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    Insulin Pharmacology

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    zainab
    This document discusses different types of insulin, including their pharmacokinetics, applications, and additional considerations. It describes rapid-acting insulins like lispro, aspart, and glulisine which have onsets of 5-15 minutes and durations of 3-4 hours. Short-acting regular insulin has an onset of 30 minutes and duration of 4-6 hours. Intermediate-acting NPH insulin has an onset of 1-2 hours and duration of 10-16 hours. Long-acting insulins like glargine, detemir, and degludec have flat peaks and durations of around 24 hours. Mixed insulins have biphasic effects similar to regular/rapid-acting

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    Insulin Pharmacology

    Uploaded by

    zainab
    40 views1 page
    This document discusses different types of insulin, including their pharmacokinetics, applications, and additional considerations. It describes rapid-acting insulins like lispro, aspart, and glulisine which have onsets of 5-15 minutes and durations of 3-4 hours. Short-acting regular insulin has an onset of 30 minutes and duration of 4-6 hours. Intermediate-acting NPH insulin has an onset of 1-2 hours and duration of 10-16 hours. Long-acting insulins like glargine, detemir, and degludec have flat peaks and durations of around 24 hours. Mixed insulins have biphasic effects similar to regular/rapid-acting

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    this summarized pharmacology of insulin.

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    Insulin pharmacology

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    This document discusses different types of insulin, including their pharmacokinetics, applications, and additional considerations. It describes rapid-acting insulins like lispro, aspart, and glulisine which have onsets of 5-15 minutes and durations of 3-4 hours. Short-acting regular insulin has an onset of 30 minutes and duration of 4-6 hours. Intermediate-acting NPH insulin has an onset of 1-2 hours and duration of 10-16 hours. Long-acting insulins like glargine, detemir, and degludec have flat peaks and durations of around 24 hours. Mixed insulins have biphasic effects similar to regular/rapid-acting

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    40 views1 page

    Insulin Pharmacology

    Uploaded by

    zainab
    This document discusses different types of insulin, including their pharmacokinetics, applications, and additional considerations. It describes rapid-acting insulins like lispro, aspart, and glulisine which have onsets of 5-15 minutes and durations of 3-4 hours. Short-acting regular insulin has an onset of 30 minutes and duration of 4-6 hours. Intermediate-acting NPH insulin has an onset of 1-2 hours and duration of 10-16 hours. Long-acting insulins like glargine, detemir, and degludec have flat peaks and durations of around 24 hours. Mixed insulins have biphasic effects similar to regular/rapid-acting

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    Types of insulin Pharmacokinetics Application Additional considerations [1]

    Rapid-acting insulin
    Lispro  Onset: 5–15 minutes  Basal-bolus insulin regimen  Insulin analogs
    Aspart  Peak: ∼ 1 hour  Sliding scale insulin regimen  Rapid absorption due to immediate dissociation into individual
    glulisine  Duration: 3–4 hour insulin molecules
     No time interval between injection and meal necessary
     Usually combined with long-acting insulin
    Short-acting insulin
    Regular insulin  Onset: ∼ 30 minutes  Standard insulin option for lowering blood  Recommended interval between injections and meals: 15–30
     Peak: 2–3 hours glucose levels in an acute setting (see minutes
     Duration: 4–6 hours “Hyperglycemic crises”)  Often used in combination with long-acting insulin
     Sliding scale insulin regimen  The only insulin available for intravenous use
     Basal supported oral therapy (BOT)
    Intermediate-acting insulin
    NPH insulin  Onset: 1–2 hours  Glucocorticoid-induced hyperglycemia (see  Crystalline suspension consisting of regular insulin (with a high
     Peak: 6–10 hours weight-based NPH insulin regimen for level of solubility) and protamine (with a low level of solubility)
     Duration: 10–16 hours glucocorticoid-induced hyperglycemia)  Recommended interval between injections and meal, if it is the
     Insulin regimens for enteral and parenteral only antidiabetic drug used: 30–60 minutes
    nutrition  Often used in combination with rapid-acting or short-acting
     Basal-bolus insulin regimen for treatment- insulin
    resistant type 2 diabetes mellitus  Usually administered twice daily
    Long-acting insulin
    Insulin glargine  Onset: 1–4 hours  Basal-bolus insulin regimen  Insulin analogs
    Insulin detemir  Peak: flat; not defined  Basal supported oral therapy (BOT)  More consistent effect and longer duration of action compared
    degludec  Duration: ∼ 24 hours to NPH insulin
     Often used in combination with rapid or short-acting insulin
     Administered once or twice daily
    Mixed insulin
    Mixed insulin  Biphasic effect  Basal-bolus insulin regimen  Typically a mixture of NPH insulin and either rapid-acting
     Short-term effect similar to that of insulin or regular insulin, in a predefined ratio
    regular insulin/lispro/aspart  Administered 2–3 times daily
     Long-term effect similar to that of  Only requires one injection per application without the need to
    NPH insulin mix fast- and intermediate-acting insulin

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