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    FDA-Labeled Indications and Dosage (Adult) : Dermatologic Disturbance in Mood

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    georgepiper292
    The document discusses heroin use and its effects on the body. When taken orally, heroin undergoes metabolism and acts as a prodrug for morphine. When injected, it crosses the blood-brain barrier rapidly due to its acetyl groups, causing intense euphoria by binding to opioid receptors in the brain.

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    FDA-Labeled Indications and Dosage (Adult) : Dermatologic Disturbance in Mood

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    georgepiper292
    16 views2 pages
    The document discusses heroin use and its effects on the body. When taken orally, heroin undergoes metabolism and acts as a prodrug for morphine. When injected, it crosses the blood-brain barrier rapidly due to its acetyl groups, causing intense euphoria by binding to opioid receptors in the brain.

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    The document discusses heroin use and its effects on the body. When taken orally, heroin undergoes metabolism and acts as a prodrug for morphine. When injected, it crosses the blood-brain barrier rapidly due to its acetyl groups, causing intense euphoria by binding to opioid receptors in the brain.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    16 views2 pages

    FDA-Labeled Indications and Dosage (Adult) : Dermatologic Disturbance in Mood

    Uploaded by

    georgepiper292
    The document discusses heroin use and its effects on the body. When taken orally, heroin undergoes metabolism and acts as a prodrug for morphine. When injected, it crosses the blood-brain barrier rapidly due to its acetyl groups, causing intense euphoria by binding to opioid receptors in the brain.

    Copyright:

    © All Rights Reserved
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    Overview As with other opiates, heroin is used both as a pain-killer and a recreational

    drug.
    One of the most common methods of heroin use is via intravenous injection. When taken orally,
    heroin undergoes extensive first-pass metabolism via deacetylation, making it a prodrug for the
    systemic delivery of morphine.[1] When the drug is injected, however, it avoids this first-pass
    effect, very rapidly crossing the blood-brain barrier due to the presence of the acetyl groups,
    which render it much more lipid-soluble than morphine itself.[2] Once in the brain, it is
    deacetylated into 3- and 6-monoacetylmorphineand morphine, which bind to μ-opioid
    receptors resulting in intense euphoria with the feeling centered in the gut.

    Levorphanol is an analgesic opioid that is FDA approved for the {{{indicationType}}} of chronic
    pain, pain (moderate to severe) and premedication for anesthetic procedure - Surgical
    procedure. Common adverse reactions
    include cardiovascular: hypotension, dermatologic: pruritus, gastrointestinal: constipation, nause
    a, vomitingpsychiatric: altered mental status, disturbance in mood.

    Adult Indications and Dosage


    FDA-Labeled Indications and Dosage (Adult)
     Dosage should be individualized based on degree of pain, clinical setting, physical
    condition of the patient, and kind and dose of concurrent medication
     Pain, chronic: initial, total daily dose 1/15 to 1/12 of total daily dose of oral morphine;
    wait 72 h between dose adjustments
     Pain (Moderate to Severe): up to 1 mg IV injection in divided doses, may repeat in 3
    to 6 h as needed; max 4 to 8 mg daily
     Pain (Moderate to Severe): 1 to 2 mg IM/SC, may repeat in 6 to 8 h as needed; max
    3 to 8 mg IM daily
     Pain (Moderate to Severe): 2 mg orally, may repeat in 6 to 8 h as needed; may
    increase dose up to 3 mg every 6 to 8 h if needed; max 6 to 12 mg daily
     Premedication for anesthetic procedure - surgical procedure: 1 to 2 mg IM/SC 60 to
    90 min before surgery

    Pediatric Indications and Dosage


    FDA-Labeled Indications and Dosage (Pediatric)
     Safety and effectiveness in pediatric patients have not been established
    Off-Label Use and Dosage (Pediatric)
    Guideline-Supported Use
    There is limited information about Off-Label Guideline-Supported Use of Levorphanol in pediatric
    patients.
    Non–Guideline-Supported Use
    There is limited information about Off-Label Non–Guideline-Supported Use of Levorphanol in
    pediatric patients.

    Contraindications
     Levorphanol is contraindicated in patients hypersensitive to levorphanol tartrate.

    Off-Label Use and Dosage (Adult)


    Guideline-Supported Use
    There is limited information about Off-Label Guideline-Supported Use of Levorphanol in adult
    patients.
    Non–Guideline-Supported Use
    There is limited information about Off-Label Non–Guideline-Supported Use of Levorphanol in
    adult patients.

    Pediatric Indications and Dosage


    FDA-Labeled Indications and Dosage (Pediatric)
     Safety and effectiveness in pediatric patients have not been established
    Off-Label Use and Dosage (Pediatric)
    Guideline-Supported Use
    There is limited information about Off-Label Guideline-Supported Use of Levorphanol in pediatric
    patients.
    Non–Guideline-Supported Use
    There is limited information about Off-Label Non–Guideline-Supported Use of Levorphanol in
    pediatric patients.

    Contraindications
     Levorphanol is contraindicated in patients hypersensitive to levorphanol tartrate.

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