Ziprasidone Drug Study

ziprasidone
A Drug Study Presented to

Lendell Kelly B. Ytac, RN
Faculty, INAHS BSN-Program
Davao Oriental State University
_____________________________________________
In Partial Fulfillment
of the requirements for
NCM 117
Care of Clients with Maladaptive Patterns of Behavior
(Acute and Chronic)
By
Clint S. Ancog
Student Nurse, BSN-3A
March 18, 2022

Name of Drug Dosage/ Mechanism of Indication Contraindication Side Effects/ Nursing
Frequency/ Action Adverse Effects Responsibilities
Time/ Route
Generic Name: Route: P.O. Unknown; may Schizophrenia, Breastfeeding, SIDE
ziprasidone Onset: several hr be mediated acute agitation, hypersensitivity, acute EFFECTS: ● Tell patient to
hydrochloride Peak: 1-3 days through both acute MI, heart Frequent (30%– take with food.
Duration: dopamine type 2 psychosis, failure, QT 16%): ● Explain therapy
Brand Name: Unknown (D2) and bipolar prolongation Headache, and need for
Geodon, Zeldox serotonin type 2 disorder, drowsiness, follow up
Route: I.M. (5-HT2) mania, dizziness. laboratory testing.
Drug Classification: Onset: Unknown antagonism psychotic Precautions: Occasional: ● Caution patient
Antipyschotic Peak: 1 hr depression Pregnancy, children, Rash, orthostatic to avoid driving
Duration: geriatric patients, hypotension, and other
Chemical make-up Unkown Pharmacokineti cardiac/renal/hepatic weight gain, hazardous
and effect: cs: Well, disease, breast cancer, restlessness, activities until
Ziprasidone is a ➣ To treat absorbed after diabetes, seizure constipation, drug effects are
piperazine compound schizophrenia PO disorders, AV block, dyspepsia. known.
having 1,2- administration. CNS depression, Rare: ● Instruct patient
benzothiazol-3-yl- CAPSULES Food increases abrupt Hyperglycemia, to move slowly
and 2-(6-chloro-1,3- bioavailability. discontinuation, priapism. when sitting up or
dihydro-2-oxindol-5- ADULTS. Protein agranulocytosis, standing, to avoid
yl)ethyl substituents Initial: 20 mg binding: 99%. ambient ADVERSE dizziness from
attached to the twice daily with Metabolized in temperature increase, EFFECTS: sudden blood
nitrogen atoms. food. Dosage liver. Excreted in suicidal ideation, pressure drop.
increased as feces. Not torsades de pointes, CNS: EPS, ● Advise patient to
indicated removed by strenuous exercise pseudo avoid sun exposure
every 2 or more hemodialysis. parkinsonism, and to wear
days. Usual: 20 to akathisia, sunscreen and
80 mg twice daily dystonia, tardive protective clothing
with food. Pharmacodyna dyskinesia; when going
Maximum: 80 mics: drowsiness, outdoors.
mg twice daily. Ziprasidone has insomnia,
a very high 5- agitation,
I.M. INJECTION HT2A/D2
ADULTS. affinity ratio, anxiety,
Initial: 10 to 20 binds to multiple headache,
mg. 10 mg dose serotonin seizures,
may be given receptors in neuroleptic
every 2 hr up to addition to 5- malignant
maximum dose; HT2A, and syndrome,
20 mg dose may blocks dizziness,
be given every 4 monoamine tremors, facial
hr up to maximum transporters droop
dose. which prevents
Maximum: 40 5HT and NE CV: Orthostatic
mg daily for no reuptake. On the hypotension,
longer than 3 other hand, tachycardia,
consecutive days. ziprasidone has a prolonged
low affinity for QT/QTc,
➣ To treat acute muscarinic hypertension,
manic or mixed cholinergic M1, sudden
episodes of histamine H1, death, heart
bipolar disorder and alpha1- failure (geriatric
adrenergic patients),
CAPSULES receptors. torsades de
ADULTS. pointes
Initial: 40 mg
twice daily. with HEMA:
food on day 1; Agranulocytosis
then increased to
60 or 80 EENT: Blurred
mg on day 2 with vision, diplopia
food with further
adjustments as ENDO:
needed. Hypoglycemia
GI: Nausea,
vomiting,
➣ As adjunct to anorexia,
lithium or constipation,
valproate for jaundice, weight
maintenance gain, diarrhea,
treatment of dry mouth,
bipolar I disorder abdominal pain
CAPSULES GU: Priapism

ADULTS.
Same dose INTEG: Rash,
patient was injection-site
initially stabilized pain, sweating,
on that falls DRESS, Steven’s
within 40 to 80 Johnson
mg twice daily Syndrome
and taken with
food. RESP: Infection,
cough
References:
Schull, P. (2013). McGraw-Hill Nurse’s Drug Handbook Seventh Edition. McGraw-Hill Companies, Inc.
Skidmore-Roth, L. (2021). Mosby’s 2021 Nursing Drug Reference, 3251 Riverport Lane St. Louis, Missouri 63043
Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. Drugbank: a comprehensive resource for
in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34 (Database issue):D668-72. 16381955.

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ziprasidone

A Drug Study Presented to

March 18, 2022

CAPSULES GU: Priapism

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