Scribd Logo
Upload

Welcome to Scribd!

  • 42 views

    Celiac Diseases

    Uploaded by

    Abdullahi Shirwac
    Celiac disease is an autoimmune disorder of the small intestine that is triggered by ingesting gluten. It damages the lining of the small intestine and prevents nutrient absorption. It is strongly associated with certain genetic variations and has a complex interplay between genetic, immunological, and environmental factors. The only treatment is a strict lifelong gluten-free diet to avoid complications like malnutrition, osteoporosis, and intestinal cancer. Early diagnosis and treatment are important to prevent long-term health issues.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Celiac Diseases

    Uploaded by

    Abdullahi Shirwac
    42 views2 pages
    Celiac disease is an autoimmune disorder of the small intestine that is triggered by ingesting gluten. It damages the lining of the small intestine and prevents nutrient absorption. It is strongly associated with certain genetic variations and has a complex interplay between genetic, immunological, and environmental factors. The only treatment is a strict lifelong gluten-free diet to avoid complications like malnutrition, osteoporosis, and intestinal cancer. Early diagnosis and treatment are important to prevent long-term health issues.

    Original Title

    Celiac diseases

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Celiac disease is an autoimmune disorder of the small intestine that is triggered by ingesting gluten. It damages the lining of the small intestine and prevents nutrient absorption. It is strongly associated with certain genetic variations and has a complex interplay between genetic, immunological, and environmental factors. The only treatment is a strict lifelong gluten-free diet to avoid complications like malnutrition, osteoporosis, and intestinal cancer. Early diagnosis and treatment are important to prevent long-term health issues.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    42 views2 pages

    Celiac Diseases

    Uploaded by

    Abdullahi Shirwac
    Celiac disease is an autoimmune disorder of the small intestine that is triggered by ingesting gluten. It damages the lining of the small intestine and prevents nutrient absorption. It is strongly associated with certain genetic variations and has a complex interplay between genetic, immunological, and environmental factors. The only treatment is a strict lifelong gluten-free diet to avoid complications like malnutrition, osteoporosis, and intestinal cancer. Early diagnosis and treatment are important to prevent long-term health issues.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 2

    Celiac diseases

    Celiac disease, also known as gluten-sensitive enteropathy, is an autoimmune disorder of the small
    intestine that occurs in genetically predisposed individuals. It is triggered by the ingestion of gluten, a
    protein found in wheat, rye, barley, and other grains. When a person with celiac disease consumes
    gluten, their immune system responds by damaging the lining of the small intestine, making it difficult
    for the body to absorb nutrients from food.

    The physiology of celiac disease involves a complex interplay between genetic, immunological, and
    environmental factors. The condition is strongly associated with certain genetic variations, particularly
    those in the human leukocyte antigen (HLA) genes. These genes help regulate the immune system and
    are found on chromosome 6. When a person with celiac disease is exposed to gluten, their immune
    system produces antibodies that attack the gluten proteins as well as the lining of the small intestine.
    This causes inflammation and damage to the epithelial cells that line the intestine, leading to
    malabsorption of nutrients, diarrhea, abdominal pain, and other symptoms.

    Celiac disease can affect people of all ages, but it is more commonly diagnosed in children and young
    adults. It is estimated to affect around 1% of the world's population, although many cases go
    undiagnosed. Individuals with a family history of celiac disease are at increased risk of developing the
    condition, as are those with certain autoimmune disorders, such as type 1 diabetes and autoimmune
    thyroid disease.

    The treatment of celiac disease involves complete avoidance of gluten-containing foods. This can be
    challenging, as gluten is found in many common foods, including bread, pasta, cereal, and baked goods.
    However, there are now many gluten-free alternatives available, including cereals, flours, and breads
    made from rice, corn, and other grains. Individuals with celiac disease must also be careful when eating
    out, as gluten can be present in sauces, dressings, and other hidden sources. They should work closely
    with a registered dietitian to ensure they are getting all the nutrients they need from their diet.

    Left untreated, celiac disease can lead to a range of complications, including osteoporosis, anemia, and
    intestinal cancer. It is essential that individuals with celiac disease are diagnosed as early as possible so
    they can begin treatment and prevent long-term damage.
    In conclusion, celiac disease is an autoimmune disorder of the small intestine that affects individuals
    who are genetically susceptible to gluten. It is characterized by inflammation and damage to the lining of
    the small intestine, leading to malabsorption of nutrients and other digestive symptoms. The most
    effective treatment is a strict gluten-free diet, which requires careful attention to food labels and eating
    habits. Early diagnosis and treatment are essential to prevent long-term complications.

    References:

    Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for coeliac disease and related terms. Gut.
    2013;62(1):43-52.

    Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. American College of Gastroenterology
    Clinical Guidelines: Diagnosis and Management of Celiac Disease. Am J Gastroenterol. 2013;108(5):656-
    676.

    National Institute of Diabetes and Digestive and Kidney Diseases. Celiac Disease. Accessed April 20,
    2021. https://www.niddk.nih.gov/health-information/digestive-diseases/celiac-disease

    You might also like