Data Systems At-A-Glance

June 2022
The following table provides a feature/function view available in the various Agilent data systems.

OpenLab CDS OpenLab ChemStation OpenLab EZChrom MassHunter

Instrument Control/ Connectivity
LC    
GC    
LC/MSD  
GC/MSD  
Triple Quad GC/MS 
Triple Quad LC/MS 
LC/TOF 
LC/Q-TOF 
GC/Q-TOF 
CE Limited1  CE/MS
Supercritical Fluid Chromatography (SFC)   
MicroGC   
Headspace    
CTC PAL    2
35900E A/D converter   
SS420X A/D converter   
Non-Agilent  Waters 

Architecture
Client/Server, Networked    LC/(Q-)TOF
Supports virtualization   
1 Supports the configuration and use of a CE with the same feature set as an LC System. See OpenLab CDS CE Support Guide for more details.
2 PAL3 supported only with StreamSelect software.

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 OpenLab CDS OpenLab ChemStation OpenLab EZChrom MassHunter
Techniques & Solutions
Fraction Collection  
(see Fraction Collection Support)
GPC/ SEC   
2D LC   LC/(Q-)TOF
Aromatics in Gasoline GC/MS
Enviro Quant GC/MS
Drug Quant/Drug Analysis GC/MS
RGA/NGA  Macros

Acquisition Features
Data Analysis
Peak Integration during acquisition Data Analysis Snapshot Online Integration 
Snapshot
Scheduled runs 
Smart Sequencing  GC/MS
Priority run   
Graphical Acquisition method viewer 
Retention Time Lock (RTL)    
Backflush Wizard    

Data Analysis Features

Isoabsorbance Plot   
3D Plot  
Spectrum extraction (DAD or MS)   DAD 
Chromatogram extraction from Iso Plot   
Non-Linear calibration    
UV Peak Purity   
MS Peak Purity   Qual
Sample Purity   Qual
Peak Explorer 
UV Library Searching  
MS Library Searching   
Accurate Mass Feature Finding and ID 
MS/MS Data Analysis tools 
Custom Calculations/ Editor  Quant

Reporting
 
Reporting capability/tool  Classic & Intelligent Advanced & Intelligent 
Reporting Reporting
Customizable reports    
Report templates    
Automated sequence summary report    Quant
Cross-sequence reporting    QRS

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 OpenLab CDS OpenLab ChemStation OpenLab EZChrom MassHunter

Storage/ Administration
(Refer to the your CDS HW/SW Requirements guides to ensure version compatibility for each product listed below)

OpenLab Server, OpenLab Server, OpenLab Server,

Secure centralized storage OpenLab ECM XT, OpenLab ECM XT, OpenLab ECM XT, See footnote3
OpenLab ECM OpenLab ECM OpenLab ECM
Workstation (AFS),
Secure local storage for workstations Secure Workstation Workstation (AFS)
Workstation Plus
Central Administration    LC/(Q-)TOF

Data Integrity Features

Access control    
Secure storage    See footnote3
Audit trails    Limited4
Secure Workstation,
OpenLab Server,
Revisions Workstation Plus & 
OpenLab ECM XT, 
Client/Server5
OpenLab ECM
Secure ChemStation,
eSignatures OpenLab Server, OpenLab
  See footnote3
ECM XT, OpenLab ECM

Customization
6
Software Development Kit (SDK)   Quant
Macros support  GC/MS
Scripting  LC/MS

3 LC/MS Triple Quad, GC/MS Triple Quad, and GC/MSD require OpenLab ECM. LC/(Q-)TOF require OpenLab Server/ECM XT (Basic Server not
supported). GC/(Q-)TOF not supported on any secure storage and related functions (e.g. eSignatures). LC/MSD not supported on MassHunter.
4 For GC/MS, see the 5991-6909EN MassHunter Compliance White Paper.
For LC/MS, see 5994-0573EN MassHunter Compliance White Paper.
For LC/TOF and LC/QTOF, see 5994-2902EN MassHunter Compliance White Paper.
5 OpenLab CDS with OpenLab Server, OpenLab ECM XT, or OpenLab ECM.
6 SDK is available with limited capabilities and requires product management approval prior to quote and sale.

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 OpenLab CDS OpenLab ChemStation OpenLab EZChrom MassHunter
Supported Add-ons 7

2D Data Analysis Software (GC Image) 

2D LC Software 
Allotrope Data Format  
Analytical Studio Reviewer (ASR)   LC/MS
Bio-SEC Software 
BioConfirm 
Buffer Advisor Software 
MSD
Deconvolution Reporting Software
ChemStation
(DRS)
Data Analysis
GPC/ SEC Software   
LC/MS Deconvolution/

Bioanalysis Software
Lab Advisor Diagnostics
(LC & LC/MS only)    
MS Source & Compound Optimizer Method Parameter
FIA 
Override
Mass Profiler Professional (MPP) 
LC/(Q-)TOF &
MassHunter WalkUp WorkStation Only  LC/SQ Data
Analysis
Match Compare   
Method Scouting Wizard 
QualA (Automated Verification) 
Sample Scheduler  
7 Purification addons are addressed under Fractionation Collection Support.

Libraries
NIST & Wiley/NIST Library   
NIST Format,
PBM Format
(*.L),
Supported MS Library formats NIST Format NIST Format
MassHunter
format, PCD, &
PCDL

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 OpenLab CDS OpenLab ChemStation OpenLab EZChrom MassHunter
Fraction Collection Support

Timed  
Volume  
Manual  
Peak - UV  
Peak - MS 
Integrated delay calibration  
Recovery collection  
Requires Sequence
Single run submission 
Submission
Refer to OpenLab
Graphical sample /fraction
CDS Fraction 
management
Collection Details
Online sampling diagram 
WalkUp and Fractionation 
Dynamic tray configuration

(reconfiguration)
Support parking lot position 
Refer to OpenLab
Pooling CDS Fraction 
Collection Details
Clustering * 
Data analysis – fraction results review  
Alignment of fractions and signals

across multiple detectors
Refer to OpenLab
Reinjection CDS Fraction 
Collection Details
Automated Reinjection 
Refer to OpenLab
Fraction purity analysis CDS Fraction 
Collection Details
Fraction report template  

Supported Add-ons for Purification

Automated Purification Software 
A to Prep 
MassHunter WalkUp for Fractionation 
*Must have LC driver 3.2 or newer

This document has been updated to reflect all current software versions shipping at the time of publication date.

Information, descriptions, and specifications in this publication are subject to change without notice.

DE72941926

© Agilent Technologies, Inc., 2022

Printed in the USA, June 14, 2022
5991-7503EN

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