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IM Sample Exam

This document contains 23 multiple choice questions testing knowledge about various aspects of autoimmune diseases and basic immunology concepts. The questions cover topics like classification of autoimmune diseases; cells involved in adaptive immunity; causes of autoimmunity; characteristics of rheumatoid arthritis, SLE, systemic sclerosis, and psoriatic arthritis; environmental factors in SLE pathogenesis; and functions of pattern recognition receptors and epithelial barriers.

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Jedidiah Gassmen
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64 views4 pages

IM Sample Exam

This document contains 23 multiple choice questions testing knowledge about various aspects of autoimmune diseases and basic immunology concepts. The questions cover topics like classification of autoimmune diseases; cells involved in adaptive immunity; causes of autoimmunity; characteristics of rheumatoid arthritis, SLE, systemic sclerosis, and psoriatic arthritis; environmental factors in SLE pathogenesis; and functions of pattern recognition receptors and epithelial barriers.

Uploaded by

Jedidiah Gassmen
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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1. Which among these autoimmune diseases is considered rheumatoid factor negative?

a) Rheumatoid Arthritis
b) SLE
c) Psoriatic arthritis
d) Systemic sclerosis

2. All of the following are classified as connective tissue disease except.


a. SLE
b. RA
c. SSc
d. Gout

3. Cells that are prime players of adaptive immunity.


a. B & T cells, macrophage
b. Macrophage & T cells
c. B& Tcells
d. Dendritic cells, T helper cells, NK cells

4. This results when the orchestrated process which efficiently rids the host of the pathogenic
organism is disrupted.
a. Connective tissue diseases
b. Autoimmunity
c. Immunologic tolerance
d. Central tolerance

5. Which of the following appropriately clescribes Rheumatoid arthritis


a. Chronic, inflammatory, symmetric polyarthritis
b. Chronic, inflammatory, asymmetric polyarthritis
c. Chronic, non-inflammatory, symmetric polyarthritis
d. Chronic, inflammatory, symmetric oligoarthritis

6. The antibody responsible in RA?


a. ANA
b. ACPA
c. RF
d. ESR
7. The following hand deformities are seen in RA except?
a. Bouchard nodes (OA)
b. Boutonnier deformity
c. Swan neck
d. Piano key

8. Extraarticular syndrome of RA inclucled except?


a. Felty's
b. Caplan's
c. Sjogren's
d. APAS

9. Which among the following play a role in SLE pathogenesis?


a. Deficiency of C1a, C2, C4
b. Persistence of antibody, hypomethylated DNA
c. Normal Innate and adaptive immunity response
d. Male gender

10. Which among these environmental factors play a definite role in the pathogenesis of SLE?
a. UVB
b. EBV(probable)
c. Estrogen (probable)
d. Alfalfa sprouts (possible)

11. The most frequent sign/symptoms of SLE at the onset.


a. Skin, arthralgia/arthritis (percent at onset)
b. Fever, fatigue, weight loss (percent at any time)
c. Renal s/s
d. Cardiac s/s

12. True of SLE diagnosis


a. When Diagnosing SLE it must fu fill »4 of the ACR/SLICC criteria
b. signs and symptoms of SLE may present simultaneously or serially at the time of the day
c. Classification criteria has been developed for diagnosis of SLE
d. Anti ds DNA must be positive to make a diagnosis of SI.E
13. Goal of SLE management
a. Achieve the lowest possible disease activity
b. Negative ANA
c. maximize drug toxicity
d. poor quality of life

14. Pathophysiology of systemic sclerosis includes


a. Vasculitis, inflammation&autoimmunity, fibrosis
b. Vasculitis, autoimmunity,inflam nation
c. Vasculopathy, inflammation, fibrosis
d. Vasculopathy, inflammation & autoirmunity

15. Hallmark sign and symptom of SSc


a. Skin thickening
b. Sclerodactyly
c. Interstitial lung disease/ILD
d. Raynaud's

16. Which among the following are the domains of psoriatic arthritis?
a. Nail changes, dactylitis, enthesitis, axial disease,skin, peripheral arthritis
b. Nail changes, skin and axial disease only
c. Nail changes, skin psoriasis, inflammatory back pain
d. Nail changes, skin, axial, peripheral arthritis

17. Autoimmune disease presenting as inflammatory low back pain, ankylosing spondylitis is
associated with?
a. HLA B37
b. HLB A37
c. HLA- B27
d. HLB-A27

18. Some features of the history may reveal important clues to the diagnosis of patients. The
follcwing is correctly paired except.
a. Gout - middle age men, postmenopausal women (osteoporosis)
b. Osteoarthritis - elderly women and athletes
c. Rheumatoid arthritis -young males (females)
d. Behcet's disease- Turkish, Arabics

19. Gouty arthritis is caused by which crystal deposit?


a. Calcuim pyrophosphate crystal
b. Pyrophosphate crystal
c. Monosodium urate crystal
d. Magnesium rate crystal

20. Which describes septic arthritis?


a. Acute monoarthritis, synovial fluid wbc count >500,000/cumm, +MSU crystals (?)
b. Acute monoarthritis, synovial fluid wbc count5,000/cumm, no crystals seen
c. Chronic monoarthritis, synovial fluid wbe count 30,000/cumm, no bacteria seen
d. Chronic monoarthritis, synovial fluid wbc count 500/cumm, no crystals seen

21. The following are examples of pathogen associated molecular patterns (PAMPS) EXCEPT
a. Dectin glucans
b. Heat shock proteins
c. SSRNA
d. Lipoteichoic acid

22. True about pattern recognition receptors (PRRs) EXCEPT


a. They are cellular receptors for PAMPs and DAMPs
b. They activate signal transduction events that promote antimicrobial and proinflammatory functions
of the cells in which they are expressed
c. Found in the blood and extracellular fluid (plasma membrane, endosomal membrane,
cytoplasm)
d. Examples are TLRs and scavenger receptors

23. Functions of epithelial barriers EXCEP


a. Form physical barriers between microbes and host tissue
b. Produce antimicrobial chemicals that impede the entry of microbes
c. Presence of intraepithelial lymphocytes facilitate killing of microbes and infected cells
d. Activate T cells in adaptive immune response

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