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    Pathophysiology of Jaundice

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    Nathan Vince Cruz
    The document discusses the pathophysiology of jaundice. There are two main types - unconjugated and cholestatic. Unconjugated jaundice occurs when there is inadequate transport or enzyme systems in the liver cells, preventing conjugation of bilirubin and its movement into the bile system. This leads to increased bilirubin levels. Cholestatic jaundice occurs when there is obstruction or damage to the bile capillaries of the liver, preventing bilirubin transport into the small intestine and causing it to re-enter the bloodstream, increasing bilirubin levels. Both types result in hyperbilirubinemia and the classic yellowish discoloration of skin and eyes seen

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    Pathophysiology of Jaundice

    Uploaded by

    Nathan Vince Cruz
    555 views1 page
    The document discusses the pathophysiology of jaundice. There are two main types - unconjugated and cholestatic. Unconjugated jaundice occurs when there is inadequate transport or enzyme systems in the liver cells, preventing conjugation of bilirubin and its movement into the bile system. This leads to increased bilirubin levels. Cholestatic jaundice occurs when there is obstruction or damage to the bile capillaries of the liver, preventing bilirubin transport into the small intestine and causing it to re-enter the bloodstream, increasing bilirubin levels. Both types result in hyperbilirubinemia and the classic yellowish discoloration of skin and eyes seen

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    Pathophysiology of Jaundice

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    The document discusses the pathophysiology of jaundice. There are two main types - unconjugated and cholestatic. Unconjugated jaundice occurs when there is inadequate transport or enzyme systems in the liver cells, preventing conjugation of bilirubin and its movement into the bile system. This leads to increased bilirubin levels. Cholestatic jaundice occurs when there is obstruction or damage to the bile capillaries of the liver, preventing bilirubin transport into the small intestine and causing it to re-enter the bloodstream, increasing bilirubin levels. Both types result in hyperbilirubinemia and the classic yellowish discoloration of skin and eyes seen

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    555 views1 page

    Pathophysiology of Jaundice

    Uploaded by

    Nathan Vince Cruz
    The document discusses the pathophysiology of jaundice. There are two main types - unconjugated and cholestatic. Unconjugated jaundice occurs when there is inadequate transport or enzyme systems in the liver cells, preventing conjugation of bilirubin and its movement into the bile system. This leads to increased bilirubin levels. Cholestatic jaundice occurs when there is obstruction or damage to the bile capillaries of the liver, preventing bilirubin transport into the small intestine and causing it to re-enter the bloodstream, increasing bilirubin levels. Both types result in hyperbilirubinemia and the classic yellowish discoloration of skin and eyes seen

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    Pathophysiology of Jaundice -> Alcoholic stool

    Unconjugated

    Hepatocellular

    Inadequate
    intracellular transport
    or enzyme systems

    Hepatocellular
    injury

    Destruction of red blood cells


    or muscle tissue exceeds
    normal conversion limit

    Movement of
    bilirubin
    diglucoronide into
    Biliary system

    Conjugation of bilirubin into


    bilirubin diglucoronide by
    inadequate intracellular
    transport or enzyme systems

    Cholestatic

    Obstruction/dama
    ge in the hepaticbile capillary
    membrane
    Inability to
    transport bilirubin
    into small
    intestine

    Regurgitation of bile
    pigments into
    bloodstream

    Bilirubin

    Bilirubin

    Bilirubin
    Hyper
    bilirubinemia

    bilirubin
    secretion
    Urobilinoge
    n
    Stercobu
    lin
    Clay/Pale colored stool (Alcoholic
    stool)

    Yellowish
    discoloration of
    the skin/eyes

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