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    4th Lecture On Nerve Physiology by Dr. Roomi

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    Mudassar Roomi
    This document summarizes key concepts from a lecture on nerve physiology: 1) Nerve fibers can conduct impulses in either direction, termed orthodromic or antidromic conduction. Orthdromic conduction is from synapses along axons, while antidromic fails at the first synapse. 2) Properties of nerve fibers include excitability, conductivity, refractory periods, and the all-or-none principle. 3) Stimulating a nerve trunk produces a compound action potential with multiple peaks, due to varied conduction velocities of myelinated and unmyelinated fibers.

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    4th Lecture On Nerve Physiology by Dr. Roomi

    Uploaded by

    Mudassar Roomi
    333 views8 pages
    This document summarizes key concepts from a lecture on nerve physiology: 1) Nerve fibers can conduct impulses in either direction, termed orthodromic or antidromic conduction. Orthdromic conduction is from synapses along axons, while antidromic fails at the first synapse. 2) Properties of nerve fibers include excitability, conductivity, refractory periods, and the all-or-none principle. 3) Stimulating a nerve trunk produces a compound action potential with multiple peaks, due to varied conduction velocities of myelinated and unmyelinated fibers.

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    This document summarizes key concepts from a lecture on nerve physiology: 1) Nerve fibers can conduct impulses in either direction, termed orthodromic or antidromic conduction. Orthdromic conduction is from synapses along axons, while antidromic fails at the first synapse. 2) Properties of nerve fibers include excitability, conductivity, refractory periods, and the all-or-none principle. 3) Stimulating a nerve trunk produces a compound action potential with multiple peaks, due to varied conduction velocities of myelinated and unmyelinated fibers.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    333 views8 pages

    4th Lecture On Nerve Physiology by Dr. Roomi

    Uploaded by

    Mudassar Roomi
    This document summarizes key concepts from a lecture on nerve physiology: 1) Nerve fibers can conduct impulses in either direction, termed orthodromic or antidromic conduction. Orthdromic conduction is from synapses along axons, while antidromic fails at the first synapse. 2) Properties of nerve fibers include excitability, conductivity, refractory periods, and the all-or-none principle. 3) Stimulating a nerve trunk produces a compound action potential with multiple peaks, due to varied conduction velocities of myelinated and unmyelinated fibers.

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    Nerve physiology

    4rd lecture
    By Dr. Mudassar Ali Roomi (MBBS, M. Phil)

    January 31, 2013

    ORTHODROMIC & ANTIDROMIC CONDUCTION


    An axon can conduct in either direction. In vitro, when an action potential is initiated in the middle of nerve fiber, two impulses travel in opposite directions. In the natural situation, impulses pass in one direction only, i.e. from synaptic junctions or receptors along axons to their termination. Such a conduction is called orthodromic conduction. Conduction in the opposite direction is called antidromic conduction. Because synapses, unlike axons, permit conduction in one direction only, an antidromic impulse will fail to pass the first synapse they encounter and die out at that point (law of forward conduction).

    January 31, 2013

    Properties of nerve fibers


    Nerve fiber has many properties: 1. Excitability: The units of excitability are:
    Rheobase Chronaxie

    2. Conductivity i.e. propagation of nerve impulse 3. Refractory period 4. All or none law (all or nothing principle)
    January 31, 2013 3

    biphasic action potential


    If both electrodes are placed on the surface of the axon, there is no potential difference between them at rest. When the nerve is stimulated and an impulse is conducted past the two electrodes, a characteristic sequence of potential changes results. As the wave of depolarization reaches the electrode nearest the stimulator, this electrode becomes negative relative to the other electrode. When the impulse passes to the portion of the nerve between the two electrodes, the potential returns to zero, and then, as it passes the second electrode, the first electrode becomes positive relative to the second. This sequence is called a biphasic action potential.

    January 31, 2013

    COMPOUND ACTION POTENTIAL


    It is the multi peaked action potential recorded from a nerve trunk. If we stimulate a nerve trunk like sciatic nerve the record obtained consists of multiple peaks. A nerve trunk is composed of large number of nerve fibers. Some are myelinated and some are unmyelinated. So, there is variable velocity of conduction.
    January 31, 2013 5

    COMPOUND ACTION POTENTIAL (cont)


    The recording electrode will record the action potential first from the fastest fiber and then from slow fibers leading to multipeaked record formation. 3 main peaks: A, B, C. A peak is further divided into alpha, beta, gamma, delta. A & B types are myelinated & C type is unmyelinated. Compound action potential is basis of physiological classification of nerve fibers.

    January 31, 2013

    Electrophysiologic classification of nerve fibers

    January 31, 2013

    Sensory classification of nerve fibers

    January 31, 2013

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