Gonorrhea-Slides 2020

Gonorrhea Curriculum
Gonorrhea
Neisseria gonorrhoeae
1
Learning Objectives
Upon completion of this content, the learner will be able to:
1. Describe the epidemiology of gonorrhea in the U.S.
2. Describe the pathogenesis of Neisseria gonorrhoeae.
3. Discuss the clinical manifestations of gonorrhea.
4. Identify common methods used in the diagnosis of
gonorrhea.
5. List CDC-recommended treatment regimens for gonorrhea.
6. Summarize appropriate prevention counseling messages for
patients with gonorrhea.
7. Describe public health measures for the prevention of
gonorrhea.
2
Lessons
I. Epidemiology: Pathogenesis
II. Clinical manifestations
III. Diagnosis
IV. Patient management
V. Prevention
3
Lesson I: Epidemiology:
4
Gonorrhea Curriculum Epidemiology
Risk Factors
• Multiple or new sex partners or inconsistent
condom use
• Urban residence in areas with disease
prevalence
• Adolescents, females particularly
• Lower socio-economic status
• Use of drugs
• Exchange of sex for drugs or money
5
Gonorrhea Curriculum Epidemiology
Transmission
• Efficiently transmitted by:
– Male to female via semen
– Female to male urethra
– Rectal intercourse
– Fellatio (pharyngeal infection)
– Perinatal transmission (mother to infant)
• Gonorrhea associated with increased
transmission of and susceptibility to HIV
infection
6
Lesson II: Pathogenesis
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Gonorrhea Curriculum Pathogenesis
Microbiology
• Etiologic agent: Neisseria gonorrhoeae
• Gram-negative intracellular diplococcus
• Infects mucus-secreting epithelial cells
8
Gonorrhea Curriculum Pathogenesis
Gonorrhea: Gram Stain of

Urethral Discharge
9
Source: CDC/NCHSTP/Division of STD Prevention, STD Clinical Slides
Lesson III: Clinical

Manifestations
10
Gonorrhea Curriculum Clinical Manifestations
Genital Infection in Men
• Urethritis – Inflammation of urethra
• Epididymitis – Inflammation of the

epididymis
11
Male Urethritis
• Symptoms
– Typically purulent or mucopurulent urethral
discharge
– Often accompanied by dysuria
– Discharge may be clear or cloudy
• Asymptomatic in 10% of cases
• Incubation period: usually 1-14 days for
symptomatic disease, but may be longer
12
Gonococcal Urethritis:
Purulent Discharge
Source: Seattle STD/HIV Prevention Training Center at the University of Washington: 13

Connie Celum and Walter Stamm
Epididymitis
• Symptoms: unilateral testicular pain and
swelling
• Infrequent, but most common local
complication in males
• Usually associated with overt or
subclinical urethritis
14
Swollen or Tender Testicles

(Epididymitis)
15
Source: Seattle STD/HIV Prevention Training Center at the University of Washington
Genital Infection in Women
• Most infections are asymptomatic
• Cervicitis – inflammation of the cervix
• Urethritis – inflammation of the urethra
16
Cervicitis
• Non-specific symptoms: abnormal vaginal
discharge, intermenstrual bleeding, dysuria,
lower abdominal pain, or dyspareunia
• Clinical findings: mucopurulent or purulent
cervical discharge, easily induced cervical
bleeding
• 50% of women with clinical cervicitis have
no symptoms
• Incubation period unclear, but symptoms
may occur within 10 days of infection
17
Gonococcal Cervicitis
18
Urethritis
• Symptoms: dysuria, however, most
women are asymptomatic
• 40%-60% of women with cervical
gonococcal infection may have urethral
infection
19
Complications in Women
• Accessory gland infection
– Bartholin’s glands
– Skene’s glands
• Pelvic Inflammatory Disease (PID)
• Fitz-Hugh-Curtis Syndrome
– Perihepatitis
20
Bartholin’s Abscess
21
Syndromes in Men and Women
• Anorectal infection
• Pharyngeal infection
• Conjunctivitis
• Disseminated gonococcal infection (DGI)
22
Gonococcal Ophthalmia
23
Disseminated Gonorrhea—
Skin Lesion
24
Gonorrhea Infection in
Children
• Perinatal: infections of the conjunctiva,
pharynx, respiratory tract
• Older children (>1 year): considered

possible evidence of sexual abuse
25
Lesson IV: Diagnosis
26
Gonorrhea Curriculum Diagnosis
Diagnostic Methods
• Culture tests
• Non-culture tests
– Amplified tests (NAATs)
• Polymerase chain reaction (PCR) (Roche Amplicor)
• Transcription-mediated amplification (TMA) (Gen-Probe
Aptima)
• Strand displacement amplification (SDA) (Becton-Dickinson
BD ProbeTec ET)
– Non-amplified tests
• DNA probe (Gen-Probe PACE 2, Digene Hybrid Capture II)
– Gram stain
27
Gonorrhea Curriculum Diagnosis
Clinical Considerations
• In cases of suspected sexual abuse
– Legal standard is culture with multiple
tests to confirm the identity of Neisseria
gonorrhoeae
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Lesson V: Patient
Management
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Gonorrhea Curriculum Management
Antimicrobial Susceptibility of
N. gonorrhoeae
• Fluoroquinolones are no longer
recommended for therapy for gonorrhea
acquired in Asia, the Pacific Islands
(including Hawaii), and California.
• CDC no longer recommends
fluoroquinolones as a first-line therapy
for gonorrhea in MSM.
30
Treatment for Uncomplicated

Infections of the Cervix, Urethra,
and Rectum
Cefixime 400 mg Orally Once or
Ceftriaxone 125 mg IM Once or
1Ciprofloxacin 500 mg Orally Once or
1Ofloxacin 400 mg Orally Once or
1Levofloxacin 250 mg Orally Once
1 Contraindicated in pregnancy and children. Not recommended for infections

acquired in California, Asia, or the Pacific, including Hawaii.
31
Co-treatment for
Chlamydia trachomatis
If chlamydial infection is not ruled out:
Azithromycin 1g Orally Once or
Twice a day for

Doxycycline 100 mg Orally
7 days
32
Special Considerations:
Pregnancy
• Pregnant women should NOT be
treated with quinolones or tetracyclines
• Treat with alternate cephalosporin
• If cephalosporin is not tolerated, treat
with spectinomycin 2 g IM once
33
Alternative Regimens
• Spectinomycin 2 g in a single IM dose
• Single-dose cephalosporin regimens

– Ceftizoxime 500 mg IM
– Cefoxitin 2 g IM with Probenecid 1 g orally
34
Follow-Up
• A test of cure is not recommended if a
recommended regimen is administered.
• If symptoms persist, perform culture for
N. gonorrhoeae.
– Any gonococci isolated should be tested for
antimicrobial susceptibility.
35
Lesson VI: Prevention
36
Gonorrhea Curriculum Prevention
Screening
• Pregnancy
– A test for N. gonorrhoeae should be performed at
the first prenatal visit for women at risk or those
living in an area in which the prevalence of N.
gonorrhoeae is high.
– Repeat test during the 3rd trimester for those at
continued risk.
• Other populations can be screened based on
local disease prevalence and patient’s risk
behaviors.
37
Partner Management
• Evaluate and treat all sex partners for N.
gonorrhoeae and C. trachomatis infections if
contact was within 60 days of symptoms or
diagnosis.
• If a patient’s last sexual intercourse was >60
days before onset of symptoms or diagnosis, the
patient’s most recent sex partner should be
treated.
• Avoid sexual intercourse until therapy is
completed and both partners no longer have
symptoms.
38
Reporting
• Laws and regulations in all states
require that persons diagnosed with
gonorrhea are reported to public health
authorities by clinicians, labs, or both.
39
Patient Counseling/Education
• Nature of disease
– Usually symptomatic in males and asymptomatic in
females
– Untreated infections can result in PID, infertility, and
ectopic pregnancy in women and epididymitis in men
• Transmission issues
– Efficiently transmitted
• Risk reduction
– Utilize prevention strategies
40
Case Study
41
Gonorrhea Curriculum Case Study
History: Robert Forbes

• 33-year-old male who presents to his doctor reporting
a purulent urethral discharge and dysuria for 3 days
• Lives in Dallas with history of travel to Hawaii 3 weeks
ago
• New female sex partner (Laura) for 2 months. They
have unprotected vaginal intercourse 4 times/week, the
last time being 2 days ago. No oral or rectal sex.
• Also had a one-time sexual encounter with a woman
he met in Hawaii 3 weeks ago (Monica)
• No history of urethral discharge or STDs, no sore
throat or rectal discomfort. Negative HIV test 1 year
ago.
42
Physical Exam
• Vital signs: blood pressure 98/72, pulse 68,
respiration 14, temperature 37.2° C
• Cooperative, good historian
• Chest, heart, musculoskeletal, and abdominal
exams within normal limits
• No flank pain on percussion, normal rectal
exam, no sores or rashes
• The genital exam reveals a reddened urethral
meatus with a purulent discharge, without
lesions or lymphadenopathy.
43
Questions
1. What should be included in the
differential diagnosis?
2. Which laboratory tests are appropriate
to order or perform?
3. What is the appropriate treatment
regimen?
44
Laboratory
Results of laboratory tests:
• Urethral culture: showed growth of a Gram-negative
diplococcus that was oxidase-positive. Biochemical
and FA conjugate testing confirmed this isolate to be
N. gonorrhoeae.
• DNA probe for chlamydia: negative
• RPR: nonreactive
• HIV antibody test: negative
4) What is the diagnosis based on all available

information?
5) Who is responsible for reporting this case to the local
health department?
45
Partner Management
Robert’s sex partners within 6) Laura was examined
the past 3 months: and her lab results
•Laura: Last exposure - came back negative
Unprotected vaginal sex 2 for gonorrhea and
days ago chlamydia. How
•Monica: Last exposure - should Laura be
Unprotected oral (Robert managed?
was receptive partner) and 7) What tests should
vaginal sex 3 weeks ago Jerilyn and Monica
while he was in Hawaii have?
•Jerilyn: Last exposure -
Unprotected vaginal sex 3
months ago
46
Follow-Up
Robert returns 1 month later for an employer-
sponsored flu shot. He took his medications as
directed, is asymptomatic, and has had no sex
partners since his office visit to you.
8) Does Robert need a test of cure?
9) What are appropriate prevention counseling

messages for Robert?
47

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Gonorrhea Curriculum

Lesson II: Pathogenesis

Gonorrhea: Gram Stain of

Lesson III: Clinical

Genital Infection in Men

• Urethritis – Inflammation of urethra

• Epididymitis – Inflammation of the

Source: Seattle STD/HIV Prevention Training Center at the University of Washington: 13

Swollen or Tender Testicles

Genital Infection in Women

• Most infections are asymptomatic

• Cervicitis – inflammation of the cervix

• Urethritis – inflammation of the urethra

Syndromes in Men and Women

• Older children (>1 year): considered

Lesson IV: Diagnosis

Treatment for Uncomplicated

Ceftriaxone 125 mg IM Once or

1Ciprofloxacin 500 mg Orally Once or

1Ofloxacin 400 mg Orally Once or

1Levofloxacin 250 mg Orally Once

1 Contraindicated in pregnancy and children. Not recommended for infections

Azithromycin 1g Orally Once or

Twice a day for

• Single-dose cephalosporin regimens

Lesson VI: Prevention

History: Robert Forbes

4) What is the diagnosis based on all available

8) Does Robert need a test of cure?

9) What are appropriate prevention counseling

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