Thyroid Disorders

Khalid Al-Shali MBBS, MSc, FRCP(C), FACP

Assistant Professor, Department of Medicine
Introduction
Thyroid disorders:
Hypothyroidism
Hyperthyroidism and
thyrotoxicosis
Graves disease
Thyroiditis
Toxic adenoma
Toxic multinodular
goitre
Thyrotoxicosis factitia
Struma ovarii
Hydatidiform mole
TSH-secreting pituitary
adenoma


Nontoxic goitre
Thyroid nodules & thyroid
cancer
Benign thyroid nodules
Thyroid cancer
Papillary carcinoma
Follicular carcinoma
Medullary carcinoma
Anaplastic carcinoma
Lymphoma
Cancer metastatic to
the thyroid

Hypothyroidism
Etiology:
Primary:
Hashimotos thyroiditis with or without goitre
Radioactive iodine therapy for Graves disease
Subtotal thyroidectomy for Graves disease or nodular goitre
Excessive iodine intake
Subacute thyroiditis
Rare causes
Iodide deficiency
Goitrogens such as lithium; antithyroid drug therapy
Inborn errors of thyroid hormone synthesis
Secondary: Hypopituitarism
Tertiary: Hypothalamic dysfunction (rare)
Peripheral resistance to the action of thyroid hormone
Hypothyroidism
Clinical features
Cardiovascular signs:
Bradycardia
Low voltage ECG
Pericardial effusion
Cardiomegaly
Hyperlipidemia
Constipation, ascites
Weight gain
Cold intolerance
Rough, dry skin
Puffy face and hands
Hoarse, husky voice
Yellowish color of skin due to
reduced conversion of carotene
to vitamin A
Respiratory failure
Menorrhagia, infertility, hyper-
prolactinemia

Renal function:
Impaired ability to excrete a
water load
Anemia:
Impaired Hb synthesis
Fe deficiency due to:
Menorrhagia
Reduced intestinal absorption
Folate def. due to impaired
intestinal absorption
Pernicious anemia
Neuromuscular system:
Muscle cramps, myotonia
Slow reflexes
Carpal tunnel syndrome
CNS symptoms:
Fatigue, lethargy, depression
Inability to concentrate
Hypothyroidism
Diagnosis:
A iFT4 and hTSH is diagnostic of primary hypothyroidism
Serum T3 levels are variable (maybe in normal range)
+ve test for thyroid autoantibodies (Tg Ab & TPO Ab) PLUS an
enlarged thyroid gland suggest Hashimotos thyroiditis
With pituitary myxedema FT4 will be i but serum TSH will be
inappropriately normal or low
TRH test may be done to differentiate pituitary from hypothalamic
disease. Absence of TSH response to TRH indicates pituitary
deficiency
MRI of brain is indicated if pituitary or hypothalamic disease is
suspected. Need to look for other pituitary deficiencies.
If TSH is h & FT4 & FT3 are normal we call this condition
subclinical hypothyroidism

Hashimotos Thyroiditis
Hashimotos thyroiditis is a commom cause of hypothyroidism
and goitre especially in children and young adults.
It is an autoimmune disease that involves heavy infiltration of
lymphocytes that totally destroys normal thyroidal architecture
Three different autoantibodies are present: Tg Ab, TPO Ab, and
TSH-R Ab (block)
It is familial and may be associated with other autoimmune
diseases such as pernicious anemia, adrenocortical
insufficiency, idiopathic hypoparathyroidism, and vitiligo.
Shmidts syndrome consists of Hashimotos thyroiditis, adrenal
insufficiency, hypoparathyroidism, DM, ovarian failure, and
(rarely) candidal infections.

Hashimotos Thyroiditis
Symptoms & Signs:
Usually presents with goitre in a patient who is euthyroid or has mild
hypothyroidism
Sex distribution: four females to one male
The process is painless
Older patients may present with severe hypothyroidism with only a small,
firm atrophic thyroid gland
Transient symptoms of thyrotoxicosis can occur during periods of
hashitoxicosis (spontaneously resolving hyperthyroidism)
Lab:
Normal or low thyroid hormone levels, and if low, TSH is elevated
High Tg Ab and/or TPO Ab titres
FNA bx reveals a large infiltration of lymphocytes PLUS Hurthle cells
Complications:
Permanent hypothyroidism (occurs in 10-15% of young pts)
Rarely, thyroid lymphoma

Management of Hypothyroidism
Start patient on L-thyroxine 0.05-0.1mg PO OD. L-thyroxine
treats the hypothyroidism and leads to regression of goitre.
If patient is elderly or has IHD start 0.025mg PO OD.
Check TSH level after 4-6 weeks to adjust the dose of L-
thyroxine.
In case of secondary hypothyroidism monitor FT4 instead of
TSH.
Hypothyroidism during pregnancy:
Check TFT every month. L-thyroxine dose requirement tends to go
up as the pregnancy progresses.
If patient has concommitant hyperprolactinemia and
hypercholesterolemia, treat if not normalized after adequate
thyroid replacement.
Myxedema Coma
Medical emergency, end stage of untreated hypothyroidism
Characterized by progressive weakness, stupor, hypothermia,
hypoventilation, hypoglycemia, hyponatremia, shock, and death
The patient (or a family member) may recall previous thyroid disease,
radioiodine therapy, or thyroidectomy
Hx is of gradual onset of lethargy progressing to stupor or coma. A hx
of amenorrhea or impotence with pituitary myxedema
PE reveals iHR and marked hypothermia (as low as 24C)
The pt is usually an obese elderly woman with yellowish skin, a hoarse
voice, a large tongue, thin hair, puffy eyes, ileus, and slow reflexes. An
anterior neck scar may be present. Scanty pubic or axillary hair with
pituitary myxedema
Lab: low FT4, TSH high, normal, or low, cholesterol high or N, serum
Na low
ECG: bradycardia and low voltage
May be ppt by HF, pneumonia, excessive fluid administration, narcotics
Management of Myxedema Coma
Initiate therapy if presumptive clinical diagnosis after TSH, FT3
FT4 drawn. Also draw serum cortisol, ACTH, glucose.
General measures:
Patient should be in ICU setting
Support ventilation as respiratory failure is the major cause of death
in myxedema coma
monitors ABG`s
support blood pressure; hypotension may respond poorly to pressor
agents until thyroid hormone is replaced
hypothermia will respond to thyroxin therapy ; in interim use
passive warming only
hyponatremia will also be corrected by thyroxine therapy in majority
of cases
hypoglycemia requires IV glucose
avoid fluid overload
Management of Myxedema Coma
Specific measure:
L-thyroxine 0.2-0.5 mg IV bolus, followed by 0.1 mg IV OD until oral
therapy is tolerated
Results in clinical response in hours
Adrenal insufficiency may be precipitated by administration of
thyroid hormone therefore hydrocortisone 100 mg IV q 8h is
usually given until the results of the initial plasma cortisol is
known.
Identify and treat the underlying precipitant cause
Graves Disease
Most common form of thyrotoxicosis
May occur at any age but mostly from 20-40
5 times more common in females than in males
Syndrome consists of one or more of the following:
Thyrotoxicosis
Goitre
Opthalmopathy (exopthalmos) and
Dermopathy (pretibial myxedema)
It is an autoimmune disease of unknown cause
15% of pts with Graves have a close relative with the
same disorder

Graves Disease
Pathogenesis:
T lymphocytes become sensitized to Ag within the thyroid gland
and stimulate B lymphocytes to synthesize Ab to these Ag
One such Ab is the TSH-R Ab(stim), which stimulates thyroid cell
growth and function
Graves may be ppt by pregnancy, iodide excess, viral or bacterial
infections, lithium therapy, glucocorticoid withdrawal
The opthalmopathy and dermopathy associated with Graves may
involve lymphocyte cytokine stimulation of fibroblasts in these
locations causing an inflammatory response that leads to edema,
lymphocytic infiltration, and glycosaminoglycans deposition
The tachycardia, tremor, sweating, lid lag, and stare in Graves is
due to hyperreactivity to catecholamines and not due to increased
levels of circulating catecholamines
Graves Disease
Clinical features:
I Eye features: Classes 0-6, mnemonic NO SPECS
Class 0: No signs or symptoms
Class 1: Only signs (lid retraction, stare, lid lag), no symptoms
Class 2: Soft tissue involvement (periorbital edema, congestion
or redness of the conjunctiva, and chemosis)
Class 3: Proptosis (measured with Hertel exopthalmometer)
Class 4: Extraocular muscle involvement
Class 5: Corneal involvement
Class 6: Sight loss (optic nerve involvement)

Graves Disease
Clinical features:
II Goitre:
Diffuse enlargement of thyroid
Bruit may be present
III Thyroid dermopathy (pretibial myxedema):
Thickening of the skin especially over the lower tibia
The dermopathy may involve the entire leg and may extend
onto the feet
Skin cannot be picked up between the fingers
Rare, occurs in 2-3% of patients
Usually associated with opthalmopathy and very hTSH-R Ab



Graves Disease
Clinical features:
IV Heat intolerance
V Cardiovascular:
Palpitation, Atrial fibrillation
CHF, dyspnea, angina
VI Gastrointestinal:
Weight loss, happetite
Diarrhea
VII Reproductive:
amenorrhea, oligo-
menorrhea, infertility
Gynecomastia
VIII Bone:
Osteoporosis
Thyroid acropachy

IX Neuromuscular:
Nervousness, tremor
Emotional lability
Proximal myopathy
Myasthenia gravis
Hyper-reflexia, clonus
Periodic hypokalemic
paralysis
X Skin:
Pruritus
Onycholysis
Vitiligo, hair thinning
Palmar erythema
Spider nevi
Graves Disease
Diagnosis:
Low TSH, High FT4 and/or FT3
If eye signs are present, the diagnosis of Graves disease can be
made without further tests
If eye signs are absent and the patient is hyperthyroid with or
without a goitre, a radioiodine uptake test should be done.
Radioiodine uptake and scan:
Scan shows diffuse uptake
Uptake is increased
TSH-R Ab (stim) is specific for Graves disease. May be a useful
diagnostic test in the apathetic hyperthyroid patient or in the pt
who presents with unilateral exopthalmos without obvious signs or
laboratory manifestations of Graves disease

Treatment of Graves Disease
There are 3 treatment options:
Medical therapy
Surgical therapy
Radioactive iodine therapy
Treatment of Graves Disease
A. Medical therapy:
Antithyroid drug therapy:
Most useful in patients with small glands and mild disease
Treatment is usually continued for 12-18 months
Relapse occurs in 50% of cases
There are 2 drugs:
Neomercazole (methimazole or carbimazole): start 30-40mg/D for
1-2m then reduce to 5-20mg/D.
Propylthiouracil (PTU): start 100-150mg every 6hrs for 1-2m then
reduce to 50-200 once or twice a day
Monitor therapy with fT4 and TSH
S.E.: 5%rash, 0.5%agranulocytosis (fever, sore throat), rare:
cholestatic jaundice, hepatocellular toxicity, angioneurotic edema,
acute arthralgia
Management of Graves disease
A. Medical therapy:
Propranolol 10-40mg q6hrs to control tachycardia,
hypertension and atrial fibrillation during acute phase of
thyrotoxicosis. It is withdrawn gradually as thyroxine levels
return to normal
Other drugs:
Ipodate sodium (1g OD): inhibits thyroid hormone synthesis
and release and prevents conversion of T4 to T3
Cholestyramine 4g TID lowers serum T4 by binding it in the gut

Management of Graves disease
B. Surgical therapy:
Subtotal thyroidectomy is the treatment of choice for patients
with very large glands
The patient is prepared with antithyroid drugs until euthyroid
(about 6 weeks). In addition 2 weeks before the operation
patient is given SSKI 5 drops BID to diminish vascularity of
thyroid gland
Complications (1%):
Hypoparathyroidism
Recurrent laryngeal nerve injury
Management of Graves Disease
C. Radioactive iodine therapy:
Preferred treatment in most patients
Can be administered immediately except in:
Elderly patients
Patients with IHD or other medical problems
Severe thyrotoxicosis
Large glands >100g
In above cases it is desirable to achieve euthyroid state first
Hypothyroidism occurs in over 80% of cases.
Female should not get pregnant for 6-12m after RAI.

Management of Graves Disease
Management of opthalmopathy:
Management involves cooperation between the
endocrinologist and the opthalmologist
A course of prednisone immediately after RAI therapy
100mg daily in divided doses for 7-14 days then on alternate
days in gradually diminishing dosage for 6-12 weeks.
Keep head elevated at night to diminish periorbital edema
If steroid therapy is not effective external x-ray therapy to the
retrobulbar area may be helpful
If vision is threatened orbital decompression can be used


Management of Graves Disease
Management during pregnancy:
RAI is contraindicated
PTU is preferred over neomercazole
FT4 is maintained in the upper limit of normal
PTU can be taken throughout pregnancy or if surgery is
contemplated then subtotal thyroidectomy can be performed
safely in second trimester
Breastfeeding is allowed with PTU as it is not concentrated
in the milk
Toxic Adenoma
(Plummers Disease)
This is a functioning thyroid adenoma
Typical pt is an older person (usually > 40) who has
noted recent growth of a long-standing thyroid nodule
Thyrotoxic symptoms are present but no infiltrative
opthalmopathy. PE reveals a nodule on one side
Lab: low TSH, high T3, slightly high T4
Thyroid scan reveals hot nodule with suppressed
uptake in contralateral lobe
Toxic adenomas are almost always follicular
adenomas and almost never malignant
Treatment: same as for Graves disease
Toxic Multinodular Goitre
Usually occurs in older pts with long-standing MNG
PE reveals a MNG that may be small or quite large
and may even extend substernally
RAI scan reveals multiple functioning nodules in the
gland or patchy distribution of RAI
Hyperthyroidism in pts with MNG can often be ppt by
iodide intake jodbasedow phenomenon.
Amiodarone can also ppt hyperthyroidism in pts with
MNG
Treatment: Same as for Graves disease. Surgery is
preferred.
Subacute Thyroiditis
Acute inflammatory disorder of the thyroid gland most likely due to viral
infection. Usually resolves over weeks or months.
Symptoms & Signs:
Fever, malaise, and soreness in the neck
Initially, the patient may have symptoms of hyperthyroidism with
palpitations, agitation, and sweat
PE: No opthalmopathy, Thyroid gland is exquisitely tender with no signs of
local redness or heat suggestive of abscess formation
Signs of thyrotoxicosis like tachycardia and tremor may be present
Lab:
Initially, T4 & T3 are elevated and TSH is low, but as the disease
progresses T4 & T3 will drop and TSH will rise
RAI uptake initially is low but as the pt recovers the uptake increases
ESR may be as high as 100. Thyroid Ab are usually not detectable in serum

Subacute Thyroiditis
Management:
In most cases only symptomatic Rx is necessary e.g.
acetaminophen 0.5g four times daily
If pain, fever, and malaise are disabling a short course of
NSAID or a glucocorticoid such as prednisone 20mg three
times daily for 7-10 days may be necessary to reduce the
inflammation
L-thyroxine is indicated during the hypothyroid phase of the
illness. 10% of the patients will require L-thyroxine long term
Other Forms of Thyrotoxicosis
Thyrotoxicosis Factitia:
Due to ingestion of excessive amounts of thyroxine
RAI uptake is nil and serum thyroglobulin is low
Struma Ovarii:
Teratoma of the ovary with thyroid tissue that becomes hyperactive
No goitre or eye signs. RAI uptake in neck is nil but body scan
reveals uptake of RAI in the pelvis.
Hydatidiform mole:
Chorionic gonadotropin is produced which has intrinsic TSH-like
activity.
TSH-secreting pituitary adenoma:
FT4 & FT3 is elevated but TSH is normal or elevated
Visual field examination may reveal temporal defects, and CT or
MRI of the sella usually reveals a pituitary tumour.
Thyroid storm (Thyrotoxic crisis)
Usually occurs in a severely hyperthyroid patient caused by a
precipitating event such as:
Infection
Surgical stress
Stopping antithyroid medication in Graves disease
Clinical clues
fever hyperthermia
marked anxiety or agitation coma
Anorexia
tachycardia tachyarrhythmias
pulmonary edema/cardiac failure
hypotension shock
confusion

Thyroid storm (Thyrotoxic crisis)
Initiate prompt therapy after free T4, free T3, and TSH drawn
without waiting for laboratory confirmation.
Therapy
1. General measures:
Fluids, electrolytes and vasopressor agents should be used as
indicated
A cooling blanket and acetaminophen can be used to treat the
pyrexia
Propranolol for betaadrenergic blockade and in addition
causesdecreased peripheral conversion of T4T3 but watch
for CHF.
The IV dose is 1 mg/min until adequate beta-blockade has been
achieved. Concurrently, propranolol is given orally or via NG tube
at a dose of 60 to 80 mg q4h
Thyroid storm (Thyrotoxic crisis)
Therapy
2. Specific Measures:
PTU is the anti-thyroid drug of choice and is used in high doses:
1000 mg of PTU should be given p.o. or be crushed and given via
nasogastric tube, followed by PTU 250mg p.o. q 6h. If PTU
unavailable can give methimazole 30mg p.o. every 6 hours.
One hour after the loading dose of PTU is given give iodide which
acutely inhibits release of thyroid hormone, i.e. Lugols solution 2-3
drops q 8h OR potassium iodide (SSKI) 5 drops q 8h.
Dexamethasone 2 mg IV q 6h for the first 24-48 hours lowers body
temperature and inhibits peripheral conversion of T4-T3
With these measures the patient should improve dramatically in the
first 24 hours.
3. Identify and treat precipitating factor.
Nontoxic Goitre
Enlargement of the thyroid gland from TSH stimulation which in
turn results from inadequate thyroid hormone synthesis
Etiology:
Iodine deficiency
Goitrogen in the diet
Hashimotos thyroiditis
Subacute thyroiditis
Inadequate hormone synthesis due to inherited defect in thyroidal
enzymes necessary for T4 and T3 biosynthesis
Generalized resistance to thyroid hormone (rare)
Neoplasm, benign or malignant
Nontoxic Goitre
Symptoms and Signs:
Thyroid enlargement, diffuse or multinodular
Huge goitres may produce a positive Pemberton sign (facial
flushing and dilation of cervical veins on lifting the arms over the
head) especially when they extend inferiorly retrosternally
Pressure symptoms in the neck with upward or downward
movement of the head
Difficulty swallowing, rarely vocal cord paralysis
Most pts are euthyroid but some are mildly hypothyroid
RAI uptake and scan:
Uptake may be normal, low, or high depending on the iodide pool
Scan reveals patchy uptake with focal areas of increased and
decreased uptake corresponding to hot and cold nodules
respectively
Management of Nontoxic Goitre
L-thyroxine suppressive therapy:
Doses of 0.1 to 0.2mg daily is required
Aim is to suppress TSH to 0.1-0.4 microU/L (N 0.5-5)
Suppression therapy works in 50% of cases if
continued for 1 year
If suppression does not work or if there are
obstructive symptoms from the start then surgery is
necessary
Benign Thyroid Nodules
Thyroid nodules are common especially among older women
Etiology:
Focal thyroiditis
Dominant portion of multinodular goitre
Thyroid, parathyroid, or thyroglossal cysts
Agenesis of a thyroid lobe
Postsurgical remnant hyperplasia or scarring
Postradioiodine remnant hyperplasia
Benign adenomas:
Follicular
Colloid or macrofollicular
Hurthle cell
Embryonal
Rare: Teratoma, lipoma, hemangioma

Thyroid Cancer
Approximate frequency of malignant thyroid tumours
Papillary carcinoma (including mixed papillary
and follicular
75%
Follicular carcinoma 16%
Medullary Carcinoma 5%
Undifferentiated carcinomas 3%
Miscellaneous (e.g. lymphoma, fibrosarcoma,
squamous cell ca, teratoma, & metastatic ca)
1%
Papillary Carcinoma
Usually presents as a nodule that is firm, solitary, cold on
isotope scan, and usually solid on thyroid US
In MNG, the cancer is usually a dominant nodule that is larger,
firmer and different from the rest of the gland
10% of papillary ca present with enlarged cervical nodes
Grows very slowly and remains confined to the thyroid gland
and local lymph nodes for many years.
In later stages they can spread to the lung
Death usually from local disease or lung metastases
May convert to undifferentiated carcinoma
Many of these tumours secrete thyroglobulin which can be used
as a marker for recurrence or metastasis of the cancer

Follicular Carcinoma
Differs from follicular adenoma by the presence of capsular or
vascular invasion
More aggressive than papillary ca and can spread either by
local invasion of lymph nodes or by blood vessel invasion with
distant metastases to bone or lung
Death is due to local extension or to distant bloodstream
metastasis with extensive involvement of bone, lungs & viscera
These tumours often retain the ability to concentrate RAI
A variant of follicular carcinoma is the Hurthle cell carcinoma.
These tumours behave like follicular cancer except that they
rarely take up RAI
Thyroglobulin secretion by follicular carcinoma can be used to
follow the course of the disease
Management of Papillary and
Follicular Carcinoma
Patients are classified into low risk and high risk groups
The low risk group includes patients under age 45 with primary
lesions under 1cm and no evidence of intra- or extraglandular
spread. Lobectomy is adequate therapy for these patients.
All other patients are considered high risk and require total
thyroidectomy. Modified neck dissection is indicated if there is
lymphatic spread.
Surgery is usually followed by RAI ablation therapy
Patient is placed on L-thyroxine suppressive therapy
Regular F/U with thyroglobulin level, thyroid US, whole body
scan etc.

Medullary Carcinoma
A disease of the C cells (parafollicular cells)
More aggressive than papillary or follicular carcinoma but not as
aggressive as undifferentiated thyroid cancer
It extends locally, and may invade lymphatics and blood vessels
Calcitonin and CEA are clinically useful markers for DX and F/U
80% of medullary ca are sporadic and the rest are familial. There are 4
familial patterns:
FMTC without endocrine disease
MEN 2A: medullary ca + pheochromocytoma + hyperparathyroidism
MEN 2B: medullary ca + pheochromocytoma + multiple mucosal neuromas
MEN 2 with cutaneous lichen amyloidosis
The familial syndromes are associated with mutations in the ret proto-
oncogene (a receptor protein kinase gene on chrom. 10)
Dx is by FNA bx. Pt needs to be screened for other endocrine
abnormalities found in MEN 2. Family members need to be screened
for medullary ca and MEN 2 as well.
Undifferentiated (Anaplastic)
Carcinoma
This tumour usually occurs in older patients with a long history
of goitre in whom the gland suddenlyover weeks or months
begins to enlarge and produce pressure symptoms, dysphagia,
or vocal cord paralysis.
Death from massive local extension usually occurs within 6-36
months
These tumours are very resistant to therapy