Brochure 2021

Contents 目錄
02 Dean’s Message 院長的話
05 Vision & Mission 願景及使命
07 Overview 學院概況
Facts & Figures 數據資料
Faculty Progress 學院發展
Faculty Structure 學院架構
Faculty Members 學院團隊
21 Infrastructure 學院基建
28 Cutting-edge Research 前沿研究

Research Eminence 科研成就
Technological Transfer 研究轉化
45 Quality Education 品質教學

Academic Programmes 學位課程
Diverse Learning Opportunities 多元學習機會
Graduate Prospects 畢業去向
Alumni Relations 校友聯結
58 Awards & Recognitions 獎項及殊榮
61 Public Engagement & Global Linkage

大眾聯繫及全球網絡
Outreach for High Schools 中學推廣
Academic & Exchange Activities 學術及交流活動
Global Collaboration Network 全球合作網絡
Media & Social Media 傳媒及社交媒體
Publications & Promotional Videos 出版刊物及宣傳影片
80 Appendix 附錄
List of projects that began in 2020 and 2021
2020及2021年開展的科研項目
Research Publications 科研出版物
1
Dean’s Message
院長的話
Dean’s Message 院長的話
Pivot on the frontiers of science

Aspire to make glistering success
In the past two years, with removal, new potent therapeutic targets for breast cancers,
the impact of the COVID-19 nanomedicine that induces immunity to combat cancers,
pandemic, humans and the societies which are all praiseworthy indeed.
have encountered tremendous
difficulties and challenges. Yet, The accumulative number of papers published by the
all my colleagues in the Faculty FHS scholars till April 2022 is more than 1,600, with over
of Health Sciences (FHS) have 27,000 citations and more than 200 accumulative papers
made significant progresses in with impact factors higher than 10. Some of the papers
teaching and scientific research have been published in internationally renowned journals,
with conviction and fortitude to Nature, The Lancet, Nature Genetics, Advanced Science,
enhance the development and Science Advances, Journal of Clinical Investigation, Nature
innovation of research to a great extent. Communications for instance. During the outbreak of the
pandemic, FHS has spared no effort in fighting epidemic. Our
To keep pace with the development of society, FHS continuously scholars have published four articles on mental health care
optimises the academic programmes and the conditions of teaching related to the outbreak, eight papers about the achievements
and learning. In 2021, FHS made an immense academic reform, and experience of Macao’s public health sector in the fight
and established three new departments, namely the Department of against the epidemic, which are pivotal for the global anti-
Biomedical Sciences, the Department of Pharmaceutical Sciences and epidemic call. In addition, FHS has strengthened its efforts in
the Department of Public Health and Pharmaceutical Administration. knowledge transfer and industrialisation of research results
Two new programmes, the Bachelor of Science in Pharmaceutical to improve the efficiency of technological transfer and boost
Science and Technology and the Master of Science in Global Public socioeconomic benefits.
Health, are now newly offered by the Department of Pharmaceutical
Sciences and the Department of Public Health and Medicinal FHS is now entering its 10th year. Looking ahead, we
Administration. FHS also strives to establish more academic will forge ahead in pursuit of excellence in life sciences
collaborations and joint programmes with leading universities of the and medicine, particularly the cancer research and
Mainland China and overseas to provide students with more training development, overcome challenges and aspire to make
opportunities in health and medical fields, ultimately nurturing talents more glittering successes in scientific research for the
in the field of grand health for Macao and the other cities of the benefit of Macao society and the well-being of mankind.
Greater Bay Area.
Finally, on behalf of FHS, I would like to express my heartfelt
FHS’s research teams have made breakthroughs in original basic appreciation to the Macao SAR Government, the Macao
research, particularly in cancer research and precision oncology, Science and Technology Development Fund, the University
contributing to the extensive concerns and recognitions from of Macau (UM) and various sectors of the community for
the academic and industries, and also the value and significance their staunch support and guidance over the past decade that
attached by the Central Government. In December 2020, the laid a solid foundation for the development of FHS.
University of Macau has officially received the approval from
the Ministry of Education of the People’s Republic of China to
establish a national-level research centre, Frontiers Science Center
for Precision Oncology, which is the first scientific research centre
in Macao and nearby areas, focusing on the frontier scientific
research of common cancers. Affiliating with FHS and joined
with many scientists of Institute of Chinese Medical Sciences,
Institute of Applied Physics and Materials Engineering and the
Faculty of Science and Technology, Frontiers Science Center
has built seven precision oncology platforms and achieved many
research breakthroughs in the first year, such as the development Chuxia DENG
of innovative phosphorescence probes for precise tumour Dean and Chair Professor
3
Dean’s Message 院長的話
放眼科學前沿開創輝煌未來
過去兩年，在新冠肺炎的衝擊下，人類社會經歷艱巨的困難和挑戰。健康科學學院全體
同仁憑著一貫奮發求進、銳意促進科研創新與發展的信念，排除萬難，在教學和科研路
上獲得良好的進展。
為配合社會的發展，學院不斷優化學術課程及教學條件，並於2021年提出學術大改革，
新建生物醫學系、藥物科學系及公共衛生及醫藥管理系三個學系，並由新建學系開辦理
學士學位（藥物科學及科技）及理學碩士學位（全球公共衛生）兩個全新課程。學院同
時致力與國內外的項尖學府建立更多學術合作及開辦聯合培養項目，爲學生提供其他健
康醫療領域的培訓機會，期望進一步爲澳門和大灣區其他城市培養更多能投身大健康板
塊的人才。
學院研究團隊在原創性基礎研究上，尤其在癌症研究及精準腫瘤學研究領域，不斷發表
突破性的創新成果，備受學術界及業界的廣泛關注和認同，並獲得國家肯定和重視。澳
大於2020年獲國家教育部批准成立港澳地區首個前沿科學中心―「精準腫瘤學前沿科學
中心」，聚焦澳門常見腫瘤疾病的前沿科學研究工作，而依托學院建立的前沿科學中心
於運作首年已成功獲取多項研究突破，如成功研發能助精準切除腫瘤的探針、發現治療
乳腺癌的重要靶點、開發能啟動免疫系統抗癌的納米藥物等研究突破，實在難能可貴。
直至2022年4月，學院研究人員發表的研究論文類計超過1,600篇，被引用的次數已超過
27,000多次，部份刊登於著名國際期刊如《自然》、《柳葉刀》、《先進科學》等，影
響因子超過10分的論文篇數更超過200篇。新冠疫情期間，學院於國際權威期刊上發表四
篇與疫情有關的精神疾病相關研究結果，及八篇有關澳門健康衛生界的抗疫成果和經驗
的論文，對全球抗疫起著重要的參考價值，為抗擊疫情作出貢獻。此外，學院加強推動
研究成果的產業化和商品化，提高成果轉化效率和社會經濟效益。
學院正邁進創院後的第十個年頭，瞻望前程，我們會一如既往，繼續秉志前行，無懼任
何挑戰，推動尖端科學研究項目、引領生命科學、醫學，尤其是癌症等方面的研究與發
展，在科研領域上開創更燦爛的輝煌，為澳門以至全球人類的健康福祉作出貢獻。
最後，我謹代表健康科學學院衷心感謝澳門特區政府、澳門科學技術發展基金、澳門大
學及社會各界對學院的過去十年鼎力的支持和指導，為學院的發展奠下穩固的基礎。
鄧初夏
院長及講座教授
4
Vision and
Mission
願景及使命
Vision & Missions 願景及使命
Vision
願景
FHS at UM aims at becoming a leading research and education

institution in health sciences in Macao and the Far East. With
its world-class faculty members and state-of-the-art facilities,
FHS strives to advance knowledge in key areas of modern health
sciences through cutting-the-edge research, which nurtures essential
workforce of high quality for both Macao and the region to face the
health-related challenges from the rapidly changing world.
健康科學學院旨在成為澳門和遠東地區領先的研究和教育機
構。健康科學學院擁有世界一流的教學人員和實驗設施，將
通過前沿的科學研究推動現代健康科學關鍵領域的發展，為
澳門和其他地區培育高質量的專業人才以應對迅速變化的健
康相關方面的挑戰。
FHS strives to accomplish its 健康科學學院將通過以下幾方面

Mission vision through 的發展實現以上願景
advancing scientific knowledge by 通過健康科學領域廣泛主導的前沿
使命 performing cutting-the-edge research in 研究推動科學發展；
a wide range of leading areas in health 開展以高質量研究為導向的本科及
sciences; 研究生教育課程，為下一代專業人
delivering research-oriented teaching 才的發展做好準備；
programmes of high quality at both 吸引澳門和周邊地區的年輕人從事
undergraduate and postgraduate levels 健康相關領域工作；
for the preparation of professionals of 建立可協助學院持續性發展的合
the next generation; 作網絡；
attracting youngsters from local and regions 加強公眾對健康科學的認識及了解
nearby to pursue a health science-related 其在澳門和國際社會的影響。
career;
establishing a network of collaborators
and strategic partners for a sustainable
development; and
enhancing public awareness of health
sciences and recognizing its impact on
local and international communities.
Combining the strong supports from UM, the Government of Macao and the general public
of Macao, FHS is committed to moving forward with advances that ameliorate knowledge in
health sciences and ultimately benefit the well being of mankind and the society.
在澳門大學、澳門特區政府和廣大市民的鼎力支持下，健康科學學院致力向前邁進，不
斷完善健康科學知識，最終惠及人類和社會的福祉。
6
Overview
學院概況
Overview 學院概況
Facts & Figures

數據資料
9
years since publications
establishment 1,600 + 出版物
成立年數
200+
1 st
Frontiers Science Center in HK-
Macao area approved by Ministry
of Education- Frontiers Science
accumulative publications with
impact factor ≥10
影響因子高於10的累計出版物
Center for Precision Oncology

citations
由國家教育部批准建設的港澳地區首個
前沿科學中心―精準腫瘤學前沿科學中心 27,000+ 引用次數
125~150
UM THE World University Rankings
2022 by subject: life sciences
澳門大學在泰晤士高等教育世界大學學科
（生命科學）排名
1%
rank of Essential Science Indicators
(ESI) in the research fields of “Clinical
Medicine”, “Pharmacology & Toxicology”,
“Psychiatry/ Psychology”, “Biology &
Biochemistry”, “Materials Science” and
“Chemistry”.
健康科學學院的卓越研究成果使澳門
大學在臨床醫學、藥理學與毒理學、
精神病學/心理學、生物學與生物化
學、化學及材料科學等學科領域進入
(as of 30 April 2022 截至2022年4月30日) 基本科學指指標（ESI）前1%
8
4 8
joint laboratories partnered research units and core
with top academic and facilities with world-class
research institutions infrastructur
與一流學術及科研機構建立的配備了尖端先進的設備的科研
聯立實驗室中心及核心實驗中心
3 departments
學系 6 academic programmes
學術學科
40+
academic staff from
prestigious universities
來自頂尖學府的教學人員
150+ 150+
undergraduate students researchers
本科生研究人員
300+ 100+
postgraduate students research projects
1:3
the faculty-student ratio of
undergraduate programme
研究生科研項目本科課程的師生比例
9
Faculty Progress
學院發展
Development Timeline
發展歷程
10
(as of 30 April 2022 截至2022年4月30日)
11
UM World Rankings by Subject Continually Rises

澳門大學研究學科國際排名節節上升
Recently, UM has generated high volume of high-quality research outputs in various research subjects, particularly the area
in health sciences have made numerous breakthroughs. The global rankings of the health sciences-related subjects rise on an
annual basis, and several subjects are classified as world-leading.
近年，澳門大學多項研究學科產出大量高質量研究成果，尤其於健康科學領域更屢獲突破，相關研究學科的
國際排名隨年節節攀升，部份學科更被評為國際領先。
UM THE World University Rankings by Subject (Life Sciences) from 2019 to 2022
澳門大學在泰晤士高等教育世界大學學科（生命科學）排名
12
The success and impact of FHS are also shown by the fact that health sciences-related subjects of UM, including clinical
medicine, pharmacology & toxicology, biology & biochemistry, chemistry and psychiatry/psychology have entered top 1%
rank of the Essential Science Indicators so called the ESI.
健康科學學院快速發展的另一項標誌是澳門大學的健康科學領域相關列學科，即臨床醫學、藥理學與毒理學、生
物學與生物化學、化學及精神病學／心理學研究進入了國際基礎科學指標ESI前1%。
13
Research Publications
科研出版物
FHS has an excellent record of published research, both in discipline-specific journals and more high-profile publications
such as Nature, The Lancet, Nature Communications, Advanced Science, etc. The acuumulative number of papers
published by FHS scholars increased from 43 in 2014 to over 1,600 in April 2022, with over 27,000 citations and over 200
accumulative publications with impact factor ≥10.
學院人員在特定學科的期刊及一些高端科研期刊如《自然》、《柳葉刀》、《自然通訊》、《先進科學》等
發表了大量的學術文章，數目由2014年的 43 篇增至2022年4月累計超過 1,600 篇，論文獲引用超過 27,000
次，而影響因子高於10的累計出版物已超過 200 篇。
Number of Publication
出版物數量
Number of Publication
出版物數量
Year 年份
% of Publication of IF over 10
影響因子高於10的出版物百份比
影響因子高於10的出版物百份比
% of Publication of IF over 10
Year 年份
14
Citations of Publication
出版物被引用次數
Citations of Publication
出版物被引用次數
Year 年份
15
Research Grants
科研資助
FHS researchers strive to carry out research studies on key health issues of both Chinese and global societies. From 2014
to 2021, FHS initiated over 200 projects which were approved by UM, the Science and Technology Development Fund,
Macao SAR (FDCT), the National Natural Science Foundation of China (NSFC), Ministry of Science and Technology of
China (MOST), the Guangdong Science and Technology Department (GDST), etc.
健康科學學院研究團隊一直致力進行中國及國際社會關注的健康科學相關的科學研究。由2014至2021年期
間，學院開展了由澳門大學、澳門科學技術發展基金、國家自然科學基金、國家科技部、廣東省科技廳等資
助的200多個研究項目。
Total Grant Amount in Million MOP Internal Grant 內部資助

研究資助總額（百萬澳門元） External Grant 外部資助
Million MOP 百萬澳門元
Patents 專利
(as of 31 December 2021 截至2021年12月31日)
16
Faculty Structure
學院架構
17
Faculty Members
學院團隊
FHS has an excellent team of academic members, and some academic members were graduated from various prestigious
institutes worldwide, such as Harvard University, University of Oxford, Tsinghua University, etc. They guide and inspire
the students in the lifelong quest of knowledge with strong passion.
健康科學學院擁有傑出教學團隊，部份教學人員畢業於包括哈佛大學、牛津大學、清華大學等的全球著名學
府。教學團隊對教學充滿熱忱，以啟導學生終身追求知識為己任。
18
3 Chair Professors
講座教授
1 Distinguished Professor
特聘教授
9 Professors
教授
16 Associate Professors
副教授
9 Assistant Professors
助理教授
4 Senior Instructors
高級導師
1 UM Macao Fellow
澳門大學濠江學者
1 Research Assistant
Professor
研究助理教授
19
New Faces
新成員
Dr. Chon Lok LEI is a physicist-turned-computational biologist, with interests in

computational modelling of biological/physiological systems and applications in
safety pharmacology and cardiac electrophysiology. He completed his doctoral degree
at the Computational Biology group in the Department of Computer Science at the
University of Oxford, and he received his undergraduate degree and the Dean’s List
in Physics from Imperial College London. He has joined FHS as a UM Macao Fellow
since 2021, before which he had experience in teaching and lecturing at the University
of Oxford.
李俊樂博士是一位物理學出身的計算生物學家，著重研究生物/生理系統
的計算模型，以至應用於安全藥理學和心臟電生理學中。他在牛津大學計
算機科學系完成他的博士學位，並在倫敦帝國學院獲得物理學學位，更獲
頒院長嘉許名單。他自2021年以澳大濠江學者加入健康科學學院。此前，
他曾在牛津大學累積教學經驗。
Dr. Heng SUN obtained his PhD in 2014 from the University of Chinese Academy
of Science – Shanghai Institute of Biological Sciences. Then he worked as a visiting
researcher at National Institute of Health, USA and later joined FHS as a postdoctoral
fellow. He was promoted to Research Assistant Professor in 2021. He has published more
than 20 peer reviewed papers in the cancer research field. He currently focuses on the
inter- and intra-tumor heterogeneity in breast cancers and mechanisms of breast cancer
initiation, development, metastasis and anti-cancer drug resistance.
孫恒教授於2014年在中國科學院大學上海生命科學研究院獲得博士學位。他曾
在美國國家健康研究院從事訪問學者研究，隨後加入健康科學學院從事博士後
研究，並於2021年晉升為助理研究教授。他在癌症研究領域已經發表了20多篇
同行評審的研究論文。他目前的研究主要集中於乳腺癌的腫瘤間和腫瘤內異質
性情況，及其在乳腺癌發生、發展、轉移及藥物耐受中的作用機制。
20
Infrastructure
學院基建
Infrastructure 學院基建
Frontiers Science Center for Precision Oncology

精準腫瘤學前沿科學中心
4 Core facilities
核心實驗中心 4 Research centres
研究中心
30+ Laboratories
實驗室 4 Joint laboratories
聯合實驗室
As a research-oriented academic unit, FHS has established more than 30 research laboratories, four
research centres and four core facilities. They are all equipped with state-of-the-art equipment and all
nicely incorporate into an outstanding infrastructure for high-quality research outputs. Upon the approval
of Ministry of Education, UM established the first Frontiers Science Center in Hong Kong and Macao in
2021, namely “Frontiers Science Center for Precision Oncology”, which carries out cutting-edge scientific
research of common cancers in Macao. In addition to precision oncology, FHS particularly focuses on
cancer research, stem cell biology, aging-associated diseases, and data science.
作為一個以學術研究為導向的科研單位，健康科學學院擁有超過30個研究實驗室、4個研究中心及
4個核心實驗中心，配備了最尖端先進的器材，搭建起了完善的基礎設施，助力學院取得了許多高
質量的科研產出。澳門大學更獲國家教育部批准於2021年建設港澳地區的首個前沿科學中心―精
準腫瘤學前沿科學中心，聚焦澳門常見多發腫瘤疾病的前沿科學研究工作。除了精準腫瘤學，健
康科學學院也非常重視現代生物醫學與健康科學內的幾個特定研究範疇，包括癌症研究、幹細胞
與發育、衰老及數據科學等。
22
Ministry of Education Frontiers Science Center for

Precision Oncology, University of Macau
國家教育部澳門大學精準腫瘤學前沿科學中心
The successful establishment of FSCPO assists in shaping the long term

development plan, and leads the research and development in life sciences,
medicine, and cancers in particular in the Guangdong-Hong Kong-Macao
Greater Bay Area. FSCPO also targets at making outstanding contributions to
and publishing ground-breaking outputs in original research. In addition, FSCPO
strengthens the research and development of the critical technologies, develops
innovative products, and promotes scientific knowledge transformation, all
of which provide cancer patients with high-end, customized and personalized
precision medicine prevention, diagnosis and therapeutics.
國家教育部澳門大學精準腫瘤學前沿科學中心的成功建設助力粵港澳大
灣區的遠景發展規劃，引領地區在生命科學、醫學，尤其是癌症等方面
的研究與發展。在原創性研究成果方面，做出突出性的貢獻，發表突破
性的成果。《前沿科學中心》將加強對關鍵技術的研發，開發原創性產
品，促進科技成果轉化，為癌症患者提供高端化、定制化、個人化的精
準醫學預防、診斷及治療技術。
In a short period, i.e. after one year of operation, FSCPO has made many
research breakthroughs, and published over 60 research articles in high-impact
journals, in which 24 articles were published in journals with impact factors of
10. FSCPO has attracted much attention and recognition from academia and
medical industry.
在成立短短一年，中心已獲得多個突破性研究發現，並於高影響因子的
雜誌上發表超過60篇研究論文，影響因子超過10佔25篇，研究成果備受
學術界、醫學業界關注和認同。
23
Research Centres
研究中心
To strengthen the research capacity, FHS has established four research centres. The long-term objectives
of the research centres are to provide strong support to teaching and training, and to foster collaborations
within FHS, intra-institutional with other faculties and externally with other research units. Moreover, the
research centres aim to advance research for improving human health and life quality.
為了加強研究能力，學院建立四所研究中心。研究中心的長遠目標是對教學和培訓提供強而有力
的支持，並促進學院內、學校內以及校外研究單位的合作。另外，研究中心的設立是為了推動研
究，達至改善人類健康及生活質素為目的。
focusing on signal transduction and carcinogenesis, cancer

Cancer Centre genetics, epigenetics, and epidemiology, etc.
癌症中心研究重點著重於信號轉導和癌症發生、癌症遺傳學、表觀遺
傳學和流行病學等。
conducting research and providing training to local personnel

Centre for Precision who engage in precision medicine and focusing on the
Medicine Research development of personalized therapeutic treatments
and Training
Research 精準醫學研究和培訓中心
旨在為本地從事精準醫學的人仕進行研究和培訓，根據患者
特質研發量體訂製的個性化治療方案。
Centres focusing on molecular reproduction and development, stem
研究中心 Centre of Reproduction, cell biology and biotechnology, and cell and molecular
Development and Aging biology of aging
生殖、發育及衰老中心研究重點將著重於分子生殖和發育、幹細胞生物學和生物技
術及衰老的細胞與分子生物學。
developing better diagnostic and therapeutic approaches

Institute of Translational in hope to accelerate the transformation of science and
Medicine technology
轉化醫學研究所加快科研成果轉化，以優化治療和診斷方法為目標。
24
Core Facilities
核心實驗中心
FHS has established four core facilities: Animal Research Core, Bioimaging and Stem Cell Core, Genomics,
Bioinformatics and Single Cell Analysis Core, and Proteomics, Metabolomics and Drug Development Core,
which are a pillar of FHS’s research infrastructure and play a vital role in enhancing synergy and fostering
multidisciplinary research approach. Every core facility focuses on different areas of contemporary research
methodology in biomedical sciences, and provides specialized services to users in FHS and other units in UM
through the operation of the state-of-the-art equipment and the acquisition of professional experiences in the
core. The core facilities highly support the innovative research in FHS and UM.
為提升科研水準及加強跨學科研究，健康科學學院設立了四個核心實驗中心，分別是動物研究核心實
驗中心，生物成像及幹細胞核心實驗中心，基因組學、生物信息學及單細胞分析核心實驗中心，以及
蛋白質組學、代謝組學及藥物開發核心實驗中心。作為學院科研設施的支柱，每個核心實驗中心，基
於現代生物科學研究的基本和高端技術需要，配備了最先進的科研設施，為健康科學學院及澳門大學
其他單位研究人員提供及時服務和建議，大大推動了健康科學學院及澳門大學的科研創新。
25
Biological Imaging &

Animal Research Core Stem Cell Core
動物研究核心實驗中心生物成像及幹細胞核心實驗中心
Stem Cell
Animal Facility 幹細胞
實驗動物中心
Microscopy & Bioimaging
Transgenic & Knockout 顯微鏡學和生物成像
轉基因和基因敲除 Histopathology
組織病理學
Flow Cytometry
Core Facilities 流式細胞儀
Genomics, Bioinformatics & 核心實驗中心 Proteomics, Metabolomics

Single Cell Analysis Core & Drug Development Core
基因組學、生物信息學及蛋白質組學、代謝組學及
單細胞技術核心實驗中心藥物開發核心實驗中心
Proteomics
蛋白質組學
Genomics & Bioinformatics
基因組學及生物信息學 Metabolomics
代謝組學
Single Cell Analysis
單細胞分析 Drug Development
藥物開發
26
Joint Laboratories
聯合實驗室
FHS has established four joint laboratories with leading academic or research institutions for developing close strategic
partnerships and carrying out joint research. The objectives of the joint laboratories are to integrate multiple-omics
techniques for cancer prevention, prediction and its driving mechanisms, and to find means for cancer treatments. The
joint laboratories also strive for promoting the industrialization and commercialization of major cancer research results,
and improving the efficiency of transformation of results and economic and social benefits.
健康科學學院與其他一流學術或科研機構強強聯合，建立了四個聯合實驗室，發展緊密的戰略合作夥
伴關係。聯合實驗室致力綜合多種組學技術，在癌症預防、預測與發生機理等方面進行深入研究，以
尋找針對癌症幹細胞的療法，提供衛生護理服務及研究及開展創新型的臨床分析。聯合實驗室亦推動
研究成果的產業化和商品化，提高成果轉化效率和經濟社會效益。
Joint Cancer Laboratory of University of Macau - Institute of Cancer Joint Innovation Laboratory of University of Macau -
and Basic Medicine, Chinese Academy of Sciences Guangzhou KingMed Diagnostics Group Co., Ltd.
澳門大學-中國科學院腫瘤與基礎醫學研究所聯合癌症實驗室澳門大學-金域醫學聯合創新實驗室
Joint Cancer Laboratory of University of Macau - Joint Cancer Stem Cell Laboratory of University of Macau -
The Chinese University of Hong Kong Tongji University
澳門大學-香港中文大學聯合腫瘤實驗室澳門大學-同濟大學聯合腫瘤幹細胞實驗室
27
Cutting-edge
Research
前沿研究
Cutting-edge Research 前沿研究
FHS’s biomedical research is dedicated to ensuring cancer precision medicine, stem

cell and tissue regeneration, bioinformatics and medical big data, aging and related
diseases, neuropsychiatry, brain sciences, and biological imaging, etc. In recent
years, FHS’s research in the field of health sciences has been fruitful, and the number
and quality of publications in internationally renowned journals are enhancing on an
annual basis. Publications have been published in Nature, Lancet, Advanced Science,
etc. FHS has made great contribution to the fact that UM’s several related disciplines,
namely pharmacology and toxicology, clinical medicine, psychiatry/ psychology
and biology/ biochemistry, rank among the top 1% of the world’s Essential Science
indicators (ESI). In addition, upon the approval of Ministry of Education, UM
established the first cutting-edge scientific research centre in Hong Kong and Macao,
namely “Frontiers Science Center for Precision Oncology” in 2021, in which FHS
researchers carry out cutting-edge scientific research of common cancers in Macao.
健康科學學院致力癌症精準醫學、幹細胞及組織再
生、生物信息及醫療大數據、衰老及相關疾病、神經
精神醫學、腦科學，以及生物影像等。近年來，健康
科學學院在健康科學領域的研究碩果纍纍，每年於著
名國際期刊如《自然》、《柳葉刀》、《先進科學》
等發表的研究論文數量及質量逐年增加，並助力澳門
大學的藥理與毒理學、臨床醫學、精神病學/心理學和
生物學/生物化學等多個相關學科躋身世界頂尖基本科
學指標（ESI）前1%。澳門大學更獲國家教育部批准建
設港澳地區的首個前沿科學中心―精準腫瘤學前沿科
學中心，由健康科學學院研究人員主導，聚焦在澳門
常見多發腫瘤疾病的前沿科學研究工作。
Members of FHS have won many national innovation gold awards, Macao
Scientific and Technological R&D Award for Postgraduates, and the Business
Awards of Macau for innovation, and also successfully obtained numerous
patents. FHS continues to collaborate with hospitals, higher education institutes
and enterprises in Guangdong-Hong Kong-Macao Greater Bay Area for
enhancing the technological transfer and benefiting the well-being of mankind.
健康科學學院人員團隊多次獲得全國創新金獎、澳門研究生科技研發
獎、澳門商務大獎―創新大獎等，並擁有多項授權專利，持續與粵港澳
大灣區的高校、醫院及企業合作，致力科研成果產業化及造福社群。
29
Research Eminence
科研成就
Precision Oncology 精準腫瘤學
Prof. Chuxia DENG and his research team have successfully

developed a novel cancer precision medicine strategy by integrating
tumour organoid culture, genome sequencing, and bioinformatic
analysis in collaboration with Kiang Wu Hospital. This strategy
is a new breakthrough in precision medicine and can provide
personalised treatment suggestions for nasopharyngeal carcinoma
(NPC) patients of different subtypes. The study was published in
Nature Communications.
鄧初夏教授及其研究團隊和鏡湖醫院合作運用腫瘤類器官
培養、基因組測序、生物信息學分析等研究手段對鼻咽癌
患者的腫瘤突變基因和藥物敏感性進行綜合分析，研發出
一套精準治療癌症的新策略，能夠為不同亞型的鼻咽癌患
者提供個體化治療指導建議，是癌症精準醫學領域的重大
突破性進展。該研究成果已獲《自然—通訊》刊登。
Prof. Deng and his team have also discovered the connection
between the ubiquitinated proteasome system and drug resistance.
They found that the inhibition of proteasome activity can block
broad drug resistance in multiple types of cancer. The findings could
help address drug resistance in cancer patients, and the study was
published in Advanced Science.
鄧初夏教授及其研究團隊亦發現了泛素化蛋白酶體系統與藥
物耐受之間的聯繫，研究顯示通過抑制蛋白酶體的活性可以
阻斷多種類型癌症的廣譜耐藥性。該研究成果有助解決癌症
病人的耐藥性問題並已在《先進科學》刊登。
Together with Dr. Kai MIAO, Prof. Deng has discovered that
that NOTCH1 activation can rescue BRCA1 deficiency and
promote triple-negative breast cancer (TNBC) formation.
Drugs targeting NOTCH1-regulated pathways can effectively
inhibit the growth of TNBC. The study was published in
鄧初夏教授與苗凱博士發現NOTCH1蛋白激活可以促進
三陰性乳腺癌的形成，針對其分子調控通路的靶向藥物
可以有效阻止三陰乳腺腫瘤的生長，為這種致命疾病的
臨床治療提供了有效方案。該研究成果已於《自然—通
訊》中發表。
30
Prof. Deng‘s team has also explored the role of mechanism of

FGFR2 activation in tumor initiation and progression and the
underlying causes of resistance to targeted therapies, and has
developed combination targeted therapy with immunotherapy for
Triple-Negative Breast Cancer (TNBC). The study was published
in Advanced Science.
鄧初夏帶領的研究團隊亦深入研究三陰性乳腺癌的發生機制
以及免疫療法，揭示纖維細胞生長因子受體2(FGFR2)驅動三
陰性乳腺癌並建立小鼠模型，成功研發出靶向及免疫聯合療
法精準治療三陰性乳腺癌。該研究成果已在《先進科學》中
發表。
Prof. Deng’s team made a breakthrough in the field of cancer precision medicine through its
collaboration with Conde S Januário Hospital, the Affiliated Hospital of Southwest Medical
University, the First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University
Cancer Center, and Zhuhai People’s Hospital. The research team used patient-derived
organoids (PDOs), in vitro drug screening, and other techniques to provide individualised
treatment suggestions for breast cancer patients, especially those with advanced breast
cancer. The study was published in Advanced Science.
鄧初夏的研究團隊聯合澳門仁伯爵綜合醫院、西南醫科大學附屬醫院、中山大學附屬
第一醫院、中山大學附屬腫瘤醫院和珠海市人民醫院的研究團隊，運用腫瘤類器官培
養、體外藥敏篩查等研究手段，為不同的乳腺癌患者、尤其是晚期乳腺癌患者提供個
體化治療指導建議，治療效果良好。有關治療策略已在《先進科學》上刊登。
A collaborative work among Prof. Deng, Prof. Xiaoling XU and

Prof. Qiang CHEN found that breast cancer susceptibility gene
1 (BRCA1) plays an important role in regulating mitophagy and
mitochondrial dynamics: it maintains a healthy mitochondrial
network and reduces inflammasome activity, which blocks the
recurrence and metastasis of breast cancer after surgery. The study
was published as a cover article in Advanced Science.
由鄧初夏教授、徐曉玲教授及陳強教授共同合作研究發現乳
腺癌相關基因1（BRCA1）可通過促進線粒體自噬及降低炎
症小體活性，抑制手術後乳腺癌的復發及轉移。該研究成果
是由鄧初夏教授、徐曉玲教授、陳強教授等共同完成《先進
科學》發表，並作為封面文章。
31
Prof. Ningyi SHAO collaborated with

Prof. Or GOZANI in Stanford University
and Pawel K. MAZUR in MD Anderson
Cancer Center, and found that NSD3
protein is involved in the tumourigenesis
of squamous cell lung cancer, and that
NSD3 may be an effective target for the
treatment of this type of cancer. This is
a landmark discovery, and the study was
published in Nature.
澳門大學健康科學學院邵寧一教授、
史丹福大學Or Gozani教授和安德森
癌症中心Pawel K. MAZUR教授合
作，發現NSD3蛋白參與肺鱗狀細胞
癌的腫瘤發生過程，並揭示了NSD3 Prof. Joong Sup SHIM’s team has
可能是治療肺鱗狀細胞癌的有效靶 found that RB1-mutant small cell
點，是一項里程碑式的新發現。該研 lung cancer (SCLC) cells are highly
究成果已於國際著名期刊《自然》上 sensitive to the inhibitors of aurora
發表。 kinase A (AURKA) and microtubule
dynamics, and the vast majority
of SCLC (up to 90%) has loss-of-
function mutations in the tumour
suppressor RB1. This type of SCLC
could be potentially hypersensitive to
AURKA and microtubule dynamics
inhibitors. Based on this finding,
the team successfully induced cell
death in this type of SCLC, providing
new promising treatment options for
SCLC. The study was published in
Prof. Xiaoling XU and her research team have discovered a tumour evolution
process through which the tumours initiate from cells with single nucleotide 沈仲燮教授的研究團隊發現 RB1
variants (SNVs) by performing simultaneous single nucleotide variant (SNV) and 突變的小細胞肺癌對極光激酶
copy number variation (CNV) analysis. The team has also identified a novel tumour A（Aurora Kinase A 或 AURKA）
metastasis suppressor ‘PLEKHA5’, whose deficiency promotes cancer metastasis 和微管動力抑制劑高度敏感。他
to the liver and/or lung. This discovery represents a significant progress in breast 們也發現極高比例（約90%）的小
cancer metastasis research. The study was published in Nature Communications. 細胞肺癌出現抑癌基因RB1的功能
缺失性突變。這類小細胞肺癌對
徐曉玲教授的研究團隊運用全外顯子測序技術，同時對BRCA1缺陷的乳腺組
AURKA和微管動力抑製劑高度敏
織和腫瘤進行了單細胞的單核甘酸突變和拷貝數變異分析，揭示了腫瘤的進
感，團隊便以此誘導小細胞肺癌細
化過程。研究團隊更發現了一個新的乳腺癌轉移抑制基因PLEKHA5，這個
胞死亡。因此，該研究為小細胞肺
基因的缺失會促進乳腺癌的轉移，是乳腺癌領域的一個重要發現。該研究成
癌治療提供了新的選擇。該研究成
果已在《自然—通訊》上發表。
果已於《自然—通訊》上發表。
32
Prof. Lijun DI and his research team have discovered, through

meta-analysis, that supplementing estrogen (hormonere
placement therapy, or HRT) to ovarian cancer patients
with ovariectomy (surgical removal of one or both ovaries)
may help improve the effectiveness of chemotherapy and
make recurrence less likely. To some extent, this finding is
distinct from conventional assumptions of ovarian cancer
therapy. The research work was published in Theranostics
狄利俊教授的團隊透過元分析發現，為做過卵巢切除
手術的卵巢癌患者補充雌激素（激素替代療法）有
助於提升化療效果及減低復發風險，該研究結果一定
程度上顛覆了以往醫學界對卵巢癌治療的觀點，並獲
《Theranostics》刊登。
Precision Oncology/Bioinformatics 精準腫瘤學 / 生物信息學
Prof. San Ming WANG and his research team completed a three-year
study on cancer prevention in the Chinese population. This study
determined the frequency of mutation-carrying and the number of
carriers of BRCA1/BRCA2 gene mutations in the Chinese population
and laid a solid foundation for cancer prevention through large-scale
populational genetic testing. The research work was published in
Medical Genetics, a sister journal of British Medical Journal.
王山鳴教授及其研究團隊完成了一項歷時三年的中國人群癌症
預防研究。該研究確定了中國人群中BRCA1/BRCA2基因突變
的攜帶頻率和攜帶者數量，為在中國人群中運用大規模人群基
因突變檢測進行癌症預防打下堅實基礎。該研究成果在《英國
醫學雜誌》子刊《醫學遺傳學雜誌》發表。
Androgens play an essential role in the growth of prostate

cancer cells, but the exact mechanism remains unclear.
Prof. Edwin Chong Wing CHEUNG and his research
team were among the first to show how the androgen
receptor regulates gene expression in the 3D structure of
genome to mediate the development of prostate cancer.
This important finding could potentially help prostate
cancer treatment. The research work was published in
Genome Research.
雄激素在前列腺癌細胞的生長中發揮重要作用，但
其運作機制仍然充滿未知。張仲榮教授及其研究團
隊首創性發現雄激素受體如何在基因組的三維結構
下調控基因表達，以介導前列腺癌的發展，其發現
可望有助治療前列腺癌。該研究成果已在《基因組
研究》上發表。
33
Caveolin-1 (CAV1) is an important tumour suppressor in breast

cancer. Its deficiency and mutation can affect the autophagy and
lysosome, thus making breast cancer cells more susceptible to A research team led by Prof. Kathy Qian LUO
autophagy/lysosome inhibitors. Prof. Hanming SHEN and his has found that tumour cells can express more
research team suggest that CAV1’s deficiency and mutation can be desmosomal proteins of desmocollin-2 (DSC2) and
used as a biomarker in the selection of breast cancer patients for plakophilin-1 (PKP1) to help them form cell clusters
using autophagy/lysosome inhibitors in cancer therapy. Prof. Shen in the circulatory system, so that circulating tumour
has proved that autophagy can, in principle, resist starvation and cells can survive in the blood stream and have a
other stress conditions and promote cell survival. This important stronger metastatic ability. This discovery provides
finding has been published in Molecular Therapy Oncolytics. new insights into how circulating tumour cells
survive in the circulatory system, which may help
Caveolin‑1（CAV1）是一種乳腺癌抑制基因，人體缺少了它或
develop new anti-metastasis therapies. The study
它發生突變時，就會影響癌細胞的自噬作用和溶酶體功能，增加
was published in Science Advances.
患上乳腺癌的風險。沈漢明教授及其研究團隊發現可以用CAV1的
缺失或突變作為生物指標，指導在臨床上是否適合用自噬抑制劑羅茜教授帶領的研究團隊發現腫瘤細胞可以
作為治療乳腺癌的手段。沈教授證明細胞自噬原則上是抵抗飢餓通過表達更多的細胞膜橋粒蛋白（ DSC2和
及應急狀態的一個重要的促進細胞生存的機制。該研究成果已在 PKP1）來幫助它們在循環系統中形成細胞
《Molecular Therapy Oncolytics》發表。團，從而使得循環腫瘤細胞可以在血液循環
中存活並具有更強的轉移能力，為開發新型
抗癌轉移療法提供了新思路。該項研究成果
已於《科學進展》上發表。
Precision Oncology/Bioimaging 精準腫瘤學 / 生物成像
Prof. Qi ZHAO and his research team have developed a new

nanozyme technology that can enhance the anti-tumour effects of
chimeric antigen receptor (CAR) T cells by reshaping the tumour
microenvironment. This technology can be used to improve the
ability of the patient’s own immune system to fight tumours. The
study was published in Small.
趙琦教授及其研究團隊成功研發出一種新型納米酶技術，利用
重塑腫瘤的微環境來增強嵌合抗原受體(CAR) T 細胞的抗腫
瘤效果，從而提高病人自身免疫系統抗腫瘤的能力。該研究成
果為CAR-T細胞治療實體腫瘤的一個重大突破性的進展，並已
獲《Small》刊登。
34
Prof. Tzu-Ming LIU and his research team have 劉子銘教授及其研究團隊與聖彼

developed a new phosphorescence imaging method to 德堡國立大學Sergey P. Tunik教
map tumour hypoxia, which can help precisely detect and 授、東芬蘭大學Igor O. Koshevoy
remove cancerous tumours. This is an interdisciplinary 教授和台灣大學周必泰教授共同
collaboration between Prof. Liu’s team and Prof. Sergey P 合作，開發腫瘤微環境缺氧的創
TUNIK at Saint Petersburg State University, Prof. Igor O 新影像量測方法，以靜脈注射錸
KOSHEVOY at the University of Eastern Finland and Prof. 系錯合物的磷光分子探針，穿過
Pi-Tai CHOU at Taiwan University. The research team 血管障壁後功能化膠原纖維，使
synthesised a new class of rhenium (ReI) diimine carbonyl 組織本身成為光讀取式的氧氣濃
complexes that can penetrate vessel walls after bolus 度計，協助醫生精準切除未能被
injections. Then, the extravasated probes functionalise the 醫學影像偵測的腫瘤。該研究成
collagen as an optically measurable tissue oxygen metre. 果已於《先進科學》中發表。
It can help surgeons identify satellite tumours commonly
neglected in medical imaging. The study was published in
Advanced Science.
Prof. Zhen YUAN and his research team have developed a photodynamic diagnostic agent
with multi-modal molecular imaging contrast function and near-infrared light excitation,
which can help improve the precision of photodynamic treatment of deep tumours, thereby
improving treatment efficacy. The study was published in Biomaterials.
袁振教授及其研究團隊開發了一種具多模態分子影像造影功能、近紅外光激
發的光動力診療劑，有助提高光動力治療深層腫瘤的精準度，改善治療效
果。該研究成果獲《生物材料》刊登。
35
Prof. Yuan and his team have also developed an efficient strategy to prepare ultra-
small organic polymer probes for second near-infrared (NIR-II) photoacoustic
imaging-guided cancer diagnostic tests and phototherapy. The study paves the
way for clinical applications of organic semiconductor nanoprobes and a novel
avenue for the development of organic semiconducting nanoagent for future
cancer translation studies. The research study was published in Advanced
Functional Materials.
袁振教授及其研究團隊亦開發了一種超小尺寸生物相容性極好的聚合
物點，並將其應用於近紅外二區光聲腫瘤診斷和光熱治療。該研究為
有機半導體納米探針的臨床轉化應用開闢了一條新途徑，其成果發表
於《先進功能材料》。
Precision Oncology/Nanomaterials 精準腫瘤學 / 納米材料
Prof. Yunlu DAI and 代雲路教授及其研究

his research team have 團隊設計並合成了富
designed and synthesised 氧金屬多酚配位納米
an oxygen-enriched 倍增器，將放療產生
metal-phenolic X-ray 的離子化能量集中在 Prof. Dai and his research team have also designed and
nanoprocessor to enhance synthesised a versatile H2S nanomodulator, which can precisely
腫瘤微環境，同時產
the therapeutic effects of target tumour areas for precise photothermal treatment and
生 ROS誘導癌細胞
anti-tumour radiotherapy. rapidly release hydrogen sulphide to alleviate inflammation.
損傷，能深層次強化
The nanoprocessor can This functional nanomodulator has great potential to modulate
improve radiodynamic 抗腫瘤放療的治療效
果。該新型治療策略 inflammation and adaptive immune responses, thereby optimising
therapy and enhance anti-
已刊登於《先進科 photothermal therapy, with broad clinical applications. The
tumour immune response
study was published in Advanced Materials.
by focusing the ionised 學》。
energy generated by 代雲路教授及其研究團隊首次設計及合成出一種多功能硫
radiotherapy in the tumour 化氫納米調節劑，可以緩解使用光熱治療癌症時所產生的
microenvironment while 炎症反應，優化了癌症治療策略。該研究成果已刊登於《
generating ROS to induce 先進材料》。
cancer cell damage. The
study was published in
Advanced Science.
36
In addition, Prof. Dai and his reserach team synthesised a

polyphenol-based nanomedicine that can evoke highly efficacious
cancer immunosurveillance while localising therapy on primary
tumour and minimising systemic side effects. The study was
published in Angewandte Chemie International Edition.
此外，代雲路教授及其研究團隊更通過研究多酚及其衍生
物相結合的納米藥物，實現了腫瘤化療與光動力治療的巧
妙結合，有效抑制腫瘤的生長和轉移。該新型治療策略已
於《德國應用化學》上發表。
Prof. Dai’s research group has also designed and synthesised Besides, the team led by Prof. Dai has successfully developed a
a novel nanomedicine, which can evoke potent anti-tumour Metal-Phenolic Network (MPN)-based nanomedicine, which
immunoresponse, inhibit tumour growth, and stimulate long- combines cancer sonodynamic therapy (SDT) and metabolic
lasting immunological memory. The study is a new breakthrough therapy. This nanomedicine can reverse immunosuppressive tumor
in melanoma immunotherapy and proposes a promising anti- microenvironment (TME) and evoke highly efficacious cancer
tumour strategy. The research findings were published in Nature immunosurveillance, leading to the inhibition of tumor growth and
Communications. metastasis. This study was published in the ACS Nano.
成功研發新型納米藥物，能高效抑制黑色素瘤的轉移及另外，代教授帶領的研究團隊製成基於多酚與金屬離子
促進抗腫瘤免疫反應。該納米藥物能顯著地抑制腫瘤生相結合的納米藥物，其在血液環境中結構穩定，循環
長並激活長久的特異免疫記憶，為下一代癌症免疫療法時間長，可有效積累於腫瘤組織，實現了通過調節腫瘤
帶來新希望。相關研究成果已獲《自然-通訊》刊登。微環境來提高聲動力療效，能有效抑制腫瘤的生長及轉
移。此新型治療策略已刊登於國際著名學術期刊《ACS
Nano》。
Precision Oncology/-OMICS 精準腫瘤學 / 多組學研究
Prof. Edwin Chong Wing CHEUNG and his research team have collaborated with
Prof. Chunhui HOU and Prof. Yonglong CHEN in the Southern University of Science
and Technology and Prof. Li LI in Huazhong Agricultural University, and reported
significant discoveries on the establishment of three-dimensional (3D) genome
structures during Xenopus tropicalis embryonic development. The research result helps
better understand the various defects and diseases caused by genetic abnormalities,
such as the occurrence of cancer. The study was published in Nature Genetics.
張仲榮教授及其研究團隊與南方科技大學侯春暉和陳永龍教授及華中
農業大學李立教授合作，並發現熱帶爪蟾胚胎發育過程中基因組三維
結構的動態變化。該研究成果有助更好地了解因基因異常而導致的各
種缺陷和疾病，例如癌症的發生等，已獲《自然－遺傳學》刊登。
37
Neuropsychiatry 神經精神醫學
Four articles on mental health care by Prof. Yutao XIANG and his research team suggested that
the novel coronavirus (COVID-19) outbreak has presented great challenges for China in terms
of mental health services. They suggest that timely and sufficient psychological interventions
should be provided for different sub-populations in need. Compared to the traditional face-to-
face psychological intervention, online mental health interventions, including hotline services,
are more appropriate, more flexible, and safer during the COVID-19 epidemic. The related
articles were published in Lancet and Lancet Psychiatry.
項玉濤教授及其研究團隊發表了四篇有關心理健康的文章，指出COVID-19疫情期
間中國的精神衛生服務面臨新的巨大挑戰，應為有需要的各類人群提供及時的、
充分的心理干預。與傳統的面對面心理干預相比，線上心理諮詢模式更實用，也
更為靈活、更為安全。這些文章已在國際權威的《柳葉刀》系列期刊上發表。
Stem Cell Developments 幹細胞與發育
Prof. Ren-He XU and his research team have discovered a new

way to enhance fat engraftment with the use of mesenchymal
stromal cells derived from human embryonic stem cells.
This type of mesenchymal stromal cells has the potential as
an innovative, cell-based biomaterial to support lipofilling
widely used in cosmetic surgery. The related research finding
was published in Biomaterials.
Cardiac muscles cells are considered difficult to regrow 徐仁和教授及其研究團隊發現人胚幹細胞經滋養層分化

and the differentiation process is costly. To address this 的間充質幹細胞具有顯著治療效果，該細胞可望作為
problem, Prof. Guokai CHEN and his research team 一種新型生物材料通過促進脂肪移植而廣泛用於整容手
invented two new methods to generate heart cells in vitro 術。該研究成果已獲國際知名期刊《生物材料》刊登。
with high consistency and quality, without using expensive
and complicated supplements. This is a key step toward the
generation of heart cells for cell therapy and drug screening.
The study was published in Cell Reports.
成年的心肌細胞普遍被認為是難以再生、且分化價
格高昂的細胞，然而由陳國凱教授及其研究團隊
則顛覆這個傳統的說法。研究團隊發現了兩個新方
法，可在無需使用昂貴和複雜的培養成分的情況
下，於體外生成高品質的心肌細胞。該研究將可用
於藥物檢驗，甚至臨床細胞治療，已獲《細胞報
導》刊登。
38
Other Area 其他領域
Prof. Chris Koon Ho WONG and his research team have made a
breakthrough in understanding the dormancy mechanism of fungal spores
which are the main infectious agent of fungal pathogens that can cause
deadly infections in humans. This discovery holds promise for protecting
immunocompromised people, such as COVID-19 patients, from deadly
infections caused by fungal pathogens. The study has received considerable
attention in the field of biology and has been featured on the cover of Nature
Microbiology. The study is also featured in Faculty Opinions, ScienceNet,
BioArt, and a Nature Microbiology ‘News and Views’ article written by the
world-renowned fungal biologist Jean-Paul Latgé at The Institut Pasteur.
黃冠豪教授及其研究團隊在真菌研究上取得了重大進展。該研究
重新定義了真菌孢子休眠，並揭示了真菌孢子在進入休眠期之前
如何影響它們的致病毒力，從而幫助了解預防真菌感染的辦法，
為免疫力弱的人群如新冠病患帶來喜訊。相關研究成果在生物學
領域備受矚目，並已獲《自然－微生物》以封面論文形式刊登，
期刊亦邀請了巴斯德研究所世界著名真菌生物學家Jean-Paul Latgé
對是次研究專題報導作出總結，知名生物學公眾號BioArt、科學網
（ScienceNet）及Faculty Opinions也對該研究進行了報導和討論。
Research Funding 研究撥款
Members of FHS have received research funds from UM, the Science and Technology Development Fund, Macao SAR (FDCT), the
National Natural Science Foundation of China (NSFC), Ministry of Science and Technology (MOST) and the Guangdong Science and
Technology Department (GDST) in the past years. The funding solidifies our research strengths, helps FHS further enhance the research
leadership and continue to excel in research and create impact with innovation research to benefit mankind.
健康科學學院研究團隊獲得由澳門大學、澳門科學技術發展基金、國家自然科學基金、國家科技部和廣東省科技
廳的研究資助，這些資助鞏固了我們的研究實力，幫助健康科學學院進一步提升研究領導力，並繼續在研究中脫
穎而出，並通過創新研究造福人類。
Total Grant Amount in Million MOP (Number of Grants)

研究資助總額（百萬澳門元）（研究資助數量）
UM Internal Grant FDCT Research Grant FDCT Key Grant FDCT Joint Grant NSFC Others
Grant 研究資助/ 澳門大學內部澳門科學技術發展基金澳門科學技術發展基金澳門科學技術發展基金國家自然科學其它
Year 年份研究資助研究資助重點研發專項資助聯合資助基金
5.48 9.42 13.00 8.88 -- --

2020
(15) (7) (1) (6) -- --
-- 26.78 -- 6.80 4.44 9.94
2021
-- (18) -- (4) (2) (3)
39
Technological Transfer
研究轉化
Currently, expensive, laborious, and time-
consuming models of cancer drug discovery
greatly limit the viability of personalized
medicine for cancer treatment. Therefore, it is
extremely urgent to establish a new preclinical
drug screening model to solve these problems of
personalized medicine. Prof. Chuxia DENG and
his research team have used the time course-based
monitoring system of the bioluminescent sensor
C3, which can monitor cell apoptosis, to conduct 目前，昂貴、費力和費時的癌症藥物發現
high-throughput drug screening at the cellular 模型極大地限制了個體化藥物用於癌症治
level for identifying high-efficiency drugs for 療的可行性。因此，建立新的臨床前篩藥
specific cancer types, and then to use the mouse 模型來解決個性化醫學的這些問題顯得極
3D-TSC-like and human 3D-TSC platforms for 為迫切。鄧初夏教授及其研究團隊使用能
the drug sensitivity tests. It was found that the 夠監測細胞凋亡的生物螢光傳感器 C3的
results of the drug sensitivity tests of using the 時程監測系統，進行了基於細胞水平的高
3D-organoids can be available within seven days. 通量藥物篩選進而鎖定了針對特定癌症
類型的高效藥物，並接著使用鼠類和人類
In addition, the histological data and RNA-seq 3D-TSC平台測試藥物敏感性，發現可在試
analysis demonstrated that the 3D-TSCs can 驗七天內出來三維腫瘤片藥敏實驗結果。
accurately retain the immune components of their
original tumours, thus enabling immunotherapy 此外，組織學和RNA序列分析表明3D-TSC
with specific immune checkpoints successfully 能夠準確保留其原始腫瘤的免疫成分，從而
targeting PD-1 and PD-L1 antibodies. More 能夠成功實現針對PD-1和PD-L1抗體的免疫
surprisingly, using the 3D-TSC platform, label- 檢查點免疫治療效果。更為驚喜的是利用
free multiphoton fluorescence imaging showed 3D-TSC平台，無標記的多光子螢光成像顯
that the drug-treated 3D-TSC exhibited lipofuscin 示藥物處理過的3D-TSC表現出脂褐素自發
autofluorescence which can be used for a time- 螢光特徵，可用於對藥物反應和功效進行時
course monitoring of drug response and efficacy. 程監測。3D-TSC是一種創新的臨床前篩藥
3D-TSC is an innovative preclinical drug screening 方法，該方法結合了化學生物學技術、轉基
method that combines the advantages of chemical 因螢光報告技術和代謝性螢光色素的光譜成
biology techniques, transgenic fluorescent reporter 像的優勢，可加速開發精準癌症治療方案。
techniques, and spectral imaging of metabolic
fluorochromes to accelerate the formulation of 該研究在鄧初夏教授的指導下，由其博士
precision cancer therapies. 生邢富強完成三維腫瘤片藥敏試驗、劉子
銘教授提供無標記光學影像技術支持，南
This work was supervised by Prof. Deng, and his 方科技大學王冠宇教授合作參與。相關研
PhD student, Fuqiang XING, completed the drug 究獲澳門特別行政區政府資助，以及鏡湖
sensitivity test using the 3D-TSC. Prof. Tzu-Ming 醫院的支持。
LIU provided technical support for the label-free
optical imaging, and Prof. Guanyu WANG of
Southern University of Science and Technology
participated collaboratively in the study. The work
was funded by the Macao SAR Government and
40 supported by Kiang Wu Hospital.
Prof. Tzu-Ming LIU and his research

team have founded a company called
‘Catydid. The team has developed a
blood fluorescence monitor which can
see through the fluorescence in the blood
to help doctors detect serious illnesses
such as sepsis, shock, kidney failure,
and heart failure at an early stage. In
addition, the team has also started a
project to observe the microenvironment
of tumours through a multi-photon
microscopy platform, with a particular
focus on the relationship between cancer
cells and macrophages, in order to
discover the pathology of tumours and
help design targeted drugs to enhance
the effectiveness of precision oncology.
Prof. Liu has begun some preliminary

design and initiated plans with the
manufacturer for developing the machine
and assembling it into a system that can
be used in hospitals. They planned to
conduct a large-scale of clinical trials
under the support of the government
and investors. They have filed patent
applications in China, Taiwan and US.
His team also won the Outstanding
Award in the Seventh China Innovation
and Entrepreneurship Competition
(Jiangsu Region) and the Sixth 劉子銘教授及其研究團隊開設一間名為「看透你Catydid」的科技公司，主
Biomedical Industry Technopreneurship 要是利用團隊的研究開發一台血液螢光監測儀的醫療產品，其核心技術是
Competition in Jiangsu. 可以看透血液裏面的螢光，並有如天氣預報般幫助醫生早期發現敗血症、
休克、腎衰竭、心臟衰竭等重症。此外，研究團隊還開展通過多光子顯微
系統平台來觀察腫瘤的微環境，尤其關注癌細胞和巨噬細胞之間的關係，
從而發現腫瘤的病理，協助設計標靶藥物，提升癌症的精準治療。
劉子銘教授亦開始技術商業化與臨床轉化的工作，打造雛型機，進行首批
小量的臨床試驗，未來將尋求政府與投資人的支持，進行更大規模的臨床
驗證。此外，劉子銘教授的團隊已經根據這個重要發現，開始申請包括中
國、台灣、美國的專利，並參與第七屆中國創新創業大賽（江蘇賽區）暨
第六屆「創業江蘇」科技創業大賽生物醫藥行業賽，獲得優秀獎。
41
Prof. Ren-He XU and his research team have discovered a new

way to enhance fat engraftment with the use of mesenchymal
stromal cells (MSCs) derived from human embryonic stem
cells. This type of MSCs has the potential to be used as an
innovative, cell-based biomaterial to support lipofilling
widely used in cosmetic surgery. The related research finding
has been published in Biomaterials. Prof Xu’s team has
found that T-MSCs enhance fat graft survival and retain graft
weight comparable to the stromal vascular fraction or MSCs
derived from fat tissues which are the techniques currently
used in clinics to improve fat engraftment. Prof. Xu has also
found that T-MSCs help glue dissociated fat tissues to form a
capsulated graft within as early as 24 hours of transplantation
and facilitate graft remodelling by forming new blood vessels
and adipocyte regeneration. A patent application has been filed
in both China and US on the novel utilization of T-MSCs.
Prof. Qi ZHAO and his research team have designed two

novel immunotherapeutic antibody drugs targeting an immune
checkpoint B7-H3. Two antibody drugs can be used to promote
the anti-tumour immunity of the patient’s own immune system
against non-small cell lung cancer. Four related research papers
徐仁和教授及其研究團隊發現人胚幹細胞經滋養層分 have been published in renowned journals including Journal of
化的間充質幹細胞具有顯著治療效果，該細胞可望作 Hematology & Oncology. Three patent applications have been
為一種新型生物材料通過促進脂肪移植而廣泛用於 filed in China, and the research work is supported by Macao
整容手術。相關研究成果已獲國際知名期刊《生物材 SAR Government and the National Key R&D Program of China.
料》刊登。研究團隊發現T-MSC能提高脂肪移植物的趙琦教授及其研究團隊，研發了具有自主知識產權的
存活率並維持移植物的重量，與臨床常用的基質血管多個抗體藥物，尤其是研究團隊研發了具有突破性的
成分和成體來源的MSC相比，毫不遜色。徐仁和教 B7-H3抗體藥物（雙特異抗體與 CART 細胞 )，在此
授還發現T-MSC在移植後的24小時內，像膠水一樣將基礎上進行小鼠動物實驗，展示出優異的抑制腫瘤的
分散的脂肪小粒聚集在一起，形成被囊膜包裹的移植效果。相關研究成果已在《Journal of Hematology &
物，並通過新生血管形成和脂肪細胞的再生促進移植 Oncology》等國際一流學術期刊上發表四篇論文，並申
物的功能重建。徐教授已就這項T-MSC的新用途申請請三項中國發明專利，研發還獲得了澳門特別行政區政
了中國及美國專利。府和國家重點研發計劃資助。
42
In recent years, many medical reports have shown 近年不少醫學報告指出，很多非小細胞肺癌使用酪氨酸激酶抑制劑

that many non-small cell lung cancer (NSCLC) 後，不久就會產生抗藥性。雖然轉用新一代藥物有可能消除這個問
patients can develop resistance to EGFR tyrosine 題，但病人經過幾次療程後，有可能又對新藥產生抗藥性。因此，從
kinase inhibitors in a relatively short period of 生物醫學的角度來說，這個過程有機會不斷重覆，言而一直轉換藥物
treatment. Although this problem might be mitigated 往往不利治療。為了打破困局，郭珩輝教授及其研究團隊開發了抑制
by changing to the next generation of new drug 性抗體「A9(B8)IgG」，以腫瘤壞死因子-α轉化酶（TACE- ADAM17
treatment, patients can still develop resistance to ）作為標靶。這項研究顯示，這種抗體與酪氨酸激酶抑制劑結合使
the new drug after several rounds of treatment. This 用，能夠增強抑制劑的效力，克服EGFR突變引致的抗藥性。憑著這
process can go on and on, and shifting from drug to 項發現作為基礎，郭教授與謝瑞瑜教授在2021年初獲得一項美國專
drug often hampers the treatment. Prof. Henry Hang 利。
Fai KWOK and his research team have developed a
new inhibitory antibody named A9(B8) IgG, which
targets Tumour Necrosis Factor‑α Converting
Enzyme (TACE/ADAM17). The study suggested
that this antibody, when used in combination with
EGFR‑TKI, can potentiate the anticancer effects of
EGFR‑TKI and overcome drug resistance due to
EGFR mutations. Prof. Kwok and Prof. Ruiyu XIE
have filed a US patent application for this antibody
and its development.
Prof. Kwok has aimed at animal venom and pioneered the

creation of a high-throughput screening and identification
platform for peptides from the perspective of transcriptome
and proteomics. He has also established a new biomolecule
venom library from scorpions and other venomous animal
species, thereby obtaining a batch of potentially active
anti-cancer polypeptides, and investigating into specific
targets via a variety of cancer-related signaling pathways/
Prof. Kwok has recently 郭珩輝教授最近最近公 receptors, such as ion channels, transient receptor potential
unveiled a novel concept on 佈了一個新概念，即設 channels, membrane non-receptor molecules and integrins.
designing a bioactive venom- 計一種以生物活性毒液為 In the recently published research report, Prof. Kwok and
based peptide as a potent and 基礎的肽作為一種名為 his research team have proposed a new theory of designing a
specific anticancer prototype Gonearrestide (P13) 的強 more potent and specific anti-cancer template drug based on
drug template named 效和特異性抗癌原型藥物 the active venom peptide AcrAP1.
Gonearrestide (P13). In 模板。此外，他們還提出郭珩輝教授以動物的毒液為目標，開拓性地從轉錄組
addition, they also proposed 了在他們新發現以毒液為及蛋白組學的角度，創立了一種高通量篩選及鑒定
a stem cell application on 基礎、名為M6的肽，通過多肽的平台，且從蝎子和其他具有毒性的動物品種建
their newly discovered 激活成纖維細胞生長因子立一個新的生物分子毒液庫，從而獲取了一批具有潛
venom-based peptide named 和轉化生長因子 - β來維持在活性的抗癌多肽，並對各種與癌症相關的如離子通
M6 to maintain the self- 人類胚胎幹細胞的自我更道、瞬時受體電位通道、膜非受體分子和整合蛋白進
renewal of human embryonic 新。於 2020年，郭珩輝教行了研究以作為特異性靶點。在最近發表的研究報告
stem cells by activating 授申請 P13及 M6多肽之中中，郭教授及其研究團隊提出了一種基於活性毒液肽
fibroblast growth factor and 國和PCT專利。 AcrAP1，設計出效能更強，特異性更高的抗癌模板藥
transforming growth factor- 物新學說。
beta signaling. A China
patent and a PCT patent on
P13 and M6 peptides were
filed in 2020.
43
Prof. Wenhua ZHENG and his research team have innovatively

discovered the new effect of artemisinin, i.e. artemisinin has
neuroprotective and therapeutic effects, especially in Alzheimer’s
disease, stroke and other nervous system damage diseases. Prof.
Zheng found that artemisinin and its derivatives can inhibit the
growth and metastasis of tumour cells and prolong the survival
time of animals. Artemisinin derivatives can also kill several drug-
resistant tumours, delay the formation of tumour drug resistance,
and enhance the anti-tumour immune function of the animals.
The research team also found that artemether, a derivative of
artemisinin, offers protection against cerebral ischemia injury, a
finding with great significance for the field of stroke prevention
and treatment. The related research work was published in Free
Radical Biology and Medicine and Redox Biology.
Prof. Zheng is applying for a Chinese invention patent, and will apply for a US patent and an
Australian patent. Based on the new efficacy of the water extract of Artemisia annua, it can be
developed into a functional health food for its preventive effect, and developed into a clinical first-
line drug for its therapeutic effect. Meanwhile, based on its water-soluble physical and chemical
properties, the products can be formulated as tablets, granules, and oral liquids.
鄭文華教授及其研究團隊創新性地發現了青蒿素的新效用，即青蒿素有神經保護作用，尤
其在阿爾茨海默症和腦卒中等神經系統損傷疾病中都有很好的預防和治療作用。鄭文華
教授發現青蒿素及其衍生物可以抑制腫瘤細胞的生長和轉移，並延長動物的生存時間。青
蒿素衍生物還可殺死一些耐藥腫瘤或延緩腫瘤耐藥性的形成，也能增強動物的抗腫瘤免
疫功能。研究所團隊亦發現青蒿素衍生物蒿甲醚可以保護腦缺血損傷，為預防及治療腦中
風具有重要的意義。這些研究成果已在《Free Radical Biology and Medicine》及《Redox
Biology》上發表。
鄭文華教授正在申請中國發明專利，後續將有序申請美國專利和澳洲專利。基於黃花
蒿水提物的新功效，針對其預防作用，可以開發成功能性保健食品，並可以開發成臨
床一線用藥。同時基於其溶於水的理化特性，可以開發成不同製劑形式的製劑產品，
例如片劑、顆粒劑、口服液等。
44
Quality
Education
品質教學
Quality Education 品質教學
FHS had a major academic reform in 2021, 健康科學學院在2021年進行了學術改革，

and the objective of the reform is to foster 目標培養更多能夠滿足社會在於健康科學、
more outstanding personnel who can fulfill 生物醫學和藥物科學領域發展的人力需求，
the manpower demand for the development 改革包括引入新的學術課程、優化現有的學
in the areas of health science, biomedical 術課程，以及在健康科學學院設立學系。透
science and pharmaceutical science in the 過三個學系：生物醫學系、藥物科學系、公
society. The reform included the introduction 共衛生及醫藥管理系的優秀教學團隊，健康
of new academic programmes, improvements 科學學院目前提供或與澳門大學其他單位聯
in the existing academic programmes and 合提供三個學士學位課程及四個碩士學位課
establishment of departmental units in FHS. 程。健康科學學院也提供一個聚焦生物醫藥
FHS now offers or jointly offers with other 學之博士課程。
units at UM three bachelor’s programmes
and four master’s programmes, and they are
delivered by our excellent team of teachers
with outstanding background and strong
passion from three departments: Department
of Biomedical Sciences, Department of Public
Health and Medicinal Administration and
Department of Pharmaceutical Sciences. In
addition, FHS also offers a PhD programme in
biomedical sciences.
46
Academic Programmes
學位課程
Bachelor’s Programmes 學士學位課程
UM has played a leadership role in nurturing professionals in various fields.

UM implements a “4-in-1” education model that consists of discipline-
specific education, general education, research and internship education, and
community and peer education. Currently, UM has Asia’s largest residential
college system. The residential colleges and the faculties work in concert to
help students achieve well-rounded development.
澳門大學積極培養能引領社會發展的多元人才，學生培養模式與國際接
軌，創新地實施「四位一體」教育模式，融合專業、通識、研習和社群
教育，加強學生的全人發展。澳門大學擁有亞洲最具規模的住宿式書院系
統，書院與學院制度相輔相成，從多方位培養人才。
47
Bachelor of Science in Biomedical Sciences

理學士學位（生物醫學）課程
The Bachelor of Science in Biomedical Sciences programme offers students with the opportunity to explore
the essence of human beings, learn about biological and chemical systems of human body and apply this
interdisciplinary knowledge to medical issues that are related to health and diseases. Graduates are well
equipped with a strong foundation for a career in health professions, and many graduates choose to pursue
further studies in professional schools or continue their post graduate studies.
In the 2020/2021 and 2021/2022 academic years, this programme admitted 36 and 60 students respectively. The
total number of active students as at the end of 2021 is 138 students. In addition, two cohorts of students with a total
of 43 students have graduated in these two years. Amongst, 60% of the graduates have chosen to pursue a further
study such as a PhD study or medical study after their undergraduate study, while approximately a quarter of the
graduates entered the labour market within six months after their graduation.
理學士學位（生物醫學）課程向學生提供學生一個探索人類的本質、瞭解與人體有關的生物和化學系
統，並應用這些跨學科的知識於與健康和疾病相關醫學問題的一個機會，畢業生具備發展健康科學相
關職業生涯所需的穩固知識基礎。
於2020/2021和2021/2022兩學年，本課程分別錄取了36名和60名學生，而截至2021年底，在讀學生總
數為138學生。此外，這兩個學年有兩批、共43名學生畢業，其中60%的畢業生選擇繼續深造，包括入
讀博士生課程、醫學課程等，約四分之一的畢業生在畢業後六個月內投進入勞動力市場。
Bachelor of Science in Bioinformatics

理學士學位（生物信息學）課程
Bioinformatics is one of the fast-developing fields in the 21st century in view of the need for in-depth study
areas of health sciences. It applies research and analytical tools that integrate the knowledge of computer
science, information technology and statistics to understand biological data and solve problems. The objective
of the programme is to nurture professionals in bioinformatics, who are the important building block to develop
Macao as a smart city. The graduates of the programme are fully capable to pursue a career in the medical
sector, as well as biomedical, pharmaceutical and biotechnological industries.
This programme was first launched in the 2019/2020 academic year. In the 2020/2021 and 2021/2022 academic
years, this programme admitted 21 and 18 students respectively. As at the end of 2021, the three cohorts
constitute a total of 45 active students.
進入21世紀，在社會對開拓健康科學研究範疇的需求推動下，生物信息學發展非常迅速。本學科整
合計算機科學、資訊科學和統計學知識的研究和分析工具，以瞭解生物數據和解決問題。本課程將結
合生物學、健康科學、信息科學和計算機科學等領域，旨在教育和培訓生物信息學領域的專業人才為
目標。本課程的目標是培養生物信息學專業人才，畢業生將成為發展澳門作為智慧城市的重要組成部
分，能完全勝任醫療領域相關的工作，以及從事生物醫學、製藥和生物技術行業。
本課程於2019/2020學年首次收生，在2020/2021和2021/2022兩學年，本課程分別錄取21名和18名學
生。截至2021年底，這三學年在讀學生人數為45名學生。
48
Bachelor of Science in Pharmaceutical Sciences and Technology

理學士學位（藥物科學及科技）課程
Pharmaceutical Sciences and Technology forms the foundational scientific basis of the physical, chemical, biological
and the biomedical aspects of drug properties and actions combining a broad range of scientific disciplines that are
critical to the discovery and development of new drugs and therapies. Through this undergraduate programme,
students can gain a well-rounded understanding of drug discovery and development, and can master the relevant
laws and regulations. The graduates are well equipped with generic, subject-specific and transferable knowledge and
skills suited to a career in the pharmaceutical industry, drug laboratory-based scientific disciplines. Pursuing further
post-graduate studies or professional studies such as pharmacy are also popular options for graduates.
藥物科學及科技結合了物理、化學、生物學和生物醫學領域的科學基礎，是對研究和開發新藥物和療
法起著至關重要作用的一門學科。透過本課程，學生能夠對藥物研究和開發領域得到全面了解，並能
掌握相關法律法規。畢業生皆具備專業的知識及技能，可投身製藥行業及其他藥物相關實驗室發展科
研事業，或可選擇繼續深造包括報讀藥劑專業培訓課程及其他專業方向的研究生課程。
(The new programme will be offered in 2022/2023 academic year.)

(此課程為2022/2023學年新開辦課程。)
49
Master Programmes 碩士學位課程
Master of Science in Data Science with Specialization in Precision Medicine

理學碩士學位（數據科學 — 精準醫學）課程
With the advances in technology, there is an increasing trend in applying large-scale, high-output approaches and techniques in biology
and medical research to generate large data. Hence, a huge amount of data is constantly generated and stored in databases. There is a
solid need to process the information and extract knowledge quickly from this rapidly growing collection of data, which defines the
discipline of Data Science. Precision Medicine is an emerging approach for disease treatment and prevention that considers individual
variability in genes, environment, and lifestyle for each person. Students enrolled in this programme first comprehend the knowledge
in the professional areas such as computer science, statistics, and information technology, and subsequently learn and study how a large
pool of data can be practically and effectively applied in Precision Medicine. The graduates of this programme are well equipped with
a strong foundation for a career in an interdisciplinary work in biomedical and big data analytics in the medical, pharmaceutical, and
biotechnology sectors.
This programme was first launched in the 2019/2020 academic year, and 5 students from this cohort graduated in the 2021 summer.
In the 2020/2021 and 2021/2022 academic years, this programme admitted 11 and 28 students respectively. As at the end of 2021, this
programme has 40 active students.
隨著科技不斷進步，生物與醫學科研逐步傾向運用大規模及高產出方法去進行大數據處理，因此大量數據不斷產出並儲
存。數據科學是一門學習快速的運用及處理大量的數據，以提取重要信息的學科。「精準醫學」是一門嶄新的醫學模
式，是針對個別的病患情況，當中包括對其基因、環境因素和生活方式差異進行分析，從而採取適切的治療和預防方
法。入讀本課程的學生通過融匯計算機科學、統計學和信息學等多方面的專業領域知識，學習和研究如何將大數據有效
地應用於精準醫學。本課程修讀年期為兩年，畢業生將具備良好的背景基礎，並能在醫學、製藥和生物技術領域，開展
生物醫學和大數據分析跨學科工作。
本課程於2019/2020學年起開辦，首批為數5名學生於2021年夏季畢業。於2020/2021和2021/2022兩學年，本課程分別錄取
11名和28名學生。截至2021年底，本課程有40名在讀學生。
Master of Science in Global Public Health

理學碩士學位（全球公共衛生）課程
Global Public Health is in the field of science that prevents disease,

improves health and promotes life quality of the whole population.
Global Public Health covers interdisciplinary study areas that involve
knowledge in epidemiology, biostatistics, environmental health,
nutrition, food safety, social medicine, health services and risk
management. The understanding of global public health is critical for
the society to improve public wellbeing and manage the disasters that
affect global community.
全球公共衛生屬於預防疾病、改善健康和提高全民生活質量的科學
領域。全球公共衛生涵蓋跨學科研究領域，涉及流行病學、生物統
計學、環境健康、營養、食品安全、社會醫學、衛生服務和風險管
理方面的知識。瞭解全球公共衛生，對於社會改善公共福祉和應對
全球性的災害至關重要。
(The new programme will be offered in 2022/2023 academic year.)

(此課程為2022/2023學年新開辦課程。)
50
PhD Programme 哲學博士學位課程
Doctor of Philosophy in Biomedical Sciences

哲學博士學位（生物醫藥）課程
Biomedical scientists bridge the gap between the basic sciences and medicine, conduct research in order to comprehend human
disease and find ways to improve human health. Students interested in conducting independent research and gaining laboratory
experience might benefit from the PhD programme offered by FHS. Students in the programme are supervised individually by
an academic staff at a professoriate rank to carry out a research project in a wide array of contempanory aspects in health and
biomedical sciences for a research dissertation. Our PhD programme is designed to educate learners who aspire to pursue careers
as research scientists, scholars, or academic careers in health and biomedical science.
In the 2020/2021 and 2021/2022 academic years, this programme admitted 62 and 75 students respectively. The total number
of active students as at the end of 2021 is 237 students. In addition, 73 students have graduated in these two academic years.
Most of the graduates were successively recruited as post-doctoral researchers, assistant professors and associate professors by
top universities including Yale University, University of Maryland, Baylor College of Medicine, Southern Medical University,
Chongqing University, etc., providing the vital driving force for health and biomedical related areas.
生物醫學科學家填補了基礎科學與醫學之間的空隙，開展研究以了解人類疾病，努力尋求改善人類健康的方法。健康
科學學院開設之哲學博士（生物醫藥）課程給予有興趣的學生一個機會在教授級學術人員指導下，在當代健康和生物
醫學科學的廣闊領域內從事獨立研究工作及撰寫研究論文。本課程旨在培育有志從事生物學與生物醫學科學研究的學
生，成為健康和生物醫學科學領域中傑出的科研人員。
於2020/2021和2021/2022兩學年，本課程分別錄取62名和75名學生。截至2021年底，在校學生總數為237人。此外，73
名學生於這兩個學年學生畢業，大部份畢業生相繼被頂尖學府羅致為博士後研究人員、助理教授及副教授，包括耶魯
大學、馬里蘭大學、貝勒醫學院、南方醫科大學、重慶大學等，成為生物醫學領域高質量的新力軍。
51
Diverse Learning Opportunities

多元學習機會
“2+4” Joint Programme

“2+4” 聯合培養計劃
The “2+4” programme is jointly launched by UM and Zhejiang
University. Eligible students who are interested in becoming a
medical doctor will be recommended to School of Medicine of
Zhejiang University after the completion of first two years of
studies in Bachelor of Sciences in Biomedical Sciences offered
by Department of Biomedical Sciences for the admission to
its medical programme. Graduates of the programme receive
a bachelor’s degree of Bachelor of Science in Biomedical
Sciences from UM and a bachelor’s degree of Bachelor of
Medicine in Clinical Medicine from Zhejiang University.
“2+4”聯合培養計劃由澳門大學和浙江大學聯合開辦。在
完成生物醫學系開辦的理學士學位（生物醫學）課程前
兩年學習後，有興趣從醫且符合條件的學生將獲推薦參
加本計劃，並到浙江大學醫學院修讀醫學課程。完成本
計劃的學生將獲得澳門大學生物醫學理學士學位和浙江
大學臨床醫學學士學位。
“3+2” Joint Programme
“3+2” 聯合培養計劃
(The relevant professional requirement to be a medical doctor in Macao is
governed by Regulamento Administrativo n.º 23/2021.) The “3+2” programme is jointly launched by UM and the Queen’s
(在澳門成為醫生的相關專業要求詳見第 23/2021 號行政法規。) University Belfast. Students are required to complete three years
of study in Bachelor of Science in Biomedical Sciences followed
by two years in Bachelor of Science in Food Quality, Safety and
Nutrition at Queen’s University Belfast. Upon the successful
completion of this programme, students will receive a bachelor’s
degree of Bachelor of Science in Biomedical Sciences from UM
and a bachelor’s degree of Bachelor of Science (Honours) in Food
Quality, Safety and Nutrition from Queen’s University Belfast.
“3+2”聯合培養計劃由澳門大學和貝爾法斯特女王大學聯
合開辦。在完成健康科學學院理學士學位（生物醫學）
課程前三年學習後，符合條件的學生將獲推薦到貝爾法
斯特女王大學，修讀兩年的食品質量、安全和營養學課
程。成功完成本計劃的學生，將獲得澳門大學頒授的生
物醫學理學士學位，以及貝爾法斯特女王大學頒授的食
品質量、安全和營養學士學位。
(The new programme will be offered in 2022/2023 academic year and will
come into operation upon publication in Macao SAR Gazette. The completion
of this joint programme does not fulfill the professional qualification for a
dietician in Macao, and the requirement for this profession is governed by
Regulamento Administrativo n.º 23/2021.)
(此課程為2022/2023學年新開辦課程，並將於《澳門特別行政區公
報》公佈後正式運作。完成本聯合培養計劃者不具備澳門營養師專
業的註冊資格，該專業資格要求詳見第 23/2021 號行政法規。)
52
Joint Doctorate Programmes

博士聯合培養計劃
The joint doctorate programmes offer PhD students the opportunities to benefit from shared research
excellence between FHS and its prestigious partners. Students will expose to two cultrual approaches to
enrich their experience in learning and research. They also obtain better networking for future job prospects.
FHS is now offering joint doctorate programmes with more than ten prestigous educational and research
institutes, some of them are University of Chinese Academy of Sciences, Southern University of Science
and Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of
Basic Medicine and Cancer, Chinese Academy of Sciences.
博士聯合培養計劃能讓參與計劃的博士生同時享有健康科學學院及其他優秀的合作單位的研究和學
術資源，使學生取得更豐富的學習和研究經歷，開拓他們的人際網絡，有助他們的職業生涯發展。
學院目前與十多所頂尖學院或研究機構並同培養博士，其中包括中國科學院大學、南方科技大學、
中科院深圳先進技術研究院、中科院基礎醫學與腫瘤研究所等。
Independent Research Opportunity International Competition Opportunity

獨立研究機會國際比賽機會
The Independent Research Programme serves to provide The International Genetically Engineered Machine (iGEM) Competition is
an opportunity for undergraduate students to participate an international team competition made up of predominantly undergraduate
in research projects and gain research experience on students interested in the field of synthetic biology. It provides an opportunity
top of their undergraduate studies. In this way, students for undergraduate students to apply their biomedical knowledge into
can experience the research work earlier and enhance application developments, build up their research abilities and broaden
their enthusiasm and confidence with the professors’ their horizons. FHS has joined the iGEM competition since 2019. The
supervision. teams under the supervision of FHS have won gold and silver medals for
獨立研究計劃讓學生在本科學習之外，有機會參 three consecutive years.
與研究項目，獲取研究經驗。在教授的指導下，國際基因工程機器（iGEM）比賽是一項國際團隊競賽，主要由
學生可以更早地體驗研究工作，增強他們的積極對合成生物學領域感興趣的本科生組成，為本科生提供一個利用
性和信心。生物醫學知識於應用開發、培養研究能力和開闊視野的機會。健
康科學學院自 2019年開始組織學生參加 iGEM 比賽。在過往三
年，學院所指導的團隊在這項國際比賽中均取得優秀的成績，勇
奪金獎及銀獎。
53
Graduate Prospects
畢業去向
4.6%
UG Graduates Goverment
政府機構
本科畢業生
24.1% 8.1%
University & Education Healthcare Industry
Organization 醫療衛生行業
大學與教育機構 3.5%
R&D
44.8% 研發機構
Further Studies
升學
14.9%
Others
其他
Master & PhD Graduates

5.1%
Healthcare Industry
碩士博士畢業生醫療衛生行業
8.5%
R&D
研發機構
62.7%
University & Education
Organization
大學與教育機構
22.0%
Others
其他
1.7%
Further Studies
升學
54
Shaolin ZHANG: My doctoral research training at UM has enabled me to blaze a new trail through
brambles on my academic path
張少林校友：讀博的科研訓練使我能在教研路上披荊斬棘
選擇澳大追逐夢想
張少林是澳門大學健康科學學院的第一位博士
畢業生，當他在西南大學攻讀碩士的時候已立
志從事藥物研究。為了感受不同地域的學術氛
圍，拓展自身的國際視野，他鎖定新加坡、香
港及澳門的大學作為博士深造的地方。在一次
機緣巧合的情況下，他與學院從事藥物研究的
譚建業教授會面，瞭解澳門大學的教學模式和
課程內容的特色，對學院的教學及科研充滿信
心，更因譚教授的研究領域與他的興趣吻合，
因此最終決定選擇入讀澳門大學，並進入譚教
授研究團隊開展博士研究學習。
博士生涯鍛鍊抗壓能力
Shaolin ZHANG (third from left) is the first PhD graduate from FHS of UM
張少林 (左三)是澳門大學健康科學學院的第一位博士畢業生現時在重慶大學藥學院任職副教授的張少林
表示，在讀博時最大的挑戰是如何面對學業
壓力。在學院建設初期，縱使儀器設備並未完
Chose UM to pursue his dream 善，他亦要在重重困難中致力把研究工作做
Shaolin ZHANG is the first PhD graduate from FHS of UM. He determined 好，從而學懂在壓力中積極面對並尋求解決辦
to specialise in pharmaceutical research when he was pursuing 法，不坐著抱怨。他慶幸當初能有機會成為
his master’s degree at Southwestern University. To experience the 學院初起步的一份子，與學院一同努力參與建
academic atmosphere of different regions and expand his international 設實驗室，經歷設備從零到完善組建，昔日的
horizon, he targeted universities in Singapore, Hong Kong and Macao 學習經驗使他今天能勇於面對工作上不同的挑
for his doctoral studies. On one occasion, he met Prof. Kin Yip TAM 戰，積極地把壓力轉化為動力。
of FHS, whose research interest is drug development, and got a grip
on the teaching mode and the characteristics of the curriculum of FHS.
Then, he gained full confidence in the teaching and research of FHS.
Finally, he decided to pursue his doctoral studies at UM, and joined
Prof. Tam’s research team
Developed his resilience in UM

Shaolin is currently an associate professor of the School of
Pharmaceutical Sciences at Chongqing University. He said that the
experiences he obtained during his doctoral studies empowered him to
transform pressure at work into motivation. He recalled that the biggest
challenge he faced when he was a PhD student was the pressure from
his studies. In the early stage of the establishment of FHS when the Shaolin ZHANG (middle) Shaolin is currently an associate professor of
the School of Pharmaceutical Sciences at Chongqing University.
laboratories were not fully equipped, he had encountered lots of problems 張少林(中)現時在重慶大學藥學院任職副教授
in conducting research. He confronted the problems and solved them
instead of just complaining, and tried his best to get the research done
despite difficulties. He is glad that he has grown up hand in hand with
FHS, and partaken in the entire construction of the laboratories in FHS
from scratch.
55
The key to his success: Think outside the Box 多元思維助他成功突圍

As a new academic, apart from the heavy teaching load, the 作為一名新晉的教學人員，除了要處理繁重的教學工
biggest challenge for Shaolin now is to apply for research 作，張少林面對最大的挑戰是申請研究經費進行研究。
funding. He is grateful for Prof. Tam who has guided him to 他憶述讀博期間，當研究的過程中遇上瓶頸時，幸好當
adjust his thinking pattern when he encountered a bottleneck 時得到譚教授及時糾正自己的思維誤區，並引導自己調
period in his PhD study. He said that Prof. Tam corrected his 整思考模式，拋開已有的任何限制或已知結論，從原點
misconceptions and directed him to leave aside any existing 出發思考，竟有意想不到的答案出現。這些經驗培養了
limitations or known conclusions and rethink from the original 他的多角度思維能力，讓他能在設置研究課題及內容
point, and this led him to find the unexpected answers. 時，能跳出框架思考，最終他的研究項目能在海量的申
This experience inspired him to think outside the box while 請中突圍而出，成功獲得研究經費資助。
designing his research topics and content, and eventually his
research projects got funded successfully out of numerous 勉勵學弟學妹積極嘗試
competitive applications. 他鼓勵學弟妹們遇到困難時，必須保持積極的心態，縱
使問題未必能夠立即迎刃而解，但總會找到新的出路。
His encouragement for juniors 他認為世上沒有不會做的事，只有不想做的事。已經
He encouraged the students in FHS to stay positive when 畢業多年的張少林仍然心繫母校，不時關注大學及學院
coming across dilemma. “Even though we may not be able to 的活動動態。他表示：「健康科學學院就像我的第二個
solve problems immediately, we will always find a new way 家，希望學院能越辦越好，培養更多的人才。」
out later. It is not because things are difficult that we do not
dare, it is because we do not dare that they are difficult.” After
graduation, Shaolin stays connected with his alma mater. He
says, “FHS is my second home, and I wish FHS every success
in its efforts to scale new heights and continue to cultivate
more talents.”
Zhijun HE: Undergraduate Courses in FHS Have Paved a Solid Foundation for My Further
Exploration in Research
何智鈞校友：本科的學習燃點我對科研的熱愛
Enthused over the learning of science inch by inch 一步步踏入科研之路

Zhijun HE mentioned that he was interested in biology and 何智鈞受訪時提到自小對生物及化學有著濃厚的興
chemistry when he was small. Thus, he decided to study 趣，因而選擇就讀澳門大學健康科學學院的生物醫藥
biomedical sciences in FHS of UM. He was well equipped 學本科課程，他在本科時期學到許多實驗操作技能，
with various experimental skills via his bachelor studies, 並在大學二年級時成為郭珩輝教授的科研團隊的一
and he became a member of Prof. Henry Hang Fai KWOK’s 份子，親身參與研究工作。縱使在科研路上不斷跌跌
research team to participate in his research project when he 碰碰，但何智鈞憑著堅持不懈的探索精神，在重重
was a sophomore. Despite the ups and downs, Zhijun has been 挑戰中堅持到底，最終得到正面的實驗結果。在本科
relentlessly pursuing his efforts in his research work. In the 三年級時，他更獲得參與「國際遺傳工程機器大賽」
spirit of perseverance, he eventually succeeded in obtaining the （iGEM）的機會，一項以合成生物學作主題的國際頂
positive results of the experiments through adversity. In his third 級科技賽事。在學院教授們的悉心指導下，他與其他
year of study, he participated in the International Genetically 同學組成的團隊獲得金獎殊榮。這些珍貴的本科學研
Engineered Machine Competition (iGEM), a top international 及比賽經歷燃點他對科研的熱愛，鼓舞著他在研究的
technology competition focusing on synthetic biology. Under 道路上奮力前行。
the guidance of the FHS professors, he and his fellow members
won the gold medal. These valuable undergraduate research
and competition experiences have kindled his love for research
and inspired him to pursue further.
56
紮實的課程成為最有力的墊腳石
何智鈞在2020年取得澳門大學生物醫藥學學士學位後，
前往清華大學攻讀碩士，主攻腫瘤學研究領域。他希望
能夠研發有效治療腦腫瘤的藥物，提升癌症患者的治療
品質，為人類健康盡一點綿力。何智鈞認為學院的課程
為他奠下了紮實的基礎，他在本科時學習了不同的實際
操作技術，包括細胞培養、聚合酶連鎖反應檢測、西
方墨點法等，不論在理論方面和實踐方面，都能運用自
如。這些基礎為他進修碩士課程建立穩定的基石，在研
究工作上更能得心應手。他覺得健康科學學院各個實驗
室都有為學生們提供良好的學研機會，只要同學們有興
趣及願意參與，教授們都會給予他們課程以外的研究機
會，何智鈞認為這是十分難得的體驗，不但有助加強學
Zhijun HE delivers a speech in an international conference 生的實驗設計及操作技巧，還可以培養他們獨立的思考
何智鈞於國際研討會上發言
及解決問題的能力，大大提升他們的科研實力。
視科學研究為享受
The most powerful stepping stone: Solid Courses
何智鈞感謝郭教授給予他很多親身參與研究的機會，並時
After obtaining his bachelor’s degree in Biomedical Sciences at
常勉勵他享受做實驗的過程，使他對科研的熱愛與日俱
UM, Zhijun continued his master’s programme, specializing in
增。昔日老師的教導與支持，是他終身受用的瑰寶。何智
oncology at Tsinghua University. He aims to develop effective
鈞說：「大學期間學到的技能讓我可以在研究工作上好好
medicine for brain tumours that brings a better treatment for
發揮，對實驗設計和儀器操作都能駕輕就熟，使我有更充
cancer patients. Zhijun says, “The undergraduate courses in
裕的時間從事更多的研究工作，好好享受科研的樂趣。」
FHS have paved a solid foundation for my further exploration
他鼓勵學弟、學妹們可趁課餘時間主動參與實驗室的科研
and developed my interests in research. FHS provides many
工作，通過這樣一個投入精力、發展興趣的過程，才會對
courses to cultivate students’ skills in conducting experiments,
科研產生一種持久的熱愛。
including cell culture, PCR and western blot, which can be
applied well theoretically and practically. What I have learned
in my undergraduate studies laid a solid foundation for my
postgraduate studies.” In addition, Zhijun pointed out that
all FHS research teams welcome undergraduate students to
take part in the research work on top of their undergraduate
studies. These precious research experiences can develop
students’ experimental design and operational skills, sharpen
their independent and critical thinking skills, which strengthen
students’ research abilities.
Research is my amusement
Zhijun was so grateful for Prof. Kwok who has provided him
many research opportunities, encouraged him to enjoy the
process of conducting experiments, and nurtured his ongoing
Zhijun HE (first from left) wins the gold medal in iGEM
love for scientific research. These all are his lifelong benefits. 何智鈞 (左一)在「國際遺傳工程機器大賽」獲得金獎殊榮
“What I gained from my undergraduate studies has built
transferable skills for my research competency,” says Zhijun.
“The ease of experimental design and operations allows me to
focus more on the content of studies.” Zhijun encouraged the
current students to participate in research after class, which can
help them develop a lasting love for research in such a process
of devoting efforts and cultivating interests.
57
Awards &
Recognitions
獎項及殊榮
Awards & Recognitions 獎項及殊榮
The FHS academic staff, research teams and students have received plentiful honors and distinctions over the years.
The following list is not exhaustive.
多年來，學院的教學人員、研究隊伍及學生獲得多個獎項及榮譽。以下為部份獎項名單。
Winner/Winning Team Award Awarding Unit

得獎者/隊伍獎項頒授單位
Prof. Ren-he XU’s team Excellence Award Guangdong-Hong Kong-Macao Greater Bay Area High-value
徐仁和教授的隊伍優秀獎 Patent Portfolio Layout Competition 2021
2021年粵港澳大灣區高價值專利培育佈局大賽
Prof. Leo LEE’s team Silver Prize International Genetic Engineered Machine (iGEM)
李子安教授的隊伍銀獎 competition 2021
2021國際遺傳工程機器大賽
Wei SANG (PhD Student) SLB/JLB Trainee Outstanding Research Society for Leukocyte Biology and Journal of Leukocyte
桑瑋（博士生） Award Biology
研究生傑出科研獎白細胞生物學學會和白細胞生物學雜誌
Zhan ZHANG (PhD Student) Excellent Speakers Award The 2nd International Ph.D Forum of Life and Health
張展（博士生）優秀演講者 Sciences (Zhejiang University)
第二屆生命與健康科學國際博士論壇（浙江大學）
Prof. Leo LEE’s team Gold Prize International Genetic Engineered Machine (iGEM)
李子安教授的隊伍金獎 competition 2020
Top five in the Environment Track 2020國際遺傳工程機器大賽
環保類別 (項目躋身國際前5名)
Shuai LI (PhD Student) Scientific and Technological R&D Award The Macao S&T Award 2020
黎帥（博士生） for Postgraduates 2020年度澳門科學技術獎
研究生科技研發獎
Jingjing LI (PhD Student) Scientific and Technological R&D Award The Macao S&T Award 2020
李晶晶（博士生） for Postgraduates 2020年度澳門科學技術獎
研究生科技研發獎
2020
International Genetically Engineered Machine
Competition
Fu Hengyi
UM Macau
Best Environment Project Nominee
Giant Jamboree
November 13 – 22, 2020
59
Public
Engagement
& Global
Linkage
大眾聯繫及全球網絡
Public Engagement & Global Linkage 大眾聯繫及全球網絡
Outreach for High Schools

中學推廣
The Pursuit of Research

科研探索之旅
Since 2021, FHS has regularly organized the science

popularization activity “The Pursuit of Research” for exposing
the high school students to scientific innovations, ideas and
findings, thereby improving their science literacy. Around 100
students from 10 local high schools conducted the hands-on
experiments of health sciences on their own, through which
they learned more about scientific theories and research skills.
In addition, the participants were also given a tour of FHS’s
state-of-the-art equipment, and learned how the equipment has
contributed to UM’s research achievements.
為了推動科普發展，提升中學生的科研素養，健康科學學院
由2021年起定期舉行「科研探索之旅」。10所本地中學的100
多位學生獨自操作與健康科學相關的實驗，從而瞭解科學理
論及掌握科研技巧。此外，學生亦參加了特設的研究實驗室
導賞，參觀學院的高端儀器，瞭解高水平的科研成果。
Science Talks
科學講座
The academic members of FHS have prepared a whole array of science talks with inspiring topics
for local secondary students. The aim of these science talks is to strengthen the understanding in
health sciences and foster the interest in scientific research of the students, all of which encourage
the students to actively take part in scientific research for broadening their horizons. Students from
23 local high schools were showcased with amazing scientific innovations, ideas and findings in the
science talks for bringing them new perspectives of biomedical sciences.
健康科學學院的教學團隊為本地中學生精心設計了一系列具啟發性的科學講座，期望通過講座加深
學生對健康科學的認識，培養他們對科研的興趣，從而鼓勵他們積極探索科學世界，擴闊視野。健
康科學學院老師向23所本地中學的學生展示了精彩的科技創新、想法和發現，為學生帶來全新的科
學視角。
62
Biomedical Sciences Summer Camp Summer Laboratory Work Experience Programme
生物醫藥學夏令營暑期實驗室實習計劃
To enhance the scientific literacy of high school student, Under the Summer Laboratory Work Experience
FHS organizes the Biomedical Sciences Summer Programme lauched in 2018, the local high school
Camp every year. In addition to attending lectures students ignited a passion for health sciences by engaging
and conducting experiments of health sciences in the in the research projects led by different research teams
laboratory, around 300 participants from over 40 high of FHS. Over 100 students not only experienced the joy
schools also had the opportunity to stay at residential of research but also enriched their summer vacations
colleges to experience a university life. through the participation in the interesting hands-on
為培養中學生了解學院的課程特色及體驗大學生生 experiments in different laboratories.
活，健康科學學院每年都會在暑假期間舉辦「生物醫健康科學學院為進一步推動本澳中學生對生物醫藥研究
藥學夏令營」，來自本地超過40所中學的約300名學生的興趣，由2018年開始，在暑假期間舉辦「暑期實驗
除了參加一系列健康科學的專題講座及進行研究實驗室實習計劃」。超過參與計劃的100名學生獲安排至不
外，他們更入住了大學的住宿式書院，從課堂到舍堂同的研究實驗室實習，並在教授及研究團隊隊員的指
真切體驗大學生活。導下，親自操作實驗室內先進的儀器設施，完成相關
研究實驗計劃，尋找科研的趣味。
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Open day
開放日
UM organizes open day every year, and FHS prepares a series of diversified and a rich variety of interactive
activities, including game booths related to biomedical sciences, workshop, lab tour, and the admission sharing,
etc. Meanwhile, the participants learn the latest development, academic programmes, research achievements and the
teaching facilities of FHS.
澳門大學每年都會舉辦開放日，健康科學學院在開放日期間會安排一系列具學院特色的活動，其中包括有關生物
醫藥學的攤位遊戲、工作坊、實驗室導賞及入學分享會等精彩活動，讓參加的中學生及市民更深入瞭解學院的課
程特色、科研成果及教學設施。
Principal’s Recommended Admission Activities

「校長推薦入學計劃」活動
As one of the academic units of UM, FHS held admission sharing,

laboratory visits and programme consultation for the students
under “Principals’ Recommended Admission Scheme” and their
parents to learn more about the unique competitive advantages
of FHS’s undergraduate programmes, the career prospects of
the graduates, the joint programmes, the latest development and
the research accomplishments of FHS. The students also visited
the residential colleges and had dinner there to experience the
atmosphere of community and peer education at UM.
作為澳門大學的學術單位之一，健康科學學院為讓「校長
推薦入學計劃」的學生及其家長了解學院本科課程的獨特
優勢、畢業生出路、聯合培養計劃、最新發展、教學課程
及科研成果等，特別為他們舉辦了多項活動，包括入學講
座、實驗室導賞及課程諮詢。學生及家長還參觀了澳門大
學特色之一的住宿式書院並在書院享用晚餐，感受住宿式
書院社群教育的學習氣氛，體驗書院生活。
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Academic & Exchange Activities

學術及交流活動
Conferences and Symposia 研討會
Launched in 2014, the Macau Symposium on Biomedical Sciences is an annual hybrid event that involves both in-person and
virtual elements, aiming to provide a platform for the sharing of knowledge and research findings in biomedical sciences,
and to promote research collaboration, innovation, and development in the field. Due to the epidemic, the symposium was
suspended in 2020. The Nobel Laureates and other world-renowned scholars in biomedical sciences were invited to share
their research findings and views on cutting-edge technologies in precision medicine.
「澳門生物醫學科學研討會」自2014年至今已成功舉辦七屆，於2020年因疫情影響而停辦了一次。研討會旨在為各地
生物醫學領域的專家學者提供研究交流的學術平台，以加強科研合作、促進生物醫學的創新與發展。歷屆研討會雲集
國內外生物醫學專家、科研人員及學生線上線下參與，研討會更邀請了諾貝爾得獎者及世界知名的生物醫學專家學者
分享他們對精準醫學尖端科學技術的研究和觀點。
As stem cell research holds tremendous promise for medical

treatment and is one of the key research areas at UM, the Macau
Stem Cell Symposium attracted experts and scholars from around
the world to have in-depth discussions on the latest developments
in stem cell research yearly, aiming to boost the development of
stem cell research in the Guangdong-Hong Kong-Macao Greater
Bay Area.
幹細胞研究具醫療價值，也是澳門大學重點科研項目
之一，「澳門幹細胞研討會」每年吸引不同的國家和地
區，從事“外幹細胞＂研究領域的專家學者，分享和探
討幹細胞研究的最新技術和發展，有助推動粵港澳門大
學灣區在幹細胞領域的研究與發展。
65
The Precision Medicine Symposium, jointly

organised by the Macao Science and Technology
Development Fund and the National Natural
Science Foundation of China, and hosted by
FHS, attracted experts, scholars, and industry
practitioners from mainland China, Hong
Kong and Macao. Participants discussed the
latest development and clinical applications
of precision medicine covering a wide range
of topics, such as precise oncology, genomic
biology and disease, emerging technologies in
precision medicine, chronic diseases, and drug
development and treatment, etc.
由澳門科學技術發展基金、國家自然科學
基金委員會主辦，澳門大學健康科學學院承
辦的「精準醫療研討會」吸引來自內地、香
港和澳門的精準醫療專家學者和業界人士參
與，共同探討精準醫療及其相關範疇的最新
發展、轉化和臨床應用，內容範圍包括精準
腫瘤學、基因組生物學和疾病、精準醫學的
新興技術、慢性病、藥物研發和治療等。
The Symposium on Biomedical Sciences for Students, Post-

doctoral Fellows and Research Assistants provides a platform
for students, researchers and scholars to have in-depth
discussions on a wide range of issues in the field of biomedical
sciences, combining both in-person and virtual elements.
「學生、博士後研究員和研究助理生物醫學研討會」為澳
門、內地和海外的學生、研究人員和學者提供了交流思
想、互相學習、分享研究成果的平台，就生物醫學範疇線
上線下進行了深入的討論及交流。
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FHS Public Seminar Series 學院公開講座系列
To enhance the researchers and students of UM and the public’s understanding on the latest development of cutting-edge
technology in public health, biomedical and pharmaceutical sciences, and also to strengthen the public’s knowledge on
different health, FHS organises public seminar series. During 2020 and 2021, 19 renowned scholars and experts from China
or overseas and FHS were invited to share their professional knowledge in different aspects of health sciences and illustrate
their fruits of research.
科學發展日新月異，為了讓大學的科研人員、學生及公眾了解生物醫學、藥物科學及公共衛生的最新發展，以及加
強大眾對各種健康問題的認知，健康科學學院定期舉辦公開講座在2020及2021年期間，學院先後邀請了19位中國及
海外的著名學者及學院教授分享不同的健康科學範疇上的最新發展，以及他們的相關研究成果。
Speaker 講者 Topic 演講主題

Prof. Joong Sup SHIM Exploiting Synthetic Lethality for Cancer Precision Medicine
沈仲燮教授在癌症精準醫學中開發合成致死
Prof. Yutao XIANG Clinical Studies on Mental Health during the COVID-19 Outbreak in China
項玉濤教授新冠肺炎爆發期間對中國內心理健康的臨床研究
Prof. Shuhai LIN Stable Isotope Tracing Reveals Metabolic Reprogramming in Cancer Cells
林樹海教授穩定的同位素示踪揭示了癌細胞中的代謝重編程
Prof. Shuai GAO Investigating the Induced Pluripotent Stem Cells (iPSCs) Quality and Tracing the Transcriptome
葛翔教授 Landscapes of the Human Fetal Stem Cells
調查誘導多能幹細胞（iPSC）的質量並追踪人類胎兒乾細胞的轉錄組景觀
Dr. Lei CHEN Regulatory Mechanisms of Intestinal Homeostasis
維持腸道穩態的調控機制
Dr. Yen-Yin LIN Next-generation 3D Pathology for Precision Medicine Applications
林彥穎博士三維組織病理在精準醫學的應用
Dr. Joyce CHIU Mechano-redox Control of Integrin De-adhesion
機械-氧化還原控制的整聯蛋白去粘附
Dr. Xiaotian HE and Dr. Wenming LIU The Application of Multiplex Electrochemiluminescence Immunoassay in Oncology Research
超敏多因數電化學發光免疫分析技術在腫瘤研究中的應用
Prof. Ningyi SHAO Nature: UM & Stanford Scientists Correct a Wrong Target for Treatment of Squamous Cell Lung Cancer
邵寧一教授《自然》：澳大和斯坦福科學家糾正肺癌治療錯誤靶點
Prof. Rui SHENG Sphingosine Kinase 2 Activates Autophagy and Protects Neurons Against Ischemic Injury via its
盛瑞教授 BH3 Domain
鞘氨醇激酶 2 通過其 BH3 結構域啟動自噬並保護神經元免受缺血性損傷
Prof. Zheng YING The Pathogenesis of Neurodegenerative Diseases: Disruption of Protein and Organelle Quality Control
應徵教授蛋白質和細胞器品質控制系統在神經退行性疾病中的作用機制
Dr. Qiang CHEN BRCA1, a Tumor Suppressor, Functions from Nucleus to Cytoplasm
陳強博士乳腺癌易感基因1從細胞核到細胞質的腫瘤抑制作用
Ms. Elaine Tze Yang LO Novogene Sequencing Service
諾禾致源基因測序服務W
Prof. Junlei CHANG Blood-Brain Barrier: Molecular Characterization and Therapeutic Modification
暢君雷教授血腦屏障：分子表徵和矯正治療
Dr. Aaron LIN Chromium X: The new era of single cell is here
林然博士 10x Chromium X 介紹
Prof. Wensheng ZHANG The Role of ncBAF Complex in Mouse Embryonic Stem Cells
張文勝教授 ncBAF 複合物在小鼠胚胎幹細胞中的作用
Dr. Peng WANG Data-driven Systems Biology of Metastasis
王鵬博士數據驅動的轉移系統生物學
Prof. Bo ZHONG IL-36γ- and IL-36Ra-mediated Reciprocal Regulation of Gastrointestinal Inflammation and
鐘波教授 Tumorigenesis
IL-36γ和IL-36Ra介導的胃腸道炎症和腫瘤發生的相互調節
Prof. Xiangfei MENG Early Life Experiences Have Complex and Long-lasting Effects on Mental Health
孟祥飛教授早期生活經歷對心理健康有著複雜而持久的影響
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Seminar Series of Ministry of Education Frontiers Science Center for Precision Oncology, UM
國家教育部澳門大學精準腫瘤學前沿科學中心系列講座
Since the establishment of Ministry of Education Frontiers Science Center for Precision Oncology, UM in 2021, over 20
distinguished speakers have been invited to conduct speeches related to precision medicine research with a wide range of
topics on cancer occurrence and development, tumor microenvironment and immune regulation, cancer metastasis and drug
resistance mechanisms, and high-efficiency drug development and individualized cancer treatment, etc.
自國家教育部澳門大學精準腫瘤學前沿科學中心於2021年成立以來，超過20位傑出學者應邀主持有關精準醫療
的講座，主題涵蓋癌症的發生與發展、腫瘤微環境與免疫調控、癌症轉移及耐藥機制、高效藥物開發及癌症個
體化治療等。
Delegation Visits 代表團參訪
FHS has received more than 20 delegations from Hong Kong, mainland
China and overseas in 2020 and 2021. During their visits, FHS had in-depth
discussions with the delegations on establishing joint study programmes,
academic exchange activities, cooperative research projects, etc. Close
friendship and collaboration were developed, and some institutes even
worked out the official cooperation with FHS afterwards.
在2020及2021年期間，健康科學學院曾接待超過20個來自香港、國內
及海外的代表團。會面期間，健康科學學院與各代表團就聯合培養、
學術交流活動、科研項目合作等進行深入討論。期後，學院與各單位
發展緊密及友好合作關係，有些機構更與學院在正式的合作框架下發
展夥伴關係。
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Summer Camps for Undergraduate and Postgraduate Students of Outstanding

Mainland Universities
內地優秀大學本科生及研究生夏令營
The summer camps aim to provide learning and exchange opportunities for the undergraduate and
postgraduate students from Mainland top universities. The summer camps not only enriched their
knowledge but also served as a platform for strengthening the collaboration among the outstanding
students of the mainland universities and enhancing interaction between mainland and UM students, in
which they had an insight into the academic development and research achievements of UM.
夏令營旨在為內地頂尖學府的本科生及研究生提供學習交流的機會。夏令營既能使學生增長知識，
又促進與來自全國不同高校的優秀大學生交流，也讓內地學生與澳門大學學生互相學習，從而對澳
門大學的研究及學術情況有更深入的認識。
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Global Collaboration Network

全球合作網絡
FHS has been actively establishing strategic alliances with 健康科學學院長期致力與全球多所大學和科研機構建立
universities and research institutions worldwide. FHS has a 戰略合作關係，同時與其他中國及海外的高校和研究單
wide range of collaboration activities with other world-class 位開展了廣泛的活動，其中包括合作研究項目、聯合研
institutions and reseach institutes in China and overseas, including 究實驗室、博士生聯合培養計劃及兼職教授，實現強強
collaborative research projects, joint research laboratories, joint 聯合、跨域资源共享及推動科研創新。
doctorate programmes and adjunct professorships. These strong
alliances contributes to the cross-origin resource sharing and the 學院的合作網絡遍及全球，與眾多知名院校及科研機構
promotion of research innovation. 開展了聯合研究項目，如史丹福大學、多倫多大學、
聖彼得堡州立大學、東芬蘭大學、莫納什大學、東京大
FHS’s global network is enhanced through active research 學、華中科技大學、復旦大學、香港大學等，研究成果
collaboration with other outstanding universities and research 豐碩，包括研發創新磷光探針助精準切除腫瘤、在三維
units, such as Stanford University, University of Toronto, Saint 基因組構象分析取得重大進展、研發出一套基於藥物基
Petersburg State University, University of Eastern Finland, 因組學的全新鼻咽癌精準治療策略等。
Monash University, University of Tokyo, Huazhong University
of Science and Technology, Fudan University, The University 此外，學院與中國科學院腫瘤與基礎醫學研究所、香
of Hong Kong, etc. Reaserch breakthroughs have been made 港中文大學、同濟大學、廣州金域醫學集團股份有限
through these strong alliances, including the development of a 公司建立了四個聯合研究實驗室。這些聯合實驗室的
novel cancer precision medicine strategy by integrating tumour 成立有助學院與其他機構發展持續的夥伴關係，共同
organoid culture, significant progress in 3D genome architecture 推動創新及科技發展。
analysis, innovative phosphorescence probes for precise tumour
removal,etc. 博士聯合培養計劃能讓參與計劃的博士生同時享有健康
科學學院及其他優秀的合作單位的研究和學術資源，使
In addition, FHS has established four joint laboratories with 學生取得更豐富的學習和研究經歷，開拓他們的人際網
Institute of Cancer and Basic Medicine, Chinese Academy 絡，有助他們的職業生涯發展。
of Sciences, The Chinese University of Hong Kong, Tongji
University, Guangzhou KingMed Diagnostics Group Co.,
Ltd. Through setting up joint research units, FHS collaborates
with leading research and academic partners for synergistic
collaboration and the advancement of innovation and technology.
The joint doctorate programmes offer PhD students the

opportunities to benefit from shared research excellence
between FHS and its prestigious partners. Students will expose
to two cultrual approaches to enrich their experience in learning
and research. They also obtain better networking for future job
prospects.
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The list of units with which FHS has strategic alliances in 2020 and 2021
於2020年及2021年有合作關係的單位名單
Collaborator(s) 合作單位 Country 國家

Asia Kidney Regenerative Medicine Technology Limited China
廣州華越腎科再生醫學科技有限公司中國
Canada
BC Cancer, Provincial Health Services Authority
加拿大
Fudan University China

復旦大學中國
Fujian Normal University China

福建師範大學中國
Guangdong Cardiovascular Institute China

廣東省心血管病研究所中國
Guangdong Edible Mushroom Technology Company Limited China

廣東粵微食用菌技術有限公司中國
Guangdong Provincial People’s Hospital China

廣東省人民醫院中國
Guangdong University of Technology China

廣東工業大學中國
Guangzhou Cell-gene Biotech Company Limited China

廣州熙帝生物科技有限公司中國
Guangzhou First People’s Hospital China

廣州市第一人民醫院中國
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences China

中國科學院廣州生物醫藥與健康研究院中國
Guangzhou KingMed Diagnostics Group Company Limited China

廣州金域醫學檢驗集團股份有限公司中國
Guangzhou Medical University China

廣州醫科大學中國
Guangdong Ocean University China

廣東海洋大學中國
Guangzhou RiboBio Company Limited China

廣州市銳博生物科技有限公司中國
Guangzhou Tianhe Nuoya Biology Engineering Company Limited China

廣州市天河諾亞生物工程有限公司中國
Guangzhou Xincheng Biotechnology Company Limited China

廣州新誠生物科技有限公司中國
Huazhong University of Science and Technology China

華中科技大學中國
ImStem Biotechnology Compant Limited, Hengqin, Zhuhai China

珠海橫琴愛姆斯坦生物科技有限公司中國
Institute of Biophysics, Chinese Academy of Sciences China

中國科學院生物物理研究所中國
Institute of Cancer and Basic Medicine, Chinese Academy of Sciences China

中國科學院腫瘤與基礎醫學研究所中國
Jiangsu MedUnion Biotechnology Company Limited China

江蘇醫聯生物科技有限公司中國
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Jinan University China
暨南大學中國
Johns Hopkins Singapore Private Company Limited Singapore

約翰霍普金斯新加坡私人有限公司新加坡
Monash University Australia

蒙納士大學澳洲
Nanjing Help Regenerative Medicine Technology Company Limited China

南京艾爾普再生醫學科技有限公司中國
Nanjing Shenyou Biotechnology Company Limited China

南京申友生物技術有限公司中國
Nanjing Well Pharmaceutical Company Limited China

南京威爾藥業股份有限公司中國
National Cancer Institute U.S.A

國家癌症研究所美國
Okinawa Institute of Science and Technology School Corporation Japan

沖繩科學技術大學院大學日本
Shanghai Institute of Technology China

上海應用技術大學中國
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences China

中國科學院深圳先進技術研究院中國
Shenzhen Sciprogen Bio-pharmaceutical Company Limited China

深圳賽保爾生物藥業有限公司中國
Soochow University China

蘇州大學中國
Southern Medical University China

南方醫科大學中國
Sun Yat-sen Memorial Hospital, Sun Yat-sen University China

中山大學孫逸仙紀念醫院中國
Sun Yat-sen University China

中山大學中國
Sweden Umea University Sweden

瑞典於默奧大學瑞典
The Chinese University of Hong Kong China

香港中文大學中國
The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese University) China
暨南大學附屬第一醫院（廣州華僑醫院）中國
The First Affiliated Hospital, Sun Yat-sen University China

中山大學附屬第一醫院中國
The First People’s Hospital of Foshan China

佛山市第一人民醫院中國
The Third Affiliated Hospital of Sun Yat-sen University China

中山大學附屬第三醫院中國
The University of Hong Kong China

香港大學中國
Tongji University China

同濟大學中國
University of Chinese Academy of Sciences China

中國科學院大學中國
University of Michigan U.S.A

美國密西根大學美國
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University of Tokyo Japan
東京大學日本
University of Toronto Canada

多倫多大學加拿大
West China Hospital, Sichuan University China

四川大學華西醫院中國
Wuyi University China

五邑大學中國
Yunnan Key Laboratory of Primate Biomedical Research China

雲南中科靈長類生物醫學重點實驗室中國
Zengcheng District People’s Hospital of Guangzhou China

廣州市增城區人民醫院中國
Zhongke Zhibo (Zhuhai) Technology Company Limited China

中科智博（珠海）科技有限公司中國
Zhuhai Gene-Biocon Biological Technology Company Limited China

珠海冀百康生物科技有限公司中國
Zhuhai Shengmei Biological Diagnostic Technology Company Limited China

珠海聖美生物診斷技術有限公司中國
(The list is arranged in alphabetical order 名單是按照字母順序排列)
73
Adjunct Members
客席成員
Current Position and Affiliation

Adjunct Position 客席職位 Name 姓名現職位及在職機構
Distinguished Professor, Technion-Israel Institute of Technology
Prof. Aaron CIECHANOVER 特聘教授，以色列理工學院
阿龍·切哈諾沃教授 Nobel Laureate in Chemistry 2004
Adjunct Chair Professor 2004年諾貝爾化學獎得主
客席講座教授 Prof. Fu GAO Dean, Savaid Medical School, University of Chinese Academy of Science
高福教授院長，中國科學院大學存濟醫學院
Prof. Nan-Shan ZHONG Director, Guangzhou Institute of Respiratory Health
鍾南山所長, 廣州呼吸疾病研究所
Adjunct Distinguished Professor Prof. Gregory CHENG Physician, The University Hospital
客席特聘教授鄭彥銘教授醫生，澳門科大醫院
Prof. Chi-Chung CHAN Vice President of Biology, WuXi AppTec, Shanghai, China
陳誌中教授生物藥研發部副總裁，藥明康德 (中國上海)
Dr. Tai Ip CHAN Physician, Kiang Wu Hospital
陳泰業醫生醫生，澳門鏡湖醫院
Prof. Ligang CHEN Professor, The Affiliated Hospital of The Southwest Medical University
陳禮剛教授教授，西南醫科大學附屬醫院
Dr. Chun Wing CHEUNG Physician, Kiang Wu Hospital
張振榮醫生醫生，澳門鏡湖醫院
Prof. Yanzheng HE President, Southwest Medical University
何延政教授校長，西南醫科大學
Dr. Feng HU Physician, Kiang Wu Hospital
胡峰醫生醫生，澳門鏡湖醫院
Dr. Shui Meng LIU Physician, Kiang Wu Hospital
劉水明醫生醫生，澳門鏡湖醫院
Prof. Ligong LU Director, Zhuhai People’s Hospital
陸驪工教授院長，珠海市人民醫院
Dr. Guang Hui LUO Physician, Kiang Wu Hospital
Adjunct Professor
羅光輝博士醫生，澳門鏡湖醫院
客席教授
Dr. Hok Cheung MA Former Director, Kiang Wu Hospital
馬學章博士前院長，澳門鏡湖醫院
Dr. Baoquan PAN Physician, Kiang Wu Hospital
潘寶全博士醫生，澳門鏡湖醫院
Prof. Valter SERGO Professor of Chemistry, University of Trieste
瓦爾特謝爾戈教授教授，的里雅斯特大學
Dr. Guangli XIAO Physician, Kiang Wu Hospital
肖光莉醫生醫生，澳門鏡湖醫院
Director, Biomedical Research Institute of PKU-HKUST Medical Center in
Prof. Ting XIE
Shenzhen
解亭教授
所長，深圳北京大學香港科技大學醫學中心生物醫學研究所
Dr. Xue Bin XIE Physician, Kiang Wu Hospital
謝學斌醫生醫生，澳門鏡湖醫院
Dr. De Li XU Physician, Kiang Wu Hospital
徐德利醫生醫生，澳門鏡湖醫院
Dr. Qiang YU Senior Group Leader, Genome Institute of Singapore
于強博士高級研究主管，新加坡基因組研究所
Dr. Kin Iong CHAN Physician, Kiang Wu Hospital
陳建勇醫生醫生，澳門鏡湖醫院
Dr. Weide ZHONG Chief Physician, Guang Zhou First People Hospitala
Adjunct Professor
鐘帷德主任醫生, 廣州市第一人民醫院
客席教授
Deputy General Manager, Sinopharm Healthcare Industry Company, Sinopharm
Dr. Lu YU
Group, China
喻陸
副總經理, 國藥集團
74
Current Position and Affiliation

Adjunct Position 客席職位 Name 姓名現職位及在職機構
Dr. Yabing CAO Physician, Kiang Wu Hospital
曹亞兵博士醫生，澳門鏡湖醫院
Dr. Ian CHE Physician, Kiang Wu Hospital
謝昕醫生醫生，澳門鏡湖醫院
Dr. Wai Kuok CHU Physician, Kiang Wu Hospital
朱偉國醫生醫生，澳門鏡湖醫院
Dr. Chon Wa LAM Physician, Kiang Wu Hospital
林俊華醫生醫生，澳門鏡湖醫院
Adjunct Associate Professor Dr. Zheng Feng LU Physician, Kiang Wu Hospital
客席副教授盧正烽醫生醫生，澳門鏡湖醫院
Dr. Kam Leong NGAI Physician, Kiang Wu Hospital
倪金良醫生醫生，澳門鏡湖醫院
Dr. Xi Bin QIU Physician, Kiang Wu Hospital
丘熹彬醫生醫生，澳門鏡湖醫院
Dr. Hewick Hon Ho YU Physician, Kiang Wu Hospital
余漢濠醫生醫生，澳門鏡湖醫院
Dr. Wenli ZHU Physician, Kiang Wu Hospital
朱文立博士醫生，澳門鏡湖醫院
Dr. Tan-Hsia CHEN Physician, Hospital Conde S. Januário, Macao
Adjunct Assistant Professor 陳丹霞博士醫生，澳門仁伯爵綜合醫院
客席助理教授 Dr. Zhihui WENG Vice President of Investment, Shenzhen Share Capital
翁智輝投資副總裁, Shenzhen Share Capital
Adjunct Lecturer Dr. Enqin LI Physician
客席講師李恩琴醫生
75
Media & Social Media

傳媒及社交媒體
FHS has put intensive efforts to enhance exposure at media and social media platforms. In the past two years, news
about the research achievements and activities of FHS have been widely in local media.
健康科學學院一直致力推動學院於傳媒及社交媒體的爆光率，而本地傳媒過去曾超過多次就有關學院的科研成
果及活動作出報導。
Website Wechat Facebook

FHS has not only built up a website with a more friendly-user
interface, but also set up accounts on Facebook, Instagram,
Twitter and Weibo to connect with the university members,
other institutes and the public.
為了與大學成員、其他機構及公眾建立聯繫，學院除
了建設一個更簡易使用的網站外，亦增設了Facebook、
Instagram Twitter Weibo
Instagram、推特及微博的帳號。
76
Publications & Promotional Videos

出版刊物及宣傳影片
Faculty Publications Published at regular intervals, the bilingual brochure of

FHS reports on FHS’s achievements, academic events,
學院刊物 exchange activities, developments, etc. in the previous
academic years. FHS also publishes Weekly Newsletters
that provide the updates of FHS for the week. These
updates include the articles published, reports of
events, talks, visits, PhD oral defences and other
communications. In addition to the FHS reports and
newsletters, the admission leaflets of FHS are visually
appealing and contain useful information for the public.
學院定期出版的中英對照的小冊子報導學院上學年
的重要事項和發展。每週出版的學院通訊提供當
週學院的更新，包括發表的論文、活動、講座、訪
問、博士答辯報告及其他交流等。此外，學院亦
印製了精美的升學小冊子，將學院的資訊傳達給公
眾，信息直觀，一目了然。
Promotional Videos
宣傳影片
FHS has a collection of videos that feature

remarkable happenings, people and infrastructure
at the Faculty.
健康科學學院製作了不同的宣傳影片，記載
了學院的歷史、人、事及基建。
77
科研刊物
FHS has an excellent record of published research, both in discipline-specific journals and more high-profile publications
such as Nature, The Lancet, Nature Communications, Advanced Science, etc. The acuumulative number of papers
published by FHS scholars increased from 43 in 2014 to over 1,600 in April 2022, with over 27,000 citations and over
200 accumulative publications with impact factor ≥10.
學院人員在特定學科的期刊及一些高端科研期刊如《自然》、《柳葉刀》、《自然通訊》、《先進科學》等發
表了大量的學術文章，數目由2014年的 43 篇增至2022年4月累計超過1,600篇，論文獲引用超過 27,000次，而
影響因子高於10的累計出版物已超過 200 篇。
International Journal of Biological Sciences

國際生物科學期刊
Led by Prof. Chuxia DENG as Editor-in-chief, along with the editor board that consists of Prof. Renhe XU as Executive
Editor and a team of internationally renowned scholars, International Journal of Biological Sciences has attracted a high
number of publications with good quality in biological sciences and life sciences-related topics in recently. The quality
of the accepted and published articles is improving over the year that drives an upshift of the impact factor from 4.067 in
2018 to 6.58 in 2020. In 2020 and 2021, the journal published two special issues to report the latest research development
of the COVID-19 pandemics.
在鄧初夏教授以主編輯身份帶領下，加上徐仁和教授（執行編輯）和一眾國際著名學者組成的編輯組，《國際生物科學
期刊》近年吸引大量高質量生物學及生命科學相關論文投稿，而獲接受而刊登的論文越發優質，推動其影響因子由2018
年的4.067逐年增加至2020年的6.58。於2020及2021年，期刊發表兩期的專題特刊，報告有關新冠疫情的最新科研發展。
Issue 11 • Volume 17 • 2021 Issue 10 • Volume 16 • 2020 Issue 16 • Volume 16 • 2020
International Journal of International Journal of

Biological Sciences Biological Sciences
COVER FEATURE: Crystal structure of the MyRF ICA domain with its upstream β- COVER FEATURE: Batsaikhan Buyandelger, Eli E Bar, Kuo-Sheng Hung, et al. Histone
helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage. deacetylase inhibitor MPT0B291 suppresses Glioma Growth in vitro and in vivo partially
COVER FEATURE: Ye Yi, Philip N.P. Lagniton, Sen Ye, Enqin Li and Ren-He Xu.
Pei Wu, Xiangkai Zhen, Bowen Li, Qian Yu, Xiaochen Huang, Ning Shi through acetylation of p53
COVID-19: what has been learned and to be learned about the novel coronavirus disease
Ivyspring Ivyspring Ivyspring

International Publisher International Publisher International Publisher
Issue 15 • Volume 17 • 2021 Issue 6 • Volume 17 • 2021
COVER FEATURE: PiRNA-63049 inhibits bone formation through Wnt/β-catenin COVER FEATURE: Hang Fai Kwok. Review of Covid-19 vaccine clinical trials - A puzzle
signaling pathway. Gaoyang Chen, Shang Wang, Canling Long, Zhenmin Wang, Xin Chen, Wanze Tang, with missing pieces
Xiaoqin He, Zhiteng Bao, Baoyu Tan, William W Lu, Zhizhong Li, Dazhi Yang, Guozhi Xiao, Songlin Peng
Ivyspring Ivyspring
International Publisher International Publisher
78
Book Publications
書籍出版
The two books which were edited by Prof. Henry Hang Fai KWOK cover current
advanced research related to natural-based biomolecules as a potential medicinal
therapy in different aspects. They include recent studies on bioactive molecules
derived from frog skins, fungus, plants, and venoms (e.g. peptide/toxin/immunotoxin/
secondary metabolite) for targeted cancer therapy, immunotherapy, etc. to address
the future challenges in these fields. Furthermore, an open discussion on using novel
disease-specific natural-based protein/peptide/toxin along with FDA approved drugs
as combinatorial treatment is also included in the contents. A group of excellent
researchers/scientists from ten different countries/regions involved as authors,
including the world-renowned scholar and founder of the Laboratory of Molecular
Biology in the U.S. National Cancer Institute (NCI) – Prof. Ira PASTAN from the
National Institutes of Health (NIH).
兩本由郭珩輝教授編輯的書籍涵蓋了當前天然生物分子作為一種藥物療法的相關
最新研究。這種天然生物分子包括來自青蛙皮膚、真菌、植物和毒液（例如肽／
毒素／免疫毒素／次級代謝物）的生物活性分子用於靶向癌症治療、免疫治療等
的研究，以應對這些領域的未來挑戰。此外，內容還包括討論關使用新型疾病特
異性的天然蛋白質/肽/毒素與 FDA 批准的藥物作為組合治療。一群來自九個不
同國家/地區的優秀研究人員/科學家作為書籍的合著者，其中包括世界知名學者
和美國國家癌症研究所（NCI）分子生物學實驗室的創始人 — 美國國立衛生研
究院（NIH）的Ira Pastan教授。
The fifth edition of Medical Genetics of which Prof. Chuxia DENG is one of the
chief editors covers Precision Medicine and Preventive Medicine. This version
supplements the progress and the frontier knowledge in medical science-related
modern life science research based on the characteristics of disease prevention
and health-related biomedicine.
由鄧初夏教授為主編輯之一的《醫學遺傳學》第五版結合精準醫學、預防醫
學，本著治未病、大健康等有關生物醫學的特點，合理補充一些與醫學密切
相關的現代生命科學研究的進展和前緣沿知識。
79
Appendix
附錄
Appendix 附錄
The projects that start in 2020 and 2021

2020及2021年開展的科研項目
Functional study of BRCA1 in breast tumorigenesis

Functional genomics of reproduction, development and aging
Mitophagy: Novel regulatory mechanisms and implication in health and disease
Functional study of breast cancer associated gene 1 (BRCA1) in breast cancer formation
Novel regulatory mechanisms of mitophagy and its implication in health and disease
Functional genomics of reproduction, development and aging
Epigenetic regulation and fate determination of human embryonic stem cell-derived MSCs following xenotransplantation
Importance of autophagy and lysosome in cancer cell biology
Identification of polarity-inhibiting factors associating with premature aging
Anti-tumour effects of an ADAM17 inhibitory antibody on pancreatitis-induced pancreatic ductal adenocarcinoma
Targeting B7-H3 with awakened natural killer cells for therapy of non-small cell lung cancer
Establishment of a C. elegans model of HSAN1 disease
Determine BRCA gene mutation in Macau population
Diagnose Acute Mesenteric Ischemia with Serum Fluorochromics
Development of anticancer dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1
Mechanistic and Functional Studies on the Pro-effector of Type VI Secretion System 2 in Pathogenic Vibrio parahaemolyticus
Metal-Organic Framework Based Fluorescent Nanoprobes for Detection of Formaldehyde and Adenosine Triphosphate
Functional analysis of S100A9 in BRCA1 associated mammary tumorigenesis
Research on Asian Psychotropic Prescription Patterns on bipolar disorder (REAP-BD)
Identification of tumor suppressors for cholangiocarcinoma in liver-specific Smad4/Pten knockout mice using Crispr-Cas9 system
Elucidating the role of GRK2 and GRK6 in the β-arrestin signaling in ovarian cancer and its potential clinical application
NIR-II light-responsive oxygen-independent hybrid nanoplatform for multiscale photoacoustic imaging-guided
photothermal/photodynamic synergistic cancer therapy
Molecular and functional characterization of Tbf1 – an essential transcriptional regulator of ribosomal protein genes and a
probable virulence factor – in the fungal pathogen Candida
Therapeutic targeting of RB1 tumor suppressor mutation in lung cancer cells by aurora kinase A inhibition
Functional characterization of Rad51 Recombinase (rad51) in zebrafish gonadal differentiation and function
The Molecular Mechanisms of ERK5 Regulation on Pluripotency and Differentiation in Human Pluripotent Stem Cells
Functional study of Cul3 as a liver tumor suppressor and drug sensitivity regulator
The molecular mechanism of lipid substrates in metabolism and pluripotency of human pluripotent stem cells
Potential impacts of environmental pollutant bisphenol A (BPA) on inner ear development and hearing disorders How does it work?
Protective effect and molecular mechanism of artemisinin and its derivatives on acute ischemic injury of nerve cells
Biobanking and precision oncology of several high-risk tumors in Macao and surrounding areas
Drug repurposing approach for the rapid discovery of therapeutics for SARS-CoV-2 infection_Anti-NCP epidemic
Proteomic and metabolic analyses reveal the role of fatty acid metabolic reprogramming and protein myristoylation in
highly metastatic ovarian cancer cells
Dual-Modal Nanochannel Sensor Based on Ion Current and Fluorescence
Alternations of cell migration pathways caused by prelamin A and aging
Novel regulatory role of WIPI2 in mitophagy and its biological function
A bioactivity screen for fungal secondary metabolites with useful pharmaceutical properties
Bromodomain and Extraterminal motif (BET) as a precision cancer target for SMAD4-deficient colorectal cancer
Label-free monitoring the apoptosis dynamics with multiphoton metabolic imaging of lipofuscin and porphyrin
81
Appendix 附錄
Elucidate the mechanisms through which metastatic breast cancer cells and macrophages interact and co-evolve to further
enhance cancer metastasis and tumor growth
Functional Characterization of the AR Transcriptional Network in Prostate Cancer
Deciphering the mRNP code in epithelial morphogenesis
Diagnose Diabetes Mellitus Conditions at its Early Stage with Metabolic Fluorochromic Imaging and Spectroscopy
Understanding the molecular mechanism of Caspofungin Paradoxical Effect in the human fungal pathogen Aspergillus fumigatus
Novel pharmacological effects of Remdesivir on the autophagy-lysosome system in the host cells and the implication in
its anti-viral activity
Molecular mechanism of Vibrio parahaemolyticus RhsP toxin release and RhsPI immunity protein as a protection
against gastroenteritis
Development of anti-B7-H3 CART and bispecific antibodies against non-small cell lung cancer
Precision medicine research for refractory breast cancer based on circulating tumor cells derived organoids
Preclinical study of Category 5 New Chinese Medicine Akebia Fruit (Yu Zhi Zi) Extract on the treatment of depression
Dual-modal photoacoustic and ultrasound imaging-guided cancer phototherapy with bacteria as the multifunctional
theranostics agent
Functions of post-translational modifications of key epigenetic and transcriptional regulatory factors in malignant
tumor development
BRCA mutation Standard Database in Chinese population: construction, characterization, and clinical application
The mechanism of chromosome 11q13 amplification in resistance to anti-PD-1 therapy of esophageal squamous cell cancer
Discovery of anti-Alzheimer's disease drugs targeting Sigma-1 receptor and study of the underlying mechanisms
Translational research on overcoming breast cancer drug resistance by inhibiting proteasome activity and enhancing
protein damage
Role and mechanism of animal venom peptide family BmKDfsin3/4 members against HBV/HCV and the related-
hepatocellular carcinoma mediated by p38 MAPK signal pathway
Study of FGFR2 and ATP11B as driving factors in BRCA1-associated breast tumorigenesis and metastasis, and their
inhibitory strategies
Directed evolution and function characterization of synthetic immune molecules with high throughput screening
Reversal of multidrug resistance and industrialization of breast cancer based on P-glycoprotein-targeted Ganoderma
lucidum active substance
多模態腦功能影像引導的經顱磁刺激早期幹預小兒唐氏綜合征
Overcoming broad drug resistance in cancer treatment through enhancing sensitivity of chemotherapy
Near-infrared activated photoacoustic probe for real-time monitoring of tumor infiltrating lymphocyte changes in tumor evolution
Novel conjugated polymer theranostic nanoplatform with both near-infrared II imaging and gas therapy functions
IGF-1信號通路在青蒿素保護神經細胞免於澱粉樣蛋白損傷中的作用及其機制
鑒定三陰性乳腺癌的癌症驅動突變並開發有效治療方法
82
Appendix 附錄
科研出版物
Representative Publications 代表性科研出版物

Lei, J. H. P., Lee, M. H., Miao, K., Huang, Z. B., Yao, Z. C., Zhang, A. P., Xu, J., Zhao, M., Huang, Z. N., Zhang, X., Chen,
S., Jiaying, N. G., Feng, Y. Z., Xing, F. Q., Chen, P., Sun, H., Chen, Q., Xiang, T. X., Chen, L., Xu, X. L., and Deng, C.
X. (2021) Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple-Negative Mammary Tumorigenesis That
is Sensitive to Immunotherapy. Adv Sci (Weinh) 8 (21), e2100974
Won, M., Park, K. A., Kim, S., Ju, E., Ko, Y., Yoo, H., Ro, H., Lee, J., Oh, J., Lee, E. G., Kim, S. Y., Nam, S. W., Shen, H.
M., Yeo, M. K., Kim, J. M., and Hur, G. M. (2021) ANKRD13a Controls Early Cell-Death Checkpoint by Interacting with
Rip1 Independent of Nf-kappaB. Cell Death Differ
Hwang, H. Y., Shim, J. S., Kim, D., and Kwon, H. J. (2020) Antidepressant Drug Sertraline Modulates AMPK-Mtor
Signaling-Mediated Autophagy via Targeting Mitochondrial VDAC1 Protein. Autophagy, 1-17
Chen, Q., Lei, J. H. P., Bao, J. L., Wang, H. T., Hao, W. H., Li, L., Peng, C., Masuda, T., Miao, K., Xu, J., Xu, X. L., and
Deng, C. X. (2020) BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor
Metastasis. Adv Sci 7 (6), 1903616
Liu, J. L., Adhav, R., Miao, K., Su, S. M., Mo, L. H., Chan, U. I., Zhang, X., Xu, J., Li, J. J., Shu, X. D., Zeng, J. M.,
Zhang, X., Lyu, X., Pardeshi, L., Tan, K. L., Sun, H., Wong, K. H., Deng, C. X., and Xu, X. L. (2020) Characterization
of BRCA1-Deficient Premalignant Tissues and Cancers Identifies Plekha5 as a Tumor Metastasis Suppressor. Nat Commun
11 (1), 4875
Wang, H. T., Guo, S., Kim, S. J., Shao, F. Y., Ho, J. W. K., Wong, K. U., Miao, Z. Q., Hao, D. P., Zhao, M., Xu, J., Zeng,
J. M., Wong, K. H., Di, L. J., Wong, A., Xu, X. L., and Deng, C. X. (2021) Cisplatin Prevents Breast Cancer Metastasis
through Blocking Early EMT and Retards Cancer Growth Together with Paclitaxel. Theranostics 11 (5), 2442-2459
Zhang, B. Y., Lyu, J. F., Yang, E. J., Liu, Y. F., Wu, C. J., Pardeshi, L., Tan, K. L., Chen, Q., Xu, X. L., Deng, C. X., and
Shim, J. S. (2020) Class I Histone Deacetylase Inhibition is Synthetic Lethal with BRCA1 Deficiency in Breast Cancer
Cells. Acta Pharm Sin B 10 (4), 615-627
Zhao, S. Y., Long, Y. K., Su, Y. P., Wang, S. B., Zhang, Z. T., and Zhang, X. J. (2021) Cobalt-Enhanced Mass Transfer
and Catalytic Production of Sulfate Radicals in MOF-Derived Ceo2 * Co3 O4 Nanoflowers for Efficient Degradation of
Antibiotics. Small 17 (43), e2101393
Xu, F., Tong, M., Tong, C. S. W., Chan, B. K. C., Chu, H. Y., Wong, T. L., Fong, J. H. C., Cheung, M. S. H., Mak, K. H. M.,
Pardeshi, L. S., Huang, Y. H., Wong, K. H., Choi, G. C. G., Ma, S., and Wong, A. S. L. (2021) A Combinatorial CRISPR-
Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment. Cancer Res 81 (24), 6219-6232
Wang, M., Xu, Y. W., Zhang, Y. C., Chen, Y. H., Chang, G., An, G., Yang, X. Y., Zheng, C. H., Zhao, J. X., Liu, Z. T., Wang,
D. Z., Miao, K., Rao, S., Dai, M., Wang, D., and Zhao, X. Y. (2021) Deciphering the Autophagy Regulatory Network via
Single-Cell Transcriptome Analysis Reveals a Requirement for Autophagy Homeostasis in Spermatogenesis. Theranostics
11 (10), 5010-5027
Li, K. K., Wu, R. F., Zhou, M. Y., Tong, H. B., and Luo, K. Q. (2021) Desmosomal Proteins of DSC2 and PKP1 Promote
Cancer Cells Survival and Metastasis by Increasing Cluster Formation in Circulatory System. Sci Adv 7 (40), eabg7265
Lu, G., Wang, L. M., Zhou, J., Liu, W., and Shen, H. M. (2021) A Destiny for Degradation: Interplay between Cullin-RING
E3 Ligases and Autophagy. Trends Cell Biol 31 (6), 432-444
Sun, H., Zeng, J. M., Miao, Z. Q., Lei, K. C., Huang, C., Hu, L. L., Su, S. M., Chan, U. I., Miao, K., Zhang, X., Zhang, A.
P., Guo, S., Chen, S., Meng, Y., Deng, M., Hao, W. H., Lei, H. P., Lin, Y., Yang, Z. L., Tang, D. J., Wong, K. H., Zhang, X.
H. D., Xu, X. L., and Deng, C. X. (2021) Dissecting the Heterogeneity and Tumorigenesis of BRCA1 Deficient Mammary
Tumors via Single Cell RNA Sequencing. Theranostics 11 (20), 9967-9987
Sun, X. D., Zhou, Y., Zhang, R. B., Wang, Z. Q., Xu, M., Zhang, D. L., Huang, J. L., Luo, F. T., Li, F. F., Ni, Z. H., Zhou, S. R., Chen,
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Precision Oncology/Bioinformatics 精準腫瘤學 / 生物信息學

Lei, I. M., Jiang, C., Lei, C. L., de Rijk, S. R., Tam, Y. C., Swords, C., Sutcliffe, M. P. F., Malliaras, G. G., Bance, M.,
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Precision Oncology/Nanomaterials 精準腫瘤學 / 納米材料

Zhang, D., and Zhang, X. J. (2021) Bioinspired Solid-State Nanochannel Sensors: From Ionic Current Signals, Current,
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Wang, C. F., Wang, W. J., Tan, J. Y., Zhang, X. J., Yuan, D. Q., and Zhou, H. C. (2021) Coordination-Based Molecular
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Zhang, Z., Li, B., Xie, L. S., Sang, W., Tian, H., Li, J., Wang, G. H., and Dai, Y. L. (2021) Metal-Phenolic Network-
Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy.
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Wang, G. H., Xie, L. S., Li, B., Sang, W., Yan, J., Li, J., Tian, H., Li, W., Zhang, Z., Tian, Y., and Dai, Y. L. (2021) A
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Xiao, L., An, T. T., Wang, L., Xu, X. L., and Sun, H. D. (2020) Novel Properties and Applications of Chiral Inorganic
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Tao, J. S., Wei, Z. J., Xu, M., Xi, L., Cheng, Y. X., Lee, S. M. Y., Ge, W., and Zheng, Y. (2021) Particle Integrity and Size
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Zhang, Z., Sang, W., Xie, L. S., Li, W. X., Li, B., Li, J., Tian, H., Yuan, Z., Zhao, Q., and Dai, Y. L. (2020) Polyphenol-Based
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Precision Oncology/-OMICS 精準腫瘤學 / 多組學研究

Ding, R. B., Chen, P., Rajendran, B. K., Lyu, X. Y., Wang, H. T., Bao, J. L., Zeng, J. M., Hao, W. H., Sun, H., Wong, A.
H. H., Valecha, M. V., Yang, E. J., Su, S. M., Choi, T. K., Liu, S. M., Chan, K. I., Yang, L. L., Wu, J. B., Miao, K., Chen,
Q., Shim, J. S., Xu, X. L., and Deng, C. X. (2021) Molecular Landscape and Subtype-Specific Therapeutic Response of
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Zhang, P. W., Ang, I. L., Lam, M. M. T., Wei, R., Lei, K. M. K., Zhou, X. W., Lam, H. H. N., He, Q. Y., and Poon, T.
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Xenopus Tropicalis Genome. Nat Genet 53 (7), 1075-1087
Neuropsychiatry 神經精神醫學
Xiang, Y. T., Jin, Y., and Cheung, T. (2020) Joint International Collaboration to Combat Mental Health Challenges During
the Coronavirus Disease 2019 Pandemic. Jama Psychiat 77 (10), 989-990
Zhao, Y. J., Bai, W., Su, Z. H., Ng, C. H., and Xiang, Y. T. (2021) Long-Term Effects on Survivors with COVID-19. Lancet
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Yang, Y., Li, W., Zhang, Q., Zhang, L., Cheung, T., and Xiang, Y. T. (2020) Mental Health Services for Older Adults in
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Xiang, Y. T., Yang, Y., Li, W., Zhang, L., Zhang, Q. G., Cheung, T., and Ng, C. H. (2020) Timely Mental Health Care for
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Xiang, Y. T., Li, W., Zhang, Q., Jin, Y., Rao, W. W., Zeng, L. N., Lok, G. K. I., Chow, I. H. I., Cheung, T., and Hall, B. J.
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Stem Cell Developments 幹細胞與發育

Borkar, R., Wang, X. Y., Zheng, D. J., Miao, Z. Q., Zhang, Z. W., Li, E. Q., Wu, Y. J., and Xu, R. H. (2021) Human
ESC-Derived MSCs Enhance Fat Engraftment by Promoting Adipocyte Reaggregation, Secreting CCL2 and Mobilizing
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Xu, F. X., Deng, C. H., Ren, Z. L., Sun, L. Y., Meng, Y., Liu, W. W., Wan, J. B., and Chen, G. K. (2021) Lysophosphatidic
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Cell Rep 37 (9), 110063
Other Areas 其他領域

Li, D., Shao, N. Y., Moonen, J. R., Zhao, Z., Shi, M., Otsuki, S., Wang, L., Nguyen, T., Yan, E., Marciano, D. P., Contrepois,
K., Li, C. G., Wu, J. C., Snyder, M. P., and Rabinovitch, M. (2021) ALDH1A3 Coordinates Metabolism with Gene Regulation
in Pulmonary Arterial Hypertension. Circulation 143 (21), 2074-2090
Li, S., Peng, T. M., Zhao, X., Silva, M., Liu, L. L., Zhou, W. S., Chen, L. G., and Zheng, W. H. (2021) Artemether Confers
Neuroprotection on Cerebral Ischemic Injury through Stimulation of the Erk1/2-P90rsk-CREB Signaling Pathway. Redox
Biol 46, 102069
Li, Z. M., Zhang, P., Zhang, R. T., Wang, X. Y., Tse, Y. C., and Zhang, H. J. (2021) A Collection of Toolkit Strains Reveals
Distinct Localization and Dynamics of Membrane-Associated Transcripts in Epithelia. Cell Rep 35 (5), 109072
Liu, K. F., Tan, S. G., Niu, S., Wang, J., Wu, L. L., Sun, H., Zhang, Y. F., Pan, X. Q., Qu, X., Du, P., Meng, Y. M., Jia, Y. F.,
Chen, Q., Deng, C. X., Yan, J. H., Wang, H. W., Wang, Q. H., Qi, J. X., and Gao, G. F. (2021) Cross-Species Recognition of
SARS-CoV-2 to Bat ACE2. Proc Natl Acad Sci U S A 118 (1)
Wang, T. L., Zhou, Z. F., Liu, J. F., Hou, X. D., Zhou, Z., Dai, Y. L., Hou, Z. Y., Chen, F., and Zheng, L. P. (2021) Donut-
Like MOFs of Copper/Nicotinic Acid and Composite Hydrogels with Superior Bioactivity for rh-bFGF Delivering and Skin
Wound Healing. J Nanobiotechnology 19 (1), 275
Lin, G. W., Xu, C. G., Chen, K., Huang, H. Q., Chen, J. P., Song, B., Chan, J. K. C., Li, W. Y., Liu, W. P., Shih, L. Y., Chuang, W. Y.,
Kim, W. S., Tan, W., Peng, R. J., Laurensia, Y., Cheah, D. M. Z., Huang, D. C., Cheng, C. L., Su, Y.-J., Tan, S. Y., Ng, S. B., Tang, T.
P. L., Han, K. D., Wang, V. Y. F., Jia, W. H., Pei, Z., Li, Y. J., Gao, S., Shi, Y. Y., Hu, Z. B., Zhang, F., Zhang, B., Zeng, Y. X., Shen,
H. B., He, L., Ong, C. K., Lim, S. T., Chanock, S., Kwong, Y. L., Lin, D., Rothman, N., Khor, C. C., Lan, Q., and Bei, J. X. (2020)
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Contents 目錄

02 Dean’s Message 院長的話

05 Vision & Mission 願景及使命

28 Cutting-edge Research 前沿研究

45 Quality Education 品質教學

58 Awards & Recognitions 獎項及殊榮

61 Public Engagement & Global Linkage

Pivot on the frontiers of science

FHS at UM aims at becoming a leading research and education

FHS strives to accomplish its 健康科學學院將通過以下幾方面

Facts & Figures

Center for Precision Oncology

(as of 30 April 2022 截至2022年4月30日)

UM World Rankings by Subject Continually Rises

Total Grant Amount in Million MOP Internal Grant 內部資助

(as of 31 December 2021 截至2021年12月31日)

Dr. Chon Lok LEI is a physicist-turned-computational biologist, with interests in

Frontiers Science Center for Precision Oncology

Ministry of Education Frontiers Science Center for

The successful establishment of FSCPO assists in shaping the long term

focusing on signal transduction and carcinogenesis, cancer

conducting research and providing training to local personnel

developing better diagnostic and therapeutic approaches

Biological Imaging &

Core Facilities 流式細胞儀

Genomics, Bioinformatics & 核心實驗中心 Proteomics, Metabolomics

FHS’s biomedical research is dedicated to ensuring cancer precision medicine, stem

Precision Oncology 精準腫瘤學

Prof. Chuxia DENG and his research team have successfully

Prof. Deng‘s team has also explored the role of mechanism of

A collaborative work among Prof. Deng, Prof. Xiaoling XU and

Precision Oncology 精準腫瘤學

Prof. Ningyi SHAO collaborated with

Prof. Lijun DI and his research team have discovered, through

Precision Oncology/Bioinformatics 精準腫瘤學 / 生物信息學

Precision Oncology 精準腫瘤學

Androgens play an essential role in the growth of prostate

Precision Oncology 精準腫瘤學

Caveolin-1 (CAV1) is an important tumour suppressor in breast

Precision Oncology/Bioimaging 精準腫瘤學 / 生物成像

Prof. Qi ZHAO and his research team have developed a new

Prof. Tzu-Ming LIU and his research team have 劉子銘教授及其研究團隊與聖彼

Precision Oncology/Bioimaging 精準腫瘤學 / 生物成像

Precision Oncology/Nanomaterials 精準腫瘤學 / 納米材料

Prof. Yunlu DAI and 代雲路教授及其研 究

In addition, Prof. Dai and his reserach team synthesised a

Precision Oncology/-OMICS 精準腫瘤學 / 多組學研究

Stem Cell Developments 幹細胞與發育

Prof. Ren-He XU and his research team have discovered a new

Cardiac muscles cells are considered difficult to regrow 徐仁和教授及其研究團隊發現人胚幹細胞經滋養層分化

Other Area 其他領域

Research Funding 研究撥款

Total Grant Amount in Million MOP (Number of Grants)

5.48 9.42 13.00 8.88 -- --

Prof. Tzu-Ming LIU and his research

Prof. Liu has begun some preliminary

Prof. Ren-He XU and his research team have discovered a new

Prof. Qi ZHAO and his research team have designed two

In recent years, many medical reports have shown 近年不少醫學報告指出，很多非小細胞肺癌使用酪氨酸激酶抑制劑

Prof. Kwok has aimed at animal venom and pioneered the

Prof. Yunlu DAI and 代雲路教授及其研究