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    Phytoestrogens: - by Deepankar Srigyan

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    Deepankar Srigyan
    Phytoestrogens are plant compounds that can bind to estrogen receptors in the body and have estrogenic or antiestrogenic effects. Major sources of phytoestrogens include soy products, flaxseed, whole grains, fruits and vegetables. Phytoestrogens may help prevent cancer, alleviate menopausal symptoms, prevent osteoporosis, and benefit cardiovascular health. They exert their effects by binding to estrogen receptors and modulating estrogen levels and metabolism.

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    Phytoestrogens: - by Deepankar Srigyan

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    Deepankar Srigyan
    121 views13 pages
    Phytoestrogens are plant compounds that can bind to estrogen receptors in the body and have estrogenic or antiestrogenic effects. Major sources of phytoestrogens include soy products, flaxseed, whole grains, fruits and vegetables. Phytoestrogens may help prevent cancer, alleviate menopausal symptoms, prevent osteoporosis, and benefit cardiovascular health. They exert their effects by binding to estrogen receptors and modulating estrogen levels and metabolism.

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    Phytoestrogens

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    Phytoestrogens are plant compounds that can bind to estrogen receptors in the body and have estrogenic or antiestrogenic effects. Major sources of phytoestrogens include soy products, flaxseed, whole grains, fruits and vegetables. Phytoestrogens may help prevent cancer, alleviate menopausal symptoms, prevent osteoporosis, and benefit cardiovascular health. They exert their effects by binding to estrogen receptors and modulating estrogen levels and metabolism.

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    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    121 views13 pages

    Phytoestrogens: - by Deepankar Srigyan

    Uploaded by

    Deepankar Srigyan
    Phytoestrogens are plant compounds that can bind to estrogen receptors in the body and have estrogenic or antiestrogenic effects. Major sources of phytoestrogens include soy products, flaxseed, whole grains, fruits and vegetables. Phytoestrogens may help prevent cancer, alleviate menopausal symptoms, prevent osteoporosis, and benefit cardiovascular health. They exert their effects by binding to estrogen receptors and modulating estrogen levels and metabolism.

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    Phytoestrogens

    - By Deepankar Srigyan
    Phytoestrogens
     Phytoestrogens, sometimes called "dietary estrogens",
    are a diverse group of naturally occurring nonsteroidal
    plant compounds that, because of their structural similarity
    with estradiol (17-β-estradiol), have the ability to cause
    estrogenic or/and antiestrogenic effects.
     Classification:
    Food Sources of Isoflavones :
    (e.g. of isoflavones - Genistein and Daidzein)

     Soybeans
     Soy meal
     Soy grits
     Soy flour
     Tofu, fermented soy products (miso, etc)
     Soy milk
     Lentils
     Dried beans (haricot, broad, kidney, lima)
     Chickpeas
     Processed foods (lunch meats, meal replacement
    beverages, donuts)
    Food Sources of Lignans :
     Flaxseed
     Whole grain cereals (wheat, wheat germ,
    barley, hops, rye, rice, brans, oats)
     Fruits, vegetables, seeds (cherries, apples,
    pears, stone fruits, sunflower seeds, carrots,
    fennel, onion, garlic)
     Beer from hops, bourbon from corn
    Food Sources of Coumestans :
     Alfalfa sprouts

     Soybean sprouts
    Mechanism of action :
     Phytoestrogens exert their effects primarily through
    binding to estrogen receptors (ER). There are two variants
    of the estrogen receptor, alpha (ER-α) and beta (ER-β)
    and many phytoestrogens display somewhat higher
    affinity for ER-β compared to ER-α.
     In addition to interaction with ERs, phytoestrogens may
    also modulate the concentration of endogenous estrogens
    by binding or inactivating some enzymes, and may affect
    the bioavailability of sex hormones by binding or
    stimulating the synthesis of sex hormone binding
    globuline (SHBG).
     Additional anticarcinogenic effects:
     Aromatase enzyme inhibition
     Antioxidant properties
    Estrogen Receptors :
     ER-α
     Uterus, testis, pituitary, ovary, epididymis, and
    adrenal gland.
     ER-β
     brain, kidney, prostrate, ovary, lung, bladder,
    intestine, and epididymis.
    Phytoestrogens in Human Health :
     Cancer preventive
     Post-menopausal supplement
     Prevention of osteoporosis
     Cardiovascular health
     Fertility (premenopausal)
     Breast enhancement
    Post-menopausal therapy :
     In 2002, the Women’s Health Initiative
    (WHI) trial of estrogen/progestin
    therapy was halted midtrial due to high
    incidence of breast cancer and
    cardiovascular disease.
     Consumption of 30mg/d soy isoflavones
    may reduce hot flushes by 30-50%.
    Prevention of osteoporosis :
     Isoflavone intake increases bone mineral
    density.
     Can be useful in preventing post-
    menopausal osteoporosis.
     Diets rich in phytoestrogens can protect
    long-term bone loss.
    Cardiovascular health :
     Average intake of 47g/day soy protein
    results in 9% decrease in total
    cholesterol,13% decrease in LDL
    cholesterol, and a trend towards HDL
    cholesterol.
     Flavanoids decrease platelet
    aggregation.
    Studies :
     Soy foods plays a protective role on breast
    cancer risk in Asian populations.
    （ Key et al.,1999 ）
     In Western diet, soy consumption is
    infrequently than lignans which are more
    widespread in foods .
    （ De et al.,2001 ）
     Western population have 4-7 times of
    breast cancer rates than Asia.
    （ De et al.,2001 ）
    ... be ambitious!

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