CYROLITE, ACRYLITE and XT polymers

The worlds most advanced medical acrylics

Product Overview

Evonik offers a range of high-performance polymers and compounds for various medical device applications.

CYROLITE and XT polymer acrylic-based multipolymer compounds are transparent, impact-modified compounds that offer exceptional chemical resistance, high heat deflection temperature, outstanding impact strength, and simple processing.

ACRYLITE MD acrylic polymer is a pure PMMA and ideal for medical diagnostic applications because it offers the highest optical clarity, transparency and UV transmission. ACRYLITE MD is available in several grades including a high-ow grade, making it easy to process into thin-walled moldings or parts with complex designs.

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Applications

CYROLITE applications Luer locks Dialyzer housings Protection caps and covers Blood / plasma separators Collection and specimen vessels Connectors and injection ports Catheter accessories Chest drainage units Valve assemblies Meter housings Flow controls IV and lab filter housings Drip chambers IV adapters Yankauers Inhalation mouthpieces and spacers

XT polymer applications Many applications similar to CYROLITE that require high chemical resistance. Medical packaging competing with PETG Paper and soap dispenser housings Appliance housings Vacuum canisters Food packaging

ACRYLITE MD applications Diagnostic cuvettes Diagnostic test packs Optical sensor view ports Crystallography trays Microfluidics Rotors

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Key Properties
ACRYLITE MD CYROLITE G-20 CYROLITE G-20 HIFLO CYROLITE GS-90 CYROLITE CG-97 CYROLITE Med 2 XT polymer

Impact-modied

(in lms only)

EtO-stable

Gamma / E-beam stable

High ow Superior gamma / E-beam stable Good chemical resistance Superior lipid resistance Superior lipid and alcohol resistance

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Chemical Resistance

All Evonik medical polymers offer resistance to bodily fluids and many chemicals, especially plasticizers. However, for superior chemical resistance, including resistance to alcohol and lipids, CYROLITE CG-97 and CYROLITE Med 2 compounds are in a class of their own.

Lipid Resistance at 1.2 % Strain, 20 Hours, 23 C

140

Alcohol (IPA) Resistance at 0.9 % Strain, 5 Hours, 23 C

160

120

140

100

120

80

% Elongation Retention
G-20 G-20 HIFLO GS-90 CG-97 Med 2 TABS/ MABS Lipid Resistant PC

% Elongation Retention

100

60

80

40

40

20

20

0 G-20 G-20 HIFLO GS-90 CG-97 Med 2 TABS/ MABS Lipid Resistant PC

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Sterilization
Evonik high-performance polymers deliver the highest level of sterilization stability in the industry. All grades of CYROLITE compounds are engineered for applications where gamma or E-beam sterilization is required, as they invariably demonstrate no loss in properties. Every grade offers unique characteristics and a variety of benefits. Parts made from CYROLITE G-20, CYROLITE G-20 HIFLO, and CYROLITE Med 2 initially shift color upon irradiation. The color returns to near normal after four to five weeks. CYROLITE GS-90 and CYROLITE CG-97 are designed specifically for gamma and E-beam sterilized products and may exhibit a very slight color change to a pleasing permanent blue-green tint after irradiation. Medical parts may, therefore, be immediately sent to market after sterilization. Parts made from XT polymer are suitable for EtO sterilization. A color shift occurs upon gamma and E-beam sterilization. Thin walled parts and films only show a very slight color shift.

Sterilization Methods
ACRYLITE MD CYROLITE G-20 CYROLITE G-20 HIFLO CYROLITE GS-90 CYROLITE CG-97 CYROLITE Med 2 XT polymer

EtO-Gas

(in lms only) (in lms only)

Gamma

E-beam

Steam Key: Good

Exceptional

Effects of Gamma Irradiation on Yellowness Index (2.5 Mrads / 25 kGy)

15

10

Yellowness Index

12

15

18

22

25

-5

-10

Days After Irradiation

G-20/G-20 HIFLO GS-90 CG-97 Med 2 TABS/MABS Lipid Resistant PC

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Properties
Bondability CYROLITE and XT polymer acrylic-based multipolymer compounds offer excellent and consistent bonding to PVC tubing and other compatible plastics and are superior to ABS or similar materials. Parts can be solvent or thermal-bonded. Typical bonding solvents are: cyclohexanone (excellent for bonding vinyl), tetrahydrofuran, methyl methacrylate monomer, methyl ethyl ketone and toluene. Cyanoacrylate and UV-curable adhesives are also recommended. It is important to remember that all solvents should be tested for suitability and applicability and should be handled only by qualified persons familiar with their potential hazards.

Welding Evonik medical polymers can be readily welded using high frequency, ultrasonic, vibration, spin or hot plate welding.

Optical properties Transparent Evonik medical polymers offer high light transmission with little haze. They can be easily pigmented or dyed to provide a wide variety of transparent and opaque colors.

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Medical Diagnostics
ACRYLITE MD acrylic polymers are available in two grades that vary according to processing conditions and are well suited for diagnostic applications. ACRYLITE MD L40 has been found to be non-hemolytic, non-cytotoxic, non-pyrogenic, non-sensitizing, and non-mutagenic. Performance formulations offer: Exceptional ultra-violet light transmittance Excellent optical clarity Maximum flow characteristics Good dimensional stability Regulatory compliance for quality control Total cost-of-use advantage over glass ACRYLITE MD polymer Proven UV Transmission Improvement
70

60 ACRYLITE MD L40 polymer ACRYLITE L40 polymer

50

% Transmittance

40

30

20

10

0 260

265

270

275

280

285

290

% Transmittance

Produced to the rigorous standards of production quality control for UV transmittance, ACRYLITE MD polymers offer 87.7% light transmittance at 340 nm critical to insuring consistent measurement response. Along with UV transmittance, ACRYLITE MD polymers offer excellent transparency and cleanliness for maximum visible inspection capabilities exceeding that of other polymers and standard acrylic.

Wavelength (nm)

ACRYLITE MD polymer vs. Competitive Materials

100 90 80 70 60 50 40 30 20 10 0 240 ACRYLITE MD GPPS PC TABS

260

280

300

320

340

360

380

400

420

440

460

480

Wavelength (nm)

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Processability

Evonik medical polymers are easy to injection mold and are readily adaptable to tooling designed for comparable plastics like styrene, vinyl, ABS and polycarbonate. The cycle time in injection molding is excellent, and the regrind can be readily used. All grades offer exceptional ease of processing. CYROLITE Med 2 and CYROLITE G-20 HIFLO compounds show particularly good flow. In addition, CYROLITE GS-90 compound offers excellent processability at low temperatures, and its high flow, as measured by the spiral flow test, is perfect for extremely thin-walled applications and complex multicavity molds. Additional specialty medical grades available from Evonik are CYREX acrylic-polycarbonate alloys and Vu-Stat static dissipative acrylic multipolymer compounds.

Spiral Flow (In) 0.125 Depth, Melt at 450F, Mold at 105F

35 33 31 29 27 25 23 21 19 17 15

Inches

PCTG

TABS

Lipid Resist HIGH CYROLITE CYROLITE CYROLITE CYROLITE PC at 625F FLOW PC G-20 CG-97 Med 2 G-20 at 575F HIFLO

VU-STAT

CYROLITE GS-90

Processing Recommendations for Injection Molding

ACRYLITE MD CYROLITE G-20 175 (80) 400 475 (204 246) 380 460 (193 238) 120 180 (49 82) CYROLITE G-20 HIFLO 175 (80) 380 460 (193 238) 360 460 (182 238) 120 180 (49 82) CYROLITE GS-90 160 (71) 410 470 (210 243) 375 450 (190 232) 120 180 (49 82) CYROLITE CG-97 160 (71) 420 480 (215 249) 410 480 (210 249) 120 180 (49 82) CYROLITE Med 2 160 (71) 420 480 (215 249) 425 480 (218 249) 120 180 (49 82) XT polymer

Drying Temperature F (C) Melt Temperature F (C) Cylinder Temperature F (C) Mold Temperature F (C)

160 (71) 410 470 (210 243) 410 470 (210 243) 80 160 (25 71)

180 (82) 400 475 (204 246) 400 475 (204 246) 120 170 (49 77)

Note: Drying time for ACRYLITE MD, XT polymer, and all CYROLITE grades is three four hours. The optimal melt temperature is the lowest temperature at which the mold is completely lled. For best clarity, use a hot tool with good cooling and temperature control.

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Regulatory Compliance
Evonik products comply with the following Tripartite, ISO 10993-1, USP, and FDA regulations. All medical grades below comply with RoHS requirements, REACH requirements Dec. 2008, are free of REACH-SVHC substances, and are DEHP, Mercury, Latex and BPA free.

Regulatory requirements
ACRYLITE MD L40 CYROLITE G-20 CYROLITE G-20 HIFLO CYROLITE GS-90 CYROLITE CG-97 CYROLITE Med 2 XT polymer

Food contact

4 4
(8RG grade not tested)

USP Class VI

ISO 10993-1 (Tripartite)

Notes: 1 Products meet FDA food contact requirements of 21CFR177.1010 and 21CFR180.22, as appropriate to the specic product and use.
2 3 4

Class VI United States Pharmacopoeia tests for determining the suitability of a plastic material intended for use in fabricating containers or accessories thereto, for parenteral preparations. Indicated products have been found to be non-hemolytic, non-cytotoxic, non-pyrogenic, non-sensitizing, and non-mutagenic when tested following the Tripartite and ISO 10993-1 protocols. In natural and 301 tints only. Others colors not tested.

Technical Support
Evonik Cyros Technical Service Center utilizes a broad range of extrusion, thermoforming, injection molding, and testing equipment for product and process evaluations. Our Technical Service Engineers are available for on-site assistance in customer plants as needed. Visit our TechKnowlogy Center at www.acrylite-polymers.com to access frequently asked questions, physical properties, processing conditions, regulatory compliance information, tips for trouble shooting and more.

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Important: This information and all further technical advice is based on our present knowledge and experience. However, it implies no liability or other legal responsibility on our part, including with regard to existing third party intellectual property rights, especially patent rights. In particular, no warranty, whether express or implied, or guarantee of product properties in the legal sense is intended or implied. We reserve the right to make any changes according to technological progress or further developments. The customer is not released from the obligation to conduct careful inspection and testing of incoming goods. Performance of the product described herein should be veried by testing, which should be carried out only by qualied experts in the sole responsibility of a customer. Reference to trade names used by other companies is neither a recommendation, nor does it imply that similar products could not be used. CYROLITE, XT, ACRYLITE, CYREX and Vu-Stat are registered trademarks of Evonik Cyro LLC.

Americas Evonik Cyro LLC 379 Interpace Parkway Parsippany, NJ 07054 USA tel: +1 800-631-5384 email: cyrolite@evonik.com www.acrylite-polymers.com www.cyrolite.com

Europe Evonik Rhm GmbH Kirschenallee 64293 Darmstadt Germany email: plexiglas.polymers@evonik.com www.plexiglas.de www.evonik.com

Asia Pacific Evonik Degussa Shanghai Co. Ltd. 55 Chundong Road Xinzhuang Industrial Park Shanghai 201108 tel: +8621-61191000, ext. 1380 or 1393 email: cyrolite@evonik.com www.cyro.com www.cyrolite.com

3578B-0110-1BRp10-11cyro

2010 Evonik Cyro LLC. All Rights Reserved.