Angiotensin Ii Receptor Blockers (ARBS) : Danielle Trisha L. Mallari

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ANGIOTENSIN II

RECEPTOR BLOCKERS
(ARBS)
Danielle Trisha L. Mallari
• Used in the treatment of conditions such as high blood pressure (hypertension), heart
failure, or kidney disease in people with diabetes.
• Angiotensin II receptor blockers (ARBs) help relax your blood vessels, which lowers
your blood pressure and makes it easier for your heart to pump blood.
• ARBs and the similar-attributed ACE inhibitors are both indicated as the first-line
antihypertensives in patients developing hypertension along the left-sided heart
failure. However, ARBs appear to produce less adverse effects compared to ACEs.
MECHANISM OF ACTION:

• Blood vessels supply blood and oxygen to the heart. This constant supply helps the heart
function. Angiotensin II is a made by our body, and it tightens the muscles of our blood
vessels. Angiotensin II also contributes to salt and water retention in our bodies.
Increased salt in the body and tightened blood vessels may cause our blood pressure to
rise. High blood pressure harms blood vessels.
• Both ARBs and ACE inhibitors act on angiotensin II. But while ACE inhibitors limit the
formation of angiotensin II, ARBs block certain receptors of angiotensin II. These
receptors, known as AT1 receptors, are found in the heart, blood vessels, and kidneys.
• When blood vessels tighten, they become narrow. This puts blood under greater pressure
as it’s forced to move through a smaller-than-normal space. When ARBs block angiotensin
II, this reduces the tightening of blood vessels. Blood pressure is then lowered.
EXAMPLES OF ANGIOTENSIN II RECEPTOR
BLOCKERS INCLUDE:
• Azilsartan (Edarbi)
• Candesartan (Atacand)
• Eprosartan
• Irbesartan (Avapro)
• Losartan (Cozaar)
• Olmesartan (Benicar)
• Telmisartan (Micardis)
• Valsartan (Diovan)
USES FOR ANGIOTENSIN II RECEPTOR
BLOCKERS

• Doctors prescribe these drugs to prevent, treat or improve symptoms in various


conditions, such as:
• High blood pressure
• Heart failure
• Kidney failure in diabetes
• Chronic kidney diseases
SIDE EFFECTS AND CAUTIONS

• Few people have side effects when taking angiotensin II receptor blockers. Possible side
effects include:
• Dizziness
• Elevated blood potassium level (hyperkalemia)
• Localized swelling of tissues (angioedema)
• There have been some reports of intestinal problems in those taking olmesartan. Talk to
your doctor if you develop severe diarrhea or lose a lot of weight while taking olmesartan.
• Because angiotensin II receptor blockers can injure a developing fetus, don't take them if
you are pregnant or plan to become pregnant.
GUIDELINES

• ARBs can be taken on an empty or full stomach. Follow the label directions on how
often to take this medication. The number of doses you take each day, the time
allowed between doses, and how long you need to take the medication will depend
on the type of ARB prescribed, as well as your condition.
• • While taking this medication, have your blood pressure and kidney function
checked regularly, as recommended by the doctor.

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