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    CBRE-Monod Chemostat Model

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    KARTHIK VINOD
    1. The Monod chemostat model describes microbial growth under continuous culture conditions in a bioreactor with dilution. 2. At steady state, the rate of biomass accumulation equals the input and output flow rates. 3. The specific growth rate is described by the Monod equation as a function of substrate concentration. 4. For a sterile feed, the substrate concentration can be solved directly from the model equations.

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    CBRE-Monod Chemostat Model

    Uploaded by

    KARTHIK VINOD
    17 views8 pages
    1. The Monod chemostat model describes microbial growth under continuous culture conditions in a bioreactor with dilution. 2. At steady state, the rate of biomass accumulation equals the input and output flow rates. 3. The specific growth rate is described by the Monod equation as a function of substrate concentration. 4. For a sterile feed, the substrate concentration can be solved directly from the model equations.

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    1. The Monod chemostat model describes microbial growth under continuous culture conditions in a bioreactor with dilution. 2. At steady state, the rate of biomass accumulation equals the input and output flow rates. 3. The specific growth rate is described by the Monod equation as a function of substrate concentration. 4. For a sterile feed, the substrate concentration can be solved directly from the model equations.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    17 views8 pages

    CBRE-Monod Chemostat Model

    Uploaded by

    KARTHIK VINOD
    1. The Monod chemostat model describes microbial growth under continuous culture conditions in a bioreactor with dilution. 2. At steady state, the rate of biomass accumulation equals the input and output flow rates. 3. The specific growth rate is described by the Monod equation as a function of substrate concentration. 4. For a sterile feed, the substrate concentration can be solved directly from the model equations.

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    © All Rights Reserved
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    Tdeal Chemostatt (modide- v

    eneral eq is
    I-o tDtA] O Cif Con of compí
    A =o at imlet od
    understeady state ,

    (omp i anteving
    to COmp i (in
    nput-FF (onxowrcte) i Con" o omp
    Output Fa at outet
    Rate of
    Gi'sappeaance of i om Va (-) Ve-Volume o
    Teactos due to TeaxD
    Teacto
    -i-3 Tate o
    Rode o mation
    Poltprmatiom = VR Cfi) Cno: o moes ot i
    isapaned pes unit

    Vo lume) time
    .becomes x

    Fif F+ Va (-16) - 0
    VA(-) - Fif-Fei
    r ta-fif E Ci-i
    VR
    Ve

    Ve Vo VR Spau hime
    F Vol: lowrate F

    E Diluion sate
    unit time VR Space veloci ty
    unit t i m e-
    Can be wsiten as
    AR-DC-CE2
    D lurion Tate
    tos Constant density s4stem
    o mean
    D= L Space veloaity
    =

    Tesiqence time.

    Monad Chemostat model


    Tox Cellulas teax'S mar qtowth va
    Pmax
    P- Pmax
    S ofo1
    ks tS

    We know that,
    s-D[-CE)
    X=
    tof Comp
    DS x- Xf) toó bioma SS
    P =D [P-Pe) tos PToduct
    TS = D [s-SE) D Substtate
    Tate oenmation o biomass
    Tx-dx
    dt -
    But, P d
    Xdt
    P X = dx
    dt
    from and
    Px-dx- dx
    dt
    -
    PSpeake qrowth
    But 1x =D Lx-xE] Yate

    P X DX-Dxf
    =

    Dxf= D- -

    Sterile eed is used, mo cels /biomass present


    = O D-)
    We krow that, gield z5 -AX

    =-0X= ASx ya\s x =


    - ASya|s
    Px=D[x-MEJ D(-Yas) [s-SE)=

    PX = D[s-SJ
    - Yals

    Px
    Yx|s
    DISS-PX -0-
    Yas
    eq'
    Kewshng t
    monod
    usig

    PLS-s]- PmaxSx-0
    ks+Y
    -L
    Yels P Tf-x] + Ymax SX
    ks +S
    Because Yals=- AX
    AS

    As -AX
    Yxs
    - Cant be o
    Va|s
    DD f-XJ+ max
    S=0- ks+S
    DxF-DX + PmaxSX = 0
    ks+S

    Dxf+X tmoxS-DJ-o
    ks
    D+xmoS -D-o ks+S
    Monod
    chemostat
    DS-s-moxS O model
    ks+S]Yas eas
    Dhen youve Sterile eed , Xf= o and x =XsBene
    Xsterile PmaxSsterile
    ks+Ssteri le
    -= o
    PrnaxSshesile -D =O
    ks+Ssterile rnax-Dj sslerie = DkS

    Pmax
    Ssterile =
    Dks +Dssterile
    S Sterile D ks
    Pmax-D

    when sterile eed is used


    This is the Sushate con
    Subshtuting im ,

    DSF-S] mox SX O
    -

    Cks+s)Ys

    FmaxS X
    Dsf-s =

    Cts+ 9s
    Yis S s J ks+s=Xsterile
    maxS

    Xsterle Y\s Sf- ks D


    Pmax-D

    Ihis is monod chemos tat model.


    Substate Optake and Poduct
    omationm

    Sbshate Uplake i
    without exacellulon dt
    Ys x +msX

    when Tate expvessed m terms of Spqiouwth vate,


    x=PX.
    s PX +ms X
    als
    But PPrmaxS
    ks+S

    Ys PmaxS +ms |>


    s ts)yaJ
    S-0 only maintainance.
    Witn extracellulas.pct
    +P +mg X
    Vas YP1s Sp sp 7aBe o
    PX+PX tmsX
    Ys
    P+ms X
    ypls
    Geneyal Case when biomass, Subshate and
    and pdt
    pedt
    omation is here m
    chemcslat
    Vmax max sate
    max owth Tte
    Pmax F,St
    m MM Constant Xi,P do X,s,P
    kd dea4th iate.

    genesal eq is
    dMMo+ Kq-Re
    d
    Sinae chemostat is Staady state
    dM 0
    biomass Subshate at
    FX FSi FP
    FX FP
    Mo
    pXV
    pxv

    kdxv
    toi BiomasS 9 kd
    FXi-FX+PxV-kdxV =0
    FCxi-X) =Ptkd VX
    Fx-Ki) (-kd] xv
    =D = Dx-XiJ=P-kd]x-0
    V
    his is the
    genenal eq"
    To stenle cuture, Xi=0 and Pkd sP
    DX =PX= D= (kdech
    D- tms
    kmtS
    = Dkm+ DS Pm S
    Dkm-Pm-D) S
    S Dk
    Pn-D
    to Substiate 9
    fsi-Fs Rc =o
    Re =P+ 4 +Ms XV
    Ys Ypls
    osi-s3 =P +4 +msx
    Ys YPs
    tos pdt
    FPi-Fp +Apx V-o
    F P-J 9pXV
    D[P-R) = VpX
    P= +

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