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Prevention Keep away from heat/sparks/open flames/hot surfaces. - No smoking Wear protective gloves/protective clothing/eye protection/face protection Fire In case of fire: Use CO2, dry chemical, or foam for extinction Storage Store in a well-ventilated place. Keep cool Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) None identified
3. Composition/Information on Ingredients Component CAS No Weight % Methyl (R)-(-)-3-hydroxybutyrate 3976-69-0 99
4. First-aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention.
Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention immediately if symptoms occur.
Inhalation Remove to fresh air. Get medical attention immediately if symptoms occur.
Ingestion Clean mouth with water and drink afterwards plenty of water. Get medical attention if symptoms occur.
Most important symptoms and Difficulty in breathing. Symptoms of overexposure may be headache, dizziness, tiredness, effects nausea and vomiting Notes to Physician Treat symptomatically
5. Fire-fighting measures
Suitable Extinguishing Media Water spray. Carbon dioxide (CO 2). Dry chemical. Chemical foam. Water mist may be used to cool closed containers.
Unsuitable Extinguishing Media No information available
Flash Point 71 °C / 159.8 °F
Method - No information available
Autoignition Temperature No information available
Explosion Limits Upper No data available Lower No data available Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available
Specific Hazards Arising from the Chemical
Combustible material. Containers may explode when heated.
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Carbon monoxide (CO). Carbon dioxide (CO2).
Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
NFPA Health Flammability Instability Physical hazards 0 2 0 N/A
6. Accidental release measures
Personal Precautions Ensure adequate ventilation. Use personal protective equipment as required. Remove all sources of ignition. Take precautionary measures against static discharges. Environmental Precautions Should not be released into the environment. See Section 12 for additional Ecological Information.
Methods for Containment and Clean Sweep up and shovel into suitable containers for disposal. Remove all sources of ignition. Up
7. Handling and storage
Handling Wear personal protective equipment/face protection. Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Avoid ingestion and inhalation. Keep away from open flames, hot surfaces and sources of ignition.
Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat, sparks and flame.
8. Exposure controls / personal protection
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Engineering Measures None under normal use conditions. Ensure adequate ventilation, especially in confined areas.
Personal Protective Equipment
Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.
Respiratory Protection No protective equipment is needed under normal use conditions.
Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.
9. Physical and chemical properties
Physical State Liquid Appearance Colorless Odor No information available Odor Threshold No information available pH No information available Melting Point/Range No data available Boiling Point/Range 72 °C / 161.6 °F @ 17 mmHg Flash Point 71 °C / 159.8 °F
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Evaporation Rate No information available
Flammability (solid,gas) Not applicable Flammability or explosive limits Upper No data available Lower No data available Vapor Pressure No information available Vapor Density 4.07 Specific Gravity 1.050 Solubility No information available Partition coefficient; n-octanol/water No data available Autoignition Temperature No information available Decomposition Temperature No information available Viscosity No information available Molecular Formula C5 H10 O3 Molecular Weight 118.13
10. Stability and reactivity
Reactive Hazard None known, based on information available
Stability Stable under normal conditions.
Conditions to Avoid Incompatible products. Keep away from open flames, hot surfaces and sources of ignition.
Hazardous Polymerization Hazardous polymerization does not occur.
Hazardous Reactions None under normal processing.
11. Toxicological information
Acute Toxicity
Product Information No acute toxicity information is available for this product
Component Information Toxicologically Synergistic No information available Products Delayed and immediate effects as well as chronic effects from short and long-term exposure
Irritation No information available
Sensitization No information available
Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.
Component CAS No IARC NTP ACGIH OSHA Mexico
Methyl 3976-69-0 Not listed Not listed Not listed Not listed Not listed (R)-(-)-3-hydroxybutyra te Mutagenic Effects No information available
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STOT - repeated exposure None known
Aspiration hazard No information available
Symptoms / effects,both acute and Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting delayed
Endocrine Disruptor Information No information available
Other Adverse Effects The toxicological properties have not been fully investigated.
12. Ecological information
Ecotoxicity Do not empty into drains.
Persistence and Degradability Persistence is unlikely based on information available.
Bioaccumulation/ Accumulation No information available.
Mobility Will likely be mobile in the environment due to its volatility.
13. Disposal considerations
Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.
14. Transport information
DOT COMBUSTIBLE LIQUID, NOT REGULATED FOR TRANSPORT IN THIS QUANTITY According to 49 CRF §173.150(f)(1), this material should reclassified as NA1993, Combustible Liquid, NOS if it is shipped in bulk.
UN-No NA1993 Proper Shipping Name Combustible liquid, n.o.s. Packing Group III TDG Not regulated IATA Not regulated IMDG/IMO Not regulated 15. Regulatory information United States of America Inventory
Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory
Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed
TSCA 12(b) - Notices of Export Not applicable
International Inventories Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea (KECL).
Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
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Methyl (R)-(-)-3-hydroxybutyrate 3976-69-0 - - 223-610-0 - X X X - KE-24283
U.S. Federal Regulations
SARA 313 Not applicable
SARA 311/312 Hazard Categories See section 2 for more information
CWA (Clean Water Act) Not applicable
Clean Air Act Not applicable
OSHA - Occupational Safety and Not applicable
Health Administration
CERCLA Not applicable
California Proposition 65 This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know Not applicable
Regulations
U.S. Department of Transportation
Reportable Quantity (RQ): N DOT Marine Pollutant N DOT Severe Marine Pollutant N
U.S. Department of Homeland This product does not contain any DHS chemicals. Security
Other International Regulations
Mexico - Grade No information available
16. Other information
Prepared By Regulatory Affairs Thermo Fisher Scientific Email: EMSDS.RA@thermofisher.com
Revision Date 23-Jul-2021
Print Date 23-Jul-2021 Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard replacing the current legislation under 29 CFR 1910.1200 to align with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).
Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
