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    Aspirin Toxicity: Hassan Gul

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    This document discusses aspirin toxicity and salicylism. It describes the condition as being produced by excessive intake of salicylic acid or salicylates, marked by ringing in the ears, nausea, and vomiting. Reasons for aspirin overdose include suicide, gaining attention, child abuse, and accidents. The document outlines categories of toxicity based on amount ingested and describes the phases and symptoms of salicylate toxicity.

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    Aspirin Toxicity: Hassan Gul

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    hassan
    206 views12 pages
    This document discusses aspirin toxicity and salicylism. It describes the condition as being produced by excessive intake of salicylic acid or salicylates, marked by ringing in the ears, nausea, and vomiting. Reasons for aspirin overdose include suicide, gaining attention, child abuse, and accidents. The document outlines categories of toxicity based on amount ingested and describes the phases and symptoms of salicylate toxicity.

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    This document discusses aspirin toxicity and salicylism. It describes the condition as being produced by excessive intake of salicylic acid or salicylates, marked by ringing in the ears, nausea, and vomiting. Reasons for aspirin overdose include suicide, gaining attention, child abuse, and accidents. The document outlines categories of toxicity based on amount ingested and describes the phases and symptoms of salicylate toxicity.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    206 views12 pages

    Aspirin Toxicity: Hassan Gul

    Uploaded by

    hassan
    This document discusses aspirin toxicity and salicylism. It describes the condition as being produced by excessive intake of salicylic acid or salicylates, marked by ringing in the ears, nausea, and vomiting. Reasons for aspirin overdose include suicide, gaining attention, child abuse, and accidents. The document outlines categories of toxicity based on amount ingested and describes the phases and symptoms of salicylate toxicity.

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    The key takeaways are that aspirin toxicity or salicylism can occur due to accidental or intentional overdose of aspirin and is characterized by ringing in the ears, nausea, vomiting and other symptoms. It can have acute or chronic effects depending on factors like dosage and patient characteristics.

    There are three phases of salicylate toxicity described based on symptoms. Phase 1 involves hyperventilation and respiratory alkalosis. Phase 2 involves paradoxical aciduria despite respiratory alkalosis. Phase 3 involves dehydration, hypokalemia and metabolic acidosis.

    Salicylate toxicity is categorized based on amount ingested into: less than 150mg/kg (mild), 150-300mg/kg (mild-moderate), 301-500mg/kg (serious) and over 500mg/kg (potentially lethal).

    Aspirin Toxicity

    Hassan Gul
    Reg no: 06331613058
    Pharm-D Course (5th Sem)

    Department of Pharmacy

    5/1/2019
    Quaid-i-Azam University, Islamabad, Pakistan 1
    Aspirin Toxicity - Salicylism

    A toxic condition produced by the excessive intake of salicylic acid or


    salicylates and marked by ringing in the ears, nausea, and vomiting.

    Reasons:
    • Suicide
    • Gaining personal attention
    • Child abuse
    • Accidental

    5/1/2019 https://www.webmd.com/a-to-z-guides/aspirin-poisoning#1 2
    Conc...

    Acute ( >150 mg/kg or >6.5 g ):


    • Often present with known / intentional ingestion
    • Often younger patients without medical problems
    • Co-ingestants are common

    Chronic
    • Often unintentional, older patients, salicylate usually used for chronic
    medical problem
    • Increased mortality
    5/1/2019 https://bestpractice.bmj.com/topics/en-us/1129 3
    Categories of toxicity

    1. Less than 150 mg/kg ingested - Spectrum ranges


    from no toxicity to mild toxicity
    2. From 150-300 mg/kg ingested - Mild-to-moderate
    toxicity
    3. From 301-500 mg/kg ingested - Serious toxicity
    4. Greater than 500 mg/kg ingested - Potentially
    lethal toxicity

    5/1/2019 https://emedicine.medscape.com/article/1009987-overview 4
    Phases and symptoms of salicylate toxicity

    Phase 1: The toxicity is characterized by hyperventilation resulting from


    direct respiratory center stimulation, leading to respiratory alkalosis and
    compensatory alkaluria. Potassium and sodium bicarbonate are excreted in
    the urine. This phase may last as long as 12 hours.
    Phase 2: Paradoxical aciduria in the presence of continued respiratory
    alkalosis occurs when sufficient potassium has been lost from the kidneys.
    This phase may begin within hours and may last 12-24 hours.
    Phase 3: Includes dehydration, hypokalemia, and progressive metabolic
    acidosis. This phase may begin 4-6 hours after ingestion in a young infant or
    24 hours or more after ingestion in an adolescent or adult.

    5/1/2019 https://emedicine.medscape.com/article/1009987-overview 5
    Paradoxical aciduria

    5/1/2019 6
    https://emedicine.medscape.com/article/1009987-overview
    Symptoms to expect

    5/1/2019 http://rebelem.com/salicylate-toxicity/# 7
    Symptoms

    5/1/2019 http://rebelem.com/salicylate-toxicity/# 8
    Mechanism of Acute Aspirin Toxicity

    5/1/2019 https://www.memorangapp.com/flashcards/133597/M+4PHA5+Non-narcotic+analgesic/ 9
    Pathophysiology of Aspirin Overdosage Toxicity

    5/1/2019 https://www.ncbi.nlm.nih.gov/pubmed/364398 10
    Pathophysiology Cont...

    5/1/2019 https://www.ncbi.nlm.nih.gov/pubmed/364398 11
    Aspirin mediated liver and spleen tissue toxicity

    5/1/2019 https://www.researchgate.net/publication/260447735 12

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