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    Gastric Cancer: Stephanie Monks BMSC 3211 - Clinical Anatomy Topics

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    1) Gastric cancer, also known as stomach cancer, is the 2nd most common fatal malignancy. 2) Risk factors include H. pylori infection, diet, smoking, older age, male sex, family history, and pernicious anemia. 3) Symptoms are often vague but may include epigastric pain, nausea, vomiting, weight loss, and anemia. Late stage disease is common at presentation.

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    Gastric Cancer: Stephanie Monks BMSC 3211 - Clinical Anatomy Topics

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    steffmo
    224 views15 pages
    1) Gastric cancer, also known as stomach cancer, is the 2nd most common fatal malignancy. 2) Risk factors include H. pylori infection, diet, smoking, older age, male sex, family history, and pernicious anemia. 3) Symptoms are often vague but may include epigastric pain, nausea, vomiting, weight loss, and anemia. Late stage disease is common at presentation.

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    Clinical aspects of gastric cancer

    Original Title

    Gastric Cancer

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    1) Gastric cancer, also known as stomach cancer, is the 2nd most common fatal malignancy. 2) Risk factors include H. pylori infection, diet, smoking, older age, male sex, family history, and pernicious anemia. 3) Symptoms are often vague but may include epigastric pain, nausea, vomiting, weight loss, and anemia. Late stage disease is common at presentation.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    224 views15 pages

    Gastric Cancer: Stephanie Monks BMSC 3211 - Clinical Anatomy Topics

    Uploaded by

    steffmo
    1) Gastric cancer, also known as stomach cancer, is the 2nd most common fatal malignancy. 2) Risk factors include H. pylori infection, diet, smoking, older age, male sex, family history, and pernicious anemia. 3) Symptoms are often vague but may include epigastric pain, nausea, vomiting, weight loss, and anemia. Late stage disease is common at presentation.

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    Download as ppt, pdf, or txt
    of 15

    Gastric Cancer

    Stephanie Monks
    BMSC 3211 – Clinical Anatomy
    Topics
    The Stomach

    • Expanded part of
    gastrointestinal
    tract.
    • Functions
    – Storage and mixing
    – Secretion

    (www.uwgi.org)
    Stomach Cancer

    • Tumour
    – Abnormal swelling
    • 2nd most common fatal malignancy
    • Higher prevalence in Japan, China,
    Columbia and Finland.
    Histopathology

    Adenocarcinoma

    Adenocarcinoma Signet ring cells


    (edcenter.med.cornell.edu) (depalm.med.uth.tmc.edu)
    Risk Factors

    • H pylori infection and Chronic gastritis


    • Lifestyle (Diet or smoking)
    • Older age
    • Male
    • FAP or gastric polyps
    • Family history
    • Pernicious anaemia
    H. Pylori (www.nature.com)
    Signs and Symptoms

    • Pain in epigastrium and palpable mass


    • Nausea and vomiting
    • Anorexia and weight loss
    • Dysphagia
    • Anaemia
    • Signs and symptoms of metastases
    Investigations

    • Blood sample (FBC), faecal occult blood


    test
    • Endoscopy and biopsy
    • Barium Swallow
    • CT
    • Ultrasound scan
    • Laparoscopy
    Endoscopy

    Signet ring (www.endoatlas.com) Ulcerated AC (www.endoatlas.com)


    Barium Swallow

    Irregular luminal narrowing


    (instruct.tri-c.edu)
    CT

    CT of abdomen with
    carcinoma of the cardia
    (Wegener, 1993)
    Investigations

    • Blood sample (FBC), faecal occult blood


    test
    • Endoscopy and biopsy
    • Barium Swallow
    • CT
    • Ultrasound scan
    • Laparoscopy
    Staging
    • T (tumour)
    • N (nodal involvement)
    • M (metastases)

    CT showing
    metastases and
    ascites
    (www.murrasaca.com)
    Treatment

    • Surgery – gastrectomy, stent


    • Chemotherapy
    • Radiotherapy
    • Chemoradiation
    • Biologic therapy
    Conclusion – Gastric Cancer

    • 2nd most common fatal malignancy


    • Various risk factors (H. Pylori, diet, male)
    • Vague symptoms
    • Often present with later stage disease
    • Endoscopy, CT
    • Surgery, chemo, palliative care

    THE END
    References

    • Kumar, P. & Clarke, M. (1999). Clinical Medicine, 4th


    ed., WB Saunders
    • Underwood, J.C.E. (2001). General and Systemic
    Pathology, 3rd ed., Churchill Livingstone
    • Burkitt, H.G. & Quick, C.R.G. (2002). Essential
    surgery, 3rd ed., Churchill Livingstone
    • Sadler, T.W. (2000). Langman’s Medical Embryology,
    8th ed., Lippincott, Williams & Wilkins
    • Wegener, O.H. (1993). Whole body computed
    tomography, 2nd ed., Blackwell Scientific Publications

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