India Rising - Scientists Nov2020
India Rising - Scientists Nov2020
India Rising - Scientists Nov2020
INDIA
RISING
Downloaded from http://science.sciencemag.org/ on November 2, 2020
India excels in rocketry and nuclear science but has produced few breakthroughs in other fields.
Now, free of sanctions and swimming in cash, the world’s largest democracy
is gunning for status as a scientific powerhouse
CREDITS: ALL PALLAVA BAGLA EXCEPT BUTTERFLY: LAKSHMI NARAYANAN K./WIKIMEDIA COMMONS; RICE FIELDS: ISTOCKPHOTO.
BANGALORE, INDIA—When A. P. J. Abdul says aerospace engineer K. P. J. Reddy, head of with those of leading nations. In 2008, a land-
Kalam, the father of India’s missile program, IISc’s Laboratory for Hypersonic and Shock mark civilian nuclear pact between India and
COM; FLAG: WIKIMEDIA COMMONS; JANTAR MANTAR ASTRONOMICAL OBSERVATORY: JOERG HACKEMANN/FOTOSEARCH
inaugurated a center of excellence in aero- Wave Research. He walks past a 16-meter- the United States beckoned Indian scientists
dynamics here last November, he emphasized long steel shock tunnel, stops at a lab bench, in strategic sectors to come in from the cold;
how the new facility would boost the nation’s and picks up what looks like an ordinary access to imported precision instruments is
defenses. Indo-Russian missilemaker Brah- medical syringe. It’s outfitted with a “Reddy allowing India to make up ground in areas
Mos Aerospace helped bankroll the center tube”: a shock tunnel writ small that’s capable such as nanotechnology and supercomputing.
at the Indian Institute of Science (IISc) Ban- of generating shock waves traveling at twice Now the government intends to lift all dis-
galore as a testing ground for its next-gen- the speed of sound. Applications abound. One ciplines on a rising tide. At the Indian Sci-
eration BrahMos-II missiles and hypersonic Reddy tube called “Super Bull” boosts the ence Congress in Bhubaneswar last month,
space vehicles. Indeed, after the ceremony, success of livestock artificial insemination by Prime Minister Manmohan Singh pledged
Kalam, the octogenarian former president of slinging sperm deep into the uterus. to hike R&D expenditures dur-
India, urged BrahMos to think grander and
pioneer a reusable hypersonic cruise missile
A micro–Reddy tube delivers DNA
through a nuclear membrane for cell
Online ing the 5-year plan that begins this
spring, from around $3 billion last
that would return after dropping a payload—a transformation. Another is a juicer: sciencemag.org year to $8 billion in 2017. In an
Podcast interview
feat that could rival technology under devel- Aim it at an apple, and shock waves (http://scim.ag/ exclusive interview with Science
opment in the United States. disintegrate pulp while leaving the pod_6071) with co- (see p. 907), Singh explained
In a hangar here on the IISc Bangalore skin intact. “Juice doesn’t get any author Pallava Bagla. how his government plans to
campus, BrahMos projects and other sensi- fresher,” Reddy says. “increase gradually the propor-
tive ventures are hidden behind black cur- Such bench-top derring-do may seem tion of money that is spent on R&D and at the
tains. The military R&D is the center of incongruent with India’s reputation as a cham- same time create a system of incentives which
excellence’s raison d’être and a jewel in pion of Big Science. After the nation’s first will induce the private sector to increase their
the crown of India’s vaunted defense R&D atomic bomb test in 1974, the United States spending on science and technology.”
establishment. But what’s out in the open in and other countries slapped sanctions on India The windfall is meant to turbocharge ini-
the cavernous laboratory is far more reveal- that squeezed its supply of high-tech equip- tiatives under way to create elite research
ing about the rapid development and entre- ment and materials. Over the next 3 decades, institutions, bring expatriate Indian scientists
preneurial spirit of Indian science. India grew an indigenous civilian nuclear home, enrich science education, and equip
“I want to show you our latest invention,” power industry and a space program on par smart new laboratories. Included in this push
is South Asia’s first biosafety level–4 lab to keep pace with his field. Scientific journals for decades, says L. S. Shashidhara, a geneti-
for handling the most dangerous pathogens, took 4 months to arrive by mail. “We were out cist at the Indian Institute of Science Educa-
slated to be up and running at the National of competition before we started,” he says. tion and Research (IISER) in Pune.
Institute of Virology in Pune this spring. Everything was difficult and slow. Mashelkar While basic research and living stan-
“Funding is no longer a constraint. What we waited 6 years for installation of a phone line dards languished, India was pouring massive
once had to do abroad we can now do here,” because he refused to pay an exorbitant fee for resources into two strategic areas: rocketry
says Govindaraju Thimmaiah, a chemist at and nuclear science. The former gave rise to
the Jawaharlal Nehru Centre for Advanced both a sophisticated missile program and a
Scientific Research here. Over the next civilian space program that intends to send
5 years, an estimated $1.2 billion in public a probe to Mars and astronauts into space
funds will be funneled to a new National then onto the moon (see p. 906). India’s early
Science and Engineering Research Board. research on nuclear power, meanwhile, led the
Modeled after the U.S. National Science way to an atomic arsenal.
Foundation, the board is just now getting off India’s first atomic test ignited a nuclear
the ground and is expected to fund its first arms race with China and Pakistan—and
competitive grants this year. “It’s critical turned the nation into a nuclear pariah:
to our future, because it’s run by scientists Western countries banned most
for scientists,” says Raghunath “Ramesh” high-tech exports to India.
Mashelkar, former director general of the Self-reliance promoted techno-
$30 million, 1300-square-meter clean lab researchers who are helping midwife the several months, for instance, to import a
for nanotechnology. It’s instrumented to new lab. All is not flawless: Raghavan 2-centimeter-square piece of ultrathin zir-
the hilt. “Money is not much of a prob- and his colleagues suffer “supply-chain” conia foil for experiments with nanopo-
lem,” says materials scientist Srinivasan delays due to Indian import regulations, rous zirconium. That foil is used in the
Raghavan, one of four IISc Bangalore he says, and a sanctions hangover. It took nuclear industry, and despite the easing
of restrictions, some countries still hesi-
tate to export high-tech equipment and
Ad Astra, With a ‘Uniquely Indian Flavor’ materials to India, says IISc Bangalore’s
S. A. Shivashankar, who got the ball rolling
BANGALORE, INDIA—India’s space program has a bold agenda this year: It aims to launch five on the nanotech lab a decade ago. It will be
rockets and four satellites, all built at home. The Indian Space Research Organisation (ISRO) already fully operational next month and is expected
has 11 remote-sensing satellites in orbit—the largest constellation of civilian eyes in the sky. This to churn out 50 Ph.D. scientists a year.
record puts India securely in the global space club. State-of-the-art facilities are popping up
Part of India’s achievement is to have joined at a modest cost. ISRO’s $1.5 billion annual budget far and wide. Ensuring their smooth opera-
is almost 10 times smaller than NASA’s. But its dreams are not modest. In the coming years, ISRO tion is a challenge, however. “We readily can
plans planetary exploration missions, a reusable launch vehicle, and a program to send astronauts purchase expensive equipment,” Shashid-
into space. “In a very tough economic environment, India remains one of the few countries in the hara says. But he and others are frustrated
world which maintains and even reinforces its space program,” says Jean-Yves Le Gall, chair and CEO over Indian regulations that limit spending
of Arianespace in Paris. “This is absolutely remarkable.” on reagents and other research materials.
government approval, India could orbit a few astronauts for a week, then later send them to the behavior of wasps, “I will be evaluated as if I
moon, Radhakrishnan says. was building a road. They want a report every
The government has approved about $25 million for preliminary studies “to wet our hands” with 3 kilometers.”
technology involved in human space flight, Radhakrishnan says. The big project may run into resis- On the bright side, Indian researchers will
tance. Asked whether this is the right thrust for Indian science, C. N. R. Rao, science adviser to Indian have more opportunities to explain how they
Prime Minister Manmohan Singh, said, “I have nothing against man going anywhere, but I am more are spending their money. Major directions
worried about people on this earth.” In an interview with Science, Singh declined to endorse the in the next 5-year plan include a $350 mil-
human space flight program (see p. 907). lion Neutrino Observatory in Theni—India’s
Radhakrishnan is confident that ISRO’s vision will prevail. “India is poised to soar higher in single largest investment to date in basic
space,” he says. “But it will be done with a uniquely Indian flavor.” –P.B.
Continued on page 909
army of volunteers is building a kind of Wikipedia on TB. Some 5500 par- make it through compound optimization, animal models, preclinical,
ticipants in 130 countries respond to “work packages” posted by OSDD: and, eventually, clinical trials. If you increase your success chances, then
questions on everything from the biology of M. tuberculosis to leads on your overall costs decrease,” says Marc Marti-Renom of the National
drugs; answers are tagged and credited. Center for Genomic Analysis in Barcelona, Spain.
“OSDD is an exciting new approach to drug discovery,” says Melvin OSDD’s iterative approach has identified two drug candidates that
Spigelman, president of the TB Alliance in New York City. “It provides the it has contracted for testing. Under OSDD rules, data from program-
opportunity for virtually a limitless number of scientists to contribute to sponsored clinical trials must be open for all to see—“a clear alterna-
the solution of any given problem.” The Indian government gave OSDD tive,” OSDD states, “to expensive clinical trials conducted in secrecy at
$12 million in seed money; CSIR has requested $200 million over the high costs.” OSDD drugs will be available in the developing world as
next 5 years as the program ramps up for clinical trials and expands to generics, Brahmachari says. “When it comes to health, we need to have a
other neglected diseases such as malaria and leishmaniasis, and possibly balanced view between health as a right and health as business,” he says.
even cancer. “Drug discovery,” Brahmachari says, “is too serious a busi- For TB and other neglected diseases, drug companies might embrace that
ness to be left solely in the hands of pharmaceutical companies.” philosophy. For cancer, all bets are off. –P.B.
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