2018 Aha/Acc/Aacvpr/Aapa/Abc/Acpm/Ada/Ags/Apha/Aspc/Nla/Pcna Guideline On The Management of Blood Cholesterol: Executive Summary

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA
Guideline on the Management of Blood Cholesterol: Executive Summary

Citation
This slide set is adapted from the 2018

AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/AP
hA/ASPC/NLA/PCNA Guideline on the Management
of Blood Cholesterol: Executive Summary. Published
on [Date], available at: Journal of the American
College of Cardiology [(insert full link)] and Circulation
[(insert full link)]
The full-text guidelines are also available on the

following Web sites: ACC (www.acc.org) and
AHA (professional.heart.org)
2018 Cholesterol Guideline Writing Committee
Scott M. Grundy, MD, PhD, FAHA, Chair
Neil J. Stone, MD, FACC, FAHA, Vice Chair
Alison L. Bailey, MD, FACC, FAACVPR† Daniel W. Jones, MD, FAHA§
Craig Beam, CRE* Donald Lloyd-Jones, MD, SCM, FACC, FAHA*
Kim K. Birtcher, MS, PharmD, AACC, FNLA‡ Nuria Lopez-Pajares, MD, MPH§§
Roger S. Blumenthal, MD, FACC, FAHA, FNLA§ Chiadi E. Ndumele, MD, PhD, FAHA*
Lynne T. Braun, PhD, CNP, FAHA, FPCNA, FNLA║ Carl E. Orringer, MD, FACC, FNLA║║
Sarah de Ferranti, MD, MPH* Carmen A. Peralta, MD, MAS*
Joseph Faiella-Tommasino, PhD, PA-C¶ Joseph J. Saseen, PharmD, FNLA, FAHA¶¶
Daniel E. Forman, MD, FAHA** Sidney C. Smith, Jr, MD, MACC, FAHA*
Ronald Goldberg, MD†† Laurence Sperling, MD, FACC, FAHA, FASPC***
Paul A. Heidenreich, MD, MS, FACC, FAHA‡‡ Salim S. Virani, MD, PhD, FACC, FAHA*
Mark A. Hlatky, MD, FACC, FAHA* Joseph Yeboah, MD, MS, FACC, FAHA†††
*ACC/AHA Representative. †AACVPR Representative. ‡ACC/AHA Task Force on Clinical Practice Guidelines Liaison. §Prevention
Subcommittee Liaison. ║PCNA Representative. ¶AAPA Representative. **AGS Representative. ††ADA Representative. ‡‡PM Representative.
§§ACPM Representative. ║║NLA Representative. ¶¶APhA Representative. ***ASPC Representative. †††ABC Representative
Table 1. Applying Class
of Recommendation and
evel of Evidence to
Clinical Strategies,
Interventions,
Treatments, or
Diagnostic Testing
in Patient Care*
(Updated August 2015)
Top 10 Take-Home
Messages
2018 Cholesterol Guidelines
Top 10 Take Home Messages
1. In all individuals, emphasize a heart-healthy
lifestyle across the life course.
A healthy lifestyle reduces atherosclerotic cardiovascular
disease (ASCVD) risk at all ages. In younger individuals,
healthy lifestyle can reduce development of risk factors and is
the foundation of ASCVD risk reduction.
In young adults 20 to 39 years of age, an assessment of

lifetime risk facilitates the clinician–patient risk discussion (see
No. 6) and emphasizes intensive lifestyle efforts. In all age
groups, lifestyle therapy is the primary intervention for
metabolic syndrome.
2. In patients with clinical ASCVD, reduce low-
density lipoprotein cholesterol (LDL-C) with
high-intensity statin therapy or maximally
tolerated statin therapy.
The more LDL-C is reduced on statin therapy, the greater

will be subsequent risk reduction.
Use a maximally tolerated statin to lower LDL-C levels by

≥50%.
3. In very high-risk ASCVD, use a LDL-C threshold of 70
mg/dL (1.8 mmol/L) to consider addition of nonstatins
to statin therapy.
• Very high-risk includes a history of multiple major ASCVD events or 1
major ASCVD event and multiple high-risk conditions.
• In very high-risk ASCVD patients, it is reasonable to add ezetimibe to
maximally tolerated statin therapy when the LDL-C level remains ≥70
mg/dL (≥1.8 mmol/L).
• In patients at very high risk whose LDL-C level remains ≥70 mg/dL (≥1.8
mmol/L) on maximally tolerated statin and ezetimibe therapy, adding
a PCSK9 inhibitor is reasonable,
although the long-term safety (>3 years) is uncertain and cost-
effectiveness is low at mid-2018 list prices.
4. In patients with severe primary hypercholesterolemia
(LDL-C level ≥ 190 mg/dL[≥4.9 mmol/L]) without
calculating 10-year ASCVD risk, begin high-intensity
statin therapy without calculating 10-year ASCVD
risk.
•If the LDL-C level remains ≥100 mg/dL (≥2.6 mmol/L),
adding ezetimibe is reasonable
• If the LDL-C level on statin plus ezetimibe remains ≥100 mg/dL
(≥2.6 mmol/L) & the patient has multiple factors that increase
subsequent risk of ASCVD events, a PCSK9 inhibitor may be
considered,
although the long-term safety (>3 years) is uncertain and economic value
is low at mid-2018 list prices.
5. In patients 40 to 75 years of age with diabetes
mellitus and LDL-C ≥70 mg/dL (≥1.8 mmol/L),
start moderate-intensity statin therapy
without calculating 10-year ASCVD risk.
In patients with diabetes mellitus at higher risk,

especially those with multiple risk factors or
those 50 to 75 years of age, it is reasonable to
use a high-intensity statin to reduce the LDL-C
level by ≥50%.
6. In adults 40 to 75 years of age evaluated for primary
ASCVD prevention, have a clinician–patient risk
discussion before starting statin therapy.
Risk discussion should include a review of major risk factors
(e.g., cigarette smoking, elevated blood pressure, (LDL-C),
hemoglobin A1C [if indicated], and calculated 10-year risk of ASCVD);
• the presence of risk-enhancing factors (see No. 8);

• the potential benefits of lifestyle and statin therapies;
• the potential for adverse effects and drug–drug interactions;
• the consideration of costs of statin therapy; and
• the patient preferences & values in shared decision-making.
7. In adults 40 to 75 years of age without diabetes

mellitus and with LDL-C levels ≥70 mg/dL (≥1.8
mmol/L), at a 10-year ASCVD risk of ≥7.5%, start a
moderate-intensity statin if a discussion of
treatment options favors statin therapy.
Risk-enhancing factors favor statin therapy (see No. 8).
If risk status is uncertain, consider using coronary
artery calcium (CAC) to improve specificity (see No.
9). If statins are indicated, reduce LDL-C levels by
≥30%, and if 10-year risk is ≥20%, reduce LDL-C levels
by ≥50%.
8. In adults 40 to 75 years of age without diabetes mellitus and
10-year risk of 7.5% to 19.9% (intermediate risk), risk-
enhancing factors favor initiation of statin therapy (see No. 7).
Risk-enhancing factors include
• family history of premature ASCVD;
• persistently elevated LDL-C levels ≥160 mg/dL (≥4.1 mmol/L);
• metabolic syndrome;
• chronic kidney disease;
• history of preeclampsia or premature menopause (age <40 yrs)
• chronic inflammatory disorders (e.g., rheumatoid arthritis, psoriasis,
or chronic HIV);
• high-risk ethnic groups (e.g., South Asian);
• persistent elevations of triglycerides ≥ 175 mg/dL (≥1.97
mmol/L);
8. In adults 40 to 75 years of age without diabetes mellitus
and 10-year risk of 7.5% to 19.9% (intermediate risk), risk-
enhancing factors favor initiation of statin therapy (see No. 7).
Risk-enhancing factors include
and, if measured in selected individuals
• apolipoprotein B ≥130 mg/dL
• high-sensitivity C-reactive protein ≥2.0 mg/L
• ankle-brachial index <0.9 and l
• lipoprotein (a) ≥50 mg/dL or 125 nmol/L, especially at higher
values of lipoprotein (a).
Risk-enhancing factors may favor statin therapy in patients at 10-year

risk of 5-7.5% (borderline risk)
9. In adults 40 to 75 years of age without diabetes
mellitus and with LDL-C levels ≥70 mg/dL- 189
mg/dL (≥1.8-4.9 mmol/L), at a 10-year ASCVD risk of
≥7.5% to 19.9%, if a decision about statin therapy is
uncertain, consider measuring CAC.
• If CAC is zero, treatment with statin therapy may be withheld or
delayed, except in cigarette smokers, those with diabetes mellitus,
and those with a strong family history of premature ASCVD.
• A CAC score of 1 to 99 favors statin therapy, especially in those ≥55
years of age.
• For any patient, if the CAC score is ≥100 Agatston units or ≥75th
percentile, statin therapy is indicated unless otherwise deferred by
the outcome of clinician–patient risk discussion.
10. Assess adherence and percentage response to LDL-

C–lowering medications and lifestyle changes with
repeat lipid measurement 4 to 12 weeks after statin
initiation or dose adjustment, repeated every 3 to
12 months as needed.
• Define responses to lifestyle and statin therapy by
percentage reductions in LDL-C levels compared with
baseline.
• In ASCVD patients at very high-risk, triggers for
adding nonstatin drug therapy are defined by
threshold LDL-C levels ≥70 mg/dL (≥1.8 mmol/L) on
maximal statin therapy (see No. 3).
2018 Cholesterol Guideline
High Blood Cholesterol and ASCVD

Measurements of LDL-C and Non-HDL-C
Recommendations for Measurements of LDL-C and Non-HDL-C

COR LOE Recommendations
In adults who are 20 years of age or older and not on lipid-lowering therapy,
I B-NR measurement of either a fasting or a nonfasting plasma lipid profile is
effective in estimating ASCVD risk and documenting baseline LDL-C.
In adults who are 20 years of age or older and in whom an initial nonfasting
lipid profile reveals a triglycerides level of 400 mg/dL (≥4.5 mmol/L) or higher,
I B-NR a repeat lipid profile in the fasting state should be performed for assessment
of fasting triglyceride levels and baseline LDL-C.
Measurements of LDL-C and Non-HDL-C
Recommendations for Measurements of LDL-C and Non-HDL-C

For patients with an LDL-C level less than 70 mg/dL (<1.8 mmol/L),
IIa C-LD measurement of direct LDL-C or modified LDL-C estimate is reasonable to
improve accuracy over the Friedewald formula.
In adults who are 20 years of age or older and without a personal history of
ASCVD but with a family history of premature ASCVD or genetic
hyperlipidemia, measurement of a fasting plasma lipid profile is reasonable
IIa C-LD
as part of an initial evaluation to aid in the understanding and identification
of familial lipid disorders.
Patient Management Groups

Secondary ASCVD Prevention
Recommendations for Statin Therapy Use in Patients With ASCVD

In patients who are 75 years of age or younger with clinical
ASCVD,* high-intensity statin therapy should be initiated or
I A continued with the aim of achieving a 50% or greater
reduction in LDL-C levels.
In patients with clinical ASCVD in whom high-intensity statin

therapy is contraindicated or who experience statin-
associated side effects, moderate-intensity statin therapy
I A
should be initiated or continued with the aim of achieving a
30% to 49% reduction in LDL-C levels.

In patients with clinical ASCVD who are judged to be very
high risk and considered for PCSK9 inhibitor therapy,
I B-NR maximally tolerated LDL-C lowering therapy should include
maximally tolerated statin therapy and ezetimibe.
In patients with clinical ASCVD who are judged to be very

high risk and who are on maximally tolerated LDL-C lowering
therapy with LDL-C 70 mg/dL (≥1.8 mmol/L) or higher or a
IIa ASR non-HDL-C level of 100 mg/dL (≥2.6 mmol/L) or higher, it is
reasonable to add a PCSK9 inhibitor following a clinician–
patient discussion about the net benefit, safety, and cost.

In patients with clinical ASCVD who are on maximally
tolerated statin therapy and are judged to be at very high
IIa B-R risk and have an LDL-C level of 70 mg/dL (≥1.8 mmol/L) or
higher, it is reasonable to add ezetimibe therapy.
At mid-2018 list prices, PCSK9 inhibitors have a low cost

Value value (>$150,000 per QALY) compared to good cost value
Statement: (<$50,000 per QALY) (Section 7 provides a full discussion of
Low Value the dynamic interaction of different prices and clinical
(LOE: B-NR) benefit).

In patients older than 75 years of age with clinical ASCVD, it
is reasonable to initiate moderate- or high-intensity statin
therapy after evaluation of the potential for ASCVD risk
IIa B-R
reduction, adverse effects, and drug–drug interactions, as
well as patient frailty and patient preferences.
In patients older than 75 years of age who are tolerating

high-intensity statin therapy, it is reasonable to continue
high-intensity statin therapy after evaluation of the
IIa C-LD potential for ASCVD risk reduction, adverse effects, and
drug-drug interactions, as well as patient frailty and patient
preferences.

In patients with clinical ASCVD who are receiving maximally
tolerated statin therapy and whose LDL-C level remains 70
IIb B-R mg/dL (≥1.8 mmol/L) or higher, it may be reasonable to add
ezetimibe.
In patients with heart failure (HF) with reduced ejection

fraction attributable to ischemic heart disease who have a
reasonable life expectancy (3 to 5 years) and are not
IIb B-R already on a statin because of ASCVD, clinicians may
consider initiation of moderate-intensity statin therapy to
reduce the occurrence of ASCVD events.
Secondary Prevention
Table 4. Very High-Risk* of Future ASCVD
Events
Major ASCVD Events

Recent ACS (within the past 12 mo)
History of MI (other than recent ACS event listed above)
History of ischemic stroke
Symptomatic peripheral arterial disease (history of
claudication with ABI <0.85, or previous revascularization or
amputation)
Table 4 continued
High-Risk Conditions
Age ≥65 y
Heterozygous familial hypercholesterolemia
History of prior coronary artery bypass surgery or percutaneous coronary
intervention outside of the major ASCVD event(s)
Diabetes mellitus
Hypertension
CKD (eGFR 15-59 mL/min/1.73 m2)
Current smoking
Persistently elevated LDL-C (LDL-C ≥100 mg/dL [≥2.6 mmol/L]) despite
maximally tolerated statin therapy and ezetimibe
History of congestive HF
Severe Hypercholesterolemia (LDL-C ≥190
mg/dL [≥4.9 mmol/L])
Recommendations for Primary Severe Hypercholesterolemia (LDL-C ≥190
In patients 20 to 75 years of age with an LDL-C level of 190
I B-R mg/dL (≥4.9 mmol/L) or higher, maximally tolerated statin
therapy is recommended.
In patients 20 to 75 years of age with an LDL-C level of 190
mg/dL (≥4.9 mmol/L) or higher who achieve less than a
50% reduction in LDL-C while receiving maximally tolerated
IIa B-R statin therapy and/or have an LDL-C level of 100 mg/dL
(≥2.6 mmol/L) or higher, ezetimibe therapy is reasonable.
Recommendations for Primary Severe Hypercholesterolemia (LDL-C ≥190 mg/dL
[≥4.9 mmol/L])
In patients 20 to 75 years of age with a baseline LDL-C level
≥190 mg/dL (≥4.9 mmol/L), who achieve less than a 50%
reduction in LDL-C levels and have fasting triglycerides ≤300
IIb B-R mg/dL (≤3.4 mmol/L). while taking maximally tolerated statin
and ezetimibe therapy, the addition of a bile acid sequestrant
may be considered.
In patients 30 to 75 years of age with heterozygous FH and

with an LDL-C level of 100 mg/dL (≥2.6 mmol/L) or higher
IIb B-R while taking maximally tolerated statin and ezetimibe
therapy, the addition of a PCSK9 inhibitor may be considered.
Recommendations for Primary Severe Hypercholesterolemia (LDL-C ≥190 mg/dL
[≥4.9 mmol/L])
In patients 40 to 75 years of age with a baseline LDL-C level of
220 mg/dL (≥5.7 mmol/L) or higher and who achieve an on-
treatment LDL-C level of 130 mg/dL (≥3.4 mmol/L) or higher
IIb C-LD
while receiving maximally tolerated statin and ezetimibe
therapy, the addition of a PCSK9 inhibitor may be considered.
Among patients with FH without evidence of clinical ASCVD

Value
taking maximally tolerated statin and ezetimibe therapy,
Statement:
PCSK9 inhibitors provide uncertain value at 2018 U.S. list
Uncertain
prices.
Value
(B-NR)
Diabetes Mellitus in Adults
Recommendations for Patients With Diabetes Mellitus

In adults 40 to 75 years of age with diabetes mellitus,
I A regardless of estimated 10-year ASCVD risk, moderate-
intensity statin therapy is indicated.
In adults 40 to 75 years of age with diabetes mellitus and an
LDL-C level of 70 to 189 mg/dL (1.7 to 4.8 mmol/L), it is
reasonable to assess the 10-year risk of a first ASCVD event
IIa B-NR
by using the race and sex-specific PCE to help stratify ASCVD
risk.

In adults with diabetes mellitus who have multiple ASCVD
IIa B-R risk factors, it is reasonable to prescribe high-intensity statin
therapy with the aim to reduce LDL-C levels by 50% or more.
In adults older than 75 years of age with diabetes mellitus
IIa B-NR and who are already on statin therapy, it is reasonable to
continue statin therapy.
In adults with diabetes mellitus and 10-year ASCVD risk of
20% or higher, it may be reasonable to add ezetimibe to
IIb C-LD maximally tolerated statin therapy to reduce LDL-C levels by
50% or more.

In adults older than 75 years with diabetes mellitus, it may be
IIb C-LD reasonable to initiate statin therapy after a clinician–patient
discussion of potential benefits and risks.
In adults 20 to 39 years of age with diabetes mellitus that is
either of long duration (≥10 years of type 2 diabetes mellitus,
≥20 years of type 1 diabetes mellitus), albuminuria (≥30 mcg
of albumin/mg creatinine), estimated glomerular filtration
IIb C-LD rate (eGFR) less than 60 mL/min/1.73 m2, retinopathy,
neuropathy, or ankle-brachial index (ABI; <0.9), it may be
reasonable to initiate statin therapy.
Table 5. Diabetes-Specific Risk Enhancers That Are
Independent of Other Risk Factors in Diabetes Mellitus
Risk Enhancers
 Long duration (≥10 years for type 2 diabetes mellitus (S.4.3-20) or ≥20
years for type 1 diabetes mellitus)
 Albuminuria ≥30 mcg of albumin/mg creatinine
 eGFR <60 mL/min/1.73 m2
 Retinopathy
 Neuropathy
 ABI <0.9
Table 6. Risk-Enhancing Factors for Clinician–
Patient Risk Discussion
Risk-Enhancing Factors
 Family history of premature ASCVD (males, age <55 y; females, age <65 y)
 Primary hypercholesterolemia (LDL-C, 160–189 mg/dL [4.1–4.8 mmol/L); non–HDL-
C 190–219 mg/dL [4.9–5.6 mmol/L])*
 Metabolic syndrome (increased waist circumference, elevated triglycerides [>175
mg/dL], elevated blood pressure, elevated glucose, and low HDL-C [<40 mg/dL in
men; <50 in women mg/dL] are factors; tally of 3 makes the diagnosis)
 Chronic kidney disease (eGFR 15–59 mL/min/1.73 m2 with or without albuminuria;
not treated with dialysis or kidney transplantation)
 Chronic inflammatory conditions such as psoriasis, RA, or HIV/AIDS
 History of premature menopause (before age 40 y) and history of pregnancy-
associated conditions that increase later ASCVD risk such as preeclampsia
 High-risk race/ethnicities (e.g., South Asian ancestry)
Table 6 continued
Risk-Enhancing Factors
 Lipid/biomarkers: Associated with increased ASCVD risk
o Persistently* elevated, primary hypertriglyceridemia (≥175 mg/dL);
o If measured:
 Elevated high-sensitivity C-reactive protein (≥2.0 mg/L)
 Elevated Lp(a): A relative indication for its measurement is family
history of premature ASCVD. An Lp(a) ≥50 mg/dL or ≥125 nmol/L
constitutes a risk-enhancing factor especially at higher levels of Lp(a).
 Elevated apoB ≥130 mg/dL: A relative indication for its measurement
would be triglyceride ≥200 mg/dL. A level ≥130 mg/dL corresponds to
an LDL-C >160 mg/dL and constitutes a risk-enhancing factor
 ABI <0.9
Primary Prevention Adults 40 to 75 Years of Age
With LDL-C Levels 70 to 189 mg/dL (1.7–4.8
mmol/L)
Primary Prevention Recommendations for Adults 40 to 75 Years of Age With
LDL Levels 70 to 189 mg/dL (1.7–4.8 mmol/L)
In adults at intermediate-risk, statin therapy reduces risk of
ASCVD, and in the context of a risk discussion, if a decision is
I A made for statin therapy, a moderate-intensity statin should be
recommended.
In intermediate-risk patients, LDL-C levels should be reduced by

I A 30% or more, and for optimal ASCVD risk reduction, especially
in high-risk patients, levels should be reduced by 50% or more.
mmol/L)
Primary Prevention Recommendations for Adults 40 to 75 Years of Age With LDL
Levels 70 to 189 mg/dL (1.7–4.8 mmol/L)
For the primary prevention of clinical ASCVD* in adults 40 to 75 years
of age without diabetes mellitus and with an LDL-C level of 70 to 189
mg/dL (1.7 to 4.8 mmol/L), the 10-year ASCVD risk of a first “hard”
ASCVD event (fatal and nonfatal MI or stroke) should be estimated by
I B-NR using the race- and sex-specific PCE, and adults should be categorized
as being at low risk (<5%), borderline risk (5% to <7.5%), intermediate-
risk (≥7.5% to <20%), and high-risk (≥20%).
Clinicians and patients should engage in a risk discussion that considers

risk factors, adherence to healthy lifestyle, the potential for ASCVD
risk-reduction benefits, and the potential for adverse effects and drug–
I B-NR
drug interactions, as well as patient preferences, for an individualized
treatment decision.
mmol/L)
In intermediate-risk adults, risk-enhancing factors favor
IIa B-R initiation or intensification of statin therapy.
In intermediate-risk or selected borderline-risk adults, if the

decision about statin use remains uncertain, it is reasonable to
IIa B-NR use a CAC score in the decision to withhold, postpone or initiate
statin therapy.
mmol/L)
Primary Prevention Recommendations for Adults 40 to 75 Years of Age With LDL Levels 70
to 189 mg/dL (1.7–4.8 mmol/L)
In intermediate-risk adults or selected borderline-risk adults in whom a
CAC score is measured for the purpose of making a treatment decision,
AND
 If the coronary calcium score is zero, it is reasonable to withhold statin
therapy and reassess in 5 to 10 years, as long as higher risk conditions
are absent (diabetes mellitus, family history of premature CHD,
IIa B-NR cigarette smoking);
 If CAC score is 1 to 99, it is reasonable to initiate statin therapy for
patients ≥55 years of age;
 If CAC score is 100 or higher or in the 75th percentile or higher, it is
reasonable to initiate statin therapy.
mmol/L)
In intermediate-risk adults who would benefit from more
aggressive LDL-C lowering and in whom high-intensity statins
are advisable but not acceptable or tolerated, it may be
IIb B-R
reasonable to add a nonstatin drug (ezetimibe or bile acid
sequestrant) to a moderate-intensity statin.
In patients at borderline risk, in risk discussion, the presence of

IIb B-R risk-enhancing factors may justify initiation of moderate-
intensity statin therapy.
Table 7. Checklist for Clinician–Patient Shared
Decision-Making for Initiating Therapy
Checklist Item Recommendation
ASCVD risk  Assign to statin treatment group; use ASCVD Risk Estimator Plus.*
assessment o In lower-risk primary-prevention adults 40-75 y of age with LDL-C ≥70
mg/dL (≥1.8 mmol/L).
o Not needed in secondary prevention, in those with LDL-C ≥190 mg/dL
(≥4.9 mmol/L), or in those 40-75 y of age with diabetes mellitus.
 Assess other patient characteristics that influence risk. See Risk-Enhancing
Factors (Section 4.4.1.3. and Table 6)
 Assess CAC (Section 4.4.1.4.) if risk decision is uncertain and additional
information is needed to clarify ASCVD risk.
o Use decision tools to explain risk (e.g., ASCVD Risk Estimator Plus,*
Mayo Clinic Statin Choice Decision Aid).
Lifestyle  Review lifestyle habits (e.g., diet, physical activity, weight or body mass
modifications index, and tobacco use).
 Endorse a healthy lifestyle and provide relevant advice, materials, or
referrals. (e.g., CardioSmart, AHA Life’s Simple 7, NLA Patient Tear Sheets,
PCNA Clinicians’ Lifestyle Modification Toolbox, cardiac rehabilitation,
dietitian, smoking cessation program).
Table 7 continued

Potential net clinical  Recommend statins as first-line therapy.
benefit of  Consider the combination of statin and nonstatin
pharmacotherapy therapy in selected patients.
 Discuss potential risk reduction from lipid-lowering
therapy.
 Discuss the potential for adverse effects or drug–
drug interactions.
Table 7 continued

Cost  Discuss potential out-of-pocket cost of therapy to the
considerations patient (e.g., insurance plan coverage, tier level,
copayment).
Shared  Encourage the patient to verbalize what was heard (e.g.,
decision-making patient’s personal ASCVD risk, available options, and
risks/benefits).
 Invite the patient to ask questions, express values and
preferences, and state ability to adhere to lifestyle
changes and medications.
 Refer patients to trustworthy materials to aid in their
understanding of issues regarding risk decisions.
 Collaborate with the patient to determine therapy and
follow-up plan.
Table 8. Selected Examples of Candidates for CAC
Measurement Who Might Benefit From Knowing Their CAC
Score Is Zero
CAC Measurement Candidates Who Might Benefit from Knowing Their CAC
Score Is Zero
 Patients reluctant to initiate statin therapy who wish to understand their
risk and potential for benefit more precisely
 Patients concerned about need to reinstitute statin therapy after
discontinuation for statin-associated symptoms
 Older patients (men, 55-80 y of age; women, 60-80 y of age) with low
burden of risk factors who question whether they would benefit from
statin therapy
 Middle-aged adults (40-55 y of age) with PCE-calculated 10-year risk of
ASCVD 5% to <7.5% with factors that increase their ASCVD risk, although
they are in a borderline risk group
Monitoring in Response to LDL-C–Lowering
Therapy
Recommendation for Monitoring

COR LOE Recommendation
Adherence to changes in lifestyle and effects of LDL-C–
lowering medication should be assessed by measurement of
fasting lipids and appropriate safety indicators 4 to 12 weeks
I A after statin initiation or dose adjustment and every 3 to 12
months thereafter based on need to assess adherence or
safety.
Primary Prevention in Other Age Groups (Older
Adults)
Recommendations for Older Adults
In adults 75 years of age or older with an LDL-C level of 70 to
IIb B-R 189 mg/dL (1.7 to 4.8 mmol/L), initiating a moderate-intensity
statin may be reasonable.
In adults 75 years of age or older, it may be reasonable to stop
statin therapy when functional decline (physical or cognitive),
IIb B-R multimorbidity, frailty, or reduced life-expectancy limits the
potential benefits of statin therapy.
In adults 76 to 80 years of age with an LDL-C level of 70 to 189

mg/dL (1.7 to 4.8 mmol/L), it may be reasonable to measure
IIb B-R CAC to reclassify those with a CAC score of zero to avoid statin
therapy.
Primary Prevention in Other Age Groups
(Children and Adolescents)
Recommendations for Children and Adolescents

In children and adolescents with lipid disorders related to
obesity, it is recommended to intensify lifestyle therapy,
I A including moderate caloric restriction and regular aerobic
physical activity.
I B-NR In children and adolescents with lipid abnormalities,

lifestyle counseling is beneficial for lowering LDL-C.
In children and adolescents 10 years of age or older with an LDL-C
level persistently 190 mg/dL (≥4.9 mmol/L) or higher or 160 mg/dL
(4.1 mmol/L) or higher with a clinical presentation consistent with
IIa B-R FH (see Section 4.2.) and who do not respond adequately with 3 to
6 months of lifestyle therapy, it is reasonable to initiate statin
therapy.
In children and adolescents with a family history of either early

CVD* or significant hypercholesterolemia,† it is reasonable to
measure a fasting or nonfasting lipoprotein profile as early as age
IIa B-NR
2 years to detect FH or rare forms of hypercholesterolemia.
In children and adolescents found to have moderate or
severe hypercholesterolemia, it is reasonable to carry out
reverse-cascade screening of family members, which
IIa B-NR includes cholesterol testing for first-, second-, and when
possible, third-degree biological relatives, for detection of
familial forms of hypercholesterolemia.
In children and adolescents with obesity or other metabolic

risk factors, it is reasonable to measure a fasting lipid
IIa C-LD profile to detect lipid disorders as components of the
metabolic syndrome.

In children and adolescents without cardiovascular risk
factors or family history of early CVD, it may be reasonable
to measure a fasting lipid profile or nonfasting non HDL-C
IIb B-NR once between the ages of 9 and 11 years, and again
between the ages of 17 and 21 years, to detect moderate to
severe lipid abnormalities.
Table 9. Normal and Abnormal Lipid Values
in Childhood*†
Acceptable, Borderline, Abnormal,

mg/dL mg/dL mg/dL
170-199 (4.3-5.1
TC <170 (<4.3 mmol) ≥200 (≥5.1 mmol)
mmol)
Triglycerides (0-9
<75 (<0.8 mmol) 75-99 (0.8-1.1 mmol) ≥100 (≥1.1 mmol)
y)
Triglycerides (10-
<90 (<1.0 mmol) 90-129 (1.0-1.5 mmol) ≥130 (≥1.4 mmol)
19 y)
HDL-C >45 (>1.2 mmol) 40-45 (1.0-1.2 mmol) <40 (<1.0 mmol)
110-129 (2.8-3.3
LDL-C <110 (<2.8 mmol) ≥130 (≥3.4 mmol)
mmol)
120-144 (3.1-3.7
Non-HDL-C <120 (<3.1 mmol) ≥145 (≥3.7 mmol)
mmol)
Other Populations at Risk (Ethnicity)
Recommendation for Other Populations at Risk

COR LOE Recommendation
For clinical decision-making in adults of different
race/ethnicities, it is reasonable for clinicians to review
IIa B-NR race/ethnic features that can influence ASCVD risk so as to
adjust choice of statin or intensity of treatment.
Table 10. Racial/Ethnic Issues in Evaluation, Risk
Decisions, and Treatment of ASCVD Risk
Racial/Ethnic Groupings
Asian Americans* Hispanic/Latino Americans† Blacks Comments
Evaluation
ASCVD issues informed by ASCVD risk in people of South Race/ethnicity and country of origin, ASCVD risk assessment in black There is heterogeneity in risk according
race/ethnicity Asian and East Asian origin varies together with socioeconomic status women shows increased ASCVD to racial/ethnic group and within
by country of origin; individuals and acculturation level, may explain risk compared with their racial/ethnic groups. Native
from South Asia (see below) risk factor burden more precisely (e.g., otherwise similar white American/Alaskan populations have
have increased ASCVD risk. ASCVD risk is higher among individuals counterparts. high rates of risk factors for ASCVD
from Puerto Rico than those from compared to non-Hispanic whites.
Mexico).
Lipid issues informed by Asian Americans have lower Hispanic/Latino women have higher Blacks have higher levels of All ethnic groups appear to be at
race/ethnicity levels of HDL-C than whites. prevalence of low HDL-C compared HDL-C and lower levels of greater risk for dyslipidemia, but
There is higher prevalence of with Hispanic/Latino men. triglycerides than non-Hispanic important to identify those with more
LDL-C among Asian Indians, whites or Mexican Americans. sedentary behavior and less favorable
Filipinos, Japanese, and diet.
Vietnamese than among whites.
An increased prevalence of high
TG was seen in all Asian
American subgroups.
Metabolic issues informed Increased MetS is seen with DM is disproportionately present There is increased DM and There is increased prevalence of DM.
by race/ethnicity lower waist circumference than compared with whites and blacks. hypertension. Features of MetS vary by
in whites. There is increased prevalence of MetS race/ethnicity. Waist circumference,
DM develops at a lower lean and DM in Mexican Americans not weight, should be used to
body mass and at earlier ages. compared with whites and Puerto determine abdominal adiposity when
Majority of risk in South Asians is Ricans. possible.
explained by known risk factors,
especially those related to
insulin resistance.
Table 10 continued
Treatment
Lifestyle counseling (use Use lifestyle counseling to Use lifestyle counseling to recommend Use lifestyle counseling to Asian and Hispanic/Latino groups need
principles of Mediterranean recommend a heart-healthy diet a heart-healthy diet consistent with recommend a heart-healthy diet to be disaggregated because of
and DASH diets) consistent with racial/ethnic racial/ethnic preferences to avoid consistent with racial/ethnic regional differences in lifestyle
preferences to avoid weight gain weight gain and address BP and lipids. preferences to avoid weight preferences. Challenge is to avoid
and address BP and lipids. gain and address BP and lipids. increased sodium, sugar, and calories
as groups acculturate.
Intensity of statin therapy Japanese patients may be No sensitivity to statin dosage is seen, No sensitivity to statin dosage is Using a lower statin intensity in
and response to LDL-C sensitive to statin dosing. In an as compared with non-Hispanic white seen, as compared with non- Japanese patients may give results
lowering open-label, randomized primary- or black individuals. Hispanic white individuals. similar to those seen with higher
prevention trial, Japanese intensities in non-Japanese patients.
participants had a reduction in
CVD events with low-intensity
doses of pravastatin as
compared with placebo. In a
secondary-prevention trial,
Japanese participants with CAD
benefitted from a moderate-
intensity dose of pitavastatin.
Safety Higher rosuvastatin plasma There are no specific safety issues with Baseline serum CK values are Clinicians should take Asian race into
levels are seen in Japanese, statins related to Hispanic/Latino higher in blacks than in whites. account when prescribing dose of
Chinese, Malay, and Asian ethnicity. The 95th percentile rosuvastatin (See package insert). In
Indians as compared with race/ethnicity- specific and sex- adults of East Asian descent, other
whites. FDA recommends a specific serum CK normal levels statins should be used preferentially
lower starting dose (5 mg of are available for assessing over simvastatin.
rosuvastatin in Asians versus 10 changes in serum CK.
mg in whites). Caution is urged
as dose is uptitrated.
Table 10 continued
Risk Decisions
PCE No separate PCE is No separate PCE is available; Use PCE for blacks. Country-specific
available; use PCE for use PCE for non-Hispanic race/ethnicity, along with
whites. PCE may whites. If African-American socioeconomic status, may
underestimate ASCVD ancestry is also present, affect estimation of risk by
risk in South Asians. PCE then use PCE for blacks. PCE.
may overestimate risk in
East Asians.
CAC score In terms of CAC burden, CAC predicts similarly in In MESA, CAC score was Risk factor differences in
South Asian men were whites and in those who highest in white and MESA between ethnicities
similar to non-Hispanic identify as Hispanic/Latino. Hispanic men, with did not fully explain
white men, but higher blacks having variability in CAC. However,
CAC when than blacks, significantly lower CAC predicted ASCVD events
Latinos, and Chinese prevalence and severity over and above traditional
Americans. South Asian of CAC. risk factors in all ethnicities.
women had similar CAC
scores to whites and
other racial/ethnic
women, although CAC
burden higher in older
age.
Hypertriglyceridemia
Recommendations for Hypertriglyceridemia
In adults 20 years of age or older with moderate
hypertriglyceridemia (fasting or nonfasting triglycerides 175 to 499
mg/dL [1.9 to 5.6 mmol/L]), clinicians should address and treat
lifestyle factors (obesity and metabolic syndrome), secondary
I B-NR factors (diabetes mellitus, chronic liver or kidney disease and/or
nephrotic syndrome, hypothyroidism), and medications that
increase triglycerides.
In adults 40 to 75 years of age with moderate or severe

hypertriglyceridemia and ASCVD risk of 7.5% or higher, it is
reasonable to reevaluate ASCVD risk after lifestyle and secondary
IIa B-R factors are addressed and to consider a persistently elevated
triglyceride level as a factor favoring initiation or intensification of
statin therapy (see Section 4.4.2.).
Hypertriglyceridemia
Recommendations for Hypertriglyceridemia
In adults 40 to 75 years of age with severe hypertriglyceridemia
(fasting triglycerides ≥500 mg/dL [≥5.6 mmol/L]) and ASCVD risk of
IIa B-R 7.5% or higher, it is reasonable to address reversible causes of high
triglyceride and to initiate statin therapy.
In adults with severe hypertriglyceridemia (fasting triglycerides

≥500 mg/dL [≥5.7 mmol/L]), and especially fasting triglycerides
≥1000 mg/dL (11.3 mmol/L)), it is reasonable to identify and
address other causes of hypertriglyceridemia), and if triglycerides
are persistently elevated or increasing, to further reduce
IIa B-NR triglycerides by implementation of a very low-fat diet, avoidance
of refined carbohydrates and alcohol, consumption of omega-3
fatty acids, and, if necessary to prevent acute pancreatitis, fibrate
therapy.
Issues Specific to Women
Recommendations for Issues Specific to Women
Clinicians should consider conditions specific to women, such as
premature menopause (age <40 years) and history of pregnancy-
associated disorders (hypertension, preeclampsia, gestational
I B-NR diabetes mellitus, small-for-gestational-age infants, preterm
deliveries), when discussing lifestyle intervention and the potential
for benefit of statin therapy.
Women of childbearing age who are treated with statin therapy and
I C-LD are sexually active should be counseled to use a reliable form of
contraception.
Women of childbearing age with hypercholesterolemia who plan to
become pregnant should stop the statin 1 to 2 months before
pregnancy is attempted, or if they become pregnant while on a statin,
I C-LD
should have the statin stopped as soon as the pregnancy is
discovered.
Adults With Chronic Kidney Disease
Recommendations for Adults With CKD
In adults 40 to 75 years of age with LDL-C 70 to 189 mg/dL (1.7
to 4.8 mmol/L) who are at 10-year ASCVD risk of 7.5% or
higher, CKD not treated with dialysis or kidney transplantation
IIa B-R is a risk-enhancing factor and initiation of a moderate-intensity
statin or moderate-intensity statins combined with ezetimibe
can be useful.
In adults with advanced kidney disease that requires dialysis

IIb C-LD treatment who are currently on LDL-lowering therapy with a
statin, it may be reasonable to continue the statin.
III: No In adults with advanced kidney disease who require dialysis

B-R treatment, initiation of a statin is not recommended.
Benefit
Adults With Chronic Inflammatory Disorders
and HIV
Recommendations for Adults With Chronic Inflammatory Disorders and HIV
In adults 40 to 75 years of age with LDL-C 70 to 189 mg/dL (1.7 to 4.8
mmol/L) who have a 10-year ASCVD risk of 7.5% or higher, chronic
inflammatory disorders and HIV are risk-enhancing factors and in risk
IIa B-NR discussion favor moderate-intensity statin therapy or high-intensity
statin therapy.
In patients with chronic inflammatory disorders or HIV, a fasting lipid

profile and assessment of ASCVD risk factors can be useful as a) a guide
to benefit of statin therapy and b) for monitoring or adjusting lipid-
IIa B-NR lowering drug therapy before and 4 to 12 weeks after starting
inflammatory disease–modifying therapy or antiretroviral therapy.
In adults with RA who undergo ASCVD risk assessment with

measurement of a lipid profile, it can be useful to recheck lipid values
IIa B-NR and other major ASCVD risk factors 2 to 4 months after the patient’s
inflammatory disease has been controlled.
Statin Safety and Statin-Associated

Side Effects
Statin Safety and Statin-Associated Side
Effects
Recommendations for Statin Safety and Statin-Associated Side Effects
A clinician–patient risk discussion is recommended before
initiation of statin therapy to review net clinical benefit,
weighing the potential for ASCVD risk reduction against
I A the potential for statin-associated side effects, statin–drug
interactions, and safety, while emphasizing that side
effects can be addressed successfully.
In patients with statin-associated muscle symptoms

(SAMS), a thorough assessment of symptoms is
I A recommended, in addition to an evaluation for nonstatin
causes and predisposing factors.
Effects
In patients with indication for statin therapy, identification
of potential predisposing factors for statin-associated side
I B-R effects, including new-onset diabetes mellitus and SAMS,
is recommended before initiation of treatment.
In patients with statin-associated side effects that are not
severe, it is recommended to reassess and to rechallenge
to achieve a maximal LDL-C lowering by modified dosing
I B-R
regimen, an alternate statin or in combination with
nonstatin therapy.
Effects
In patients with increased diabetes mellitus risk or new-onset
diabetes mellitus, it is recommended to continue statin therapy,
with added emphasis on adherence, net clinical benefit, and the
I B-R core principles of regular moderate-intensity physical activity,
maintaining a healthy dietary pattern, and sustaining modest
weight loss.
In patients treated with statins, it is recommended to measure

creatine kinase levels in individuals with severe statin-associated
muscle symptoms, objective muscle weakness, and to measure
liver transaminases (aspartate aminotransferase, alanine
I C-LD aminotransferase) as well as total bilirubin and alkaline
phosphatase (hepatic panel) if there are symptoms suggesting
hepatotoxicity.
Effects
In patients at increased ASCVD risk with chronic, stable
liver disease (including non-alcoholic fatty liver disease)
when appropriately indicated, it is reasonable to use
I B-R statins after obtaining baseline measurements and
determining a schedule of monitoring and safety checks.
In patients at increased ASCVD risk with severe statin-

associated muscle symptoms or recurrent statin-associated
muscle symptoms despite appropriate statin rechallenge,
IIa B-R it is reasonable to use RCT proven nonstatin therapy that is
likely to provide net clinical benefit.
Effects

III: No Coenzyme Q10 is not recommended for routine use in
B-R patients treated with statins or for the treatment of SAMS.
Benefit
III: No In patients treated with statins, routine measurements of
C-LD creatine kinase and transaminase levels are not useful.
Benefit
Table 11. Statin-Associated Side Effects
Statin-Associated Side Effects Frequency Predisposing Factors Quality of Evidence
Statin-associated muscle symptoms (SAMS)
Myalgias (CK Normal) Infrequent (1% to 5%) in RCTs; Age, female sex, low body mass RCTs
frequent (5% to 10%) in index, high-risk medications cohorts/observational
observational studies and clinical (CYP3A4 inhibitors, OATP1B1
setting inhibitors), comorbidities (HIV,
renal, liver, thyroid, preexisting
myopathy), Asian ancestry,
excess alcohol, high levels of
physical activity, and trauma
Myositis/myopathy Rare RCTs

(CK > ULN) with concerning cohorts/observational
symptoms or objective
weakness
Rhabdomyolysis Rare RCTs
(CK >10× ULN + renal cohorts/observational
injury)
Statin-associated Rare Case reports
autoimmune myopathy
(HMGCR antibodies,
incomplete resolution)
New-onset diabetes Depends on population; more Diabetes mellitus risk RCTs/meta-analyses
frequent if diabetes mellitus risk factors/metabolic syndrome
mellitus factors are present, such as body High-intensity statin therapy
mass index ≥30, fasting blood sugar
≥100 mg/dL; metabolic syndrome,
or A1c ≥6%.
Statin-Associated Side
Effects Frequency Predisposing Factors Quality of Evidence
Liver
Transaminase elevation
3× ULN Infrequent RCTs/
cohorts/observational
Case reports
Hepatic failure Rare
Central nervous system
Memory/cognition Rare/unclear Case reports; no
increase in
memory/cognition
problems in 3 large-scale
RCTs
Cancer No definite association RCTs/meta-analyses

Statin-Associated Predisposing
Side Effects Frequency Factors Quality of Evidence
Other
Renal function Unclear/unfounded
Cataracts Unclear
Tendon rupture Unclear/unfounded
Hemorrhagic stroke Unclear
Interstitial lung Unclear/unfounded
disease
Low testosterone Unclear/unfounded
Implementation
Implementation
Recommendations for Implementation

Interventions focused on improving adherence to prescribed therapy are
recommended for management of adults with elevated cholesterol levels,
including telephone reminders, calendar reminders, integrated
I A
multidisciplinary educational activities, and pharmacist-led interventions,
such as simplification of the drug regimen to once-daily dosing.
Clinicians, health systems, and health plans should identify patients who are
not receiving guideline-directed medical therapy and should facilitate the
I B-NR initiation of appropriate guideline-directed medical therapy, using
multifaceted strategies to improve guideline implementation.
Before therapy is prescribed, a patient-clinician discussion should take place
to promote shared decision-making and should include the potential for
I B-NR ASCVD risk-reduction benefit, adverse effects, drug-drug interactions, and
patient preferences.
Cost and Value Considerations

Table 12. Proposed Integration of Level of Value Into Clinical
Guideline Recommendations*
Level of Value
Level of Value
High value: Better outcomes at lower cost or ICER <$50,000 per QALY gained
Intermediate value: $50,000 to <$150,000 per QALY gained
Low value: ≥$150,000 per QALY gained
Uncertain value: Value examined, but data are insufficient to draw a
conclusion because of absence of studies, low-quality studies, conflicting
studies, or prior studies that are no longer relevant
Not assessed: Value not assessed by the writing committee
Proposed abbreviations for each value recommendation:

Level of value: H to indicate high value; I, intermediate value; L, low value; U,
uncertain value; and NA, value not assessed.
Figure 3. Cost-Effectiveness Analysis for PCSK9 Inhibitors

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2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA

Guideline on the Management of Blood Cholesterol: Executive Summary

This slide set is adapted from the 2018

The full-text guidelines are also available on the

In young adults 20 to 39 years of age, an assessment of

The more LDL-C is reduced on statin therapy, the greater

Use a maximally tolerated statin to lower LDL-C levels by

In patients with diabetes mellitus at higher risk,

• the presence of risk-enhancing factors (see No. 8);

7. In adults 40 to 75 years of age without diabetes

Risk-enhancing factors may favor statin therapy in patients at 10-year

10. Assess adherence and percentage response to LDL-

High Blood Cholesterol and ASCVD

Recommendations for Measurements of LDL-C and Non-HDL-C

Recommendations for Measurements of LDL-C and Non-HDL-C

Patient Management Groups

Recommendations for Statin Therapy Use in Patients With ASCVD

In patients with clinical ASCVD in whom high-intensity statin

Recommendations for Statin Therapy Use in Patients With ASCVD

In patients with clinical ASCVD who are judged to be very

Recommendations for Statin Therapy Use in Patients With ASCVD

At mid-2018 list prices, PCSK9 inhibitors have a low cost

Recommendations for Statin Therapy Use in Patients With ASCVD

In patients older than 75 years of age who are tolerating

Recommendations for Statin Therapy Use in Patients With ASCVD

In patients with heart failure (HF) with reduced ejection

Major ASCVD Events

In patients 30 to 75 years of age with heterozygous FH and

Among patients with FH without evidence of clinical ASCVD

Recommendations for Patients With Diabetes Mellitus

Recommendations for Patients With Diabetes Mellitus

Recommendations for Patients With Diabetes Mellitus

In intermediate-risk patients, LDL-C levels should be reduced by

Clinicians and patients should engage in a risk discussion that considers

In intermediate-risk or selected borderline-risk adults, if the

In patients at borderline risk, in risk discussion, the presence of

Checklist Item Recommendation

Checklist Item Recommendation

Recommendation for Monitoring

In adults 76 to 80 years of age with an LDL-C level of 70 to 189

Recommendations for Children and Adolescents

I B-NR In children and adolescents with lipid abnormalities,

In children and adolescents with a family history of either early

In children and adolescents with obesity or other metabolic

Recommendations for Children and Adolescents

Recommendation for Other Populations at Risk

In adults 40 to 75 years of age with moderate or severe

In adults with severe hypertriglyceridemia (fasting triglycerides

In adults with advanced kidney disease that requires dialysis

III: No In adults with advanced kidney disease who require dialysis

In patients with chronic inflammatory disorders or HIV, a fasting lipid

In adults with RA who undergo ASCVD risk assessment with

Statin Safety and Statin-Associated

In patients with statin-associated muscle symptoms

In patients treated with statins, it is recommended to measure

In patients at increased ASCVD risk with severe statin-

Recommendations for Statin Safety and Statin-Associated Side Effects

Myositis/myopathy Rare RCTs

Cancer No definite association RCTs/meta-analyses