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    __Sunita_Mane__01_12_2024_11_05_11_PM

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    Patient ID : 011224037 Registration Time : 01-Dec-2024 02:46 PM

    Patient Name : SUNITA MANE Collection Time : 01-Dec-2024 02:46 PM


    Age : 38 Yrs Report Print Time : 01-Dec-2024 04:32 PM
    Gender
    Ref. By Doctor
    : Female
    : SELF
    Sample No *011224037*
    Client Name : Shree Multi Speciality Diagnostic centre - NZ155
    IMMUNO ASSAY
    Test Name Result Unit Bio.Ref.Range
    THYROID FUNCTION TEST
    Triiodothyronine (T3) 113.00 ng/dl 79-165
    CLIA

    Thyroxine (T4) 5.96 ug/dl 5.93-13.29


    CLIA
    TSH (Thyroid Stimulating 1.060 uIU/mL 0.35 - 5.50
    Hormone)
    CLIA

    Interpretation :
    ----Primary malfunction of the thyroid gland may result in excessive (hyper) or below normal (hypo) release of T3 or T4. In addition, as thyroid function is
    directly affected by TSH. Diagnostically, T3 concentration is more sensitive to certain thyroid conditions than T4. While T4 levels are a sensitive (and superior)
    indicator of hypothyroidism, T3 blood levels better define hyperthyroidism.
    The following potential sources of variation should be considered while interpreting thyroid hormone results:
    1)Circadian variation in TSH secretion: peak levels are seen between 2-4 am. Minimum levels seen between 6-10 am. This variation may be as much as 50%
    thus, influence of sampling time needs to be considered for clinical interpretation.
    2)Total T3 and T4 levels are seen to have physiological rise during pregnancy and in patients on steroid treatment.
    3)Circulating forms of T3 and T4 are mostly reversibly bound with Thyroxine binding globulins (TBG), and to a lesser extent with albumin and Thyroid binding
    PreAlbumin. Thus the conditions in which TBG and protein levels alter such as chronic liver disorders, pregnancy, excess of estrogens, androgens, anabolic
    steroids and glucocorticoids may cause misleading total T3, total T4 and TSH interpretations.
    4)T4 may be normal in the presence of hyperthyroidism under the following conditions : T3 thyrotoxicosis, Hypoproteinemia related reduced binding, in
    presence of drugs (eg Phenytoin, Salicylates etc)
    5)Neonates and infants have higher levels of T4 due to increased concentration of TBG
    6)TSH levels may be normal in central hypothyroidism, recent rapid correction of hypothyroidism or hyperthyroidism, pregnancy, phenytoin therapy etc.
    7)TSH values of <0.03 uIU/mL must be clinically correlated to evaluate the presence of a rare TSH variant in certain individuals which is undetected by
    conventional methods.
    8)Presence of Autoimmune disorders may lead to spurious results of thyroid hormones
    9)Various drugs can lead to interference in test results. It is recommended to evaluate unbound fractions, that is free T3 (fT3) and free T4 (fT4) for
    clinic-pathologic correlation, as these are the metabolically active forms. Because T3 concentration in serum changes faster and more markedly than T4, the T3
    level is also an excellent indicator of the ability of the thyroid to respond to both stimulatory and suppressive tests. Under conditions of strong thyroid
    stimulation, the T3 level offers a good correlation. It is especially useful in the differential diagnosis of primary (thyroid) from secondary (pituitary) and tertiary
    (hypothalamus) hypothyroidism. In primary hypothyroidism, TSH levels are significantly elevated, while in secondary and tertiary hypothyroidism, TSH levels
    are low.
    TSH levels During Pregnancy :
    First Trimester :0.1 to 2.5 μIU/mL ; Second Trimester : 0.2 to 3.0 μIU/mL ; Third trimester : 0.3 to 3.0 μIU/mL
    Reference : Carl A.Burtis,Edward R.Ashwood,David E.Bruns. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 5th Eddition. Philadelphia: WB
    Sounders,2012:2170.
    ---------------- END OF REPORT ------------------

    Scan to Validate

    Dr A Sangram Dr.M.H.Sayed
    MBBS,DPB(Pathologist) M.B.B.S & M.D(Path)
    Page 1 of 1
    Reg.No.2014114813 Reg.No.2022/5/6344

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