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    Penis

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    Wira Dharma
    This document summarizes common pathologies of the male genital tract, including the penis. It describes congenital abnormalities like hypospadias and phimosis. Inflammation of the penis can be caused by specific infections from STDs or non-specific infections. Benign tumors include condyloma acuminatum caused by HPV. Rare giant condylomas can be locally invasive. Pre-cancerous conditions like carcinoma in situ and early invasive squamous cell carcinoma are also discussed.

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    Penis

    Uploaded by

    Wira Dharma
    98 views23 pages
    This document summarizes common pathologies of the male genital tract, including the penis. It describes congenital abnormalities like hypospadias and phimosis. Inflammation of the penis can be caused by specific infections from STDs or non-specific infections. Benign tumors include condyloma acuminatum caused by HPV. Rare giant condylomas can be locally invasive. Pre-cancerous conditions like carcinoma in situ and early invasive squamous cell carcinoma are also discussed.

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    1. Penis

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    This document summarizes common pathologies of the male genital tract, including the penis. It describes congenital abnormalities like hypospadias and phimosis. Inflammation of the penis can be caused by specific infections from STDs or non-specific infections. Benign tumors include condyloma acuminatum caused by HPV. Rare giant condylomas can be locally invasive. Pre-cancerous conditions like carcinoma in situ and early invasive squamous cell carcinoma are also discussed.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    98 views23 pages

    Penis

    Uploaded by

    Wira Dharma
    This document summarizes common pathologies of the male genital tract, including the penis. It describes congenital abnormalities like hypospadias and phimosis. Inflammation of the penis can be caused by specific infections from STDs or non-specific infections. Benign tumors include condyloma acuminatum caused by HPV. Rare giant condylomas can be locally invasive. Pre-cancerous conditions like carcinoma in situ and early invasive squamous cell carcinoma are also discussed.

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    The document discusses the normal anatomy and pathology of the male genital tract, with a focus on abnormalities, inflammation, and tumors of the penis.

    Some common congenital abnormalities discussed are hypospadias, epispadias, and phimosis. Hypospadias is when the urethral opening is on the ventral side of the penis. Epispadias is when it is on the dorsal side. Phimosis is when the foreskin cannot be retracted due to its small opening size.

    Some common inflammatory conditions discussed are balanoposthitis (inflammation of the glans penis and foreskin) which can be caused by both infectious and non-infectious etiologies. Specific infections mentioned include syphilis, gonorrhea, and herpes.

    PATHOLOGY OF MALE GENITAL TRACT

    1. Penis 2. Tunica vaginalis and funiculus spermaticus 3. Testis and epididimis 4. Prostate

    PATHOLOGY OF PENIS

    PATHOLOGY OF PENIS

    Congenital Inflammation Tumor/Neoplasm

    Normal
    Corpus - 2 corpus cavernosum lateral and 1 corpus spongiosum medial contains urethra. - All corpus are connected by fibrous (tunica albuginea) - Covered by skin, in distal forms glans penis - Corpus cavernosum is an erectil organ, able to enlarge and hard when contains blood. Originated from tuberculum genitalis and urethral folds formed a part of urethra.
    4

    Congenital

    Hypospadia and Epispadia


    Hypospadia: urethra has orifisium in ventral penis (the commonest) Epispadia: uretra has orificium in dorsal of penis. An orificium is small risk for urinary tract infection. Usually related to testis descendence and bladder malformation, also other congenital deformities.

    Phymosis - Orifisium preputium is very tiny preputium cannot be pulled back through glans penis, in severe urine obstruction. - Can be caused by trauma or recurrence infection predisposition for secunder infection and carcinoma due to the chronic accumulation of smegma and other debris. - Paraphymosis is abnormal swollen of glans penis due to phymotic preputium that forcefully pulled out to the back through glans penis, causes pain urethral constriction and acute urine retention
    6

    Inflammation
    Inflammation of penis glans and preputium (specific and non-specific infection).
    Specific

    infection:

    syphilis, gonore, ulcus molle (cancroid), granuloma inguinale, limphogranuloma venerium, herpes genitalis, and other STDs (sexually transmitted diseases)
    Balanoposthitis/Non-infection:

    Glans (balanitis) and preputium (posthitis) caused by various microorganisms (staphilococus, streptococus, coliform basil, and seldom by gonococus). In phymosis and wide preputium caused by chronic smegma accumulation.
    7

    Tumor/Neoplasm

    Condyloma acuminatum

    - Benign tumor papillary growth similar to cauliflower caused by HPV (human papilloma virus) particularly type 6 &11. - Usually growth in glans and preputium (urethra, bladder and ureter can be involved) - Sexual contact - Microscopic: Squamous papilloma, acanthosis, hyperkeratosis, papilomatosis, specific feature of HPV is koilocytosis (vacuolisation of cells in stratum spinosum with atypical nuclei)
    8

    Condylomata accuminata

    Condyloma acuminatum. A complex papillary pattern composed of welldifferentiated squamous epithelium is seen. Virus-induced cytopathic changes are not particularly prominent in this case, probably because of the longstanding nature of the lesion.

    10

    Condylomata accuminata

    11

    Giant

    condyloma

    (tumor Busche Lowenstein)


    A big exophitic lesion, involving and damage some parts of penis - Caused by infection of HPV (human papilloma virus) types 6 and 11. - Local invasive, always recurrence - Microscopic: very similar to the verucous type of squamous cell (verucous carcinoma) Some experts the both lesions are similar
    -

    12

    Buschke Lwenstein

    13

    Penile cancer - Location

    14

    Carsinoma insitu

    A limited malignancy in epithel, no invasion . - variants: Bowens disease, erithroplasia queyrat, papulosis bowenoid Bowen disease: greyish spot thicken on corpus of penis. Micr: atypical superficial epithelial, lost of epithelial maturation.

    10% cases invasive squamous cell carcinoma possibility related to malignancy in visceral organs. Papulosis Bowenoid Pigmented papullar lesion on external genital. Macroscopically similar to condyloma. Microscopic: cannot be distinguished from bowens disease, in many cases sequences of DNA HPV type 16 were found.
    15

    Fig. 18.130 Squamous cell carcinoma in situ (Bowens disease) of penis. There is full-thickness atypia, with pleomorphism and high mitotic activity.

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    Bowenoid lesion

    17

    Squamous Cell carcinoma

    - 1% of all cancers in men. - Prevalency is higher in those without circumsition. - Could be achieved 10% in several Asian countries.

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    Penile cancer

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    Fig. 18.132 Outer aspect and cut surface of squamous cell carcinoma of penis showing a papillomatous pattern of growth.

    20

    Squamous cell carcinoma of penis

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    Fig. 18.140 Squamous cell carcinoma of penis with spindle cell (sarcomatoid) features. There is a blending of the carcinoma islands with the sarcoma-like component.

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    Penile cancer Natural history

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