Journal Reading HIV

Original Article
Impact of hepatitis B virus infection on HIV

response to antiretroviral therapy in a Chinese
antiretroviral therapy center
R. Yang et al. / International Journal of Infectious Diseases 28 (2014) e29e34
dr. Meldy Muzada Elfa

Pembimbing:
dr. Yanri W.S., Sp. PD
Pendahuluan
In China, approximately 700 000 people are infected with HIV in
a population of more than 1.3 billion.1
Chronic hepatitis B (CHB) occurs in about 10% of HIV-infected

individuals.3
Several studies of HIV/HBV co-infected individuals have
examined the short-term response to ART.4
[1UNAIDS/WHO Working Group on Global HIV/AIDS and STI surveillance, 2008.

[3] Yang R, et al, J Acquir Immune Defic Syndr, 48:4912, 2008.
[4] Idoko J et al. Clin Infect Dis ,49:126873, 2009.
Metode (Patient)
The study included patients from a single center and all patients
were screened for HBsAg and hepatitis C virus antibodies
Inklusi:
(1) Initiated ART January 2004-December 2011
(2) Follow-up prospectively until May 2013 or for a maximum of
60 months
(3) Had pre-ART serum samples available for testing
(4) Had a minimum of 12 months of follow-up on ART
(5) Had results of at least three follow-up laboratory tests
available
(6) Were negative for anti-HCV; and
(7) Had not received anti-HBV therapy before ART and/or
during ART other than lamivudine (3TC).
Metode (Patient)
Individuals with or without HBV received a regimen of
stavudine (d4T)/zidovudine (AZT), 3TC, and nevirapine
(NVP)/efavirenz (EFV).
Liver function was tested at baseline, at weeks 2 and 6, and
then every 3 months.
CD4 cell counts were determined at baseline, every 3 months

for the first year, and then every 612 months.
Metode (Laboratory measurements)

HBsAg and anti-HCV were tested with a third-generation
enzyme immunoassay (EIA)
Real-time PCR kits (Shanghai Kehua Biology Company) were

used to test HBV-DNA level s
HIV viral load was determined using NucliSens Easy Q HIV-1
v2.0
The CD4+ T cell count was determined by flow cytometry
Liver function was assessed using an automatic biochemical
analyzer manufactured by Rili Company
Hasil (Patient demographic data)
Hasil (Risk factors associated with ART effect)
Hasil (Baseline characteristics)
Multivariate logistic regression identified HBV co-infection (p = 0.001), baseline CD4 cell
count <200 cells/mm3 (p = 0.021), baseline HIV-RNA >5000 copies/ml (p = 0.027),
elevated liver enzymes (p = 0.031), clinical cirrhosis (p = 0.023), and side effect related
to ART (p = 0.014) as independent risk factors related to ART effect
Hasil (CD4 cell count recovery)
Median CD4+ cell count was lower in the HIV/HBV co-infected subjects compared to the
HIV mono-infected subjects at 3648 months (p = 0.041) and 4960 months (p = 0.037).
Hasil (HIV-RNA suppression)
Proportion of patients with detectable HIV-RNA was higher in HIV/HBV co-infected

subjects after receiving ART for 3748 months (p = 0.002) and 4960 months (p = 0.005).
Proportions of second-line ART usage were 10.9% (60/550) in HIV mono-infected
patients and 12.8% (10/78) in HIV/HBV co-infected patients. All second-line regimens in
this study comprised tenofovir (TDF)3TClopinavir/ritonavir (LPV/r).
Hasil (Hepatotoxicity and other side effects)
Proportion of patients with hepatotoxicity was greater in those with HIV/HBV coinfection than in those with HIV mono-infection
Among the patients using NVP who experienced hepatotoxicity, 30% were switched to
EFV.
Hasil (HBV replication and hepatitis flares)
There were significant differences among multiple groups (p = 0.0001) proportions of

HIV/HBV co-infected subjects with detectable HBV-DNA and hepatitis flares at different
durations of ART
Hasil (Deaths and HBV-related end-stage liver

diseases)
1. Nineteen out of 78 HIV/HBV co-infected subjects (24.4%) died during the
follow-up period, compared with 28 out of 550 HIV mono-infected subjects
(5.1%).
2. A more rapid occurrence of death was observed in HIV/ HBV co-infected
subjects (p = 0.0001)
3. Among the HIV/HBV co-infected subjects, 11 died of liver cirrhosis, three died
of hepatocellular carcinoma (HCC), two died of fulminant hepatitis, two died of
AIDS, and one died of tuberculosis (TB). HBV-related mortality was the most
common cause of death (16/19, 84.2%).
Hasil (Deaths and HBV-related end-stage liver

diseases)
Diskusi
We demonstrated that HBV coinfection increased the risk of ART-related
hepatotoxicity, and HBV related mortality was the most common cause of
death after ART.
Other studies have assessed the impact of hepatitis B on the response to
ART and have reported different findings.
CD4 recovery was poorer and the HIV-RNA levels were higher in patients
with CHB at 48 months post-ART.
Diskusi
CHB is associated with liver enzyme level elevations in ART recipients.
The high rate of hepatotoxicity in those with HBV co-infection is a
challenge during ART
Usage of NVP has been found to be a contributing factor
Another explanation relates to immune recovery inflammatory
syndrome.
A further possible explanation is that some HBV co-infected patients
develop 3TC resistant hepatitis B due to long-term 3TC monotherapy
According to some reports, d4T can induce abnormal liver tests both in
mice and in adult Erythrocebus patas monkeys
Diskusi
Co-infection with HIV and HBV may lead to accelerated hepatic disease
progression with higher rates of liver cirrhosis and liverrelated mortality
compared with HBV mono-infection.
In this study, HBV-related mortality accounted for 84.2% of deaths in the
HIV/HBV co-infected patients.
Despite the advent of ART, liverrelated mortality has become the leading
cause of non-AIDSrelated death in HIV-infected patients in China, whereas
cancer has become the first cause of mortality in Western countries
Kekurangan
1. Since TDF was only used as a second-line regimen in China
before 2012, none of the patients in this study received TDF
therapy.
2. Since NVP was more widely used than EFV due to its
cheaper price in China, we were unable to compare the
differences between NVP and EFV on hepatotoxicity during
ART.
3. HBsAg alone is insufficient to predict hepatotoxicity.
4. Data on alcohol intake, body mass index, TB therapy, and
the use of herbal medications, which are important to
identify the etiology of alanine aminotransferase (ALT)
elevations, were incomplete.
Kesimpulan
This study demonstrates that HBV can affect the long-term
ability to respond to ART in terms of HIV-RNA suppression and
immunological recovery at 48 months post- ART.
Occurrences of hepatotoxicity and mortality were high among
HBV co-infected patients.
Moreover, for HIV/HBV co-infected patients, it is important to
use ART that includes two agents with activity against both
HIV and HBV.
MATUR SEMBAH NUWUN

NYUWUN ASUPANNYA

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Original Article

Impact of hepatitis B virus infection on HIV

dr. Meldy Muzada Elfa

Chronic hepatitis B (CHB) occurs in about 10% of HIV-infected

[1UNAIDS/WHO Working Group on Global HIV/AIDS and STI surveillance, 2008.

CD4 cell counts were determined at baseline, every 3 months

Metode (Laboratory measurements)

Real-time PCR kits (Shanghai Kehua Biology Company) were

Hasil (Patient demographic data)

Hasil (Risk factors associated with ART effect)

Hasil (Baseline characteristics)

Hasil (CD4 cell count recovery)

Hasil (HIV-RNA suppression)

Proportion of patients with detectable HIV-RNA was higher in HIV/HBV co-infected

Hasil (Hepatotoxicity and other side effects)

Hasil (HBV replication and hepatitis flares)

There were significant differences among multiple groups (p = 0.0001) proportions of

Hasil (Deaths and HBV-related end-stage liver

Hasil (Deaths and HBV-related end-stage liver

MATUR SEMBAH NUWUN

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