Gpat 2014
Gpat 2014
Gpat 2014
GPAT-2014
1. Linctus is used to treat
(a) Gingivitis (b) Cough (c) Mouth ulcers (d) Tooth ache
2. Maximus diuretic activity of meta disulfamoyl benzene is shown when the R group is
R NH2
SO2NH2 SO2NH2
(a) –Cl, -CF3 (b) –H, -Br (c) Both (d) None
6. The choice of route of administration plays an important role in action of directly acting
cholinomimetic . Adverse effect of choline esters that may be avoided by selection of an
appropriate route of administration is
(a) Bradycardia (b) Hypotension (c) Delirium (d) Sweating
14. Of the following antibiotics, which one would be acceptable to use when treating penicillin
resistant S. pnumoinae otitis media
(a) Azithromycin (b) Clarithromycin (c) Cefuroxime (d)
Cefaclor
15. Addtion of which of the following to a large volume parntral product is not advised
(a) Active pharmaceutical ingredient (b) Preservatives
(c) Buffering agens (d) Tonicity adjusters
16. A drug suspension decomposes by zero-order kinetics with a rate constant of 2 mg mL-1 month-1
if the initial concentration is 100 mg mL-1 what is the shelf life
(a) 2 months (b) 3 months (c) 4 months (d) 5 months
N N N N
O H O O H O O H O O H O
CH3
(a) 1,3 –dimethylyriden (b) 1,3-dimethylpiperidine
(c) 2,4 –dimethylpiperidine (d) 2,4-dimethyl-1,2,3,6-tetrahydropyridine
27. The cancer that derived form ectoderm of endoderm of epithelial cells is
(a) Carcinoma (b) Sarcoma (c) Leukaemia (d) Myloid
33. Which of the following is following is true for natural killer cells
(a) They may phagocytose tumor cells
(b) Killing of cells is enhanced by interleukin-2
(c) They recognize and kill some virus-infected cells
(d) Killing of cells is stimulated by prostaglandin E2
38. All of the following is resistant to both true and pseudo cholinesterase enzymes
(a) Carbachol (b) Acetylcholine (c) Methacholine (d) Pilocarpine
45. According to Maslow’s hierarchy of motives, which of the following needs must be satisfied
before a person can attain esteem
(a) Safety (b) Cognitive (c) Self-actualization (d) Aesthetic
46. Actions and clinical uses of muscarinic cholinoceptor agonists include which on of the following
(a) Bronchodilation (asthama)
(b) Improved aqueous humor drainage (glaucoma)
(c) Decreased gastrointestinal motility (diarrhea)
(d) Decreased neuromuscular transmission and relaxation of skeletal muscle (During surgical
anesthesia)
47. Regarding the role of surfactants in pharmaceutical suspensions for oral administration which of
the following statements is false
(a) Surfactants decrease the water contact angle of dispersed drug particle
(b) Surfactants promote flocculation
(c) Surfactants with high HLB stabilize oral suspensions
(d) Surfactants increase the viscosity of the continuous phase of pharmaceutical suspensions
48. Which of the following drug is NOT used in treatment of H. Pylori infection
(a) Ampicillin (b) Clarithromycin (c) Mosapride (d) Bismuth subgallate
49. The most suitable disinfectant for decontamination of HIV contaminated endoscope is
(a) 1% Sodium hypochlorite (b) 2% Glutaraldehyde
(c) 5% phenol (d) 70% ethanol
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50. Which rule does provide the most accurate method to calculate the dose for child based on adult
dose
(a) Age is months (b) Age in years (c) Weight in pounds (d) Body surface area
54. In which method an order of a fixed number of items is placed every time an inventory level falls
to a predetermined point
(a) A-B-C method (b) Maximum and minimum method
(c) Open-to-buy method (d) Economic order quantity
57. In supercritical fluid chromatography, if using packed columns, the most common stationary
(a) A methyl – type stationary phase bonded to silica (like DB-1) for GC
(b) An aromatic-type stationary phase bonded to silica
(c) An octyldecyl (C18 ) Stationary phase bonded to silica
(d) Uncoated silica
65. The lipoprotein with the fastest electrophoretic mobility and the lowest TG content is
(a) VLDL (b) HDL (c) LDL (d) Chylomicrons
66. As per schedule ‘Y’ of the drugs and cosmetics act, the animal toxicity study requirements for
marketing of a drug depends upon tentative route and duration of administration in humans. In
This context , which one of the following statements is incorrect
(a) Single dose human use-animal toxicity for 2 weeks in 2 species
(b) Oral use for 2 weeks in humans- animal toxicity for 4 week in 2 species
(c) Aerosol use by repeated use in humans- animal toxicity for 24 weeks in 2 species
(d) Multiple daily ocular application for short duration-iregation test in 1 species for 3 weeks
67. For determining the efficacy of sterilization in an autoclave, the spores of the following organism
are used as test organisms
(a) Bacillus cereus (b) Clostridium pefringens
(c) Bacillus stearothemophilus (d) Clostridium histolyticum
69. In tran 1,2-demethyl cyclohexane, what is the orientation of the methyl groups
(a) both axial (b) Both equatorial
(c) One axial one equatorial (d) Depends on chair or boat conformation
71. Which of the plant family contains volatile oil in their trichome
(a) Rutaceae (b) papaveracease (c) Umbelliferare (d) Laminaceae
72. What is proportion of citric acid: tartaric acid: sodium bicarbonate in effervescent power
(a) 1:2:3:4 (b) 2:1:3:4 (c) 1:2:4 (d) 1:2:4:4
74. One of the first step of the citric acid cycle is isomerization of citric acid to isoctiric acid this step
is necessary because
(a) Oxidation of secondary alcohols is very difficult
(b) Reduction of secondary alcohol is very impossible
(c) Reduction of tertiary alcohols would require a very powerful oxidizing agent
(d) Oxidation of tertiary alcohols would require oxidizing agents
75. Which of the following alkyl halides would undergo SN2 reaction most rapidly
(a) CH3CH2-BR (b) CH3CH2-CL (c) CH3CH2-I (d) CH3CH2-F
76. A single dose four-way crossover, fasting, comparative bioavailability study was performed in 24
healthy, adult male subjects. Plasma drug concentrations were obtained for each subject and
following results were obtained
Product Dose Cmax(µg/ml) Tmax(h) AUC0->∞(µgh/ml)
IV injection 100 - - 1714
Oral emulsion 200 21.3 1.2 3143
Capsule 200 17.0 2.1 2822
Reference tablet 200 16.5 1.9 2844
The relative bioavailability of the drug from the capsule compared to the reference tablet is
(a) 82.33% (b) 91.68% (c) 96.22% (d) 99.22%
84. Rank the following compounds is order of increasing reactivity in electrophilic aromatic
Substitution reactions
(P) C6H6 (Q) C6H5CH3 (R) C6H5NO2
(a) Q<P<R (b) R<P<Q (c) Q<R<P (d) P<Q<R
85. The most common waveform associated with EEG is epilepsy are ……………. Waves
(P) Spike (Q) Sharp waves (R) Nonspecific waves (S) Theta waves
(a) P and R (b) P and Q (c) Q and R (d) P,Q,R and S
87. Among the electrolytes Na2SO4, CaCI2, AI2(SO4)3 and NH4CI, the most effective Coagulating
Agent for Sb2S3 sol is
(a) Na2SO4 (b) CaCl2 (c) Al2(SO4)3 (d) NH4CL
88. Arrange the given acids in increasing order as per the number of carbons present in them
(P) Capric (Q) Caprylic (R) Caproic (D) Lauric
(a) P<Q<R<S (b) R<Q<P<S (c) R<Q<P<S (d) Q<P<R<S
89. MBO is most closely associated with which theory of work motivation
(a) Equity theory (b) Expectancy theory
(c) Maslow’s need theory (d) Goal setting theory
92. When glucose reacts with bromine water, the main product is
(a) Glucaric acid (b) Glucoronic acid (c) Sorbitols (d) Gluconic acid
Ans c Cl
Cl
95. The mass spectrum of a compound with an approximate MW 137 shows tow equally intense .
peaks at m/z 136 and 138. What does the suggest
(a) The compound is alkyl iodide (b) The compound is alkyl bromide
(c) The compound is alkyl chloride (d) The compound is aryl fluoride
96. According to DPCO what will be the profit percentages that can be gained be retailer
(a) 10 (b) 12 (c) 14 (d) 16
97. As per schedule M, what will be the profit percentages that can be gained by retailer
(a) 150 m2 (b) 60 m2 (c) 30 m2 (d) 25 m2
100. Which of the following pairs does not correctly match in the element and its oxidation number
(a) Oxygen in H2O2;-2 (b) Bromine in Br2; 0
101. In the Reimer-Tiemann reaction……………. Reacts with phenol to give the ortho-formylated
product
(a) Carbene (b) Carbocation (c) Carbanion (d) Free redical
104. Match the following phytochemicals with their source and use
(P) Shatavrin (1) Buckwheat and citrus fruits, strengthens capillary walls
(Q) Resvertatrol (2) Broccoli and cabbage, protects against bladder cancer
(R) Glucosinolates (3) Purple grape, anti inflammatory, anticancer
(S) Rutin (4) Asparagus, galactogogue
(a) P-4, Q-3, R-2, S-1 (b) P-4, Q-2, R-3, S-1
(c) P-3, Q-1, R-4, S-2 (d) P-2, Q-3, R-4, S-1
105. Which RNA polymerase is the only whose product are capped
(a) RNA polymerase I (b) RNA polymerase II
(c) RNA polymerase III (d) RNA pimase
106. Match the scientist awarded with Nobel prize with their contributions
(P) Alexander Fleming (1) GPCR
(Q) Kobilka (2) β-blocker
(R) Banting (3) Penicillin
(S) Black (4) Insulin
(a) P-4, Q-3, R-2, S-1 (b) P-4, Q-2, R-3, S-1
(c) P-3, Q-1, R-4, S-2 (d) P-2, Q-3, R-4, S-1
108. Eugenol is
(a) Monoterpene alcohol (b) Sesquiterpene alcohol
(c) Aliphatic alcohol (d) Phenylpropene
115. In the carbon NMR, in what region of the spectrum does one typically observe carbons which are
part of the aromatic ring
(a) -10-0 ppm (b) 40-60 ppm (c) 80-100 ppm (d) 120-150 ppm
121. What is the renal clearance of a substance, if its concentration in plasma is 10mg, concentration
in urine is 100 mg and urine flow is 2 ml/min
(a) 0.02 ml/min (b) 0.2 ml/min (c) 2ml/min (d) 20 ml/min
125. Condensation of aldehyde (or ketones ) with α-halo ester is presence of zinc metal to give β-
hydroxy-ester is
(a) Reformatsky (b) Dieckmann condensation
(c) Claisen condensation (d) Aldol condensation
Answer 2014
1-b 2-a 3-c 4-d 5-b 6-b 7-d 8-c 9-a 10-c
11-d 12-d 13-d 14-c 15-b 16-d 17-b 18-b 19-a 20-d
21-a 22-b 23-a 24-a 25-b 26-a 27-a 28-d 29-b 30-b
31-c 32-c 33-c 34-d 35-d 36-c 37-b 38-a 39-a 40-d
41-c 42-c 43-c 44-b 45-a 46-b 47-d 48-c 49-b 50-d
51-b 52-b 53-d 54-d 55-a 56-b 57-d 58-b 59-d 60-a
61-a 62-a 63-b 64-a 65-b 66-d 67-c 68-d 69-b 70-a
71-d 72-a 73-c 74-d 75-c 76-d 77-b 78-b 79-c 80-a
81-c 82-b 83-c 84-a 85-b 86-b 87-c 88-b 89-d 90-b
91-a 92-d 93-d 94-c 95-b 96-d 97-d 98-c 99-d 100-a
101-a 102-b 103-d 104-a 105-b 106-c 107-c 108-d 109-b 110-c
111-a 112-b 113-d 114-b 115-d 116-c 117-c 118-d 119-a 120-d
121-d 122-a 123-c 124-d 125-a