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    Michael Jacksons Case

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    Rachel Blevins
    - Jackson's body was autopsied by the LA County coroner who found no evidence of trauma. The official cause of death was ruled a homicide from a combination of drugs, notably the anesthetic propofol and the anti-anxiety drug lorazepam. - A second, private autopsy revealed that Jackson was in relatively good health for his age, though he had some lung inflammation and weighed 136 pounds. His other organs were normal. - Propofol is a short-acting intravenous hypnotic agent used for anesthesia induction and maintenance. It is highly protein-bound and metabolized in the liver, with an elimination half-life of 2-24 hours but much shorter clinical effects.

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    Michael Jacksons Case

    Uploaded by

    Rachel Blevins
    70 views10 pages
    - Jackson's body was autopsied by the LA County coroner who found no evidence of trauma. The official cause of death was ruled a homicide from a combination of drugs, notably the anesthetic propofol and the anti-anxiety drug lorazepam. - A second, private autopsy revealed that Jackson was in relatively good health for his age, though he had some lung inflammation and weighed 136 pounds. His other organs were normal. - Propofol is a short-acting intravenous hypnotic agent used for anesthesia induction and maintenance. It is highly protein-bound and metabolized in the liver, with an elimination half-life of 2-24 hours but much shorter clinical effects.

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    - Jackson's body was autopsied by the LA County coroner who found no evidence of trauma. The official cause of death was ruled a homicide from a combination of drugs, notably the anesthetic propofol and the anti-anxiety drug lorazepam. - A second, private autopsy revealed that Jackson was in relatively good health for his age, though he had some lung inflammation and weighed 136 pounds. His other organs were normal. - Propofol is a short-acting intravenous hypnotic agent used for anesthesia induction and maintenance. It is highly protein-bound and metabolized in the liver, with an elimination half-life of 2-24 hours but much shorter clinical effects.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    70 views10 pages

    Michael Jacksons Case

    Uploaded by

    Rachel Blevins
    - Jackson's body was autopsied by the LA County coroner who found no evidence of trauma. The official cause of death was ruled a homicide from a combination of drugs, notably the anesthetic propofol and the anti-anxiety drug lorazepam. - A second, private autopsy revealed that Jackson was in relatively good health for his age, though he had some lung inflammation and weighed 136 pounds. His other organs were normal. - Propofol is a short-acting intravenous hypnotic agent used for anesthesia induction and maintenance. It is highly protein-bound and metabolized in the liver, with an elimination half-life of 2-24 hours but much shorter clinical effects.

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    BY

    GIANI SUKARNI
    0911013154
    PHARMACY FACULTY
    ANDALAS UNIVERSITY

    Jackson's body was flown by helicopter to the Los Angeles
    Coroner's offices in Lincoln Heights, where on June 26 a
    three-hour autopsy was performed on behalf of the Los
    Angeles County Coroner by the chief medical examiner,
    Lakshmanan Sathyavagiswaran.
    [
    Jackson's family arranged
    for a second autopsy, a practice that could yield expedited
    albeit limitedresults.


    Autopsies


    After the preliminary autopsy was completed, Craig Harvey,
    chief investigator for the coroner's office, said there was no
    evidence of trauma or foul play. On August 28, the LA County
    Coroner made an official statement classifying Jackson's
    death as a homicide. The county coroner stated that Jackson
    died from the combination of drugs in his body, with the most
    significant drugs being the anesthetic propofol and the
    anxiolytic lorazepam.


    Less significant drugs found in Jackson's body were midazolam,
    diazepam, lidocaine and ephedrine. The coroner is keeping the
    complete toxicology report private, as requested by the police
    and district attorney.
    [
    On October 1, the BBC reported that the
    autopsy report revealed that Jackson was "fairly healthy" for
    his age and that his heart was strong.

    The document stated that Jackson's most significant health
    problem was his chronically inflamed lungs, but this did not
    contribute to his death.
    His other major organs were normal and he had no
    atherosclerosis except for some slight plaque accumulation in
    his leg arteries. The autopsy stated that he weighed 136
    pounds (62 kg) with a height of 5'9" (175 cm), which equates
    to a BMI of 20.1 .

    Fox News said that this confirmed rumors that Jackson
    was emaciated,
    [
    while the Associated Press stated that
    his weight was in the acceptable range. The autopsy
    also revealed that Jackson's arms were covered with
    punctures and his face and neck were scarred. He was
    balding and had worn a wig for the last decade of his
    life. A tattooed hairline was found on his scalp


    Propofol (INN, marketed as Diprivan by AstraZeneca) is a
    short-acting, intravenously administered hypnotic agent. Its
    uses include the induction and maintenance of general
    anesthesia, sedation for mechanically ventilated adults, and
    procedural sedation. Propofol is also commonly used in
    veterinary medicine. Propofol is approved for use in more
    than 50 countries, and generic versions are available.

    Propofol


    Propofol is highly protein-bound in vivo and is
    metabolised by conjugation in the liver
    Its rate of clearance exceeds hepatic blood flow,
    suggesting an extrahepatic site of elimination as well.
    The half life of elimination of propofol has been
    estimated at between 2 and 24 hours.

    Pharmacokinetics Of Propofol



    However, its duration of clinical effect is much
    shorter, because propofol is rapidly distributed into
    peripheral tissues.
    When used for IV sedation, a single dose of propofol
    typically wears off within minutes. Propofol is
    versatile; the drug can be given for short or
    prolonged sedation as well as for general anesthesia.
    Its use is not associated with nausea as is often seen
    with opioid medications. These characteristics of
    rapid onset and recovery along with its amnestic
    effects
    [24]
    have led to its widespread use for sedation
    and anesthesia.

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