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    Cervical Cancer

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    agakshat23
    This document provides an overview of cervical cancer, including: - It is the 4th most common cancer in women worldwide and the 2nd most common in India, typically diagnosed between ages 35-55. - It was previously linked to viral infections like HPV, and is now known to be caused by HPV infection, especially high-risk strains like HPV 16 and 18. - Screening for HPV is important for prevention and management of cervical cancer through tests like Pap smears and HPV DNA testing.

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    Cervical Cancer

    Uploaded by

    agakshat23
    58 views9 pages
    This document provides an overview of cervical cancer, including: - It is the 4th most common cancer in women worldwide and the 2nd most common in India, typically diagnosed between ages 35-55. - It was previously linked to viral infections like HPV, and is now known to be caused by HPV infection, especially high-risk strains like HPV 16 and 18. - Screening for HPV is important for prevention and management of cervical cancer through tests like Pap smears and HPV DNA testing.

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    This document provides an overview of cervical cancer, including: - It is the 4th most common cancer in women worldwide and the 2nd most common in India, typically diagnosed between ages 35-55. - It was previously linked to viral infections like HPV, and is now known to be caused by HPV infection, especially high-risk strains like HPV 16 and 18. - Screening for HPV is important for prevention and management of cervical cancer through tests like Pap smears and HPV DNA testing.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    58 views9 pages

    Cervical Cancer

    Uploaded by

    agakshat23
    This document provides an overview of cervical cancer, including: - It is the 4th most common cancer in women worldwide and the 2nd most common in India, typically diagnosed between ages 35-55. - It was previously linked to viral infections like HPV, and is now known to be caused by HPV infection, especially high-risk strains like HPV 16 and 18. - Screening for HPV is important for prevention and management of cervical cancer through tests like Pap smears and HPV DNA testing.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 9

    Cervical Cancer

    By: Akshat Agarwal


    SRHU-79
    Session Outline
    ● Introduction
    ● Classification
    ● Etiology
    ● Pathology
    ● Clinical Features
    ● Diagnosis
    ● Differential Diagnosis
    ● Staging
    Introduction
    ● Ca cervix is 4th most common cancer among women
    worldwide and 2nd most common cancer among women
    in India.
    ● Majority of CA cervix cases are diagnosed between 35 &
    55 years.
    ● Until recently,CA cervix was linked with many viral
    infections as the cause, e.g CMV, HSVll & is now
    attributable to infection with Human Papilloma Virus (HPV)
    .
    ● More than 150 subtypes of HPV have been described.
    ● They are divided into
    Low Risk HPV 6 & 11

    High Risk HPV 16,18,31,33,45,52,58

    ● Screening for HPV is very important in prevention &


    management of Cervical cancer. (Universal Screening)
    ● Modalities include Pap smear, HPV DNA testing & visual
    inspection with acetic acid.
    Brief Anatomy
    ● Cervix divided into Endocervix (Columnar epithelium) &
    Exocervix (Non keratinised stratified squamous
    epithelium)
    ● Original SCJ lies at external os & due to squamous
    metaplasia new SCJ is formed.
    ● The zone between original SCJ & New SCJ is known as
    transformation zone(TZ)
    ● Mc site of CA cervix is TZ.
    ● Endocervix is mc site for Adenocarcinoma.
    Classification
    According to BETHESDA SYSTEM of classification
    Disorders detected on Pap smears
    Squamous cell abnormalities
    ● Atypical squamous cells (ASC)
    ● ASC-US - undetermined significance
    ● ASC-H - Not exclude high grade
    ● Low grade Squamous intraepithelial lesion (LSIL)
    ● High grade Squamous intraepithelial lesion (HSIL)
    ● Squamous cell carcinoma
    Glandular cell Abnormalities
    ● Atypical Glandular cells (AGC)
    ● Adenocarcinoma in Situ (AIS)
    ● Adenocarcinoma
    LSIL on Pap smear ~ CIN 1 on HPE
    HSIL on Pap smear ~ CIN 2/3 on HPE
    Histological Classification

    ● Squamous cell carcinoma


    ● Adenocarcinoma
    ● Adenosquamous carcinoma
    ● Clear cell carcinoma
    ● Rare types such as neuroendocrine carcinoma
    Thank You

    Moving on to Aetiology

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