Scribd Logo
Upload

Welcome to Scribd!

  • 25 views

    Coxiella Burnetti: - Gram Negative Coccobacilli

    Uploaded by

    Laxiya
    Coxiella burnetti is an intracellular, gram-negative bacterium that causes Q fever in animals and humans. It can survive for years in dust and soil. Infection occurs through inhalation of the bacterium, which then replicates within monocytes and macrophages in the lungs and spreads hematogenously to other organs. Clinical manifestations vary from asymptomatic to acute or chronic pneumonia, hepatitis, or endocarditis. Diagnosis involves isolation of the organism from tissues or serological testing for antibodies. Treatment is with doxycycline for at least a week for mild cases or a month for endocarditis. Vaccination can help prevent occupational exposure.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Coxiella Burnetti: - Gram Negative Coccobacilli

    Uploaded by

    Laxiya
    25 views6 pages
    Coxiella burnetti is an intracellular, gram-negative bacterium that causes Q fever in animals and humans. It can survive for years in dust and soil. Infection occurs through inhalation of the bacterium, which then replicates within monocytes and macrophages in the lungs and spreads hematogenously to other organs. Clinical manifestations vary from asymptomatic to acute or chronic pneumonia, hepatitis, or endocarditis. Diagnosis involves isolation of the organism from tissues or serological testing for antibodies. Treatment is with doxycycline for at least a week for mild cases or a month for endocarditis. Vaccination can help prevent occupational exposure.

    Original Description:

    Coxiella Burnetti Presentation

    Original Title

    Q Fever

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Coxiella burnetti is an intracellular, gram-negative bacterium that causes Q fever in animals and humans. It can survive for years in dust and soil. Infection occurs through inhalation of the bacterium, which then replicates within monocytes and macrophages in the lungs and spreads hematogenously to other organs. Clinical manifestations vary from asymptomatic to acute or chronic pneumonia, hepatitis, or endocarditis. Diagnosis involves isolation of the organism from tissues or serological testing for antibodies. Treatment is with doxycycline for at least a week for mild cases or a month for endocarditis. Vaccination can help prevent occupational exposure.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    25 views6 pages

    Coxiella Burnetti: - Gram Negative Coccobacilli

    Uploaded by

    Laxiya
    Coxiella burnetti is an intracellular, gram-negative bacterium that causes Q fever in animals and humans. It can survive for years in dust and soil. Infection occurs through inhalation of the bacterium, which then replicates within monocytes and macrophages in the lungs and spreads hematogenously to other organs. Clinical manifestations vary from asymptomatic to acute or chronic pneumonia, hepatitis, or endocarditis. Diagnosis involves isolation of the organism from tissues or serological testing for antibodies. Treatment is with doxycycline for at least a week for mild cases or a month for endocarditis. Vaccination can help prevent occupational exposure.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    You are on page 1of 6

    Coxiella burnetti

    Gram negative coccobacilli


    Intracellular replicates with in the
    host monocytes and macrophages
    Very hardy it can survive in dust and
    soil for years
    Animals get infection like this by
    breathing
    Organism concentrates in
    fetal/placental fluids & tissues
    Morphology
    Has 2 life cycle stages
    Large cell variant is vegetative form
    seen in infected monocytes and
    macrophages
    Small cell variant seen extracellularly
    and is infectious form, this can survive
    exposure to physical and chemical
    disruption.
    Pathogenesis
    Mode of Infection Inhalation
    Proliferation in lungs ,with atypical
    pneumonia
    Haematogenous spread to liver and bone
    marrow, spleen
    Disease varies from asymptomatic to acute
    subacute to chronic or granulamatous
    disease in liver, grow inside phagolysosomes
    T cell mediated granuloma formation
    Clinical Manifestations
    Mild self limiting fever, headache
    ,nausea
    Arthralgia, Myalgia & nonproductive
    cough pulmonary disease,
    meningitis ,pericarditis /endocarditis
    Fever with influenza like syndrome
    Post Q fever chronic fatigue syndrome
    Spontaneous recovery in mild cases
    Diagnosis of Q fever
    1. Isolation of Organism
    2. Serological Testing
    Isolation requires bio safety level 3
    Use of tissue culture ,lab animals and
    embryonated eggs
    Serology is ideal Using phase 1& 2
    antigens
    IgM ELISA ,Indirect immunofluorescence
    PCR
    Treatment & Prevention
    Treatment with tetracycline orally for a
    week
    In case of endocarditis for a month
    Adequate Pasteurization of milk
    Vaccine (formalinized phase 1) to
    prevent occupational exposure

    You might also like