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    BTG3

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    BTG3

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    of 2

    BACHELOR WITH BIOTECHNOLOGY AS MAJOR

    5TH SEMESTER
    BTG 522J3: Biostatistics and Bioinformatics
    CREDITS: THEORY – 4, INTERNSHIP – 2

     Course Learning Objective: Through this course, students will learn about the
    applications of statistics in life sciences and about essentials of bioinformatics.
     Expected Learning Outcomes: At the end of the course students should be able to;
    ⮚ collect, represent and compute different parameters of data.
    ⮚ establish the relationship between different data variables.
    ⮚ use basic bioinformatics tools.
    ⮚ predict protein structure and make phylogenetic trees.

    Unit – 1 (15 HOURS)


    Sample, Population, sampling techniques (random and non-random). Data collection and its
    representation (Histogram, Bar Chart, Pie chart, Frequency curve). Mean, Median, Mode and
    their comparison. Dispersion (mean deviation, standard deviation and variance, coefficient of
    variance).
    Unit – 2 (15 HOURS)
    Sampling distribution. Confidence intervals. Test of significance: standard error of mean, p-
    value & statistical significance, students’ ‘t’ test, paired and unpaired t test. Chi square test.
    F-test and analysis of variance (null hypothesis, analysis of variance ‘ANOVA’).

    Unit – 3 (15 HOURS)


    Introduction to bioinformatics and its applications. Introduction to biological databases
    (types: sequence, structure, pathway & disease database). Nucleic acid databases (NCBI,
    GenBank, EMBL). Protein databases (PIR, Swiss-Prot, PDB). Sequence similarity, identity
    and homology. Alignment: local and global alignment, pairwise and multiple sequence
    alignments, BLAST, FASTA and CLUSTALW. Introduction of PubMed.

    Unit - 4 (15 hours)


    Reading frames and identification of reading frames. Basics of genome annotation and gene
    identification tools (NCBI genome). Basic idea of phylogenetic trees. Protein structure
    analysis: importance of protein structure determination/prediction. primary structure analysis
    (protparam), secondary structure prediction (JPred, PROSECSC). Introduction to protein

    Page 1 of 2
    motifs and domains (prosite). Tertiary structure prediction methods: homology, threading and
    ab initio. Steps of homology modeling (swiss-model and BHAGEERATH).
    http://www.scfbio-iitd.res.in/bioinformatics/bioinformaticssoftware.htm

    INTERNSHIP (2 CREDITS)

    BOOKS RECOMMENDED
    1. W.W Daniel, Biostatistics: A foundation for analysis in the Health Sciences,
    JohnWiley and Sons.
    2. VB Rastogi, Biostatistics, Medtech
    3. Kulkarni, A.P., Basics of Biostatistics, CBS Publishers & Distributors
    4. Rastogi, Bioinformatics: Methods and Applications: Genomics, Proteomics and Drug
    Discovery, Prentice Hall India Learning Private Limited.
    5. Jin Xiong, Essential Bioinformatics, Cambridge University Press.
    6. Ghosh, Z. and Mallick, B, Bioinformatics – Principles and Applications, Oxford
    University Press.

    Page 2 of 2

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