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Laxative: Dean Chen June 4, 2008

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Laxative

Dean Chen
June 4, 2008
Type of laxative
• Bulk-producing agents
• Stool softeners / Surfactants
• Lubricants / Emollient
• Stimulant / Irritant
• Saline (consider a hydrating agent)
Types (continue)
Hydrating agents (osmotics)
• One more :Hyperosmotic agents

• Some Vegetable also consider laxatives


Stool softeners / Surfactants
• Site of Action: Small and large intestine
• Onset of Action: 12 - 72 hours
• Examples: docustate (Colace, Diocto)
• Stool softeners help mix fluid into stools to
soften them. This makes stools easier to pass
out of the body.
colace
• Colace Stool Softener Laxative
Capsules 50 Mg - 30 Each

• Active ingredient Docusate


Sodium (50 mg).
• Dosage form: Capsules
• List Price $11.56
Colace (cont)
• Colace is used for prevention of dry, hard stools.
• DIRECTIONS: Adults and children 12 years and older: 1
to 4 capsules Children 6 to 12 years old: 1 to 2 capsules
• PRECAUTION: The highest dose should be taken until
the first bowel movement; thereafter, a lower dose
should be taken for maintenance. The effect of Colace
on the stools may not be apparent until 1 to 3 days
after the first oral dose.
Hyperosmotic agents

• Site of Action: Colon


• Onset of Action: 0.5 - 3 hours
• Examples: Glycerin suppositories, Sorbitol,
Lactulose, and Polyethylene glycol (PEG).
• PEG found more effective in children than
lactulose
Miralax

• MiraLAX Laxative Powder


7-Day - 4.1 oz (119 g)
• Active ingredient
Polyethylene Glycol 3350,
17 g (cap filled to line).
• Dosage form is powder
• List Price $8.35
Miralax
• Use for bowel movement and constipation
• Fill up to the white line (17g) on the cup
Stir and dissolve in 4 to 8 oz of liquid
Use once a day
• Children under 16 years of age please consult
a doctor before taking it.
• Do not take more than indicated
Bulk-producing agents
• Site of Action: Small and large intestine
• Onset of Action: 12 - 72 hours
• Examples: psyllium husk (Metamucil),
methylcellulose (Citrucel), polycarbophil,
dietary fiber
• How it work: The larger stools help trigger the
bowel to contract and move the stools out.
You must use this daily to be effective
Metamucil (psyllium )

Metamucil Apple Crisp Natural Fiber


Wafers - 24
• The Dosage form is a wafer
• Active Ingredient is Psyllium
husk
• List Price $6.11
Metamucil (cont)
• Use: for daily instake of fiber and gentle
elimination w/0 chemical
• Adult should take 2 wafers with 8 oz of their
faveorite beverage. Child 6 to 12 take 1 wafer
with beverage
• Warning: choking and Allergy alart; should
consult doctor before taking it
Stimulant / Irritant
• Site of Action: Colon
• Onset of Action: 15min to 8 hours depending
the drug
• Example: Senokot , Dulcolax Bowel prep kit
• Stimulant laxatives are the harshest laxatives.
They cause the bowel to squeeze or contract
to move the stools out
Senokot (senna)
• Senokot Tablets - 20
Each
• Active ingredientEach
tablet contains: Purified
Senna (8.6 mg).
• Dosage form is tablet
• List Price $7.81
Senokot (cont)
• Use:Senokot tablets generally produce bowel
movement in 6 to 12 hours.
• Adult take 2 times a day Children under 6 1
tablet a day. It is reommended taking at bedtime
• Should not use for more than 1 week and should
not be taken with GI problems. If bowel
movement persist for more than 2 weeks
consult your doctor
Saline

• Site of Action: Small and large intestine


• Onset of Action: 0.5 - 6 hours
• Saline laxatives draw fluid into the bowel from
nearby tissue. This softens stools and helps
the bowel move them out.
Milk of Magnesia
• Phillips Milk Of Magnesia
Liquid Cherry - 26 Oz
• Liquid dosage form: liquid
• Active ingredient: Teaspoon (5
mL): Magnesium Hydroxide 400
mg.
• List Price $10.14
Milk of Magnesia (cont)
• use: To relieve occasional constipation
• Adults/Children 12 years and older: 2-4
tablespoonful (TBSP) . Children: Children 6-11
years: 1-2 tablespoonsful, .2-5 years: 1-3
teaspoonsful, all age group followed by a full
glass (8 oz.) of liquid Take at bedtime or upon
rising.
• Precaution: Consult doctor before taking. Should
not be use for more than 1 week and should top
taking if GI or allergy problem
Lubricants / Emollient
• Site of Action: Colon
• Onset of Action: 6 - 8 hours
• Example : Glycerin Suppositories, mineral oil

• Lubricant laxatives work by coating the surface


of the stools. This helps the stools hold in
water so they move out of the body more
easily
conclusion
• Contact me at dfc0102@yahoo.com
• You can access the links and the dcoument at
my web site www.deanchen.com

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