rapid palatal expansion (MARPE) on the nasomaxillary complex—a finite element method
(FEM) analysis. Prog Orthod. 2014;15:52.
13. Winsauer H, Walter A, Scherfler M, Ploder O. What are the limits of microimplant-assisted palatal
expanders? Am J Orthod Dentofac Orthop. 2017;151:3–4.
14. Bud ES, Bică CI, Păcurar M, Vaida P, Vlasa A, Martha K, et al. Observational Study Regarding Possible
Side Effects of Miniscrew-Assisted Rapid Palatal Expander (MARPE) with or without the Use of
Corticopuncture Therapy. Biology (Basel). 2021;10:187.
15. Choi S-HH, Shi K-KK, Cha J-YY, Park Y-CC, Lee K-JJ. Nonsurgical miniscrew-assisted rapid maxillary
expansion results in acceptable stability in young adults. Angle Orthod. 2016;86:713–20.
16. Walter A, Wendl B, Ploder O, Mojal S, Puigdollers A. Stability determinants of bone-borne force-
transmitting components in three RME hybrid expanders - An in vitro study. Eur J Orthod.
2017;39:76–84.
17. Liou EJ-W, Tsai W-C. A new protocol for maxillary protraction in cleft patients: Repetitive weekly
protocol of alternate rapid maxillary expansions and constrictions. Cleft Palate-Craniofacial J.
2005;42:121–7.
18. Conti MDF, Vedovello Filho M, Vedovello SAS, Valdrighi HC, Kuramae M. Lontigitudinal evaluation of
dental arches individualizated by WALA ridge. Dental Press J Orthod. 2011;16:65–74.
19. Brunetto M, Andriani J, Ribeiro SP, Locks GLU, Correa A, Correa M. LR. Three-dimensional assessment
of buccal alveolar bone after rapid and slow maxillary expansion: A clinical trial study. Am J Orthod
Dentofac Orthop. 2013;143:633–44.
20. Park JJ, Park Y-C, Lee K-J, Cha J-Y, Tahk JH, Choi YJ. Skeletal and dentoalveolar changes after
miniscrew-assisted rapid palatal expansion in young adults: A cone-beam computed tomography
study. Korean J Orthod. 2017;47:77.
21. Oliveira CB, Ayub P, Angelieri F, Murata WH, Suzuki SS, Ravelli DB, et al. Evaluation of factors related
to the success of miniscrew-assisted rapid palatal expansion. Angle Orthod. 2021;91:187–94.
22. Storto CJ, Garcez AS, Suzuki H, Cusmanich KG, Elkenawy I, Moon W, et al. Assessment of respiratory
muscle strength and airflow before and after microimplant-assisted rapid palatal expansion. Angle
Orthod. 2019;89:713–20.
23. Lin L, Ahn H-W, Kim S-J, Moon S-C, Kim S-H, Nelson G. Tooth-borne vs bone-borne rapid maxillary
expanders in late adolescence. Angle Orthod. 2015;85:253–62.
24. Lombardo L, Carlucci A, Maino BG, Colonna A, Paoletto E, Siciliani G. Class III malocclusion and
bilateral cross-bite in an adult patient treated with miniscrew-assisted rapid palatal expander and
aligners. Angle Orthod. 2018;88:649–64.
25. Shin H, Hwang C-JJ, Lee K-JJ, Choi YJ, Han S-SS, Yu HS. Predictors of midpalatal suture expansion
by miniscrew-assisted rapid palatal expansion in young adults: A preliminary study. Korean J Orthod.
2019;49:360–71.
Page 13/18
26. Li Q, Tang H, Liu X, Luo Q, Jiang Z, Martin D, et al. Comparison of dimensions and volume of upper
airway before and after mini-implant assisted rapid maxillary expansion. Angle Orthod.
2020;90:432–41.
27. Angelieri F, Cevidanes LHS, Franchi L, Gonçalves JR, Benavides E, McNamara JA Jr. Midpalatal
suture maturation: Classification method for individual assessment before rapid maxillary
expansion. Am J Orthod Dentofac Orthop. 2013;144:759–69.
28. Ladewig VM, Capelozza-Filho L, Almeida-Pedrin RR, Guedes FP, de Almeida Cardoso M. de Castro
Ferreira Conti AC. Tomographic evaluation of the maturation stage of the midpalatal suture in
postadolescents. Am J Orthod Dentofac Orthop. 2018;153:818–24.
29. Winsauer H, Vlachojannis C, Bumann A, Vlachojannis J, Chrubasik S. Paramedian vertical palatal
bone height for mini-implant insertion: a systematic review. Eur J Orthod. 2014;36:541–9.
30. Ploder O, Winsauer H, Juengling K, Grill F, Bissinger O, Wolff K-D, et al. Is There a Significant
Difference in Relapse and Complication Rate of Surgically Assisted Rapid Palatal Expansion Using
Tooth-Borne, Bone-Borne, and Orthodontic Mini-Implant–Borne Appliances? J Oral Maxillofac Surg.
2021;79:213–24.
31. Mao JJ. Mechanobiology of craniofacial sutures. J Dent Res. 2002;81:810–6.
32. Vij K, Mao JJ. Geometry and cell density of rat craniofacial sutures during early postnatal
development and upon in vivo cyclic loading. Bone. 2006;38:722–30.
33. Brunetto DP, Sant’Anna EF, Machado AW, Moon W. Non-surgical treatment of transverse deficiency in
adults using Microimplant-assisted Rapid Palatal Expansion (MARPE). Dental Press J Orthod.
2017;22:110–25.
34. Carmen M, Marcella P, Giuseppe C, Roberto A. Periodontal Evaluation in Patients Undergoing
Maxillary Expansion. J Craniofac Surg. 2000;11:491–4.
Figures
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Figure 1
Force-controlled polycyclic expansion protocol (FCPC): force control by measuring the applied force at
the end of the activating wrench. This is done by the patient twice a day with less than 500 cN turning
power allowed.
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Figure 2
Example of Maxillary expansion with MICRO4 expander in a 33.8 y.m. woman a) M4 and M5 OMI
positions b) After placement, both screws on each side were connected with alastic chains. c) This serves
as a bridge to cover the screw heads with light curing resin to assure stability during 3 months of osseo-
integration d) MICRO4 expander with small hex nut e) Initial occlusal x-ray f) After reaching maximum
opening of the jackscrew, the MICRO4 expander was removed and the small hex nut exchanged against a
wider one g) The same expander was reinserted to continue the expansion procedure without the need of
appliance reconstruction (in this case the right M5 OMI needed to be relocated and the expander slightly
adapted) h) Final occlusal x-ray after expansion stop i) Exceptional CBCT pictures were taken in this
patient due the extreme maxilla compression. Initial with closed midpalatal suture j) Four months later 17
mm midpalatal suture opening without surgical assistance. k) Two year retention with bone-borne TPA.
OMIs in position M5 removed after insertion of TPA.
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Figure 3
Measurements on CBCT after maximum of non-surgical expansion at the anterior and posterior palate.
The nasopalatine foramen (white bracket) and the greater palatine foramina on both sides (white line)
were references for measurements.
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Figure 4
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