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    Organic Chemistry Project Aspvjnirin Detailed

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    Jitesh S
    hehe

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    Organic Chemistry Project Aspvjnirin Detailed

    Uploaded by

    Jitesh S
    6 views3 pages
    hehe

    Original Title

    Organic_Chemistry_Project_Aspvjnirin_Detailed

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    © © All Rights Reserved

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    Copyright:

    © All Rights Reserved
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    Download as pdf or txt
    6 views3 pages

    Organic Chemistry Project Aspvjnirin Detailed

    Uploaded by

    Jitesh S
    hehe

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    Exploring Organic Reactions: Synthesis and Analysis of Aspirin

    Objective:
    The objective of this project is to understand the synthesis of aspirin (acetylsalicylic acid) from

    salicylic acid and acetic anhydride. In addition, the project aims to analyze the purity of the

    synthesized aspirin by determining its melting point and comparing it with the theoretical value.

    Introduction:
    Aspirin, or acetylsalicylic acid, is a widely used medication known for its analgesic,

    anti-inflammatory, and antipyretic properties. The synthesis of aspirin involves an esterification

    reaction where salicylic acid is treated with acetic anhydride. Understanding this reaction provides

    insights into organic synthesis and the importance of functional groups in medicinal chemistry.

    Materials:
    - Salicylic acid (2 grams)

    - Acetic anhydride (5 mL)

    - Sulfuric acid (few drops as a catalyst)

    - Ice bath setup

    - Beaker (50 mL)

    - Test tubes

    - Melting point apparatus or capillary tubes

    - Filtration setup (filter paper, funnel)

    - Hot plate

    - Safety goggles and gloves

    - pH indicator paper

    Procedure:
    1. Synthesis of Aspirin:

    - Begin by measuring 2 grams of salicylic acid and placing it into a beaker.

    - Add 5 mL of acetic anhydride to the beaker, and include a few drops of sulfuric acid to act as a

    catalyst.
    - Heat the mixture gently on a hot plate for approximately 10 minutes, ensuring it does not reach

    boiling.

    - Once the reaction is complete, carefully pour the mixture into a beaker filled with ice water. This

    will help precipitate the aspirin.

    - Filter the precipitated aspirin using a filtration setup and wash it with cold water to remove

    impurities.

    2. Purity Analysis:

    - To assess the purity of the synthesized aspirin, measure its melting point using a melting point

    apparatus or capillary tubes.

    - Compare the melting point obtained with the literature value of approximately 135°C for pure

    aspirin to evaluate purity.

    3. pH Test:

    - Use pH indicator paper to determine the acidity of the reaction mixture before and after the

    synthesis. This will provide insight into the reaction environment.

    Results:
    During the experiment, the melting point of the synthesized aspirin was recorded. The obtained

    melting point was compared with the standard melting point to determine the purity of the aspirin.

    Any deviations from the expected value can indicate impurities present in the final product.

    Conclusion:
    The synthesis of aspirin demonstrated fundamental principles of organic chemistry, particularly

    esterification. The experiment highlighted the significance of functional groups in drug synthesis and

    the role of purity assessment. Aspirin remains an important compound in medicinal chemistry,

    illustrating the practical applications of organic synthesis.

    References:
    - Organic Chemistry textbooks focusing on reactions and synthesis.
    - Research articles discussing the medicinal properties of aspirin.

    - Online resources like PubChem for chemical properties and synthesis techniques.

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