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    Anemia UPH

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    Yeni
    The blood smear is helpful for diagnosing the type of anemia by identifying red blood cell abnormalities. The mean corpuscular volume (MCV) confirms smear findings about cell size, such as microcytic, macrocytic, or normocytic. The mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) are less diagnostic. Red cell distribution width (RDW) and MCV from automated counting help classify anemia based on cell morphology. Megaloblastic anemias are characterized by megaloblasts in bone marrow and macrocytes in blood, usually due to folate or vitamin B12 deficiency.

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    Anemia UPH

    Uploaded by

    Yeni
    55 views24 pages
    The blood smear is helpful for diagnosing the type of anemia by identifying red blood cell abnormalities. The mean corpuscular volume (MCV) confirms smear findings about cell size, such as microcytic, macrocytic, or normocytic. The mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) are less diagnostic. Red cell distribution width (RDW) and MCV from automated counting help classify anemia based on cell morphology. Megaloblastic anemias are characterized by megaloblasts in bone marrow and macrocytes in blood, usually due to folate or vitamin B12 deficiency.

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    The blood smear is helpful for diagnosing the type of anemia by identifying red blood cell abnormalities. The mean corpuscular volume (MCV) confirms smear findings about cell size, such as microcytic, macrocytic, or normocytic. The mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) are less diagnostic. Red cell distribution width (RDW) and MCV from automated counting help classify anemia based on cell morphology. Megaloblastic anemias are characterized by megaloblasts in bone marrow and macrocytes in blood, usually due to folate or vitamin B12 deficiency.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    55 views24 pages

    Anemia UPH

    Uploaded by

    Yeni
    The blood smear is helpful for diagnosing the type of anemia by identifying red blood cell abnormalities. The mean corpuscular volume (MCV) confirms smear findings about cell size, such as microcytic, macrocytic, or normocytic. The mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) are less diagnostic. Red cell distribution width (RDW) and MCV from automated counting help classify anemia based on cell morphology. Megaloblastic anemias are characterized by megaloblasts in bone marrow and macrocytes in blood, usually due to folate or vitamin B12 deficiency.

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    R.

    Dina Garniasih

    Blood Smear
    The blood smear is very helpful in the diagnosis of

    anemia. It establishes whether the anemia is hypochromic, microcytic, normocytic, macrocytic or shows specific morphologic abnormalities suggestive of red cell membrane disorders (e.g., spherocytes, stomatocytosis or elliptocytosis) or hemoglobinopathies (e.g. Sickle cell disease, thalassemia).

    The mean corpuscular volume (MCV) confirms the

    findings on the smear with reference to the red cell size, e.g., microcytic (,70fl), macrocytic (.85fl) or normocytic (7279fl). The mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) are calculated values and generally of less diagnostic value. The MCH usually parallels the MCV. The MCHC is a measure of cellular hydration status. A high value (.35g/dL) is characteristic ofs pherocytosis and a low value is commonly associated with iron deficiency.

    MCV and red cell distribution width (RDW) indices,

    available from automated electronic blood-counting equipment, are extremely helpful in defining the morphology and the nature of the anemia and have led to a classification based on these indices.

    An Approach to the Diagnosis of Anemia by Examination of the Blood Smear

    Classification of Nature of the Anemia Based on MCV and RDW

    Approach to the Diagnosis of Anemia by MCV and Reticulocyte Count

    Causes of Normoblastic, Megaloblastic and Sideroblastic Bone Marrow Morphology

    R. Dina Garniasih

    Etiologic Classification and Major Diagnostic Features of Anemia Hemolytic

    Etiologic Classification and Major Diagnostic Features of Anemia Hemolytic

    The Clinical Features Suggestive of a Hemolytic Process

    R. Dina Garniasih

    Megaloblastic anemias are characterized by the

    presence of megaloblasts in the bone marrow and macrocytes in the blood. In more than 95% of cases, megaloblastic anemia is as a result of folate and vitamin B12 deficiency. Megaloblastic anemia may also result from rare inborn errors of metabolism of folate or vitamin B12. In addition, deficiencies of ascorbic acid, tocopherol and thiamine may be related to megaloblastic.

    Causes of Megaloblastosis

    Causes of Vitamin B12 Deficiency

    Causes of Folic Acid Deficiency

    Causes of Folic Acid Deficiency

    R. Dina Garniasih

    A variety of systemic illnesses including acute and chronic

    infections, neoplastic diseases, connective tissue disorders and storage diseases are associated with hematologic manifestations. The hematologic manifestations are the result of the following mechanisms: Bone marrow dysfunction Anemia or polycythemia Thrombocytopenia or thrombocytosis Leukopenia or leukocytosis. Hemolysis Immune cytopenias Alterations in hemostasis Acquired inhibitors to coagulation factors Acquired von Willebrand disease Acquired platelet dysfunction. Alterations in leukocyte function.

    Pathophysiology of Anemia of Chronic Disease

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