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    SR - 230316 - Critical Appraisal Checklist

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    This systematic review aimed to evaluate the rates of treatment failure, relapse, and acquired drug resistance with different durations and dose administration schedules of rifampin therapy for pulmonary tuberculosis. The review clearly stated its questions and described comprehensive search methods, including databases, reference lists, guidelines, and grey literature. Relevant expertise was represented on the multidisciplinary review team. The background provided compelling rationale for the review to inform revised treatment guidelines regarding rifampin administration and resistance.

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    SR - 230316 - Critical Appraisal Checklist

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    This systematic review aimed to evaluate the rates of treatment failure, relapse, and acquired drug resistance with different durations and dose administration schedules of rifampin therapy for pulmonary tuberculosis. The review clearly stated its questions and described comprehensive search methods, including databases, reference lists, guidelines, and grey literature. Relevant expertise was represented on the multidisciplinary review team. The background provided compelling rationale for the review to inform revised treatment guidelines regarding rifampin administration and resistance.

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    This systematic review aimed to evaluate the rates of treatment failure, relapse, and acquired drug resistance with different durations and dose administration schedules of rifampin therapy for pulmonary tuberculosis. The review clearly stated its questions and described comprehensive search methods, including databases, reference lists, guidelines, and grey literature. Relevant expertise was represented on the multidisciplinary review team. The background provided compelling rationale for the review to inform revised treatment guidelines regarding rifampin administration and resistance.

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    © All Rights Reserved
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    25 views3 pages

    SR - 230316 - Critical Appraisal Checklist

    Uploaded by

    SRI
    This systematic review aimed to evaluate the rates of treatment failure, relapse, and acquired drug resistance with different durations and dose administration schedules of rifampin therapy for pulmonary tuberculosis. The review clearly stated its questions and described comprehensive search methods, including databases, reference lists, guidelines, and grey literature. Relevant expertise was represented on the multidisciplinary review team. The background provided compelling rationale for the review to inform revised treatment guidelines regarding rifampin administration and resistance.

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    © All Rights Reserved
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    of 3

    Critical Appraisal of a Systematic Review

    Disusun oleh:

    Sri Hartati NPM 131520220006

    Mata Kuliah Systematic Review

    Program Studi Magister Epidemiologi

    Fakultas Kedokteran Universitas Padjadjaran

    2023
    Appraisal Work Sheet. Intensive course in Systematic Reviews – March 2023

    Section 1: The Question


    1. Was the review question clearly and explicitly stated?
    Yes, it was explicitly stated, although it was not in a structured questions (PICO format).
    The systematic review aimed to address two specific questions:
    a. What are the rates of treatment failure, relapse, and acquired drug resistance if
    rifampin is given only in the initial intensive phase (the first 1–2 mo), compared
    to longer duration?
    b. What are the rates of treatment failure, relapse, and acquired drug resistance
    with different dose administration schedules of therapy?

    Was it a focused review question?


    Unclear, because the PICO elements were not clearly described in a structured question.

    Identify the PICO elements of the review question.


    The first question:
    The population: in previously untreated patients with bacteriologically confirmed
    pulmonary TB (derived from abstract)
    The intervention: rifampin administration only in the initial intensive phase (the first 1-2
    months)
    The comparison: longer duration of rifampin administration
    The outcome: rates of treatment failure, relapse, and acquired drug resistance

    The second question:


    The population: in previously untreated patients with bacteriologically confirmed
    pulmonary TB (derived from abstract)
    The intervention: different dose administration schedules of therapy
    The comparison: different dose administration schedules of therapy
    The outcome: rates of treatment failure, relapse, and acquired drug resistance

    2. Was the background thorough? Balanced? Compelling (CONVINCING)?


    Yes, it was, because they highlighted:
    - The need of effective administration of rifampin amid the threat of rifampin
    resistance
    - To provide a basis for recommendations for revised treatment guidelines.

    3. Was the protocol registered?


    Unclear. The protocol could not be found in the PROSPERO and Cochrane database of
    Systematic Review.

    Who was the review team – were all necessary expertise represented?
    The review team was consists of members from respiratory and epidemiology-
    associated institutions with research experience in the topic of tuberculosis.

    Section 2: Methods section


    Did the methods describe?
    Yes, it did. They had a separate section for methods.
    Appraisal Work Sheet. Intensive course in Systematic Reviews – March 2023

    4. The search strategy:


    ● Was it adequate for finding and including all the relevant studies?
    Yes, it was, because they did a thorough search for relevant studies.

    ● What databases and sources were searched?


    They searched from:
    a. Three electronic databases (PubMed, Embase, and the Cochrane CENTRAL
    database) for randomized controlled trials studies of treatment of active TB.
    b. Additional relevant articles:
    - Reference lists of identified original articles
    - Recent systematic reviews
    - A review of all the British Medical Research Council trials
    - Recent treatment guidelines, and
    - Texts

    ● What years?
    From 1965 up to June 2008.

    ● What languages?
    English, French and Spanish.

    ● Was a librarian involved?


    Yes, it was. A medical librarian at the Montreal Chest Institute was involved.

    ● Was the grey literature included?


    Yes, it was. The references listed in number 16 are grey literature because it is not
    produced by commercial publisher.

    ● If yes – should it have been?


    Yes, it should be. A review team should try to the full to identify all randomized trial
    that have ever been started of the review question if the systematic review aims to
    review randomized trials only.

    ● If not – why not?


    N/A

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