Plumb's® 9th Edition Veterinary Drug Handbook (VDH) Errata

Below is a listing of the errata found in the first printing of the 9th edition of Plumb's® Veterinary Drug
Handbook. Please make note of these changes in your book.

Systemic Page # (Desk /

CHANGE
Monographs Pocket)
Alprazolam 38 / 52 Drug Interactions-->Tricyclic Antidepressants (2nd sentence):
However, concurrent use may [REMOVE decrease] [REPLACE
with increase] the risk of CNS and/or respiratory depression.
Aspirin 94 / 131 Dosages-->Cats-->Antithrombotic (5th sentence): A randomized,
prospective multicenter study of cats with a prior
thromboembolic event found that high-dose aspirin at 81
mg/cat PO every 72 h was inferior...
Bupivacaine HCl 144 / 199 Dosages-->Dogs-->Local analgesia: b) Using 0.5% bupivacaine
solution, 0.5 mg/kg combined with dexmedetomidine 0.1
[REMOVE mg] [REPLACE with µg]/kg.
Buprenorphine HCl 148 / 205 Pharmacokinetics-->In cats, buprenorphine is rapidly and
completely absorbed when given IM [REMOVE: but
bioavailability may only be around 50%].
Calcitonin Salmon 167 / 232 Uses/Indications-->In small animals, calcitonin has been used as
adjunctive therapy to control hypercalcemia. It potentially may
be of use [REMOVE: as an adjunct to chemotherapy for canine
mast cell tumors or] in the adjunctive treatment of pain,
particularly when originating from bone.
Cetirizine HCl 234 / 325 Drug Interactions-->REPLACE entire content in the P-
glycoprotein bullet with: P-GLYCOPROTEIN SUBSTRATES (eg,
cyclosporine, digoxin, ivermectin, vincristine): Cetirizine was
shown to be a p-glycoprotein inhibitor; therefore, avoidance
or care should be taken with co-administration of cetirizine
with p-glycoprotein substrate drugs.
Chlorpheniramine 248 / 343 Drugs Interactions-->MAO Inhibitors (including [REMOVE
amitriptyline] amitraz, [REMOVE and possibly] selegiline)
Clomipramine HCl 280 / 387 Pharmacokinetics-->1st paragraph, 4th sentence-->[REMOVE:
The presence of food decreases the area under the curve for
the parent compound by about 25% but not the metabolite.]
[REPLACE with: Oral bioavailability is ~20%. The presence of
food increases both the area under the curve and peak
concentration for the parent compound by about 25% but not
the metabolite.]
Clorazepate 291 / 402 Drug Interactions-->Tricyclic Antidepressants (2nd sentence):
However, concurrent use may [REMOVE decrease] [REPLACE
with increase] the risk of CNS and/or respiratory depression.
Cyclosporine 309 / 428 Dosages-->Dogs-->Perianal fistulas (anal furunculosis); (extra-
label): ...Cyclosporine (alone) 5 – 7.5 mg [ADD: /kg] PO every 24
hours OR 2.5 – 3 mg/kg PO every 24 hours with ketoconazole
2.5 – 5 mg/kg PO every 24 hours.

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 Darbepoetin Alfa 327 / 452 Reproductive/Nursing Safety-->2nd paragraph, 1st sentence--
>...rabbits demonstrated no overt teratogenicity at daily doses
of up to 20 [REMOVE mg][REPLACE with µg]/kg
Dexmedetomidine 351 / 486 Dosage Forms/Regulatory Status-->VETERINARY-LABELED
PRODUCTS: Dexmedetomidine Oromucosal Gel 0.[ADD:0]9
mg/mL (equivalent to 0.1 mg/mL dexmedetomidine HCl) in 3-mL
dosing syringes; Sileo® (Rx). FDA-approved for use in dogs
(NADA 141-456).
Diazepam 358 / 496 Drug Interactions-->Tricyclic Antidepressants (2nd sentence):
"However, concurrent use may [REMOVE decrease] [REPLACE
with increase] the risk of CNS and/or respiratory depression.
Enrofloxacin 427 / 591 Dosages-->Dogs-->Extra-label use of the 2.27% (22.7 mg/mL)
injection: 10 – 20 mg/kg every 24 hours IM, SC (must be diluted
in saline) or IV depending on the susceptibility and site of the
infection. If using IV, the [CHANGE 22.7% to 2.27% (22.7
mg/mL)] injection is first diluted into sterile saline (0.9% sodium
chloride) at approximately 10 times the volume of the
enrofloxacin.
Epinephrine 431 / 597 Pharmacology/Actions--> If given at a low dose IV (0.01 mg/kg),
it directly stimulates cardiac beta-1 receptors to cause increased
heart rate and contractility with resultant increased cardiac
output [remove and].
Famotidine 466 / 646 Dosages-->Dogs-->CHANGE to Dogs & Cats
Gabapentin 530 / 752 Compatibility/Compounding Considerations-->3rd sentence...
retains more than 90% potency for [REMOVE: 56 days stored at
both 4°C and 25°C] [REPLACE with: 91 days when stored at 4°C
(39.2°F) and 56 days when stored at 25°C (77°F).]
Gonadorelin 555 / 770 Dosages-->Cattle-->Using with cloprostenol sodium to
synchronize estrous cycles...Administer 86 micrograms IM (2mL;
Fertagyl® or Cystorelin®) or 100 micrograms IM [REMOVE: or
IV] (1 mL; GONABreed®)
Heparin Sodium 565 / 783 Drug Type--> Unfractionated Heparin, UHF [CHANGE to UFH]
Levetiracetam 680 / 943 Pharmcokinetics-->3rd paragraph, [CHANGE 3rd sentence to:
When immediate release and extended release tablets were
crushed and administered orally at a dose of 30 mg/kg
maximum plasma concentration, terminal half-life,
bioavailability, and clearance/bioavailability were 50.72
micrograms/mL and 53.58 micrograms/mL, 6.38 hours and
7.07 hours, 96% and 98%, and 76.8 mL/kg/h and 76.8 mL/kg/h,
respectively, and time to peak concentration was 0.66 hours
and 0.64 hours respectively.]
Levothyroxine 684 / 948 Dosages-->Cats--> Post antithyroid medication, thryoidectomy,
or radioiodine treatment: ...0.1 mg [REMOVE /kg][REPLACE
with per cat (NOT mg/kg)]
Lorazepam 710 / 986 Drug Interactions-->Tricyclic Antidepressants (2nd sentence):
"However, concurrent use may [REMOVE decrease] [REPLACE
with increase] the risk of CNS and/or respiratory depression.
Methimazole 771 / 1071 Dosages-->Cats-->...an initial dose of 5 mg/[REMOVE kg]
[REPLACE with cat] PO twice a day.
Pancuronium Bromide 903 / 1253 Dosages-->Horses--> 0.12 - [ADD: 0.2] mg/kg IV
Pyrantel Pamoate 1014 / 1405 Drug Interactions-->First paragraph-->The following drug
interactions have either been reported or are theoretical in
humans or animals receiving [REMOVE propranolol][REPLACE
with pyrantel pamoate] and may be of significance in veterinary
patients.
Ronidazole 1051 / 1455 Dosages-->Dogs--> 30 - 50 mg/kg PO twice daily for 7 days.

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 Sertraline 1064 / 1478 Drug Interactions--> [ADD] L-THYROXINE: Sertraline may
increase levothyroxine requirements.
Sufentanil 1100 / 1528 Dosages-->Rabbits-->Anesthesia (extra-label): Following a
medetomidine and carprofen premedication, sufentanil 0.5
micrograms/kg with midazolam 0.1 mg/kg combined in one
syringe and given IV for induction achieved smooth anesthesia
within 5 minutes which was maintained during surgery with
sufentanil [REMOVE 3.9][REPLACE with 0.72] micrograms/kg
per hr and midazolam 0.8 mg/kg/hr IV CRI.
Terbutaline 1120 / 1555 Overdose/Acute Toxicity-->Clinical signs of significant overdose
after systemic administration may include arrhythmias
(bradycardia, tachycardia, heart block, extrasystoles), [CHANGE:
hyperkalemia to hypokalemia], hypertension, fever, vomiting,
mydriasis, and CNS stimulation.
Tramadol 1168 / 1622 Dosages-->Small Mammals-->Analgesic-->Sugar gliders: 2 – 6
[REMOVE mg/mg][REPLACE with: mg/kg] PO every 12 hours
Trilostane 1181 / 1641 Dosages-->Cats-->Feline Hyperadrenocorticism: ...Average
dosages were 4.3 mg/kg PO once daily or 3.3 [REMOVE: kg/kg]
[REPLACE with mg/kg] PO twice daily.
Vasopressin 1200 / 1666 Dosages-->DOGS/CATS-->Adjunctive treatment of hypotension,
shock (extra-label):
a) Adjunctive post-CPCR treatment: From the RECOVER
guidelines: Vasopressin 0.5 – 5 milliUnits/kg/minute ([REMOVE:
0.003 – 0.03][REPLACE with 0.03 – 0.3] Units/kg/hour) IV CRI.
d) Hypotension that persists in dogs despite volume
resuscitation (found in septic shock); may be an indication for
vasopressin (extra-label): 0.5 – 5 milliUnits/kg/minute
([REMOVE: 0.003 – 0.03][REPLACE with 0.03 – 0.3]
Units/kg/hour) IV CRI

Page # (Desk /
Ophthalmic Products CHANGE
Pocket)
Dexamethasone 1261 / 1750 Dosage Forms / Regulatory Status-->Human-Labeled
Ophthalmic Combination Products-->Neomycin and Polymyxin B Sulfates
and Dexamethasone Ophthalmic Suspension (containing
neomycin sulfate equivalent to neomycin [CHANGE 2.5 mg to
3.5 mg], polymyxin B sulfate 10,000 units, dexamethasone 0.1%,
benzalkonium chloride 0.004%, hypromellose 2910 0.5%,
sodium chloride, polysorbate 20, HCl and/or NaOH to adjust pH,
purified water): In a 5-mL sterile ophthalmic dropper bottle;
Maxitrol®, Dexasporin®; (Rx).
Tafluprost Ophthalmic 1301 / 1805 Contraindications--> It should not be used in [ADD: pregnant
patients or in] the presence of intraocular inflammation
(uveitis), as it will worsen this condition.
Client Information: [ADD] This drug has a very high risk for
causing miscarriages or birth defects and it should generally
not be used in households with pregnant women present.

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