Acting 142 Quiz

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Sherry Ball

ACTING

ACTING_142_QUIZ

triptans), herbs and others.Serotonergic psychedelics are agonists not only of the serotonin

5-HT2A receptor but also of the serotonin 5-HT2B receptor and other serotonin receptors.A

potential risk of frequent repeated use of serotonergic psychedelics is cardiac fibrosis and

valvulopathy caused by 5-HT2B receptor activation.However, single high doses or widely

spaced doses (e.g., months) are widely thought to be safe and concerns about cardiac

toxicity apply more to chronic psychedelic microdosing or very frequent use (e.g.,

weekly).Selective 5-HT2A receptor agonists that do not activate the 5-HT2B receptor or

other serotonin receptors, such as 25CN-NBOH, DMBMPP, and LPH-5, have been developed

and are being studied.Selective 5-HT2A receptor agonists are expected to avoid the cardiac

risks of 5-HT2B receptor activation.== Potential therapeutic effects ==

Psychedelic substances which may have therapeutic uses include psilocybin, LSD, and

mescaline.During the 1950s and 1960s, lack of informed consent in some scientific trials on

psychedelics led to significant, long-lasting harm to some participants.Since then, research

regarding the effectiveness of psychedelic therapy has been conducted under strict ethical

guidelines, with fully informed consent and a pre-screening to avoid people with psychosis

taking part.Although the history behind these substances has hindered research into their

potential medicinal value, scientists are now able to conduct studies and renew research

that was halted in the 1970s.Some research has shown that these substances have helped

people with such mental disorders as obsessive-compulsive disorder (OCD), post-traumatic


stress disorder (PTSD), alcoholism, depression, and cluster headaches.It has long been

known that psychedelics promote neurite growth and neuroplasticity and are potent

psychoplastogens.There is evidence that psychedelics induce molecular and cellular

adaptations related to neuroplasticity and that these could potentially underlie therapeutic

benefits.Psychedelics have also been shown to have potent anti-inflammatory activity and

therapeutic effects in animal models of inflammatory diseases including asthma, and

cardiovascular disease and diabetes.== Surrounding culture ==

Psychedelic culture includes manifestations such as psychedelic music, psychedelic art,

psychedelic literature, psychedelic film, and psychedelic festivals.Examples of psychedelic

music would be rock bands like the Grateful Dead, Jefferson Airplane and The Beatles.Many

psychedelic bands and elements of the psychedelic subculture originated in San Francisco

during the mid to late 1960s.== Legal status ==

Many psychedelics are classified under Schedule I of the United Nations Convention on

Psychotropic Substances of 1971 as drugs with the greatest potential to cause harm and no

acceptable medical uses.In addition, many countries have analogue laws; for example, in the

United States, the Federal Analogue Act of 1986 automatically forbids any drugs sharing

similar chemical structures or chemical formulas to prohibited substances if sold for human

consumption.In July 2022, though, under the United States Food and Drug Administration,

the drug psilocybin was on track to be approved of as a treatment for depression, and

MDMA as a treatment for post-traumatic stress disorder.U.S. states such as Oregon and

Colorado have also instituted decriminalization and legalization measures for accessing

psychedelics and states like New Hampshire are attempting to do the same.J.D.Tuccille

argues that increasing rates of use of psychedelics in defiance of the law are likely to result
in more widespread legalization and decriminalization of access to the substances in the

United States (as has happened with alcohol and cannabis).

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