Kidney Transplantation: Group 9 Syazwaniyati Nurulasmira Nur Hamiza Siti Nursuhada
Kidney Transplantation: Group 9 Syazwaniyati Nurulasmira Nur Hamiza Siti Nursuhada
Kidney Transplantation: Group 9 Syazwaniyati Nurulasmira Nur Hamiza Siti Nursuhada
TRANSPLANTATION
GROUP 9
SYAZWANIYATI
NURULASMIRA
NUR HAMIZA
SITI NURSUHADA
INTRODUCTION
◦ • Kidney transplant provides better long- term survival
and improved quality of life compared to dialysis.
◦ • Patient survival and transplant success has been
progressively improving over the years.
◦ • Kidney transplant is the treatment of choice for End
Stage Renal Disease (ESRD) in eligible patients.
INDICATION
◦ • ESRD GFR less than 15ml/L.
◦ • MALIGNANCY.
◦ • HYPERTENSION.
◦ • DIABETES MELLITUS.
◦ • GENETIC DISEASES- polycystic kidney diseases.
◦ • METABOLIC DISORDERS.
◦ • CHRONIC RENAL FAILURE (CRF).
CONTRAINDICATIONS
• CARDIAC , HEPATIC AND • Cystoxic antibodies against
PULMONARY HLA antigens of donor.
Insufficiency(severe Extrarenal • Active vasculitis or
Disease) glomerulonephritis.
• Concurrent Tobacco Use • Recent or metastatic
And Morbid Obesity Puts The malignancy
Patient At Risk For Surgery.
• Psychiatric illness including
• HIV.(active infection) alcoholism and drug
• Primary oxalosis. addiction(Noncompliance)
• ABO incompatibility.
BENEFITS
Significantly reduced risk of mortality.
• Life expectancy can triple.
Reduced risk of heart attack, stroke, heart failure.
Reduced infection-related hospitalization.
Improved quality of life.
More likely to stay employed.
RISKS
Acute rejection or failure (less with current meds).
Anti-rejection medication effects:
Infection
Some malignancies, ex/skin cancer.
Increased risk of diabetes,
high blood pressure, high cholesterol.
Graft loss over time.
Overall in eligible candidates, the benefits far outweigh the risks.
THE KIDNEY DONOR
Living – parents, siblings,
Cadaver donor
Matching Recipient & Donor
Highly motivated.
Excellent medical condition with normal renal
function.
ABO blood group-compatible.
HLA-identical or haploidentical with negative cross-
match.
Common Complications of
Transplantation
Early complications Infectious complications
- Surgical complications - Cytomegalovirus
- Delayed or slow graft - BK virus
function Malignancy
- Lymphocele Chronic allograft dysfunction
Acute rejection
- Acute cellular rejection
- Antibody-mediated
rejection
Therapeutic Management
Before surgery
• Assess knowledge and reinforce teaching. Discuss concerns about surgery , the organ
donor and possible complications.
• Provide routine preoperative care
1. Pre-op blood
2. Imaging (CT scan, x-ray, ECG)
3. Consent
4. Social welfare
5. Counselor
After surgery
Complication:
transplant rejection
infection and sepsis
electrolyte imbalances
Iatragenic side effects.