Quality Control

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Most of the official drugs containing calcium and zinc are assayed
by:
A. Compleximetry
A. Compleximetry
B. gravimetry
C. precipitimetry
D. acidimetry
Type of alkaloidal assay where the total alkaloids are determined:
A. Ultimate
B. specrophotometric D. Proximate
C. chromatographic
D. Proximate
Limulus ameobocyte lysate(LAL) assay method is applicable in
the determination of:
A. pyrogens
A. pyrogens
B. Chemical impurities
C. Microorganism
D. Heavy metals
The measurement of a base of a given sample by titration with a
standard acid is:
A. Acidimetry
A. Acidimetry
B. Compleximetry
C. Alkalimetry
D. Cerimetry
The following compounds are assayed by acidimetrically, EX-
CEPT:
A. Sodium Hydroxide
C. Citric acid
B. Caffeine
C. Citric acid
D. Zinc oxide
Which of the following substances is assayed by residual alkali-
metric analysis?
A. Aspirin
A. Aspirin
B. Sodium hydroxide
C. Hydrochloric acid
D. Zinc oxide
A common sampling plan that uses master tables to interpret the
results:
A. 100% inspection
C. Military standard
B. Square root system
C. Military standard
D. simple random sampling
Materials to be sampled include the following, EXCEPT:
A. Final product
B. Records B. Records
C. Intermediate products
D. Raw materials
The process of removing an appropriate number of items from a
population in order to make interferences to the entire population
is called:
A. Sampling A. Sampling
B. Inspection
C. Statistics
D. Rejection
A tool for detecting variations in a process:
A. Pie chart
B. Bar chart C. Quality control chart
C. Quality control chart
D. T-chart

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The functions of Quality Control include the following EXCPT:
A. Analytical control
B. Inspection control C. Auditing
C. Auditing
D. Planning
The Quality Control Department is important to:
A. Ensure uniform production of high quality product
B. Safeguard public health D. All of the above
C. Ensure that the product complies with the FDA requirements
D. All of the above
The QC manager is in charge of the following, EXCEPT:
A. Specification and assay development
B. Analytical testing laboratory A. Specification and assay development
C. Research and development studies
D. Biological testing
The First-In First-Out policy must always be observed to:
A. Assures that the oldest stock is used first
B. Prevent contamination and mix-ups of materials
A. Assures that the oldest stock is used first
C. Contain the information regarding the activity if the active
ingredient
D. Prevent microbial spoilage
The kjeldahl method of analysis is used to determine:
A. Lipids
B. Carbohydrates C.Nitrogen
C.Nitrogen
D. oxygen
The ash content of an organic compound is an impurity of:
A. Carbon
B. Nitrogen C. Inorganic matter
C. Inorganic matter
D. Volatile component
The Iodine value of oils is a quantitative measure of:
A. Phenol content
B. Saturation D. unsaturation
C. Unsafonifiable matter
D. unsaturation
Analysis wherein the constituents of a sample are separated and
then the product is weighed:
A. Volmetric
B. Gravimetric
B. Gravimetric
C. Spectrophotometric
D. Chromatographic
The number of mg of KOH needed to neutralize the free acids and
saponify the esters in 1g of oil or fat:
A. acid value
C. safonification value
B. Ester value
C. safonification value
D. Iodine value
The molecular weight of NaOH is 40. How many grams of NaOH
pellets are needed to make 500mL of 1.5N solution?
A. 20
B. 30
B. 30
C.40
D. 60

If 1mL of HCL is equivalent to 1.5mL of 0.5N NaOH, the volume

of the alkali that would be consumed by 30mL of acid is:
B. 45mL
A. 4.5mL
B. 45mL

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C. 20mL
D. 30mL
The ester value determination of substances is applicable to the
following, EXCEPT:
A. Fats
C. Alcohols
B. Volatile oils
C. Alcohols
D. Fixed oils
The most effective chemical substance in removing stains of
potassium permanganate:
A. Oxalic acid
A. Oxalic acid
B. Sodium thiosulfate
C. Sodium hypochlorite
D. Ferric chloride
The following are indicators used for acid-base titrations, EX-
CEPT:
A. Methyl orange
C. Ferric alum
B. Phenolphthalein
C. Ferric alum
D. methyl red
An accurately measured sample of hydrogen peroxide 2g was
dissolved in a mixture of 20mL water and 20mL diluted sulfuric
acid and was titrated with 0.1N potassium permanganate con-
suming 30mL to reach the endpoint. Compute for the percentage
of hydrogen peroxide (MW=34) A. 2.55%
A. 2.55%
B. 5.1%
C. 2.5%
D. 5.5%
Residual method titration with disodium edentate VS is applicable
to what metal ion:
A. Calcium
B. aluminum
B. aluminum
C. Zinc
D. Magnesium
Chemical reactions that involve a charge in the valence number
of reacting substances:
A. Neutralization
C. Oxidation-reduction
B. Complexation
C. Oxidation-reduction
D. precipitation
A process wherein the sample is made to liberate iodine, which is
then titrated with a standard solution of sodium thiosulfate:
A. Direct titration
C. Iodometry
B. Residual titration
C. Iodometry
D. Iodometry
A buret with a glass stopcock can be used for:
A. alcohols
B. Acids B. Acids
C. Bases
D. Aldehydes
Iodometry is an indirect analysis of:
A. Oxidizing agents
B. Reducing agents A. Oxidizing agents
C. Acids
D.Bases
Malic acid present in cherry juice may be determined by:
A. Indirect permanganate oxidation method
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B. Direct permanganate oxidation method
C. Alkalimetry A. Indirect permanganate oxidation method
D. Acidimetry
The unsaponified matter present in animal fat is:
A. Cholesterol
B. Stigmasterol A. Cholesterol
C. Lard
D. Wax
The bisulfate method is used in the assay of volatile oils to deter-
mine:
A. Aldehyde content
A. Aldehyde content
B. Acid content
C. Ester content
D. Phenol content
The crude fiber of a drug usually consists of:
A. Cellulose
B. Cholesterol A. Cellulose
C. Stigmasterol
D. Starch
In phenol content determination of a volatile oil, the layer in the
graduated neck of the Cassia flask reached 2.7mL obtained from
a sample of 10mL after treatment with KOH solution. The percent-
age of oil is:
A. 73%
A. 73%
B. 69%
C. 7.3%
D. 27%
This determines the shelf life of a product:
A. Sampling inspection program
B. Quality control program D. Stability testing program
C. Validation program
D. Stability testing program
Amount of dissolved drug can be determined by:
A. Analytical balance
B. Dissolution tester B. Dissolution tester
C. Brookefield viscometer
D. Dioctyl phthalate spray
Trace minerals in a multivitamin preparation can be assayed faster
by:
A. Atomic absorption spectrophotometer
A. Atomic absorption spectrophotometer
B. Ultraviolet-visible spectrophotometer
C. Gas Liquid Chromatography
D. High performance liq.chromatography
Potency of a 100mg tablet at the expiry date
A. 95mg
B. 90mg B. 90mg
C. 105mg
D. 110mg
Inspection station are placed in the following areas, except:
A. Analytical laboratory
B. Manufacturing area A. Analytical laboratory
C. warehouse
D. Packaging area
In the microbial assay of antibiotics, the microorganism used for
Pen G is:
A. Staphylococcus aureus
A. Staphylococcus aureus
B. Pseudomonas aeruginosa
C. Escherichia coli
D. Bacillus subtilis
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the expiration date is:
A. The direct application and interpretation of knowledge gained
from the stability testing
B. Used to limit the period during which a preparation may be
C. A and B are correct
expected to have its labeled potency, provided it has been stored
as directed
C. A and B are correct
D. A and B are incorrect
The period of stability of a preparation is the time from the date
of manufacture of the formulation until its chemical or biological
activity is not less than __ of labeled potency:
A. 90% C. 93%
B. 95%
C. 93%
D. 99%
What I not considered as a primary packaging component?
A. Bottles
B. Vials D. Packer boxes
C. Caps
D. Packer boxes
Drug substances that are withheld from distribution until batch
certification from the FDA has been received:
A. Antibiotics
A. Antibiotics
B. Antineoplastics
C. Antihistamines
D. Antidiarrheals
Factors that can be manipulated to accelerate instability:
A. Temperature
B. Moisture D. All of the above
C. Light
D. All of the above
Cross-examination and mix0up can happen in the following situ-
ations, EXCEPT:
A. Improperly dispensed components
D. Components are kept in tightly-sealed containers
B. Wrong labels
C. Improper partitioning of production area
D. Components are kept in tightly-sealed containers
Content uniformity is to be performed for all tablets whose active
ingredients are:
A. 50mg or less
A. 50mg or less
B. 100mg or less
C. 50mg or more
D. 100mg or more
Which of the following is not a QC function?
A. In-process analysis
B. Inspection of containers D. Inventory control
C. Labeling and packaging materials
D. Inventory control
Total quality means:
A. Production is responsible for quality
B. Quality control combines strict adherence to standard C. Quality is everybody's business
C. Quality is everybody's business
D. All of the above
The presence of a cotton fiber in a liquid preparation is considered
as a/an:
A. Internal defect
C. Ocular defect
B. Critical defect
C. Ocular defect
D. Variable defect
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Materials to be sampled include the following, except:
A. Intermediate product
B. Raw materials C. Records
C. Records
D. Final products
An analyst who determines the strength, potency and percentage
purity of a drug or pharmaceutical product is performing:
A. Special method
C. pharmaceutical assaying
B. Identification test
C. pharmaceutical assaying
D. Pharmacopoeial test
The chemical factor used in calculation of percent purity of a
substance in volumetric analysis:
A. mEq weight
D. A and C
B. Molarity
C. Titer
D. A and C
The instrument used in measuring the optical activity of a sample:
A. polarimeter
B. Refractometer A. polarimeter
C. Spectrometer
D. Flame photometer
In Azeotropic method for water analysis, the solvent that can be
used is/are:
A. Water
D. B and C
B. Toluene
C. Xylene
D. B and C
Adsorption indicators are used in:
A. Complexometry
B. Acidimetry C. Precipitimetry
C. Precipitimetry
D. Alkalimetry
The moisture content of a drug may be:
A. Water of hydration
B. Water in absorbed form D. A and B
C. Water of emulsion
D. A and B
The indicator used in permanganate titration:
A. Methyl orange TS
B. Phenolphthalein TS C. Potassium permanganate VS
C. Potassium permanganate VS
D. Oxalic acid VS
The indicator of disodium edentate VS direct titration of calcium
carbonate:
A. Thymol blue
B. Hydroxynaphthol blue
B. Hydroxynaphthol blue
C. Methyl red
D. Methylene blue
Volatile oils are complex compounds composed of the following,
Except:
A. Phenols
B. Fatty acids E. B and C
C. Esters
D. Aldehydes
E. B and C
The specific method for water content determination official in the
USP/NF, except
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A. Karl Fischer method
B. Azeotropic method
D. Dew point process
C. Gravimetric method
D. Dew point process
Safety or toxicity test for infusion plastic sets is conducted using:
A. Rabbits
B. Dogs C. White mice
C. White mice
D. Guinea pig
In infrared spectrometry, the finger print region is:
A. Near IR
B. Medium IR B. Medium IR
C. Far IR
D. A and B
To find the mEq factor of an oxidizing agent, divide the molecular
weight by:
A. No. of electrons gained
A. No. of electrons gained
B. No. of electron lost
C. valence no.
D. Atomic no.
The type of chromatography where the cellulose of the filter paper
is used as the adsorbent:
A. Column chromatography
C. Paper chromatography
B. Gas chromatography
C. Paper chromatography
D. Thin Layer chromatography
A parenteral is declared to be pyrogenic if the total rise in temper-
ature of the rabbits is:
A. Less than 3.3°C in the 8 rabbits
C. More than 3.3°C in the 8 rabbits
B. More that 3.4°C in the 8 rabbits
C. More than 3.3°C in the 8 rabbits
D. Less than 3.4°C in the 8 rabbits
Microbiological assay of antibiotics may be performed by using
the following, Except
A. Test tube dilution
D. Gram staining method
B. Cylinder plate
C. Paper disc
D. Gram staining method
A term in compleximetry used to indicate a determination of a
metal in the presence of another metal is:
A. Redox
B. Masking
B. Masking
C. Linking
D. Complexing
Two substances reacting upon reaching the endpoint must have
the same:
A. Normality
C. No. of equivalents
B. Volume
C. No. of equivalents
D. Weight
All of the following are optical devices or instruments, except:
A. pH meter
B. Spectrophotometer A. pH meter
C. Colorimeter
D. Flame photometer

The method of assay for sulfonamides is:

A. Neutralization titration C. Diazotization with nitrite
B. Gravimetric

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C. Diazotization with nitrite
D. Oxidation titration
Which of the following is reducing agent?
A. Ascorbic acid
B. Potassium permanganate A. Ascorbic acid
C. Iodine
D. Hydrochloric acid
Radiant energy required in the analysis of drugs under Fluorom-
etry is in:
A. UV region
A. UV region
B. Visible region
C. IR region
D. X-ray region
In using spectrophotometer to measure the concentration of a
sample, the following data were obtained:
Absorbance of the standard solution= 0.39
Absorbance of the sample solution = 0.42
Concentration of the standard = 15mcg
A. 16.15mcg
The concentration of the sample is:
A. 16.15mcg
B. 17.5mcg
C. 15.75mcg
D. 16.0mcg
The method of assay for vit. B12 and calcium pantothenate is by:
A. Iodimetry
B. Microbal-turbidimetric method B. Microbal-turbidimetric method
C. Fluorometry
D. Oxidation titration
The pH of a solution is usually measured by using:
A. Platinum electrode
B. Glass electrode B. Glass electrode
C. Mercury electrode
D. Calomel electrode
Nuclear Magnetic Resonance (NMR) is used for:
A. Radioisotopes
B. Irradiation C. Identification of chemicals
C. Identification of chemicals
D. A and B
In the assay of acetic acid (MW = 60.05), each mL of 1N NaOH is
equivalent to:
A. O.60000g of acetic acid
B. 0.00605g of acetic acid
B. 0.00605g of acetic acid
C. 0.60050g of acetic acid
D. 0.06005g of acetic acid
Chemical analysis, which determines the amount or percentage
content of a certain component in a sample:
A. Qualitative
C. Quantitative
B. Proximate
C. Quantitative
D. Ultimate
One of the fundamental laws in spectrophotometry is
A. Pascal's law
B. Beer's law B. Beer's law
C. Boyle's law
D. Newton's law

The most effective way to clean glass apparatus:

A. Soaking in detergent C. Treatment with a solution of sodium chromate in sulfuric acid
B. Rinsing with Nitric acid

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C. Treatment with a solution of sodium chromate in sulfuric acid
D. Acetic acid
Potentiometry finds application in:
A. Biological assay
B. pH determination B. pH determination
C. Qualitative assay
D. Chromatogrphy
If a 0.2250g of sodium bicarbonate (96.5% NaHCO3) is titrated
with 0.1165N sulfuric acid. What volume of the acid is required to
reach the endpoint?
At.Wts = Na = 23; H = 1.0; C = 12; O = 16
A. 22.19mL
A. 22.19mL
B. 21.98mL
C. 21.20mL
D. 21.22mL
A sample of 0.1350g of arsenic trioxide (As2O3) was assayed
iodimetrically using 23.4mL of 0.1055N iodine solution. The per-
centage purity of the sample is:
A. 90.44 B. 89.10
B. 89.10
C. 90.54
D. 90.23
In column chromatography, the separation of the sampe mixture
into a series of narrow bands in a column is:
A. Chromatogram
C. Elution
B. Eluent
C. Elution
D. Chromatograph
In spectrophotometry procedure for assay, aside from the sapmle
or unknown, this is also required:
A. Raw material of the sample
B. Reference
B. Reference
C. Dosage form
D. Excipients
The following conditions cause a reaction to go to completion,
except:
A. Formation of a gas
C. Formation of soluble products
B. Formation of a precipitate
C. Formation of soluble products
D. Formation of slightly ionized substances
Beer's plot in spectrometry is prepared to determine:
A. Absorbance of the sample
B. Wavelength to be used D. Concentration of the sample
C. Absorbance of the blank
D. Concentration of the sample
A plot of absorbance against concentration of a standard drawn
in straight line is:
A. Charle's
B. Beer's
B. Beer's
C. Lambert's
D. Newton's
The study of the optical activity of a substance is:
A. Polarimetry
B. Refractometry A. Polarimetry
C. Spectrophotometry
D. Potentiometry
The unit of wavelength in spectrophotometry, EXCEPT:
A. Nanometer C. Millimeter
B. Micron
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C. Millimeter
D. Micrometer
Ways to prepare the sample for Infrared determination, except:
A. Use of Mull technique
B. Use of potassium bromide pellet C. Use of alcohol as solvent
C. Use of alcohol as solvent
D. Use of liquid petrolatum as solvent
Chromatography can be used to separate compounds that are:
A) Colored
B) Colorless D) A and B
C) Precipitate
D) A and B
A water content determination method that uses Xylene tube is:
A) Gravimetry
B) Karl Fischer titrimetry C) Azeotropic method
C) Azeotropic method
D) Dew point method
Calculate the normality of sulfuric acid solution using 22.5mL. The
volume of standardized NaOH used in the standardization was
20.70mL, and its normality was 1.1055:
A) 1.0171 A) 1.0171
B) 1.1071
C) 1.0175
D) 1.0711
Calculate the calcium carbonate content of a sample of chalk
weighing 0.2545g and consuming 16.67mL of 0.1150M of EDTA
solution in titration. At.Wt of Ca = 40.08; C = 12; O = 16. The
percentage of CaCO3 is:
B) 75.50
A) 75.52
B) 75.50
C) 37.76
D) 37.78
In the Statistical Quality Control, the chart used to measure the
variations in the products inspected in the production:
A) Variable chart
D) B and C
B) P-chart
C) Attribute chart
D) B and C
Substances that have the power of rotating the plane polarized
light are said to be:
A) Light sensitive
C) Optically active
B) Active constituents
C) Optically active
D) Dextrorotatory
The indicator used in the assay of weak acid reacting with a strong
base is:
A) Methyl red TS
D) Phenolphthalein TS
B) Methyl orange TS
C) Eriochrome black
D) Phenolphthalein TS
The substance being analyzed is the:
A) Titrant
B) Indicator D) Analyte
C) Salt
D) Analyte
In infrared spectrometry, water is not used as solvent for the
sample because the water will:
D) A and B
A) Absorb IR radiation
B) Dissolve the sodium chloride cell holder
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C) Not dissolve the sample
D) A and B
The law related to spectrometry wherein the power of transmitted
light decreases exponentially as the thickness of the solution
increases arithmetically is:
A) Charle's C) Lambert's
B) Beer's
C) Lambert's
D) Henry's
The end point in iodimetry using starch TS as indicator is:
A) Blue color
B) Disappearance of blue color B) Disappearance of blue color
C) Greenish blue color
D) A or C
The type of titration in ultimate assay of alkaloids is:
A) Direct
B) Residual D) B and C
C) Back
D) B and C
What would be the aldehyde content of peppermint oil if the
sample used was 15mL and the insoluble portion as read in the
graduated neck of the Cassia flask was 2.2mL. The percentage of
aldehyde content is:
A) 85.33
A) 85.33
B) 83.33
C) 84.30
D) 14.67
A sample of Magnesia Magma weighing 12.35g was dissolved
in 50mL of 1.0340N sulfuric acid and titrated unti end point is
reached consuming 24.6mL of 1.1255N sodium hydroxide solu-
tion. The percentage of MgO content is:
At.Wt. of Mg = 24.3: O = 16 A) 3.92
A) 3.92
B) 4.0
C) 3.85
D) 3.91
The alcohol content of a volatile oil can be determined by:
A) Bisulfite method
B) Complexation process C) Acetylization process
C) Acetylization process
D) A and C
The index of refraction of a volatile oil can be determined by:
A) Spectrophotometer
B) Pycnometer C) Refractometer
C) Refractometer
D) Polarimeter
Turbidimetric and nephelometric methods of assay are applied to:
A) Suspensions
B) Solutions A) Suspensions
C) Colored samples
D) A and B
The adsorbent in the thin layer chromatography may be as follows,
except:
A) Alumina
C) Calcium oxide
B) Silica gel
C) Calcium oxide
D) Silica gel G
Way to separate the constituents in gravimetric analysis:
A) Neutralization process
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B) Physical means
C) Chemical means D) B and C
D) B and C
Way to obtain the gram equivalent of a substance (GEW) is:
A) Based on the replaceable H+ ion
B) Based on the valence of the cation C) A or B
C) A or B
D) Based on atomic weight
Expression of concentration in volumetric solutions, except:
A) Normality
B) Titer B) Titer
C) Molarity
D) Molality
The assay procedures in volumetric precipitation were introduced
by the following scientists, except:
A) Arrhenius
A) Arrhenius
B) Mohr
C) Fajan
D) Volhardt
The following are characteristics of a product with quality, except:
A) Safe
B) Acceptable C) Cheap price
C) Cheap price
D) Effective therapeutically
The terms used when equivalent amounts of each reactant have
reacted are the following, except:
A) End point
A) End point
B) Equivalence point
C) Stoichiometric pont
D) Theoretical point
Constant weight in analytical procedures of drying means that
consecutive weighing after heating and cooling do not differ by:
A) More than 0.25mg
A) More than 0.25mg
B) More than 0.50mg
C) More than 0.255mg
D) Not more than 0.75mg
The concentration of an unknown sample in spectrophotometric
procedures can be calculated by:
A. Use of Beer's plot
D) A or C
B. Use of chemical factor
C) Use of mathematical formula using a reference standard data
D) A or C
In thin layer chromatography, finding the spot of the colorless
compound in the chromatogram can be done by:
A) Use of sulfuric acid spray to obtain a brown color
D) A or B
B) Use of ultraviolet radiation
C) Use of carbon tetrachloride spray
D) A or B
In paper chromatography, the data needed to compute for Rf
value:
A) Distance traveled by the solute
C) A and B
B) Distance traveled by the solvent
C) A and B
D) Distance traveled by the blank
The mobile phase in the gas chromatography is consists of:
A) Alcohol-ethyl acetate mixture
B) Alcohol-chloroform mixture C) Inert gas
C) Inert gas
D) A and B
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In gas chromatography, the result in the chromatogram is in terms
of:
A) Retention on the column
C) A and B
B) Retention of time/volume
C) A and B
D) Volume of sample injected in the column
The components of a blank used in the assay of a substance are,
except:
A) Solvent
D) Analyte
B) Reagent
C) Indicator
D) Analyte
The purpose of using a combination of indicators is:
A) To attain a sharp end point
B) To facilitate reaction A) To attain a sharp end point
C) To attain a complete reaction
D) A and B
The purity and strength of chemicals and drugs official in the
USP/NF is usually expressed in terms of:
A) Percentage
A) Percentage
B) g/mL
C) mg/mL
D) g/L
The gram equivalent of Magnesium oxide (MW = 40.30) is:
A) 0.0403
B) 0.0215 C) 21.15
C) 21.15
D) 0.4030
A sample of potassium dichromate (K2Cr2O7) weighing 1.5650g
was assayed iodometrically using 26.6mL of 0.1120N sodium
thiosulfate. Each mL of 0.1N sodium thiosulfate is equivalent to
49.03mg of K2Cr2O7. The percentage purity of the sample is:
C) 93.33
A) 93.50
B) 95.33
C) 93.33
D) 93.40
Nephelometry is based on the measurement of light that is:
A) Reflected
B) Absorbed A) Reflected
C) Transmitted
D) Adsorbed by the particles of a suspension
The infrared region of the spectrometer used to identify a sub-
stance has a wavelength range of:
A) 200 - 380 nm
D) 3 - 15 nm
B) 380 - 780 nm
C) 780 - 3000 nm
D) 3 - 15 nm
Flame spectroscopy procedures may be divided into:
A) Flame emission
B) Atomic absorption D) A and B
C) Nuclear magnetic resonance
D) A and B
The instrument used to measure sodium and potassium ions
quantitatively:
A) Colorimeter
D) Flame photometer
B) Refractometer
C) Spectrophotometer
D) Flame photometer

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The following are optical methods of analysis, except:
A) Colorimetry
B) Nephelometry C) Chromatography
C) Chromatography
D) Spectrophotometry
The calcium and sodium content of the blood can be determined
by:
A) Flame spectrometry
A) Flame spectrometry
B) Nephelometry
C) Colorimetry
D) Turbidimetry
Thiamine is assayed by:
A) Refractometry
B) Potentiometry D) Fluorimetry
C) Colorimetry
D) Fluorimetry
The term given to the functional group of an organic molecule that
absorbs maximum radiation in UV or IR region is:
A) Moiety
C) Chromophore
B) Carbonyl
C) Chromophore
D) Nitrile
Content uniformity test is conducted in:
A) 10 tablets
B) 15 tablets A) 10 tablets
C) 20 tablets
D) 30 tablets
It is the number of complete cycles that pass a given point per
second:
A) Wavelength
D) Frequency
B) Spectrum
C) Radiant energy
D) Frequency
The operating speed for paddle in a dissolution apparatus is:
A) 150 rpm
B) 100 rpm D) 50 rpm
C) 200 rpm
D) 50 rpm
Beer's plot in spectrometry is prepared to determine:
A) Absorbance of the sample
B) Wavelength to be used D) Concentration of the sample
C) Blank
D) Concentration of the sample
The pharmaceutical excipient, which affects the disintegration of
a tablet is:
A) Disintegrant
A) Disintegrant
B) Lubricant
C) Filler
D) Colorant
Antibiotics are assayed by:
A) UV-Vis Spectrometry
B) IR
D) Turbidimetry
C) NMR
D) Turbidimetry
E) Fluorimetry

USP limit for tablet content uniformity:

A) 90 - 110% D) 85 - 115%
B) 90 - 100%

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C) 95 - 105%
D) 85 - 115%
The heart of HPLC and GC:
A) Pumps
B) Injection valve
C) Column
C) Column
D) Detectors
E) Integrator
In TLC, the separation takes place on a planar surface by:
A) Dufferential migration
B) Electrostatic force
D) Capillary action
C) Relative solubility
D) Capillary action
E) Any of the above
Gas chromatography is used in the separation of:
A) Volatile liquids
B) Amino acid
A) Volatile liquids
C) Carbohydrates
D) Lipids
E) Carboxylic acid
The separation of the components of an organic dye mixture is
accomplished by using:
A) PC
B) TLC B) TLC
C) HPLC
D) GC
E) Any of the above
This is the primary cause of product instability and involves the
addition of oxygen or the removal of hydrogen:
A) Incompatibility
B) Oxidation-Reducation B) Oxidation-Reducation
C) Hydrolysis
D) Racemization
E) Decarboxylation
This is the method of analysis based on the measurement of
current resulting from the electrolysis of an electroactive species
at a given electrode potential under controlled condition:
A) Potentiometry
A) Potentiometry
B) Polarimetry
C) Polarography
D) Refractometry
E) pH measurement
The most preferred medium in dissolution testing is:
A) Alcohol
B). Acetone
D) Water
C) Ether
D) Water
E) Benzene
The following are the basic principles behind chromatographic
separation, except:
A) Partition
C) Absorption
B) Adsorption
C) Absorption
D) Ion-exchange

The stationary phase used in gas chromatography is:

A) Gas
B) Liquid
B) Liquid
C) Substrate

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D) Cellulose
E) Chromatogram
The most widely used chromatographic method in drug analysis
is:
A) Gas chromatography
B) Column chromatography C) High performance liquid chromatpgraphy
C) High performance liquid chromatpgraphy
D) Supercritical fluid chromatography
E) Thin-layer chromatography
In gas chromatography, the result of the assay is expressed in:
A) Retention on the column
B) Rf value
A) Retention on the column
C) Volume of gas used
D) Adsorbent
E) A and C
In column chromatography, the resulting patterns with several
bands is called:
A) Chromatogram
B) Eluate A) Chromatogram
C) Spectrum
D) Band
E) Chromatograph
Color of phenolphthalein in vinegar:
A) Pink
B) Yellow C) Colorless
C) Colorless
D) Orange
The primary standard used in the standardization of potassium
permanganate is:
A) Hydrogen peroxide
D) Sodium oxalate
B) Sulfuric acid
C) Potassium dichromate
D) Sodium oxalate
An organic compound that changes from one color to another at
a certain pH is called:
A) Test solution
E) Indicator
B.) Standard solution
C) Buffer
E) Indicator
To find the gram equivalent weight of Phosphoric acid, divide its
molecular weight by:
A) 1
D) 3
B) 0
C) 2
D) 3
A combining molecule containing one or more groups that donate
electrons will form ____ with a metal.
A) Complex
B) Chelate
B) Chelate
C) Sequestering agent
D) Masking agent
A chelate must always contain a/an:
A) Multivalent metal
B) Ethylenediamine group A) Multivalent metal
C) Amine group
D) Hydroxyl group
The assay of Menadione Sodium Sulfate (Vit. K) uses this method
of analysis:
A) Complexometry
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B) Alkalimetry
C) Precipitimetry D) Cerimetry
D) Cerimetry
In the standardization of HCl using pure anhydrous sodium car-
bonate as primary standard and methyl orange as indicator,
1.0mL HCl was found to be equivalent to 0.05g of sodium car-
bonate (MW = 106). The normality of HCl is:
B) 0.94 N
A) 1.0 N
B) 0.94 N
C) 0.4716 N
D) None of the above
An accurately measured sample of hydrogen peroxide 2.00g was
dissolved in a mixture of 20mL water and 20mL and 20mL diluted
sulfuric acid and was then titrated with 0.100N potassium per-
manganate consuming 30.0mL to reach the end point. Compute
for the percentage of peroxide (MW = 34) A) 2.55%
A) 2.55%
B). 5.1%
C)2.5%
D) None of the above
USP requires not less than 2.5g and not more than 3.5g of
hydrogen peroxide /100 parts. Does the sample conforms with the
standard requirement?
A) Yes A) Yes
B) No
C) Maybe
D) Cannot be determined
One twentieth molar solution of sulfuric acid is:
A) 0.05 M
B) 0.1 M A) 0.05 M
C) 0.005 M
D) 0.5 M
The titrant most commonly used for direct complexometry titration
is:
A) Zinc sulfate VS
B) Disodium edentate VS
B) Disodium edentate VS
C) Silver nitrate VS
D) Perchloric acid VS
Precipitation method using potassium chromate test solution as
indicator and silver nitrate standard solution:
A) Volhard
C) Mohr
B) Fajan
C) Mohr
D) None of the above
The titer value of 1.0mL of 0.1N ceric sulfate for arsenic trioxide
(MW = 197.94)
A) 9.496 mg
A) 9.496 mg
B) 197.84 mg
C) 9.892 mg
D) 14.838 mg
The masking agent used in the assay of Mg with EDTA in the
presence of Al is:
A) Triethanolamine
A) Triethanolamine
B) Thioglycol
C) Potassium cyanide
D) Ammonium fluoride
In the assay of ZnO (MW = 81.38), each mL of 1N of H2SO4 is
equivalent to ____ of ZnO.
A) 81.38 mg
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B) 40.69 mg
C) 27.13 mg B) 40.69 mg
D) 20.34 mg
Assay of Sodium Nitrite is an example of:
A) Neutralization
B) Precipitation D) Redox method
C) Complexation
D) Redox method
The substance used to form a film over the precipitated silver
chloride particles in Volhard's method is:
A) Nitric acid
D) Nitrobenzene
B) Sodium chloride
C) Triethanolamine
D) Nitrobenzene
Assay of NaCl in table salt by precipitation as AgCl, filtration,
drying and weighing the residue is classified as:
A) Direct precipitimetry
C) Gravimetry
B) Residual precipitimetry
C) Gravimetry
D) Gasometry
Ceric sulfate is a/an:
A) Precipitating agent
B) Oxidizing agent B) Oxidizing agent
C) Reducing agent
D) Complexing agent
The valence number of Mn in KMNO4 is:
A) +2
B) +1 D) +7
C) +5
D) +7
The apparatus used to wash down drops of standard solution
clinging to the tip of the buret is:
A) Bobcock bottle
D) Wash bottle
B) Cassia flask
C) Plastic bottle
D) Wash bottle
An sample of sodium sulfate weighing 1.800g yielded 0.900g of
barium sulfate (MW = 233.25). Calculate the percentage of sulfur
( AW = 32.06) in the sample.
A) 12.18% B) 6.870%
B) 6.870%
C) 27.48%
D) 30.44%
How many grams of drug are required to make 500 mL of 25.0%
solution?
A) 30.0 g
C) 125 g
B) 50.0 g
C) 125 g
D) 130 g
The following are methods of determining the end point in precip-
itimetry, except:
A) Use of adsorption indicators
C) Formation of turbidity
B) Cessation of precipitation
C) Formation of turbidity
D) Appearance of turbidity

The reagent that loses the electron/s in a redox reaction is the:

A) Substance that decreases in oxidation number C) Reducing agent
B) Oxidizing agent

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C) Reducing agent
D) Substance reduced
A substance that has a high degree of purity and is used in direct
standardization purposes:
A) Technical grade reagent
D) Primary standard reagent
B) USP grade reagent
C) Analyzed reagent
D) Primary standard reagent
The type of assay employed in determining the % ZnO in a sample
of Zinc White Powder using EDTA as titrant is:
A) Residual precipitimetry
C) Direct complexometry
B) Direct precipitimetry
C) Direct complexometry
D) Residual Complexometry
The experimental way of determining when equivalent amounts of
reactants have reacted together is:
A) Titration
A) Titration
B) Stoichiometric point
C) Standardization
D) Equivalence point
Calculate the calcium carbonate content of a sample of chalk
weighing 0.2545g and consuming 16.7 mL of 0.1150 M EDTA. At.
Wt. Of Ca = 40.08
A) 75.52% A) 75.52%
B) 75.50%
C) 37.76%
D) 37.78%
Twenty tablets of ascorbic acid weighed 4.2500g and a powdered
sample of 0.3075g was titrated consuming 21.5mL of 0.1085N
Iodine solution. Each mL of 0.1N Iodine is equivalent to 8.80mg
of ascorbic acid. What is the amount of ascorbic acid per dose of
two tablets? A) 283.72 mg
A) 283.72 mg
B) 141.86 mg
C) 283.22 mg
D) A and C
The official USP gravimetric methods are:
1 Assay involving direct ignition
2 Assay involving sublimation
3 Assay involving extraction
4 Assay involving precipitation followed by ignition
A) 1, 3 and 4
A) 1, 3 and 4
B) 2, 3 and 4
C) 1, 2 and 4
D) 1, 2 and 3
Alkaloidal test solutions include:
A) Valser's TS
B) Warner's TS D) All of the above
C) Mayer's TS
D) All of the above
Hexane is the best solvent for extracting:
A) Resins
B) Fats B) Fats
C) Carbohydrates
D) Acids
How many mL of water is expected from a 20 g Digitalis sample
containing 1.5% moisture?
A) 0.3 mL
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B) 30 mL
C) 3 mL A) 0.3 mL
D) None of the above
Moisture content in grams:
Wt. of empty crucible 52.452 g
Wt. of crucible & sample 61.648 g
Wt. of crucible & sample after drying to constant wt. 60.502 g
Wt. of crucible and residue left after incineration 53.006g
A) 1.146
A) 1.146
B) 1.144
C) 1.164
D) 1.166
Percent moisture:
Wt. of empty crucible 52.452 g
Wt. of crucible & sample 61.648 g
Wt. of crucible & sample after drying to constant wt. 60.502 g
Wt. of crucible and residue left after incineration 53.006g
B) 12.46%
A) 12.64%
B) 12.46%
C) 12.45%
D) 12.54%
Total ash content in grams:
Wt. of empty crucible 52.452 g
Wt. of crucible & sample 61.648 g
Wt. of crucible & sample after drying to constant wt. 60.502 g
Wt. of crucible and residue left after incineration 53.006g
C) 0.554
A) 0.545
B) 0.555
C) 0.554
D) 0.445
Percent total ash:
Wt. of empty crucible 52.452 g
Wt. of crucible & sample 61.648 g
Wt. of crucible & sample after drying to constant wt. 60.502 g
Wt. of crucible and residue left after incineration 53.006g
B) 6.02%
A) 6.20%
B) 6.02%
C) 6.22%
D) 6.92%
Find the acid value of a sample weighing 1.230 g that consumes
30.0 mL pf 0.110 N NaOH to bring about the end point using KOH
in the titration:
A) 150.54 mg/g A) 150.54 mg/g
B) 157.72 mg/g
C) 109.18 mg/g
D) 124.41 mg/g

During an in-process control testing, the following data were ob-

tained from loss on drying test:
Wt. of sample before drying 1.146 g
Wt. of tare & sample after drying 25.653 g
Wt. of tare 24.632 g B) 0.125 g
What is the weight of moisture lost?

A) 1.021 g
B) 0.125 g

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C) 1.125 g
D) 0.021 g
Calculate the water content of an antibiotic powder using 350mg
sample. The water equivalence factor (F) of the Karl Fischer
reagent is 4.6 and the volume of the reagent used was 9.2 mL.
The % of water content is:
A) 12.09%
A) 12.09%
B) 1.21%
C) 12.11%
D) A and B
Determination of iodine value of oils depends on:
A. Substitution with iodine for the hydrogen in the fatty acid
B. Addition of iodine at the double bond of the fatty acid B. Addition of iodine at the double bond of the fatty acid
C. Oxidation of the fatty acid by iodide
D. All of the above
The soluble constituents of crude drug in a certain solvent:
A) Extractive
B) Ash A) Extractive
C) Crude fiber
D) Stigmasterol
In-process specification requires that the percent loss on drying
should not exceed 0.65% of the sample weight. Based on the
given data below, what is the total amount of moisture?
Tare wt. 26.839 g
Gross wt. 36.506 g
D) 0.011 g
Gross wt. after drying 36.495 g
A) 0.237 g
B) 0.060 g
C) 9.607 g
D) 0.011 g
A reaction is led to completion by:
A. Formation of ash
B. Formation of insoluble acid D) All of the above
C) Production of slightly ionized molecules
D) All of the above
Karl Fischer electrometric titration is a method used to assay for
its:
A) Oxygen content
D) Water content
B) Nitrogen content
C) Oil content
D) Water content
Assay of atropine in Belladonna is an example of:
A) Proximate assay
B) Ultimate assay B) Ultimate assay
C) Both A and B
D) Neither A nor B
The primary standard used to standardize Karl Fischer reagent
is:
A) Potasium carbonate
C) Sodium tartrate
B) Potassium bipthalate
C) Sodium tartrate
D) Sodium oxalate
Oils with iodine value above 120 are classified as:
A) Non-drying
B) Semi-drying C) Drying
C) Drying
D) None of the above
If a sample is beeswax is found to have an acid number of 15.5
and a saponification value of 71.2, the ester value of the sample
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is:
A) 86.7
B) 55.7 B) 55.7
C) 90
D) None of the above
The temperature for ignition described as dull red heat is:
A) 500 - 1000 oC
B) 550 - 700 oC B) 550 - 700 oC
C) 500 - 750 oC
D) 300 - 450 oC
The assay of the aldehyde content of volatile oils may be done by:
A) Potassium hydrxide method
B) Bisulfite method B) Bisulfite method
C) Bobcock method
D) Gravimetric method
Quantitative determinations of alkaloids may be done by:
A) Volumetric
B) Gravimetric D) Any of the above
C) Spectrophotometric
D) Any of the above
Compute for the iodine value of corn oil 0.2048g dissolved in 10
mL chloroform and 25 mL iodobromide TS was added, mixed and
allowed to stand for one hour. Thirty mL of KI TS and 100 mL
distilled water were added and titrated with 10 mL of 0.1065 N
sodium thiosulfate. The volume of sodium thiosulfate consumed
A) 103.61
in the blank was 25.7. I is equal to 126.9.
A) 103.61
B) 103.16
C) 101.36
D) 103.66
Calculate percentage of Atropine in Belladonna powder using
10.7 g sample and adding 20 mL of 0.0225N H2SO4 and back
titrated with 12.5 mL of 0.0295N NaOH. Each mL of 0.02N H2SO4
is equivalent to 5.788g of Belladona alkaloids in terms of Atropine.
D) 0.22%
A) 5.60%
B) 0.56%
C) 0.59%
D) 0.22%
This is the acceptable tablet hardness range of chewable tablets:
A) 4 - 10 kg
B) 2 - 3 kg B) 2 - 3 kg
C) 5 - 8 kg
D) 2 - 8 kg
In normal phase chromatography:
A) Stationary phase and mobile phase are both polar
B) Stationary phase is nonpolar, mobile phase is polar C) Stationary phase is polar, mobile phase is nonpolar
C) Stationary phase is polar, mobile phase is nonpolar
D) Stationary phase and mobile phase are both nonpolar
How many samples should be tested if a batch consists of 120
bottles of paracetamol suspension when the square root method
is used?
A) 12 A) 12
B) 11
C) 10
D) 9
Fats are:
A) Esters of glycerin and fatty acid
A) Esters of glycerin and fatty acid
B) Esters of glycerin and phosphoric acid
C) Compounds of glycerol, fatty acid. Phosphoric acid and choline
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D) Steroids with one or more hydroxyl groups
E) Esters of fatty acids with high molecular weight alcohol
Acid insoluble ash is the part of the total ash, which is insoluble
in:
A) Dilute nitric acid
D) Dilute hydrochloric acid
B) Dilute acetic acid
C) Dilute sulfuric acid
D) Dilute hydrochloric acid
What would be the accepted weight range of tablets weighing
130mg?
A) 123.5 - 136.5 mg
B) 120.25 - 139.75 mg
B) 120.25 - 139.75 mg
C) 117 - 123 mg
D) 120.9 - 139.1 mg
Disintegration test is done at this temperature:
A) 36.5 - 37.5 oC
B) 36 - 37 oC C) 35 - 39 oC
C) 35 - 39 oC
D) 37 oC
Efficiency of HEPA filters is assessed using:
A) Dioctyl phthalate test
B) Water attack test A) Dioctyl phthalate test
C) Pyrogen test
D) Bubble point test
A concentration expression referring to the number of equivalents
of solute per liter of solution is:
A) Normality
A) Normality
B) Molarity
C) Molality
D) Formality
A solution of known concentration used to standardize another
solution is:
A) Primary standard
A) Primary standard
B) Dilute solution
C) Secondary standard
D) B and C
Water attack test is used in this type of glass container:
A) Type I
B) Type II B) Type II
C) Type III
D) Type III
The process by which the exact concentration of a solution is
determined is:
A) Standardization
A) Standardization
B) Neutralization
C) Titration
D) Dissolution
A person who determines the presence of pyrogens and microor-
ganisms of a pharmaceutical product is performing:
A) Microbial test
A) Microbial test
B) Identification tests
C) Pharmaceutical assaying
D) Biologic assaying
to keep samples free from moisture is:
A) Oven
B) Dessicator B) Dessicator
C) Furnace
D) Dryer

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Materials being controlled by Quality Control, except:
A) Active ingredient
B) Excipients D) Packages
C) Finished products
D) Packages
To assure stability of the product until expiry date, the label should
indicate:
A) Proper storage
A) Proper storage
B) Proper dosage
C) Proper color
D) Proper drug administration
Neutralization reactions in titrimetric methods of analysis may be:
A) Argentimetry
B) Alkalimetry B) Alkalimetry
C) Compleximetry
D) Mercurimetry
To remove stains of iodine, the most effective chemical substance
is:
A) Hydrogen sulfide
C) Sodium thiosulfate
B) Hydrogen peroxide
C) Sodium thiosulfate
D) Sodium hypochlorite
The type of ligand where EDTA belongs;
A) Unidentate
B) Bidentate C) Hexadentate
C) Hexadentate
D) Tridentate
A type of titration where the first titrant is added in excees with the
sample and the second titrant reacts with the added excess is:
A) Back
D) A and C
B) Direct
C) Residual
D) A and C
Light scattering method of analysis include/s:
A) Flourometry
B) Turbidimetry D) B and C
C) Nephelometry
D) B and C
Ferric alum TS is used as indicator in volumetric precipitation
method if the titrant is:
A) AgNO3
C) NH4SCN
B) BaCl2
C) NH4SCN
D) NH4Cl
In gravimetric analysis, when the process used in extraction to
obtain the original constituent, this method belongs to:
A) Chemical
B) Physical
B) Physical
C) Precipitation
D) Any of the above
A spectrophotometer differs from a colorimeter because it con-
sists of:
A) Prism
A) Prism
B) Lamp house
C) Cell compartment
D) Optical scale
To find the milliequivalent factor of a reducing agent, divide its
molecular weight by:
A) No. of electrons gained
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B) Valence
C) No. of electrons lost C) No. of electrons lost
D) Replaceable hydrogen
Compute for the angle of repose of the sample powder using fixed
funnel method if the height and diameter obtained was 5 cm and
13 cm respectively.
A) 37.57o A) 37.57o
B) 36.57o
C) 35.75o
D) 36o
Volatile oils are complex compounds composed of:
A) Phenols
B) Inorganic salts D) A and C
C) Hydrocarbons
D) A and C
The name of originator who introduced the adsorption dyes as an
indicator in volumetric precipitation method:
A) Volhard
D) Fajans
B) Liebig
C) Mohr
D) Fajans
Using a sampling plan by military standard 105 D, the sample size
required is obtained from:
A) Master table
A) Master table
B) Ratio and proportion
C) Samples needed
D) A and B
The acid necessary for permanganate titrations is:
A) Acetic acid
B) Sulfuric acid B) Sulfuric acid
C) Hydrochloric acid
D) Nitric acid
To control finished products in the warehouse of a company, the
distribution practice is:
A) First-in first-out
A) First-in first-out
B) Samples needed
C) Ratio and proportion
D) A and B
The number of retention samples collected by the Quality Control
Inspector from the packaging line is:
A) Two times the number required for testing
D) Any of A and C
B) Three labeled containers
C) Not less than two labeled containers
D) Any of A and C
A type of quality control chart based on the number of defectives
found is:
A) Go or no-go
D) A and C
B) Variable
C) Attribute
D) A and C
Sources of quality variations are as follows, except:
A) Technician
B) Inadequate procedure D) General manager
C) Equipment
D) General manager

Acetylation mehod of analysis in volatile oils is done to determine:

A) Phenol C) Alcohol
B) Aldehyde

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C) Alcohol
D) Ketone
In spectrometry, when a test solution is prepared and observed
identically with a reference standard, they are:
A) Isometric substances
D) B and C
B) Similar solutions
C) Similar preparations
D) B and C
The material used to make the cell holder for infrared analysis are,
except:
A) Sodium bromide A) Sodium bromide
B) Potassium chloride
C) Thymolphthalein
Calculate the water content of str C) Sodium chloride D) Thy-
molphthalein eptomycin powder weighing 4.20g as sample. The
water equivalence factor (F) of the Karl Fischer reagent was found
to be 5.1 and the volume consumed was 11.50. The % of water
is: B) 1.40
A) 1.39
B) 1.40
C) 1.41
D) 13.96
The Karl Fischer reagent used for moisture content determination
consists of the following except:
A) Pyridine
B) Acetone
B) Acetone
C) Sulfur dioxide
D) Iodine
This is the sum of all tests performed to determine the confor-
mance of the product to specifications:
A) Quality control
A) Quality control
B) Quality Assurance
C) Good manufacturing practices
D) Good documentation practices
Complex inorganic compounds that are used to determine the end
point in titration:
A) Indicators
A) Indicators
B) Standard solutions
C) Precipitating agents
D) Masking agents
The name of the originator who introduced the use of 0.1N silver
nitrate as the titrant and potassium chromate TS as the indicator
in volumetric precipitation of chlorides is:
A) Volhardt B) Mohr
B) Mohr
C) Fajan
D) Liebig
In the assay of ascorbic acid by iodimetry, it acts as:
A) Reducing agent
B) Oxidizing agent A) Reducing agent
C) Acid
D) Base
This is the weight of the substance chemically equivalent to 1 mL
of the standard solution:
A) Titrant
C) Titer
B) Equivalence point
C) Titer
D) End point

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When a strong acid is titrated against a weak base, the indicator
is:
A) Methyl red
A) Methyl red
B) Phenolphthalein
C) Methyl orange
D) Thymolphthalein
The gram equivalent weight of potassium permanganate (MW =
158.03) is:
A) 29.60
B) 31.60
B) 31.60
C) 158.03
D) 79.01
Residual titration method under EDTA titrations is applied to metal
ion:
A) Zinc
C) Bismuth
B) Calcium
C) Bismuth
D) Manganese
The measurement of a weak base in nonaqueous medium of a
given sample by titration with standard perchloric acid:
A) Acidimetry
B) Alkalimetry
B) Alkalimetry
C) Complexometry
D) Precipitimetry
Assay method that determines the presence of pyrogens in in-
jectables:
A) Rabbit test
D) A and B
B) Limulus amoebocyte lysate test
C) White mice test
D) A and B
This is used for quantitative preparation of a standard solution:
A) Pipet
B) Graduated cylinder C) Volumetric flask
C) Volumetric flask
D) Buret
Which of the following is an oxidizing agent?
A) Ascorbic acid
B) KMNO4 B) KMNO4
C) Sodium thiosulfate
D) Sodium nitrite
The concentration of official diluted alcohol is:
A) 10%
B) 50% B) 50%
C) 80%
D) 70%
The oxidation number of atomic iodine is:
A) -1
B) +2 A) -1
C) 0
D) +3
Safety and toxicity tests are conducted for:
A) Plastic tubings
B) Solutions in vial A) Plastic tubings
C) Tablets
D) Oral liquids

The type of ash where sulfuric acid is used to whiten the ash is:
A) Acid-insoluble ash B) Sulfated ash
B) Sulfated ash

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C) Loss on ignition
D) Residue on ignition
A sample of 0.1350 g of As2O3 was assayed iodimetrically using
23.4 mL of 0.1055N Iodine solution. The percentage purity of the
sample is: At.wt. of As = 74.92; O = 16
A) 90.44 A) 90.44
B) 90.23
C) 89.00
D) 90.54
Calculate the amount of caffeine extracted from coffee beans
using 1.0215g of the sample. The volume of 0.0252N H2SO4
added to the extract was 25.4 mL, the excess titrated by 21.75
mL of 0.02115N NaOH. Each mL of 0.02 N H2SO4 is equivalent
to 3.8858 mg of caffeine (C9H10O2). The percentage of caffeine
C) 3.42
is:
A) 3.40
B) 3. 5 0
C) 3.42
D) 3.60
The residue after incineration of a drug was 0.1185 g from a
sample of 7.0 g. The percentage of ash is:
A) 1.56
A) 1.56
B) 2.56
C) 2.0
D) 1.55
If a 0.4600g of potassium iodide (KI) yielded a 0.715g of silver
iodide precipitate by gravimetric assay, what would be the per-
centage purity of KI? At.wt.: Ag = 107.87; K = 39.1; I = 126/9
A) 110.90 A) 110.90
B) 110.89
C) 45.08
D) 109.90
Compute for the Rf value of a substance if the substance traveled
by the solvent is 12.5 cm and the distance traveled by the sample
is 7.5 cm:
A) 0.70 B) 0.60
B) 0.60
C) 1.67
D) 1.66
Compute for the percentage loss on ignition of magnesium sulfate
hydrated using 3.20 g sample yielding a residue of 2.15g. The loss
is:
A) 33.81% C) 32.81
B) 32.98%
C) 32.81
D) 32.75%
If a 0.3800 g sample of sodium sulfate yielded 0.55 g of barium
sulfate precipitate by gravimetric assay, what would be the per-
centage purity of sodium sulfate? At.wt.: Ba = 173.3; S = 32.06;
Na = 23; O = 16
A) 88.11
A) 88.11
B) 99.94
C) 99.15
D) 88.51
Analysis of substances that fluoresce falls under:
A) Fluorometry
B) Requires UV light D) A and B
C) Absorbance reading is obtained
D) A and B

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An instrument in spectrometry using the filter as radiant energy
device:
A) Filter photometer
A) Filter photometer
B) Infrared spectrometer
C) UV - Vis spectrometer
D) Flame photometer
Region in an electromagnetic spectrum:
A) Visible
B) Infrared D) All of the above
C) Ultraviolet
D) All of the above
Cause of quality variation due to men:
A) Fatigue due to overwork
B) Requires high salary A) Fatigue due to overwork
C) Resourceful at work
D) Health problems
Acetylene and aldehyde group present in a compound that ab-
sorbs radiant energy are called:
A) Chromophore
A) Chromophore
B) Inactive
C) Inert
D) Pharmacophore
The reading that must be obtained in a spectrophotometer:
A) Concentration error
B) Absorbance B) Absorbance
C) Retention
D) Angular rotation
The acid used in sulfated ash determination of a crude drug is:
A) Hydrochloric acid
B) Nitric acid C) Sulfuric acid
C) Sulfuric acid
D) Periodc acid
Silica from the soil that is left after treatment of the ash with diluted
HCl is the:
A) Acid-insoluble ash
A) Acid-insoluble ash
B) Sulfated ash
C) Residue on ignition
D) Loss on ignition
The end point in the water content determination using Karl Fis-
cher reagent is determined by:
A) Use of chemical indicator
B) Use of potentiometer or volumeter
B) Use of potentiometer or volumeter
C) Use of spectrometer
D) Use of chromatograph
In microbial assay, the instrumental method used to prepare the
inoculum is:
A) Turbidimetry
A) Turbidimetry
B) B) Nephelometry
C) Paper Chromatography
D) Column Chromatography
A polarimeter is used whether a substance is:
A) Dextrorotatory
B) Levorotatory D) All of the above
C) Optically active
D) All of the above

A similar preparation in spectrometry refers to:

A) Reference standard and sample identically made A) Reference standard and sample identically made
B) Reference standard greater than sample

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C) Sample greater than reference standard
D) All of the above
Stoichiometric point in titration means that:
A) Equivalent amounts of the titrant and analyte have reacted.
B) Normality or molarity of the reactants are the same. A) Equivalent amounts of the titrant and analyte have reacted.
C) End point in titration has been reached
D) A and C
In-process control tablets include the following, except:
A) Weight
B) Hardness and thickness D) Bioavailability
C) Disintegration
D) Bioavailability
Content uniformity test is to be performed for all products whose
active ingredient is:
A) 50 mg or less
A) 50 mg or less
B) 130 - 134 mg
C) 130 mg or less
D) 324 mg or more
A date limiting the time during which a preparation may be expect-
ed to have retained its labeled potency:
A) Shelf life
C) Expiry date
B) Manufacturing date
C) Expiry date
D) Half-life
To identify the place where materials have to be stored in a
material warehouse, a _____ is pasted on the container of the
material.
A) Sticker A) Sticker
B) Label
C) Ribbon
D) Tag
Caps, bottles, labels and shipping containers are considered as:
A) Active components
B) Drug products C) Packaging materials
C) Packaging materials
D) Excipient
A ____ is a specific amount produced according to a single
manufacturing order during a single period of production.
A) Batch
A) Batch
B) Lot
C) Component
D) None of the above
One batch can be broken into several:
A) Ingredients
B) Lots B) Lots
C) Components
D) None of the above
The recommended maximum limit for overage of vitamins is:
A) 30%
B) 10% A) 30%
C) 90%
D) 70%
Accelerated stability testing is, except:
A) Performed at higher temperatures to intensify degradation
through time
B) Done to determine the shelf life of the product in a short period C) Enough proof of shelf life and need not be further validated
of time
C) Enough proof of shelf life and need not be further validated
D) The initial method used to determine a product's shelf life
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______ is the comparing of attributes and dimensions of a product
against a standard to find out if the product is within the prescribed
limit.
A) Sampling B) Inspection
B) Inspection
C) Analysis
D) Action
A ______ is a definite working rule regarding N, n and c.
A) Sampling plan
B) Quality Control analysis A) Sampling plan
C) Risk management
D) Control chart

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